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Protein

Progonadoliberin-1

Gene

Gnrh1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei24Appears to be essential for biological activity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-375281 Hormone ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Progonadoliberin-1
Alternative name(s):
Progonadoliberin I
Cleaved into the following 2 chains:
Alternative name(s):
Gonadoliberin I
Gonadotropin-releasing hormone I
Short name:
GnRH-I
Luliberin I
Luteinizing hormone-releasing hormone I
Short name:
LH-RH I
Alternative name(s):
Prolactin release-inhibiting factor I
Gene namesi
Name:Gnrh1
Synonyms:Gnrh
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:95789 Gnrh1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001240422 – 90Progonadoliberin-1Add BLAST69
PeptideiPRO_000001240522 – 31Gonadoliberin-110
PeptideiPRO_000001240635 – 90Prolactin release-inhibiting factor 1Add BLAST56

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22Pyrrolidone carboxylic acidBy similarity1
Modified residuei31Glycine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP13562
PRIDEiP13562

Expressioni

Gene expression databases

BgeeiENSMUSG00000015812 Expressed in 37 organ(s), highest expression level in oocyte
CleanExiMM_GNRH1
ExpressionAtlasiP13562 baseline and differential

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP13562, 3 interactors
STRINGi10090.ENSMUSP00000106724

Structurei

3D structure databases

SMRiP13562
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GnRH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J18B Eukaryota
ENOG410ZDKS LUCA
GeneTreeiENSGT00390000008225
HOGENOMiHOG000033698
HOVERGENiHBG014746
InParanoidiP13562
KOiK05252
OMAiSGQHWSY
OrthoDBiEOG091G147V
PhylomeDBiP13562
TreeFamiTF330934

Family and domain databases

InterProiView protein in InterPro
IPR002012 GnRH
IPR019792 Gonadoliberin_I
IPR004079 Gonadoliberin_I_precursor
PANTHERiPTHR10522 PTHR10522, 1 hit
PTHR10522:SF0 PTHR10522:SF0, 1 hit
PfamiView protein in Pfam
PF00446 GnRH, 1 hit
PRINTSiPR01541 GONADOLIBRNI
PROSITEiView protein in PROSITE
PS00473 GNRH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P13562-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILKLMAGIL LLTVCLEGCS SQHWSYGLRP GGKRNTEHLV ESFQEMGKEV
60 70 80 90
DQMAEPQHFE CTVHWPRSPL RDLRGALESL IEEEARQKKM
Length:90
Mass (Da):10,337
Last modified:January 1, 1990 - v1
Checksum:i1C0766FA4826E4D9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YDB0A0A286YDB0_MOUSE
Progonadoliberin-1
Gnrh1
45Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14872 Genomic DNA Translation: AAA37717.1
CCDSiCCDS27231.1
PIRiA47578 RHMSG
RefSeqiNP_032171.1, NM_008145.3
UniGeneiMm.358309

Genome annotation databases

EnsembliENSMUST00000111095; ENSMUSP00000106724; ENSMUSG00000015812
ENSMUST00000223951; ENSMUSP00000153071; ENSMUSG00000015812
GeneIDi14714
KEGGimmu:14714
UCSCiuc007ulh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14872 Genomic DNA Translation: AAA37717.1
CCDSiCCDS27231.1
PIRiA47578 RHMSG
RefSeqiNP_032171.1, NM_008145.3
UniGeneiMm.358309

3D structure databases

SMRiP13562
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP13562, 3 interactors
STRINGi10090.ENSMUSP00000106724

Proteomic databases

PaxDbiP13562
PRIDEiP13562

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111095; ENSMUSP00000106724; ENSMUSG00000015812
ENSMUST00000223951; ENSMUSP00000153071; ENSMUSG00000015812
GeneIDi14714
KEGGimmu:14714
UCSCiuc007ulh.2 mouse

Organism-specific databases

CTDi2796
MGIiMGI:95789 Gnrh1

Phylogenomic databases

eggNOGiENOG410J18B Eukaryota
ENOG410ZDKS LUCA
GeneTreeiENSGT00390000008225
HOGENOMiHOG000033698
HOVERGENiHBG014746
InParanoidiP13562
KOiK05252
OMAiSGQHWSY
OrthoDBiEOG091G147V
PhylomeDBiP13562
TreeFamiTF330934

Enzyme and pathway databases

ReactomeiR-MMU-375281 Hormone ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events

Miscellaneous databases

PROiPR:P13562
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015812 Expressed in 37 organ(s), highest expression level in oocyte
CleanExiMM_GNRH1
ExpressionAtlasiP13562 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR002012 GnRH
IPR019792 Gonadoliberin_I
IPR004079 Gonadoliberin_I_precursor
PANTHERiPTHR10522 PTHR10522, 1 hit
PTHR10522:SF0 PTHR10522:SF0, 1 hit
PfamiView protein in Pfam
PF00446 GnRH, 1 hit
PRINTSiPR01541 GONADOLIBRNI
PROSITEiView protein in PROSITE
PS00473 GNRH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGON1_MOUSE
AccessioniPrimary (citable) accession number: P13562
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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