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Protein

Endolysin

Gene

XV

Organism
Enterobacteria phage PRD1 (Bacteriophage PRD1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endolysin involved in host peptidoglycan digestion after permeabilization of the cytoplasmic membrane by holin. Involved in host cell lysis and liberation of progeny phages. Displays strong lytic activity against chloroform-treated Gram-negative cells.2 Publications

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.2 Publications

pH dependencei

Optimum pH is 7.0-8.0.

Temperature dependencei

Inactivation temperature above 4 degrees Celsius.

GO - Molecular functioni

  • lysozyme activity Source: CACAO

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase
Biological processCytolysis, Host cell lysis by virus, Viral release from host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Endolysin (EC:3.2.1.172 Publications)
Alternative name(s):
Beta-1,4-N-acetylmuramidase
Lysozyme
Lytic enzyme
Muramidase
Protein P15
Gene namesi
Name:XV
OrganismiEnterobacteria phage PRD1 (Bacteriophage PRD1)
Taxonomic identifieri10658 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageTectiviridaeTectivirus
Virus hostiAcinetobacter calcoaceticus [TaxID: 471]
Escherichia coli [TaxID: 562]
Proteus mirabilis [TaxID: 584]
Pseudomonas aeruginosa [TaxID: 287]
Pseudomonas fluorescens [TaxID: 294]
Pseudomonas putida (Arthrobacter siderocapsulatus) [TaxID: 303]
Salmonella typhimurium [TaxID: 90371]
Vibrio cholerae [TaxID: 666]
Proteomesi
  • UP000002143 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001653481 – 149EndolysinAdd BLAST149

Structurei

3D structure databases

SMRiP13559
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 24 family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR024408 Muramidase
IPR016284 Phage_PRD1_P15_lysozyme
PfamiView protein in Pfam
PF11860 Muraidase, 1 hit
PIRSFiPIRSF001069 Lytic_enz_p15, 1 hit

Sequencei

Sequence statusi: Complete.

P13559-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQYTLWDIIS RVESNGNLKA LRFEPEYYQR RMERGDWDNS IIQNIRAANK
60 70 80 90 100
CSLGTARMIY CSSWGAVQIM GFNLYLNGAF NLSVAHFMEN EAYQVNEFRR
110 120 130 140
FLLKNGLTEY TPERLASDKA ARVKFAKVYN GAESYADLIL QACQFYGVK
Length:149
Mass (Da):17,269
Last modified:February 1, 1991 - v2
Checksum:i50ABB718032939B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14980 Genomic DNA Translation: CAA33104.1
M22161 Genomic DNA Translation: AAA32451.1
AY848689 Genomic DNA Translation: AAX45908.1
PIRiS03568 LYBPD1
RefSeqiNP_040683.1, NC_001421.2

Genome annotation databases

GeneIDi1260935
KEGGivg:1260935

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14980 Genomic DNA Translation: CAA33104.1
M22161 Genomic DNA Translation: AAA32451.1
AY848689 Genomic DNA Translation: AAX45908.1
PIRiS03568 LYBPD1
RefSeqiNP_040683.1, NC_001421.2

3D structure databases

SMRiP13559
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1260935
KEGGivg:1260935

Family and domain databases

InterProiView protein in InterPro
IPR024408 Muramidase
IPR016284 Phage_PRD1_P15_lysozyme
PfamiView protein in Pfam
PF11860 Muraidase, 1 hit
PIRSFiPIRSF001069 Lytic_enz_p15, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiENLYS_BPPRD
AccessioniPrimary (citable) accession number: P13559
Secondary accession number(s): Q3T4P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 1, 1991
Last modified: October 25, 2017
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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Main funding by: National Institutes of Health

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