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Protein

Extracellular globin-4

Gene
N/A
Organism
Lumbricus terrestris (Common earthworm)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi101Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular globin-4
Alternative name(s):
Erythrocruorin
Globin A
Globin IV
OrganismiLumbricus terrestris (Common earthworm)
Taxonomic identifieri6398 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataOligochaetaHaplotaxidaLumbricinaLumbricidaeLumbricinaeLumbricus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000525151 – 151Extracellular globin-4Add BLAST151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi6Interchain (with chain III)By similarity
Disulfide bondi7 ↔ 138By similarity
Disulfide bondi129Interchain (with chain I)By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

The extracellular hemoglobin of the earthworm consists of 12 subunits that have a hexagonal bilayer structure with a molecular weight near 3.8 million. Each one-twelfth subunit is composed primarily of disulfide linked trimers (chains A, B, and C) and monomers (chain D).1 Publication

Protein-protein interaction databases

DIPiDIP-29122N
IntActiP13579, 1 interactor

Structurei

Secondary structure

1151
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 22Combined sources14
Beta strandi26 – 28Combined sources3
Helixi29 – 45Combined sources17
Helixi47 – 53Combined sources7
Turni54 – 59Combined sources6
Helixi65 – 81Combined sources17
Turni82 – 85Combined sources4
Helixi87 – 102Combined sources16
Helixi109 – 126Combined sources18
Beta strandi127 – 129Combined sources3
Helixi132 – 146Combined sources15
Turni147 – 149Combined sources3

3D structure databases

ProteinModelPortaliP13579
SMRiP13579
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13579

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR014610 Haemoglobin_extracell
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PIRSFiPIRSF036517 Ext_hemo, 1 hit
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

P13579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ADDEDCCSYE DRREIRHIWD DVWSSSFTDR RVAIVRAVFD DLFKHYPTSK
60 70 80 90 100
ALFERVKIDE PESGEFKSHL VRVANGLDLL INLLDDTLVL QSHLGHLADQ
110 120 130 140 150
HIQRKGVTKE YFRGIGEAFA RVLPQVLSCF NVDAWNRCFH RLVARIAKDL

P
Length:151
Mass (Da):17,525
Last modified:January 1, 1990 - v1
Checksum:i4A2C7421F0DCBC2F
GO

Sequence databases

PIRiA28151

Similar proteinsi

Entry informationi

Entry nameiGLB4_LUMTE
AccessioniPrimary (citable) accession number: P13579
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: April 25, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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