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Protein

Secretogranin-2

Gene

SCG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides.

Miscellaneous

Binds calcium with a low-affinity.

GO - Molecular functioni

  • chemoattractant activity Source: HGNC
  • cytokine activity Source: HGNC

GO - Biological processi

Keywordsi

LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Secretogranin-2
Alternative name(s):
Chromogranin-C
Secretogranin II
Short name:
SgII
Cleaved into the following 2 chains:
Secretoneurin
Short name:
SN
Gene namesi
Name:SCG2
Synonyms:CHGC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000171951.4
HGNCiHGNC:10575 SCG2
MIMi118930 gene
neXtProtiNX_P13521

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7857
OpenTargetsiENSG00000171951
PharmGKBiPA34987

Polymorphism and mutation databases

BioMutaiSCG2
DMDMi143811457

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
PropeptideiPRO_000000545228 – 30Sequence analysis3
ChainiPRO_000000545331 – 617Secretogranin-2Add BLAST587
PeptideiPRO_0000005454182 – 214SecretoneurinAdd BLAST33
PeptideiPRO_0000432735527 – 566ManserinBy similarityAdd BLAST40

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151Sulfotyrosine1 Publication1
Modified residuei174PhosphoserineBy similarity1
Modified residuei268PhosphoserineBy similarity1
Modified residuei432PhosphoserineBy similarity1
Modified residuei532PhosphoserineBy similarity1
Modified residuei555PhosphoserineBy similarity1
Modified residuei556PhosphoserineBy similarity1

Post-translational modificationi

O-glycosylated.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Phosphoprotein, Sulfation

Proteomic databases

MaxQBiP13521
PaxDbiP13521
PeptideAtlasiP13521
PRIDEiP13521
ProteomicsDBi52923

PTM databases

iPTMnetiP13521
PhosphoSitePlusiP13521

Expressioni

Gene expression databases

BgeeiENSG00000171951 Expressed in 167 organ(s), highest expression level in caudate nucleus
CleanExiHS_SCG2
ExpressionAtlasiP13521 baseline and differential
GenevisibleiP13521 HS

Organism-specific databases

HPAiHPA011893
HPA075062

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113611, 5 interactors
CORUMiP13521
IntActiP13521, 7 interactors
MINTiP13521
STRINGi9606.ENSP00000304133

Structurei

3D structure databases

ProteinModelPortaliP13521
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni182 – 200O-glycosylated at one siteAdd BLAST19

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFXN Eukaryota
ENOG4111F4G LUCA
GeneTreeiENSGT00390000010895
HOGENOMiHOG000059543
HOVERGENiHBG054148
InParanoidiP13521
OMAiVGGEDWN
OrthoDBiEOG091G03GC
PhylomeDBiP13521
TreeFamiTF334018

Family and domain databases

InterProiView protein in InterPro
IPR018054 Chromogranin_CS
IPR001990 Granin
IPR038858 ScgII
PANTHERiPTHR15119 PTHR15119, 1 hit
PfamiView protein in Pfam
PF01271 Granin, 1 hit
PROSITEiView protein in PROSITE
PS00422 GRANINS_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P13521-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEAKTHWLG AALSLIPLIF LISGAEAASF QRNQLLQKEP DLRLENVQKF
60 70 80 90 100
PSPEMIRALE YIENLRQQAH KEESSPDYNP YQGVSVPLQQ KENGDESHLP
110 120 130 140 150
ERDSLSEEDW MRIILEALRQ AENEPQSAPK ENKPYALNSE KNFPMDMSDD
160 170 180 190 200
YETQQWPERK LKHMQFPPMY EENSRDNPFK RTNEIVEEQY TPQSLATLES
210 220 230 240 250
VFQELGKLTG PNNQKRERMD EEQKLYTDDE DDIYKANNIA YEDVVGGEDW
260 270 280 290 300
NPVEEKIESQ TQEEVRDSKE NIEKNEQIND EMKRSGQLGI QEEDLRKESK
310 320 330 340 350
DQLSDDVSKV IAYLKRLVNA AGSGRLQNGQ NGERATRLFE KPLDSQSIYQ
360 370 380 390 400
LIEISRNLQI PPEDLIEMLK TGEKPNGSVE PERELDLPVD LDDISEADLD
410 420 430 440 450
HPDLFQNRML SKSGYPKTPG RAGTEALPDG LSVEDILNLL GMESAANQKT
460 470 480 490 500
SYFPNPYNQE KVLPRLPYGA GRSRSNQLPK AAWIPHVENR QMAYENLNDK
510 520 530 540 550
DQELGEYLAR MLVKYPEIIN SNQVKRVPGQ GSSEDDLQEE EQIEQAIKEH
560 570 580 590 600
LNQGSSQETD KLAPVSKRFP VGPPKNDDTP NRQYWDEDLL MKVLEYLNQE
610
KAEKGREHIA KRAMENM
Length:617
Mass (Da):70,941
Last modified:April 3, 2007 - v2
Checksum:iA81C9C091DE9DF6B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JDT0C9JDT0_HUMAN
Secretogranin-2
SCG2
125Annotation score:
C9JQI2C9JQI2_HUMAN
Secretogranin-2
SCG2
144Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti273E → G in AAA36607 (PubMed:2745426).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03155561Y → H. Corresponds to variant dbSNP:rs16864976Ensembl.1
Natural variantiVAR_048755196A → V. Corresponds to variant dbSNP:rs1438157Ensembl.1
Natural variantiVAR_031556294D → G1 PublicationCorresponds to variant dbSNP:rs17852053Ensembl.1
Natural variantiVAR_031557421R → G1 PublicationCorresponds to variant dbSNP:rs17856669Ensembl.1
Natural variantiVAR_031558535D → G1 PublicationCorresponds to variant dbSNP:rs17852054Ensembl.1
Natural variantiVAR_031559564P → L. Corresponds to variant dbSNP:rs36043001Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25756 mRNA Translation: AAA36607.1
AK312452 mRNA Translation: BAG35359.1
AC012512 Genomic DNA Translation: AAY24243.1
CH471063 Genomic DNA Translation: EAW70811.1
BC022509 mRNA Translation: AAH22509.1
CCDSiCCDS2457.1
PIRiA34174
RefSeqiNP_003460.2, NM_003469.4
UniGeneiHs.516726

Genome annotation databases

EnsembliENST00000305409; ENSP00000304133; ENSG00000171951
GeneIDi7857
KEGGihsa:7857
UCSCiuc002vnm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25756 mRNA Translation: AAA36607.1
AK312452 mRNA Translation: BAG35359.1
AC012512 Genomic DNA Translation: AAY24243.1
CH471063 Genomic DNA Translation: EAW70811.1
BC022509 mRNA Translation: AAH22509.1
CCDSiCCDS2457.1
PIRiA34174
RefSeqiNP_003460.2, NM_003469.4
UniGeneiHs.516726

3D structure databases

ProteinModelPortaliP13521
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113611, 5 interactors
CORUMiP13521
IntActiP13521, 7 interactors
MINTiP13521
STRINGi9606.ENSP00000304133

PTM databases

iPTMnetiP13521
PhosphoSitePlusiP13521

Polymorphism and mutation databases

BioMutaiSCG2
DMDMi143811457

Proteomic databases

MaxQBiP13521
PaxDbiP13521
PeptideAtlasiP13521
PRIDEiP13521
ProteomicsDBi52923

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305409; ENSP00000304133; ENSG00000171951
GeneIDi7857
KEGGihsa:7857
UCSCiuc002vnm.4 human

Organism-specific databases

CTDi7857
DisGeNETi7857
EuPathDBiHostDB:ENSG00000171951.4
GeneCardsiSCG2
H-InvDBiHIX0002882
HGNCiHGNC:10575 SCG2
HPAiHPA011893
HPA075062
MIMi118930 gene
neXtProtiNX_P13521
OpenTargetsiENSG00000171951
PharmGKBiPA34987
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFXN Eukaryota
ENOG4111F4G LUCA
GeneTreeiENSGT00390000010895
HOGENOMiHOG000059543
HOVERGENiHBG054148
InParanoidiP13521
OMAiVGGEDWN
OrthoDBiEOG091G03GC
PhylomeDBiP13521
TreeFamiTF334018

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSiSCG2 human
GeneWikiiSCG2
GenomeRNAii7857
PROiPR:P13521
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171951 Expressed in 167 organ(s), highest expression level in caudate nucleus
CleanExiHS_SCG2
ExpressionAtlasiP13521 baseline and differential
GenevisibleiP13521 HS

Family and domain databases

InterProiView protein in InterPro
IPR018054 Chromogranin_CS
IPR001990 Granin
IPR038858 ScgII
PANTHERiPTHR15119 PTHR15119, 1 hit
PfamiView protein in Pfam
PF01271 Granin, 1 hit
PROSITEiView protein in PROSITE
PS00422 GRANINS_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCG2_HUMAN
AccessioniPrimary (citable) accession number: P13521
Secondary accession number(s): B2R662, Q53T11, Q8TBH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 3, 2007
Last modified: November 7, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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