MDR1

Functionⁱ

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Miscellaneous

P.falciparum resistant to the drug chloroquine have multiple copies of the gene coding for MDR.

Catalytic activityⁱ

ATP + H₂O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	413 – 420	ATP 1PROSITE-ProRule annotation		8
Nucleotide bindingⁱ	1161 – 1168	ATP 2PROSITE-ProRule annotation		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
xenobiotic transmembrane transporting ATPase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Translocase
Biological process	Transport
Ligand	ATP-binding, Nucleotide-binding

Protein family/group databases

TCDBⁱ	3.A.1.201.4 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.201.4 the atp-binding cassette (abc) superfamily

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Multidrug resistance protein (EC:7.6.2.2) Alternative name(s): Chloroquine resistance protein
Gene namesⁱ	Name:MDR1
Organismⁱ	Plasmodium falciparum (isolate FC27 / Papua New Guinea)
Taxonomic identifierⁱ	5837 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › Plasmodium falciparum

Subcellular locationⁱ

Membrane ; Multi-pass membrane protein

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 55	CytoplasmicSequence analysisAdd BLAST	55
Transmembraneⁱ	56 – 82	HelicalPROSITE-ProRule annotationAdd BLAST	27
Transmembraneⁱ	91 – 116	HelicalPROSITE-ProRule annotationAdd BLAST	26
Transmembraneⁱ	160 – 188	HelicalPROSITE-ProRule annotationAdd BLAST	29
Transmembraneⁱ	194 – 212	HelicalPROSITE-ProRule annotationAdd BLAST	19
Transmembraneⁱ	279 – 298	HelicalPROSITE-ProRule annotationAdd BLAST	20
Transmembraneⁱ	314 – 338	HelicalPROSITE-ProRule annotationAdd BLAST	25
Topological domainⁱ	339 – 788	CytoplasmicSequence analysisAdd BLAST	450
Transmembraneⁱ	789 – 809	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	830 – 850	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	908 – 928	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	929 – 949	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	1028 – 1048	HelicalPROSITE-ProRule annotationAdd BLAST	21
Transmembraneⁱ	1063 – 1083	HelicalPROSITE-ProRule annotationAdd BLAST	21
Topological domainⁱ	1084 – 1419	CytoplasmicSequence analysisAdd BLAST	336

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000093344	1 – 1419	Multidrug resistance proteinAdd BLAST		1419

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	228	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	258	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	964	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PRIDEⁱ	P13568

PRIDEⁱ

P13568

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P13568
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	57 – 345	ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST	289
Domainⁱ	378 – 662	ABC transporter 1PROSITE-ProRule annotationAdd BLAST	285
Domainⁱ	789 – 1089	ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST	301
Domainⁱ	1126 – 1416	ABC transporter 2PROSITE-ProRule annotationAdd BLAST	291

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	643 – 661	Poly-AsnAdd BLAST		19

Sequence similaritiesⁱ

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Gene3Dⁱ	1.20.1560.10, 1 hit
InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR027417 P-loop_NTPase IPR039421 Type_I_exporter
PANTHERⁱ	PTHR24221 PTHR24221, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00664 ABC_membrane, 2 hits PF00005 ABC_tran, 3 hits
SMARTⁱ	View protein in SMART SM00382 AAA, 2 hits
SUPFAMⁱ	SSF52540 SSF52540, 2 hits SSF90123 SSF90123, 2 hits
PROSITEⁱ	View protein in PROSITE PS50929 ABC_TM1F, 2 hits PS00211 ABC_TRANSPORTER_1, 2 hits PS50893 ABC_TRANSPORTER_2, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

P13568-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGKEQKEKKD GNLSIKEEVE KELNKKSTAE LFRKIKNEKI SFFLPFKCLP 
        60         70         80         90        100
AQHRKLLFIS FVCAVLSGGT LPFFISVFGV ILKNMNLGDD INPIILSLVS 
       110        120        130        140        150
IGLVQFILSM ISSYCMDVIT SKILKTLKLE YLRSVFYQDG QFHDNNPGSK 
       160        170        180        190        200
LRSDLDFYLE QVSSGIGTKF ITIFTYASSF LGLYIWSLIK NARLTLCITC 
       210        220        230        240        250
VFPLIYVCGV ICNKKVKLNK KTSLLYNNNT MSIIEEALMG IRTVASYCGE 
       260        270        280        290        300
KTILNKFNLS ETFYSKYILK ANFVEALHIG LINGLILVSY AFGFWYGTRI 
       310        320        330        340        350
IINSATNQYP NNDFNGASVI SILLGVLISM FMLTIILPNI TEYMKALEAT 
       360        370        380        390        400
NSLYEIINRK PLVENNDDGE TLPNIKKIEF KNVRFHYDTR KDVEIYKDLS 
       410        420        430        440        450
FTLKEGKTYA FVGESGCGKS TILKLIERLY DPTEGDIIVN DSHNLKDINL 
       460        470        480        490        500
KWWRSKIGVV SQDPLLFSNS IKNNIKYSLY SLKDLEAMEN YYEENTNDTY 
       510        520        530        540        550
ENKNFSLISN SMTSNELLEM KKEYQTIKDS DVVDVSKKVL IHDFVSSLPD 
       560        570        580        590        600
KYDTLVGSNA SKLSGGQKQR ISIARAIMRN PKILILDEAT SSLDNKSEYL 
       610        620        630        640        650
VQKTINNLKG NENRITIIIA HRLSTIRYAN TIFVLSNRER SDNNNNNNND 
       660        670        680        690        700
DNNNNNNNNN NKINNEGSYI IEQGTHDSLM KNKNGIYHLM INNQKISSNK 
       710        720        730        740        750
SSNNGNDNGS DNKSSAYKDS DTGNDADNMN SLSIHENENI SNNRNCKNTA 
       760        770        780        790        800
ENEKEEKVPF FKRMFRRKKK APNNLRIIYK EIFSYKKDVT IIFFSILVAG 
       810        820        830        840        850
GLYPVFALLY ARYVSTLFDF ANLEYNSNKY SIYILLIAIA MFISETLKNY 
       860        870        880        890        900
YNNKIGEKVE KTMKRRLFEN ILYQEMSFFD QDKNTPGVLS AHINRDVHLL 
       910        920        930        940        950
KTGLVNNIVI FSHFIMLFLV SMVMSFYFCP IVAAVLTFIY FINMRVFAVR 
       960        970        980        990       1000
ARLTKSKEIE KKENMSSGVF AFSSDDEMFK DPSFLIQEAF YNMHTVINYG 
      1010       1020       1030       1040       1050
LEDYFCNLIE KAIDYKNKGQ KRRIIVNAAL WGFSQSAQLF INSFAYWFGS 
      1060       1070       1080       1090       1100
FLIKRGTILV DDFMKSLFTF IFTGSYAGKL MSLKGDSENA KLSFEKYYPL 
      1110       1120       1130       1140       1150
MIRKSNIDVR DDGGIRINKN LIKGKVDIKD VNFRYISRPN VPIYKNLSFT 
      1160       1170       1180       1190       1200
CDSKKTTAIV GETGSGKSTF MNLLLRFYDL KNDHIILKND MTNFQDYQNN 
      1210       1220       1230       1240       1250
NNNSLVLKNV NEFSNQSGSA EDYTVFNNNG EILLDDINIC DYNLRDLRNL 
      1260       1270       1280       1290       1300
FSIVSQEPML FNMSIYENIK FGREDATLED VKRVSKFAAI DEFIESLPNK 
      1310       1320       1330       1340       1350
YDTNVGPYGK SLSGGQKQRI AIARALLREP KILLLDEATS SLDSNSEKLI 
      1360       1370       1380       1390       1400
EKTIVDIKDK ADKTIITIAH RIASIKRSDK IVVFNNPDRN GTFVQSHGTH 
      1410 
DELLSAQDGI YKKYVKLAK

Length:1,419

Mass (Da):162,252

Last modified:January 1, 1990 - v1

Checksum:ⁱ0F96C7C1850B33D0

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M29154 Genomic DNA Translation: AAA29646.1 X56851 Genomic DNA Translation: CAA40180.1 S53996 Genomic DNA Translation: AAD13870.1
PIRⁱ	S18204 DVZQF

Protein	Similar proteins		Species	Score	Length	Source
P13568	Multidrug resistance protein 1		PLAFO		1419	UniRef100_P13568
Multidrug resistance protein 1		PLAF7		1419
Multi-drug resistance 1 (Fragment)		PLAFA		71
Multi-drug resistance protein 1 (Fragment)		PLAFA		96
Multi-drug resistance protein 1 (Fragment)		PLAFA		94
+24

Protein	Similar proteins		Species	Score	Length	Source
P13568	Multidrug resistance protein 1		PLAFO		1419	UniRef90_P13568
Multidrug resistance protein 1		PLAF7		1419
Multi-drug resistance 1 (Fragment)		PLAFA		71
Multidrug resistance protein		PLARE		1434
Multidrug resistance protein		Plasmodium gaboni		1424
+279

Protein	Similar proteins		Species	Score	Length	Source
P13568	Multidrug resistance protein 1		PLAFO		1419	UniRef50_P13568
Multidrug resistance protein 1		PLAF7		1419
Multi-drug resistance 1 (Fragment)		PLAFA		71
Multidrug resistance protein		PLARE		1434
Multidrug resistance protein		Plasmodium gaboni		1424
+282

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M29154 Genomic DNA Translation: AAA29646.1 X56851 Genomic DNA Translation: CAA40180.1 S53996 Genomic DNA Translation: AAD13870.1
PIRⁱ	S18204 DVZQF

3D structure databases

ProteinModelPortalⁱ	P13568
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

TCDBⁱ	3.A.1.201.4 the atp-binding cassette (abc) superfamily

TCDBⁱ

3.A.1.201.4 the atp-binding cassette (abc) superfamily

Proteomic databases

PRIDEⁱ	P13568

PRIDEⁱ

P13568

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Family and domain databases

Gene3Dⁱ	1.20.1560.10, 1 hit
InterProⁱ	View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR027417 P-loop_NTPase IPR039421 Type_I_exporter
PANTHERⁱ	PTHR24221 PTHR24221, 2 hits
Pfamⁱ	View protein in Pfam PF00664 ABC_membrane, 2 hits PF00005 ABC_tran, 3 hits
SMARTⁱ	View protein in SMART SM00382 AAA, 2 hits
SUPFAMⁱ	SSF52540 SSF52540, 2 hits SSF90123 SSF90123, 2 hits
PROSITEⁱ	View protein in PROSITE PS50929 ABC_TM1F, 2 hits PS00211 ABC_TRANSPORTER_1, 2 hits PS50893 ABC_TRANSPORTER_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MDR_PLAFF
Accessionⁱ	P13568Primary (citable) accession number: P13568
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	January 1, 1990
	Last modified:	November 7, 2018
	This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)

Miscellaneousⁱ

Documents

SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P13568 (MDR_PLAFF)

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Multidrug resistance protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ