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Protein

Myosin-8

Gene

MYH8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Muscle contraction.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi181 – 188ATP8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin filament binding Source: BHF-UCL
  • ATPase activity Source: BHF-UCL
  • ATP binding Source: BHF-UCL
  • calmodulin binding Source: UniProtKB-KW
  • microfilament motor activity Source: BHF-UCL
  • myosin light chain binding Source: BHF-UCL
  • myosin phosphatase activity Source: Reactome
  • structural constituent of muscle Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Muscle protein, Myosin
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390522 Striated Muscle Contraction

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin-8
Alternative name(s):
Myosin heavy chain 8
Myosin heavy chain, skeletal muscle, perinatal
Short name:
MyHC-perinatal
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYH8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000133020.4

Human Gene Nomenclature Database

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HGNCi
HGNC:7578 MYH8

Online Mendelian Inheritance in Man (OMIM)

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MIMi
160741 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P13535

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Thick filament

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Carney complex variant (CACOV)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionCarney complex is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas. Familial cardiac myxomas are associated with spotty pigmentation of the skin and other phenotypes, including primary pigmented nodular adrenocortical dysplasia, extracardiac (frequently cutaneous) myxomas, schwannomas, and pituitary, thyroid, testicular, bone, ovarian, and breast tumors. Cardiac myxomas do not develop in all patients with the Carney complex, but affected patients have at least two features of the complex or one feature and a clinically significant family history.
See also OMIM:608837
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019810674R → Q in CACOV and DA7. 2 PublicationsCorresponds to variant dbSNP:rs121434590EnsemblClinVar.1
Arthrogryposis, distal, 7 (DA7)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA7 is characterized by an inability to open the mouth fully (trismus) and pseudocamptodactyly in which wrist dorsiflexion, but not volarflexion, produces involuntary flexion contracture of distal and proximal interphalangeal joints. Additional features include shortened hamstring muscles and short stature.
See also OMIM:158300
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019810674R → Q in CACOV and DA7. 2 PublicationsCorresponds to variant dbSNP:rs121434590EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
4626

MalaCards human disease database

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MalaCardsi
MYH8
MIMi158300 phenotype
608837 phenotype

Open Targets

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OpenTargetsi
ENSG00000133020

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
319340 Carney complex-trismus-pseudocamptodactyly syndrome
3377 Trismus-pseudocamptodactyly syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA31376

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
MYH8

Domain mapping of disease mutations (DMDM)

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DMDMi
3041707

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001234131 – 1937Myosin-8Add BLAST1937

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei66PhosphothreonineBy similarity1
Modified residuei71PhosphothreonineBy similarity1
Modified residuei132N6,N6,N6-trimethyllysineSequence analysis1
Modified residuei389PhosphotyrosineBy similarity1
Modified residuei392PhosphoserineBy similarity1
Modified residuei419PhosphothreonineBy similarity1
Modified residuei424PhosphotyrosineBy similarity1
Modified residuei625PhosphoserineBy similarity1
Modified residuei756Pros-methylhistidineBy similarity1
Modified residuei1091PhosphoserineBy similarity1
Modified residuei1095PhosphoserineBy similarity1
Modified residuei1161PhosphoserineBy similarity1
Modified residuei1236PhosphoserineBy similarity1
Modified residuei1242PhosphoserineBy similarity1
Modified residuei1260PhosphoserineBy similarity1
Modified residuei1264PhosphothreonineBy similarity1
Modified residuei1285PhosphothreonineBy similarity1
Modified residuei1291PhosphoserineBy similarity1
Modified residuei1302PhosphoserineBy similarity1
Modified residuei1305PhosphoserineBy similarity1
Modified residuei1463PhosphotyrosineBy similarity1
Modified residuei1466PhosphothreonineBy similarity1
Modified residuei1473PhosphoserineBy similarity1
Modified residuei1491PhosphotyrosineBy similarity1
Modified residuei1494PhosphoserineBy similarity1
Modified residuei1500PhosphothreonineBy similarity1
Modified residuei1513PhosphoserineBy similarity1
Modified residuei1516PhosphothreonineBy similarity1
Modified residuei1553PhosphoserineBy similarity1
Modified residuei1573PhosphoserineBy similarity1
Modified residuei1602PhosphoserineBy similarity1
Modified residuei1713PhosphoserineBy similarity1
Modified residuei1725PhosphoserineBy similarity1
Modified residuei1729PhosphothreonineBy similarity1
Modified residuei1738PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P13535

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P13535

MaxQB - The MaxQuant DataBase

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MaxQBi
P13535

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P13535

PeptideAtlas

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PeptideAtlasi
P13535

PRoteomics IDEntifications database

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PRIDEi
P13535

ProteomicsDB human proteome resource

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ProteomicsDBi
52925

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P13535

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P13535

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000133020 Expressed in 56 organ(s), highest expression level in quadriceps femoris

CleanEx database of gene expression profiles

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CleanExi
HS_MYH8

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P13535 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB016527

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110711, 14 interactors

Protein interaction database and analysis system

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IntActi
P13535, 2 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000384330

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P13535

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P13535

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 84Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST50
Domaini88 – 781Myosin motorPROSITE-ProRule annotationAdd BLAST694
Domaini781 – 813IQPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni658 – 680Actin-bindingAdd BLAST23
Regioni760 – 774Actin-bindingAdd BLAST15

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili842 – 1937Sequence analysisAdd BLAST1096

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0161 Eukaryota
COG5022 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161785

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000173959

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG004704

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P13535

KEGG Orthology (KO)

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KOi
K10352

Identification of Orthologs from Complete Genome Data

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OMAi
DMENDKQ

Database of Orthologous Groups

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OrthoDBi
47111at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P13535

TreeFam database of animal gene trees

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TreeFami
TF314375

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase

Pfam protein domain database

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Pfami
View protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P13535-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSASSDAEMA VFGEAAPYLR KSEKERIEAQ NKPFDAKTSV FVAEPKESYV
60 70 80 90 100
KSTIQSKEGG KVTVKTEGGA TLTVREDQVF PMNPPKYDKI EDMAMMTHLH
110 120 130 140 150
EPGVLYNLKE RYAAWMIYTY SGLFCVTVNP YKWLPVYKPE VVAAYRGKKR
160 170 180 190 200
QEAPPHIFSI SDNAYQFMLT DRENQSILIT GESGAGKTVN TKRVIQYFAT
210 220 230 240 250
IAVTGEKKKD ESGKMQGTLE DQIISANPLL EAFGNAKTVR NDNSSRFGKF
260 270 280 290 300
IRIHFGTTGK LASADIETYL LEKSRVTFQL KAERSYHIFY QITSNKKPDL
310 320 330 340 350
IEMLLITTNP YDYAFVSQGE ITVPSIDDQE ELMATDSAID ILGFTPEEKV
360 370 380 390 400
SIYKLTGAVM HYGNMKFKQK QREEQAEPDG TEVADKAAYL QSLNSADLLK
410 420 430 440 450
ALCYPRVKVG NEYVTKGQTV QQVYNAVGAL AKAVYEKMFL WMVTRINQQL
460 470 480 490 500
DTKQPRQYFI GVLDIAGFEI FDFNSLEQLC INFTNEKLQQ FFNHHMFVLE
510 520 530 540 550
QEEYKKEGIE WTFIDFGMDL AACIELIEKP LGIFSILEEE CMFPKATDTS
560 570 580 590 600
FKNKLYDQHL GKSANFQKPK VVKGKAEAHF SLIHYAGTVD YNITGWLDKN
610 620 630 640 650
KDPLNDTVVG LYQKSAMKTL ASLFSTYASA EADSSAKKGA KKKGSSFQTV
660 670 680 690 700
SALFRENLNK LMTNLRSTHP HFVRCIIPNE TKTPGAMEHE LVLHQLRCNG
710 720 730 740 750
VLEGIRICRK GFPSRILYGD FKQRYKVLNA SAIPEGQFID SKKASEKLLA
760 770 780 790 800
SIDIDHTQYK FGHTKVFFKA GLLGLLEEMR DEKLAQIITR TQAVCRGFLM
810 820 830 840 850
RVEYQKMLQR REALFCIQYN VRAFMNVKHW PWMKLFFKIK PLLKSAETEK
860 870 880 890 900
EMATMKEEFQ KTKDELAKSE AKRKELEEKM VTLLKEKNDL QLQVQSEADS
910 920 930 940 950
LADAEERCEQ LIKNKIQLEA KIKEVTERAE EEEEINAELT AKKRKLEDEC
960 970 980 990 1000
SELKKDIDDL ELTLAKVEKE KHATENKVKN LTEEMAGLDE TIAKLSKEKK
1010 1020 1030 1040 1050
ALQETHQQTL DDLQAEEDKV NILTKAKTKL EQQVDDLEGS LEQEKKLRMD
1060 1070 1080 1090 1100
LERAKRKLEG DLKLAQESTM DMENDKQQLD EKLEKKEFEI SNLISKIEDE
1110 1120 1130 1140 1150
QAVEIQLQKK IKELQARIEE LGEEIEAERA SRAKAEKQRS DLSRELEEIS
1160 1170 1180 1190 1200
ERLEEAGGAT SAQVELNKKR EAEFQKLRRD LEEATLQHEA MVAALRKKHA
1210 1220 1230 1240 1250
DSMAELGEQI DNLQRVKQKL EKEKSELKME TDDLSSNAEA ISKAKGNLEK
1260 1270 1280 1290 1300
MCRSLEDQVS ELKTKEEEQQ RLINDLTAQR ARLQTEAGEY SRQLDEKDAL
1310 1320 1330 1340 1350
VSQLSRSKQA STQQIEELKH QLEEETKAKN ALAHALQSSR HDCDLLREQY
1360 1370 1380 1390 1400
EEEQEGKAEL QRALSKANSE VAQWRTKYET DAIQRTEELE EAKKKLAQRL
1410 1420 1430 1440 1450
QEAEEHVEAV NAKCASLEKT KQRLQNEVED LMLDVERSNA ACAALDKKQR
1460 1470 1480 1490 1500
NFDKVLSEWK QKYEETQAEL EASQKESRSL STELFKVKNV YEESLDQLET
1510 1520 1530 1540 1550
LRRENKNLQQ EISDLTEQIA EGGKQIHELE KIKKQVEQEK CEIQAALEEA
1560 1570 1580 1590 1600
EASLEHEEGK ILRIQLELNQ VKSEVDRKIA EKDEEIDQLK RNHTRVVETM
1610 1620 1630 1640 1650
QSTLDAEIRS RNDALRVKKK MEGDLNEMEI QLNHANRLAA ESLRNYRNTQ
1660 1670 1680 1690 1700
GILKETQLHL DDALRGQEDL KEQLAIVERR ANLLQAEIEE LWATLEQTER
1710 1720 1730 1740 1750
SRKIAEQELL DASERVQLLH TQNTSLINTK KKLENDVSQL QSEVEEVIQE
1760 1770 1780 1790 1800
SRNAEEKAKK AITDAAMMAE ELKKEQDTSA HLERMKKNLE QTVKDLQHRL
1810 1820 1830 1840 1850
DEAEQLALKG GKKQIQKLEA RVRELEGEVE NEQKRNAEAV KGLRKHERRV
1860 1870 1880 1890 1900
KELTYQTEED RKNVLRLQDL VDKLQAKVKS YKRQAEEAEE QSNANLSKFR
1910 1920 1930
KLQHELEEAE ERADIAESQV NKLRVKSREV HTKISAE
Length:1,937
Mass (Da):222,763
Last modified:July 15, 1998 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA3EE2D151792E9E8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15A → R in CAA86293 (PubMed:7601129).Curated1
Sequence conflicti970E → Q (PubMed:2373371).Curated1
Sequence conflicti970E → Q (PubMed:2715179).Curated1
Sequence conflicti1072M → N in CAA35941 (PubMed:1691980).Curated1
Sequence conflicti1247N → H (PubMed:2373371).Curated1
Sequence conflicti1247N → H (PubMed:2715179).Curated1
Sequence conflicti1251 – 1252MC → DGG in CAA35941 (PubMed:1691980).Curated2
Sequence conflicti1297K → Q (PubMed:2373371).Curated1
Sequence conflicti1297K → Q (PubMed:2715179).Curated1
Sequence conflicti1377 – 1378KY → NT in CAA35941 (PubMed:1691980).Curated2
Sequence conflicti1504 – 1505EN → AH (PubMed:2373371).Curated2
Sequence conflicti1504 – 1505EN → AH (PubMed:2715179).Curated2
Sequence conflicti1847E → D (PubMed:2373371).Curated1
Sequence conflicti1847E → D (PubMed:2715179).Curated1
Sequence conflicti1914D → H in CAA86293 (PubMed:7601129).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050202326I → T. Corresponds to variant dbSNP:rs34124921Ensembl.1
Natural variantiVAR_050203636A → V. Corresponds to variant dbSNP:rs34693726EnsemblClinVar.1
Natural variantiVAR_019810674R → Q in CACOV and DA7. 2 PublicationsCorresponds to variant dbSNP:rs121434590EnsemblClinVar.1
Natural variantiVAR_030207924E → G. Corresponds to variant dbSNP:rs4372733Ensembl.1
Natural variantiVAR_0502041229M → T. Corresponds to variant dbSNP:rs35962914EnsemblClinVar.1
Natural variantiVAR_0302081261E → G2 PublicationsCorresponds to variant dbSNP:rs1063926Ensembl.1
Natural variantiVAR_0302091692W → R. Corresponds to variant dbSNP:rs8069834EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M36769 mRNA Translation: AAC17185.1
Z38133 mRNA Translation: CAA86293.1
X51592 mRNA Translation: CAA35941.1
AF067143 Genomic DNA Translation: AAC21557.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11153.1

Protein sequence database of the Protein Information Resource

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PIRi
I38055

NCBI Reference Sequences

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RefSeqi
NP_002463.2, NM_002472.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.700484

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000403437; ENSP00000384330; ENSG00000133020

Database of genes from NCBI RefSeq genomes

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GeneIDi
4626

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4626

UCSC genome browser

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UCSCi
uc002gmm.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36769 mRNA Translation: AAC17185.1
Z38133 mRNA Translation: CAA86293.1
X51592 mRNA Translation: CAA35941.1
AF067143 Genomic DNA Translation: AAC21557.1
CCDSiCCDS11153.1
PIRiI38055
RefSeqiNP_002463.2, NM_002472.2
UniGeneiHs.700484

3D structure databases

ProteinModelPortaliP13535
SMRiP13535
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110711, 14 interactors
IntActiP13535, 2 interactors
STRINGi9606.ENSP00000384330

PTM databases

iPTMnetiP13535
PhosphoSitePlusiP13535

Polymorphism and mutation databases

BioMutaiMYH8
DMDMi3041707

Proteomic databases

EPDiP13535
jPOSTiP13535
MaxQBiP13535
PaxDbiP13535
PeptideAtlasiP13535
PRIDEiP13535
ProteomicsDBi52925

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
4626
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000403437; ENSP00000384330; ENSG00000133020
GeneIDi4626
KEGGihsa:4626
UCSCiuc002gmm.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4626
DisGeNETi4626
EuPathDBiHostDB:ENSG00000133020.4

GeneCards: human genes, protein and diseases

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GeneCardsi
MYH8

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0039253
HGNCiHGNC:7578 MYH8
HPAiCAB016527
MalaCardsiMYH8
MIMi158300 phenotype
160741 gene
608837 phenotype
neXtProtiNX_P13535
OpenTargetsiENSG00000133020
Orphaneti319340 Carney complex-trismus-pseudocamptodactyly syndrome
3377 Trismus-pseudocamptodactyly syndrome
PharmGKBiPA31376

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000161785
HOGENOMiHOG000173959
HOVERGENiHBG004704
InParanoidiP13535
KOiK10352
OMAiDMENDKQ
OrthoDBi47111at2759
PhylomeDBiP13535
TreeFamiTF314375

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MYH8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4626

Protein Ontology

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PROi
PR:P13535

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000133020 Expressed in 56 organ(s), highest expression level in quadriceps femoris
CleanExiHS_MYH8
GenevisibleiP13535 HS

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYH8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13535
Secondary accession number(s): Q14910
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 15, 1998
Last modified: January 16, 2019
This is version 188 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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