UniProtKB - P13568 (MDR_PLAFF)
Protein
Multidrug resistance protein
Gene
MDR1
Organism
Plasmodium falciparum (isolate FC27 / Papua New Guinea)
Status
Functioni
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
Miscellaneous
P.falciparum resistant to the drug chloroquine have multiple copies of the gene coding for MDR.
Catalytic activityi
- ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2). EC:7.6.2.2
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 413 – 420 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1161 – 1168 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled xenobiotic transmembrane transporter activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
Keywordsi
Molecular function | Translocase |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Protein family/group databases
TCDBi | 3.A.1.201.4, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: Multidrug resistance protein (EC:7.6.2.2)Alternative name(s): Chloroquine resistance protein |
Gene namesi | Name:MDR1 |
Organismi | Plasmodium falciparum (isolate FC27 / Papua New Guinea) |
Taxonomic identifieri | 5837 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 55 | CytoplasmicSequence analysisAdd BLAST | 55 | |
Transmembranei | 56 – 82 | HelicalPROSITE-ProRule annotationAdd BLAST | 27 | |
Transmembranei | 91 – 116 | HelicalPROSITE-ProRule annotationAdd BLAST | 26 | |
Transmembranei | 160 – 188 | HelicalPROSITE-ProRule annotationAdd BLAST | 29 | |
Transmembranei | 194 – 212 | HelicalPROSITE-ProRule annotationAdd BLAST | 19 | |
Transmembranei | 279 – 298 | HelicalPROSITE-ProRule annotationAdd BLAST | 20 | |
Transmembranei | 314 – 338 | HelicalPROSITE-ProRule annotationAdd BLAST | 25 | |
Topological domaini | 339 – 788 | CytoplasmicSequence analysisAdd BLAST | 450 | |
Transmembranei | 789 – 809 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 830 – 850 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 908 – 928 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 929 – 949 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 1028 – 1048 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Transmembranei | 1063 – 1083 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1084 – 1419 | CytoplasmicSequence analysisAdd BLAST | 336 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093344 | 1 – 1419 | Multidrug resistance proteinAdd BLAST | 1419 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 228 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 258 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 964 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 57 – 345 | ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST | 289 | |
Domaini | 378 – 662 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 285 | |
Domaini | 789 – 1089 | ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST | 301 | |
Domaini | 1126 – 1416 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 291 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 643 – 661 | Poly-AsnAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 1.20.1560.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase IPR039421, Type_I_exporter |
PANTHERi | PTHR24221, PTHR24221, 2 hits |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 3 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
i Sequence
Sequence statusi: Complete.
P13568-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKEQKEKKD GNLSIKEEVE KELNKKSTAE LFRKIKNEKI SFFLPFKCLP
60 70 80 90 100
AQHRKLLFIS FVCAVLSGGT LPFFISVFGV ILKNMNLGDD INPIILSLVS
110 120 130 140 150
IGLVQFILSM ISSYCMDVIT SKILKTLKLE YLRSVFYQDG QFHDNNPGSK
160 170 180 190 200
LRSDLDFYLE QVSSGIGTKF ITIFTYASSF LGLYIWSLIK NARLTLCITC
210 220 230 240 250
VFPLIYVCGV ICNKKVKLNK KTSLLYNNNT MSIIEEALMG IRTVASYCGE
260 270 280 290 300
KTILNKFNLS ETFYSKYILK ANFVEALHIG LINGLILVSY AFGFWYGTRI
310 320 330 340 350
IINSATNQYP NNDFNGASVI SILLGVLISM FMLTIILPNI TEYMKALEAT
360 370 380 390 400
NSLYEIINRK PLVENNDDGE TLPNIKKIEF KNVRFHYDTR KDVEIYKDLS
410 420 430 440 450
FTLKEGKTYA FVGESGCGKS TILKLIERLY DPTEGDIIVN DSHNLKDINL
460 470 480 490 500
KWWRSKIGVV SQDPLLFSNS IKNNIKYSLY SLKDLEAMEN YYEENTNDTY
510 520 530 540 550
ENKNFSLISN SMTSNELLEM KKEYQTIKDS DVVDVSKKVL IHDFVSSLPD
560 570 580 590 600
KYDTLVGSNA SKLSGGQKQR ISIARAIMRN PKILILDEAT SSLDNKSEYL
610 620 630 640 650
VQKTINNLKG NENRITIIIA HRLSTIRYAN TIFVLSNRER SDNNNNNNND
660 670 680 690 700
DNNNNNNNNN NKINNEGSYI IEQGTHDSLM KNKNGIYHLM INNQKISSNK
710 720 730 740 750
SSNNGNDNGS DNKSSAYKDS DTGNDADNMN SLSIHENENI SNNRNCKNTA
760 770 780 790 800
ENEKEEKVPF FKRMFRRKKK APNNLRIIYK EIFSYKKDVT IIFFSILVAG
810 820 830 840 850
GLYPVFALLY ARYVSTLFDF ANLEYNSNKY SIYILLIAIA MFISETLKNY
860 870 880 890 900
YNNKIGEKVE KTMKRRLFEN ILYQEMSFFD QDKNTPGVLS AHINRDVHLL
910 920 930 940 950
KTGLVNNIVI FSHFIMLFLV SMVMSFYFCP IVAAVLTFIY FINMRVFAVR
960 970 980 990 1000
ARLTKSKEIE KKENMSSGVF AFSSDDEMFK DPSFLIQEAF YNMHTVINYG
1010 1020 1030 1040 1050
LEDYFCNLIE KAIDYKNKGQ KRRIIVNAAL WGFSQSAQLF INSFAYWFGS
1060 1070 1080 1090 1100
FLIKRGTILV DDFMKSLFTF IFTGSYAGKL MSLKGDSENA KLSFEKYYPL
1110 1120 1130 1140 1150
MIRKSNIDVR DDGGIRINKN LIKGKVDIKD VNFRYISRPN VPIYKNLSFT
1160 1170 1180 1190 1200
CDSKKTTAIV GETGSGKSTF MNLLLRFYDL KNDHIILKND MTNFQDYQNN
1210 1220 1230 1240 1250
NNNSLVLKNV NEFSNQSGSA EDYTVFNNNG EILLDDINIC DYNLRDLRNL
1260 1270 1280 1290 1300
FSIVSQEPML FNMSIYENIK FGREDATLED VKRVSKFAAI DEFIESLPNK
1310 1320 1330 1340 1350
YDTNVGPYGK SLSGGQKQRI AIARALLREP KILLLDEATS SLDSNSEKLI
1360 1370 1380 1390 1400
EKTIVDIKDK ADKTIITIAH RIASIKRSDK IVVFNNPDRN GTFVQSHGTH
1410
DELLSAQDGI YKKYVKLAK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M29154 Genomic DNA Translation: AAA29646.1 X56851 Genomic DNA Translation: CAA40180.1 S53996 Genomic DNA Translation: AAD13870.1 |
PIRi | S18204, DVZQF |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M29154 Genomic DNA Translation: AAA29646.1 X56851 Genomic DNA Translation: CAA40180.1 S53996 Genomic DNA Translation: AAD13870.1 |
PIRi | S18204, DVZQF |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Chemistry databases
DrugBanki | DB11638, Artenimol |
Protein family/group databases
TCDBi | 3.A.1.201.4, the atp-binding cassette (abc) superfamily |
Family and domain databases
Gene3Di | 1.20.1560.10, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase IPR039421, Type_I_exporter |
PANTHERi | PTHR24221, PTHR24221, 2 hits |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 3 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 2 hits PS50893, ABC_TRANSPORTER_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MDR_PLAFF | |
Accessioni | P13568Primary (citable) accession number: P13568 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | January 1, 1990 | |
Last modified: | February 10, 2021 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |