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Entry version 194 (02 Jun 2021)
Sequence version 1 (01 Jan 1990)
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Protein

Protein glp-1

Gene

glp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the specification of the cell fates of the blastomeres, ABa and APa (PubMed:8156602).

Proper signaling by glp-1 induces ABa descendants to produce anterior pharyngeal cells, and APa descendants to adopt a different fate (PubMed:8156602).

Contributes to the establishment of the dorsal-ventral axis in early embryos (PubMed:8156602).

Regulates germ cell mitotic proliferation probably by regulating MAP kinase phosphatase lip-1 expression (PubMed:22278922, PubMed:16319922).

Plays a negative role in lifespan (PubMed:21906946, PubMed:24332851, PubMed:28853436).

6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P13508

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein glp-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:glp-1Imported
Synonyms:emb-33Imported
ORF Names:F02A9.6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
F02A9.6 ; CE00237 ; WBGene00001609 ; glp-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini16 – 764ExtracellularSequence analysisAdd BLAST749
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei765 – 786HelicalSequence analysisAdd BLAST22
Topological domaini787 – 1295CytoplasmicSequence analysisAdd BLAST509

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown causes an increase in lifespan and a moderate increase in aak-2 phosphorylation (PubMed:24332851). RNAi-mediated knockdown in a rsks-1 mutant background reduces the formation of proximal germ cell tumors (PubMed:22278922).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi529G → E in ar202; formation of proximal germ cell-derived tumors. 1 Publication1
Mutagenesisi929L → F in 2144; moderate increase in aak-2 phosphorylation. 1 Publication1
Mutagenesisi974R → C in 2141; reduces number of germline progenitors at the semi-permissive temperature (20 degrees Celsius). All germ cells differentiate at the restrictive temperature(25 degrees Celsius). Increases longevity and reduces nucleoli size (20 degrees Celsius). Increased longevity and reduced nucleoli size phenotypes are suppressed in an ncl-1 mutant background (20 degrees Celsius). Autophagy levels are increased due the up-regulation of transcription factor pha-4 and its autophagy-related target genes. Increases lipase activity. The increase in autophagy and lipase activity is partially suppressed in a lipl-4 RNAi-mediated background. 3 Publications1
Mutagenesisi1043G → E in q224; at the restrictive temperature of 25 degrees Celsius, loss of interaction of lag-3 with lip-1 promoter. Loss of mpk-1 isoform b expression probably due to a lack of germline. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 15Sequence analysisAdd BLAST15
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000759416 – 1295Protein glp-1Add BLAST1280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi23 ↔ 35PROSITE-ProRule annotation
Disulfide bondi29 ↔ 46PROSITE-ProRule annotation
Disulfide bondi48 ↔ 57PROSITE-ProRule annotation
Disulfide bondi121 ↔ 131PROSITE-ProRule annotation
Disulfide bondi126 ↔ 140PROSITE-ProRule annotation
Disulfide bondi142 ↔ 151PROSITE-ProRule annotation
Disulfide bondi158 ↔ 169PROSITE-ProRule annotation
Disulfide bondi163 ↔ 178PROSITE-ProRule annotation
Disulfide bondi180 ↔ 189PROSITE-ProRule annotation
Disulfide bondi201 ↔ 206PROSITE-ProRule annotation
Disulfide bondi220 ↔ 229PROSITE-ProRule annotation
Disulfide bondi236 ↔ 248PROSITE-ProRule annotation
Disulfide bondi242 ↔ 257PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi244N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi245N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi259 ↔ 268PROSITE-ProRule annotation
Disulfide bondi275 ↔ 286PROSITE-ProRule annotation
Disulfide bondi280 ↔ 296PROSITE-ProRule annotation
Disulfide bondi298 ↔ 307PROSITE-ProRule annotation
Disulfide bondi329 ↔ 342PROSITE-ProRule annotation
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi336 ↔ 347PROSITE-ProRule annotation
Disulfide bondi349 ↔ 358PROSITE-ProRule annotation
Disulfide bondi373 ↔ 384PROSITE-ProRule annotation
Disulfide bondi378 ↔ 394PROSITE-ProRule annotation
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi396 ↔ 405PROSITE-ProRule annotation
Disulfide bondi411 ↔ 422PROSITE-ProRule annotation
Disulfide bondi416 ↔ 431PROSITE-ProRule annotation
Disulfide bondi433 ↔ 442PROSITE-ProRule annotation
Disulfide bondi450 ↔ 461PROSITE-ProRule annotation
Disulfide bondi455 ↔ 467PROSITE-ProRule annotation
Disulfide bondi469 ↔ 478PROSITE-ProRule annotation
Disulfide bondi496 ↔ 519PROSITE-ProRule annotation
Disulfide bondi501 ↔ 514PROSITE-ProRule annotation
Disulfide bondi510 ↔ 526PROSITE-ProRule annotation
Disulfide bondi536 ↔ 560PROSITE-ProRule annotation
Disulfide bondi542 ↔ 555PROSITE-ProRule annotation
Disulfide bondi551 ↔ 567PROSITE-ProRule annotation
Disulfide bondi582 ↔ 595PROSITE-ProRule annotation
Disulfide bondi591 ↔ 607PROSITE-ProRule annotation
Glycosylationi609N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi675N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P13508

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P13508

PRoteomics IDEntifications database

More...
PRIDEi
P13508

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Acts on ABp development during 4-cell and 12-cell stages, and on ABa development during 12-cell and 28-cell stages.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001609, Expressed in adult organism and 38 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with sel-10.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
41485, 94 interactors

Database of interacting proteins

More...
DIPi
DIP-26562N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P13508

Protein interaction database and analysis system

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IntActi
P13508, 13 interactors

Molecular INTeraction database

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MINTi
P13508

STRING: functional protein association networks

More...
STRINGi
6239.F02A9.6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P13508

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 58EGF-like 1PROSITE-ProRule annotationAdd BLAST40
Domaini117 – 152EGF-like 2PROSITE-ProRule annotationAdd BLAST36
Domaini154 – 190EGF-like 3PROSITE-ProRule annotationAdd BLAST37
Domaini190 – 230EGF-like 4PROSITE-ProRule annotationAdd BLAST41
Domaini232 – 269EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST38
Domaini271 – 308EGF-like 6PROSITE-ProRule annotationAdd BLAST38
Domaini316 – 359EGF-like 7PROSITE-ProRule annotationAdd BLAST44
Domaini369 – 406EGF-like 8PROSITE-ProRule annotationAdd BLAST38
Domaini407 – 443EGF-like 9PROSITE-ProRule annotationAdd BLAST37
Domaini446 – 479EGF-like 10PROSITE-ProRule annotationAdd BLAST34
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati496 – 532LNR 1PROSITE-ProRule annotation1 PublicationAdd BLAST37
Repeati536 – 577LNR 2PROSITE-ProRule annotation1 PublicationAdd BLAST42
Repeati581 – 612LNR 3PROSITE-ProRule annotation1 PublicationAdd BLAST32
Repeati961 – 990ANK 1PROSITE-ProRule annotation1 PublicationAdd BLAST30
Repeati994 – 1023ANK 2PROSITE-ProRule annotation1 PublicationAdd BLAST30
Repeati1030 – 1062ANK 3PROSITE-ProRule annotation1 PublicationAdd BLAST33
Repeati1074 – 1103ANK 4PROSITE-ProRule annotation1 PublicationAdd BLAST30
Repeati1107 – 1136ANK 5PROSITE-ProRule annotation1 PublicationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1177 – 1244DisorderedSequence analysisAdd BLAST68

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1182 – 1244Polar residuesSequence analysisAdd BLAST63

Keywords - Domaini

ANK repeat, EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005264_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P13508

Identification of Orthologs from Complete Genome Data

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OMAi
SNDINEC

Database of Orthologous Groups

More...
OrthoDBi
7525at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P13508

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR035993, Notch-like_dom_sf
IPR000800, Notch_dom
IPR010660, Notch_NOD_dom
IPR011656, Notch_NODP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 2 hits
PF00008, EGF, 1 hit
PF06816, NOD, 1 hit
PF07684, NODP, 1 hit
PF00066, Notch, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01452, LNOTCHREPEAT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 5 hits
SM00181, EGF, 11 hits
SM00179, EGF_CA, 6 hits
SM00004, NL, 3 hits
SM01338, NOD, 1 hit
SM01339, NODP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF90193, SSF90193, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 3 hits
PS00010, ASX_HYDROXYL, 2 hits
PS00022, EGF_1, 10 hits
PS01186, EGF_2, 8 hits
PS50026, EGF_3, 10 hits
PS01187, EGF_CA, 1 hit
PS50258, LNR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P13508-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVLLILLAF FAPIASQLMG GECGREGACS VNGKCYNGKL IETYWCRCKK
60 70 80 90 100
GFGGAFCERE CDLDCKRGEK CIYDVYGENP TCICQDCEDE TPPTERTQKG
110 120 130 140 150
CEEGYGGPDC KTPLFSGVNP CDSDPCNNGL CYPFYGGFQC ICNNGYGGSY
160 170 180 190 200
CEEGIDHCAQ NECAEGSTCV NSVYNYYCDC PIGKSGRYCE RTECALMGNI
210 220 230 240 250
CNHGRCIPNR DEDKNFRCVC DSGYEGEFCN KDKNECLIEE TCVNNSTCFN
260 270 280 290 300
LHGDFTCTCK PGYAGKYCEE AIDMCKDYVC QNDGYCAHDS NQMPICYCEQ
310 320 330 340 350
GFTGQRCEIE CPSGFGGIHC DLPLQRPHCS RSNGTCYNDG RCINGFCVCE
360 370 380 390 400
PDYIGDRCEI NRKDFKFPDI QSCKYNPCVN NATCIDLKNS GYSCHCPLGF
410 420 430 440 450
YGLNCEQHLL CTPTTCANGG TCEGVNGVIR CNCPNGFSGD YCEIKDRQLC
460 470 480 490 500
SRHPCKNGGV CKNTGYCECQ YGYTGPTCEE VLVIEKSKET VIRDLCEQRK
510 520 530 540 550
CMDLASNGIC NPECNLEECN FDGGDCSGGQ RPFSKCQYPA RCADQFANGV
560 570 580 590 600
CNQECNNEEC LYDGLDCQSE LFRCPAHIRK HCIERRGDGV CNLECSFIGC
610 620 630 640 650
GFDGGDCNNG TEAIILSDIR IKVQIDPIEF QATGGETLMQ ISANLRATVR
660 670 680 690 700
IQRDELGPLV FRWDGEHEME RVEMNSSKLE DQFVLSHHVR RYRQAVVTGI
710 720 730 740 750
VLYLEVEEIC KPEFCRFSTA QSVVDLIAAG LVKSDGRMSL GLPITEAMVA
760 770 780 790 800
VPKRNEIDEG WSRSQVILFA CIAFLAFGTV VAGVIAKNGP ERSRKRKMVN
810 820 830 840 850
ATVWMPPMES TNEKGRRNQS NHSSQCSLLD NSAYYHPNTK RHCSDYSTGY
860 870 880 890 900
NGEQYSQIYP QTLANGYPGD YNELNFDFQS ETFAPADLPA DEIPLHVQAA
910 920 930 940 950
GPDAITAPIT NESVNQVDSK YRRRVLHWLA ANVRGKPEDV ITTEAIRCLK
960 970 980 990 1000
AGADVNARDC DENTALMLAV RAHRVRLSVV LLREGANPTI FNNSERSALH
1010 1020 1030 1040 1050
EAVVNKDLRI LRHLLTDKRL LKEIDELDRN GMTALMLVAR ELGKHQVEMA
1060 1070 1080 1090 1100
ELLLSKGAKL DYDGAARKDS NKYKGRTALH YAAMHDNEEM VIMLVRRSSN
1110 1120 1130 1140 1150
KDKQDEDGRT PIMLAAKEGC EKTVQYLALN DASLGIVDSM DMTAAQVAEA
1160 1170 1180 1190 1200
SYHHELAAFL RQVANERHRN DIMRQQIVKS GHGAKSGRQT VKNIKRAGSR
1210 1220 1230 1240 1250
KTPTSAASSR ETNHLTPPPS DGSFSSPSPH YYPTTTSTPN RMETSPEYMF
1260 1270 1280 1290
NHEMAPPVNA MWYTTPPPYQ DPNYRHVPPN TAFQNAEQMN GSFYC
Length:1,295
Mass (Da):144,079
Last modified:January 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i422AAD0A2DEEF3B4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M25580 Genomic DNA Translation: AAA28058.1
BX284603, Z29116 Genomic DNA Translation: CAA79620.1

Protein sequence database of the Protein Information Resource

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PIRi
A32901

NCBI Reference Sequences

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RefSeqi
NP_499014.1, NM_066613.4

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
F02A9.6.1; F02A9.6.1; WBGene00001609

Database of genes from NCBI RefSeq genomes

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GeneIDi
176286

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_F02A9.6

UCSC genome browser

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UCSCi
F02A9.6, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25580 Genomic DNA Translation: AAA28058.1
BX284603, Z29116 Genomic DNA Translation: CAA79620.1
PIRiA32901
RefSeqiNP_499014.1, NM_066613.4

3D structure databases

SMRiP13508
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi41485, 94 interactors
DIPiDIP-26562N
ELMiP13508
IntActiP13508, 13 interactors
MINTiP13508
STRINGi6239.F02A9.6

Proteomic databases

EPDiP13508
PaxDbiP13508
PRIDEiP13508

Genome annotation databases

EnsemblMetazoaiF02A9.6.1; F02A9.6.1; WBGene00001609
GeneIDi176286
KEGGicel:CELE_F02A9.6
UCSCiF02A9.6, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
176286
WormBaseiF02A9.6 ; CE00237 ; WBGene00001609 ; glp-1

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
HOGENOMiCLU_005264_0_0_1
InParanoidiP13508
OMAiSNDINEC
OrthoDBi7525at2759
PhylomeDBiP13508

Enzyme and pathway databases

SignaLinkiP13508

Miscellaneous databases

Protein Ontology

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PROi
PR:P13508

Gene expression databases

BgeeiWBGene00001609, Expressed in adult organism and 38 other tissues

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR035993, Notch-like_dom_sf
IPR000800, Notch_dom
IPR010660, Notch_NOD_dom
IPR011656, Notch_NODP_dom
PfamiView protein in Pfam
PF12796, Ank_2, 2 hits
PF00008, EGF, 1 hit
PF06816, NOD, 1 hit
PF07684, NODP, 1 hit
PF00066, Notch, 3 hits
PRINTSiPR01452, LNOTCHREPEAT
SMARTiView protein in SMART
SM00248, ANK, 5 hits
SM00181, EGF, 11 hits
SM00179, EGF_CA, 6 hits
SM00004, NL, 3 hits
SM01338, NOD, 1 hit
SM01339, NODP, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF90193, SSF90193, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 3 hits
PS00010, ASX_HYDROXYL, 2 hits
PS00022, EGF_1, 10 hits
PS01186, EGF_2, 8 hits
PS50026, EGF_3, 10 hits
PS01187, EGF_CA, 1 hit
PS50258, LNR, 3 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLP1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13508
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 2, 2021
This is version 194 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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