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Protein

Cytochrome b-245 light chain

Gene

CYBA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi94Iron (heme axial ligand)Sequence analysis1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • electron transfer activity Source: BHF-UCL
  • heme binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW
  • protein heterodimerization activity Source: BHF-UCL
  • SH3 domain binding Source: BHF-UCL
  • superoxide-generating NADPH oxidase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport
LigandHeme, Iron, Metal-binding, NADP

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5668599 RHO GTPases Activate NADPH Oxidases
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

Transport Classification Database

More...
TCDBi
5.B.1.1.1 the phagocyte (gp91(phox)) nadph oxidase family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome b-245 light chain
Alternative name(s):
Cytochrome b(558) alpha chain
Cytochrome b558 subunit alpha
Neutrophil cytochrome b 22 kDa polypeptide
Superoxide-generating NADPH oxidase light chain subunit
p22 phagocyte B-cytochrome
p22-phox
Short name:
p22phox
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYBAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000051523.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2577 CYBA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608508 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P13498

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei91 – 127Add BLAST37

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Granulomatous disease, chronic, cytochrome-b-negative, autosomal recessive (ARCGD)10 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections.
See also OMIM:233690
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01275524G → R in ARCGD. 4 PublicationsCorresponds to variant dbSNP:rs28941476EnsemblClinVar.1
Natural variantiVAR_07186025G → D in ARCGD. 1 Publication1
Natural variantiVAR_06057625G → V in ARCGD. 1 PublicationCorresponds to variant dbSNP:rs179363891EnsemblClinVar.1
Natural variantiVAR_06057752L → P in ARCGD. 1 PublicationCorresponds to variant dbSNP:rs179363890EnsemblClinVar.1
Natural variantiVAR_06057853E → V in ARCGD. 1 PublicationCorresponds to variant dbSNP:rs179363893EnsemblClinVar.1
Natural variantiVAR_00512390R → Q in ARCGD. 1 PublicationCorresponds to variant dbSNP:rs104894513EnsemblClinVar.1
Natural variantiVAR_06057990R → W in ARCGD. 1 PublicationCorresponds to variant dbSNP:rs179363892EnsemblClinVar.1
Natural variantiVAR_00512494H → R in ARCGD. 1 PublicationCorresponds to variant dbSNP:rs104894510EnsemblClinVar.1
Natural variantiVAR_005125118S → R in ARCGD. 2 PublicationsCorresponds to variant dbSNP:rs104894514EnsemblClinVar.1
Natural variantiVAR_060580124A → V in ARCGD. 2 PublicationsCorresponds to variant dbSNP:rs179363894EnsemblClinVar.1
Natural variantiVAR_060581125A → T in ARCGD. 2 PublicationsCorresponds to variant dbSNP:rs119103269EnsemblClinVar.1
Natural variantiVAR_005126156P → Q in ARCGD. 2 PublicationsCorresponds to variant dbSNP:rs104894515EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi157P → Q: Loss of interaction with NOXO1. 1 Publication1

Keywords - Diseasei

Chronic granulomatous disease, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
1535

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
CYBA

MalaCards human disease database

More...
MalaCardsi
CYBA
MIMi233690 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000051523

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
379 Chronic granulomatous disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27075

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00514 Dextromethorphan

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CYBA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
311033459

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001449072 – 195Cytochrome b-245 light chainAdd BLAST194

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei147PhosphothreonineCombined sources1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki149Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei168PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The heme prosthetic group could be coordinated with residues of the light chain, the heavy chain, or both, and it is possible that more than one heme is present per cytochrome b-245.
Phosphorylation at Thr-147 enhances NADPH oxidase activity by promoting p47phox binding.By similarity
Ubiquitinated at Lys-149 likely by RNF145.By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P13498

MaxQB - The MaxQuant DataBase

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MaxQBi
P13498

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P13498

PeptideAtlas

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PeptideAtlasi
P13498

PRoteomics IDEntifications database

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PRIDEi
P13498

ProteomicsDB human proteome resource

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ProteomicsDBi
52920

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P13498

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P13498

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000051523 Expressed in 205 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

More...
CleanExi
HS_CYBA

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P13498 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P13498 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009492

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain). Interacts with SH3PXD2A (By similarity). Interacts with DUOX1, DUOX2 and TPO. Interacts with NOX3 and NOX4. Interacts with calprotectin (S100A8/9).By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107915, 13 interactors

Database of interacting proteins

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DIPi
DIP-37650N

Protein interaction database and analysis system

More...
IntActi
P13498, 10 interactors

Molecular INTeraction database

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MINTi
P13498

STRING: functional protein association networks

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STRINGi
9606.ENSP00000261623

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1195
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P13498

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P13498

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P13498

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi133 – 189Pro-richAdd BLAST57

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the p22phox family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IXYN Eukaryota
ENOG4111MI6 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000002290

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000001585

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051278

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P13498

KEGG Orthology (KO)

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KOi
K08009

Identification of Orthologs from Complete Genome Data

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OMAi
KIEWAMW

Database for complete collections of gene phylogenies

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PhylomeDBi
P13498

TreeFam database of animal gene trees

More...
TreeFami
TF328901

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007732 Cyt_b558_asu

The PANTHER Classification System

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PANTHERi
PTHR15168 PTHR15168, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05038 Cytochrom_B558a, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF019635 Cytochr_b558a, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P13498-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQIEWAMWA NEQALASGLI LITGGIVATA GRFTQWYFGA YSIVAGVFVC
60 70 80 90 100
LLEYPRGKRK KGSTMERWGQ KYMTAVVKLF GPFTRNYYVR AVLHLLLSVP
110 120 130 140 150
AGFLLATILG TACLAIASGI YLLAAVRGEQ WTPIEPKPRE RPQIGGTIKQ
160 170 180 190
PPSNPPPRPP AEARKKPSEE EAAVAAGGPP GGPQVNPIPV TDEVV
Length:195
Mass (Da):21,013
Last modified:November 2, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i428427AD19398240
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BNP7H3BNP7_HUMAN
Cytochrome b-245 light chain
CYBA
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR52H3BR52_HUMAN
Cytochrome b-245 light chain
CYBA
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPX1H3BPX1_HUMAN
Cytochrome b-245 light chain
CYBA
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BT77H3BT77_HUMAN
Cytochrome b-245 light chain
CYBA
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPZ7H3BPZ7_HUMAN
Cytochrome b-245 light chain
CYBA
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01275524G → R in ARCGD. 4 PublicationsCorresponds to variant dbSNP:rs28941476EnsemblClinVar.1
Natural variantiVAR_07186025G → D in ARCGD. 1 Publication1
Natural variantiVAR_06057625G → V in ARCGD. 1 PublicationCorresponds to variant dbSNP:rs179363891EnsemblClinVar.1
Natural variantiVAR_06057752L → P in ARCGD. 1 PublicationCorresponds to variant dbSNP:rs179363890EnsemblClinVar.1
Natural variantiVAR_06057853E → V in ARCGD. 1 PublicationCorresponds to variant dbSNP:rs179363893EnsemblClinVar.1
Natural variantiVAR_00512272Y → H3 PublicationsCorresponds to variant dbSNP:rs4673EnsemblClinVar.1
Natural variantiVAR_00512390R → Q in ARCGD. 1 PublicationCorresponds to variant dbSNP:rs104894513EnsemblClinVar.1
Natural variantiVAR_06057990R → W in ARCGD. 1 PublicationCorresponds to variant dbSNP:rs179363892EnsemblClinVar.1
Natural variantiVAR_00512494H → R in ARCGD. 1 PublicationCorresponds to variant dbSNP:rs104894510EnsemblClinVar.1
Natural variantiVAR_005125118S → R in ARCGD. 2 PublicationsCorresponds to variant dbSNP:rs104894514EnsemblClinVar.1
Natural variantiVAR_060580124A → V in ARCGD. 2 PublicationsCorresponds to variant dbSNP:rs179363894EnsemblClinVar.1
Natural variantiVAR_060581125A → T in ARCGD. 2 PublicationsCorresponds to variant dbSNP:rs119103269EnsemblClinVar.1
Natural variantiVAR_005126156P → Q in ARCGD. 2 PublicationsCorresponds to variant dbSNP:rs104894515EnsemblClinVar.1
Natural variantiVAR_060582171E → G1 PublicationCorresponds to variant dbSNP:rs72667005Ensembl.1
Natural variantiVAR_054801174V → A5 PublicationsCorresponds to variant dbSNP:rs1049254EnsemblClinVar.1
Natural variantiVAR_060583193E → D1 PublicationCorresponds to variant dbSNP:rs72667006Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M21186 mRNA Translation: AAA90925.1
BT006861 mRNA Translation: AAP35507.1
AC116552 Genomic DNA No translation available.
BC006465 mRNA Translation: AAH06465.1
AH002664 Genomic DNA Translation: AAA52134.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS32504.1

Protein sequence database of the Protein Information Resource

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PIRi
A28201

NCBI Reference Sequences

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RefSeqi
NP_000092.2, NM_000101.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.513803

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000261623; ENSP00000261623; ENSG00000051523

Database of genes from NCBI RefSeq genomes

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GeneIDi
1535

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1535

UCSC genome browser

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UCSCi
uc002flb.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

CYBAbase

CYBA mutation db

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21186 mRNA Translation: AAA90925.1
BT006861 mRNA Translation: AAP35507.1
AC116552 Genomic DNA No translation available.
BC006465 mRNA Translation: AAH06465.1
AH002664 Genomic DNA Translation: AAA52134.1
CCDSiCCDS32504.1
PIRiA28201
RefSeqiNP_000092.2, NM_000101.3
UniGeneiHs.513803

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WLPNMR-A149-168[»]
ProteinModelPortaliP13498
SMRiP13498
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107915, 13 interactors
DIPiDIP-37650N
IntActiP13498, 10 interactors
MINTiP13498
STRINGi9606.ENSP00000261623

Chemistry databases

DrugBankiDB00514 Dextromethorphan

Protein family/group databases

TCDBi5.B.1.1.1 the phagocyte (gp91(phox)) nadph oxidase family

PTM databases

iPTMnetiP13498
PhosphoSitePlusiP13498

Polymorphism and mutation databases

BioMutaiCYBA
DMDMi311033459

Proteomic databases

EPDiP13498
MaxQBiP13498
PaxDbiP13498
PeptideAtlasiP13498
PRIDEiP13498
ProteomicsDBi52920

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
1535
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261623; ENSP00000261623; ENSG00000051523
GeneIDi1535
KEGGihsa:1535
UCSCiuc002flb.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1535
DisGeNETi1535
EuPathDBiHostDB:ENSG00000051523.10

GeneCards: human genes, protein and diseases

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GeneCardsi
CYBA
GeneReviewsiCYBA

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0013335
HGNCiHGNC:2577 CYBA
HPAiCAB009492
MalaCardsiCYBA
MIMi233690 phenotype
608508 gene
neXtProtiNX_P13498
OpenTargetsiENSG00000051523
Orphaneti379 Chronic granulomatous disease
PharmGKBiPA27075

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IXYN Eukaryota
ENOG4111MI6 LUCA
GeneTreeiENSGT00390000002290
HOGENOMiHOG000001585
HOVERGENiHBG051278
InParanoidiP13498
KOiK08009
OMAiKIEWAMW
PhylomeDBiP13498
TreeFamiTF328901

Enzyme and pathway databases

ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5668599 RHO GTPases Activate NADPH Oxidases
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CYBA human
EvolutionaryTraceiP13498

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1535

Protein Ontology

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PROi
PR:P13498

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000051523 Expressed in 205 organ(s), highest expression level in blood
CleanExiHS_CYBA
ExpressionAtlasiP13498 baseline and differential
GenevisibleiP13498 HS

Family and domain databases

InterProiView protein in InterPro
IPR007732 Cyt_b558_asu
PANTHERiPTHR15168 PTHR15168, 1 hit
PfamiView protein in Pfam
PF05038 Cytochrom_B558a, 1 hit
PIRSFiPIRSF019635 Cytochr_b558a, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCY24A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13498
Secondary accession number(s): Q14090, Q9BR72
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 2, 2010
Last modified: November 7, 2018
This is version 190 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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