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Protein

Ribonuclease inhibitor

Gene

RNH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ribonuclease inhibitor activity Source: UniProtKB

GO - Biological processi

  • mRNA catabolic process Source: UniProtKB
  • regulation of angiogenesis Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribonuclease inhibitor
Alternative name(s):
Placental ribonuclease inhibitor
Short name:
Placental RNase inhibitor
Ribonuclease/angiogenin inhibitor 1
Short name:
RAI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNH1
Synonyms:PRI, RNH
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000023191.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10074 RNH1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
173320 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P13489

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi262W → A: Binding affinity decreased 5000-fold over the wild type for RNASE2; when associated with A-264 and A-319. 1 Publication1
Mutagenesisi264W → A: Substantially decreased binding affinity for RNASE2. Binding affinity decreased 5000-fold over the wild type for RNASE2; when associated with A-262 and A-319. 1 Publication1
Mutagenesisi319W → A: Substantially decreased binding affinity for RNASE2. Binding affinity decreased 5000-fold over the wild type for RNASE2; when associated with A-262 and A-264. 1 Publication1
Mutagenesisi376W → A: 40-fold reduction in binding affinity for RNASE2. 1 Publication1
Mutagenesisi435 – 436YD → AA: Substantially decreases binding affinity for RNASE1, ANG and RNASE2. 2 Publications2
Mutagenesisi458R → A: 25-fold reduction in binding affinity for RNASE2. 1 Publication1
Mutagenesisi461Missing : A significant decrease in binding affinity with RNASE1, slight decrease for the ANG ligand, no real change in binding affinity for RNASE2. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
6050

Open Targets

More...
OpenTargetsi
ENSG00000023191

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34447

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RNH1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
132573

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000973432 – 461Ribonuclease inhibitorAdd BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei82PhosphothreonineCombined sources1
Modified residuei91PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.
At least 30 of the 32 cysteine residues are in the reduced form.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P13489

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P13489

MaxQB - The MaxQuant DataBase

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MaxQBi
P13489

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P13489

PeptideAtlas

More...
PeptideAtlasi
P13489

PRoteomics IDEntifications database

More...
PRIDEi
P13489

ProteomicsDB human proteome resource

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ProteomicsDBi
52913

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00550069

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P13489

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P13489

SwissPalm database of S-palmitoylation events

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SwissPalmi
P13489

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000023191 Expressed in 231 organ(s), highest expression level in skin of leg

CleanEx database of gene expression profiles

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CleanExi
HS_RNH1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P13489 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P13489 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039223
HPA040781

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111977, 73 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P13489

Protein interaction database and analysis system

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IntActi
P13489, 33 interactors

Molecular INTeraction database

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MINTi
P13489

STRING: functional protein association networks

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STRINGi
9606.ENSP00000346402

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A4YX-ray2.00A/D2-461[»]
1Z7XX-ray1.95W/Y1-461[»]
2BEXX-ray1.99A/B2-461[»]
2Q4GX-ray1.95W/Y1-461[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P13489

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P13489

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P13489

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati20 – 48LRR 1Add BLAST29
Repeati49 – 76LRR 2Add BLAST28
Repeati77 – 105LRR 3Add BLAST29
Repeati106 – 133LRR 4Add BLAST28
Repeati134 – 162LRR 5Add BLAST29
Repeati163 – 190LRR 6Add BLAST28
Repeati191 – 219LRR 7Add BLAST29
Repeati220 – 247LRR 8Add BLAST28
Repeati248 – 276LRR 9Add BLAST29
Repeati277 – 304LRR 10Add BLAST28
Repeati305 – 333LRR 11Add BLAST29
Repeati334 – 361LRR 12Add BLAST28
Repeati362 – 390LRR 13Add BLAST29
Repeati391 – 418LRR 14Add BLAST28
Repeati419 – 447LRR 15Add BLAST29

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 112 X 5 AA tandem repeats of S-L-D-I-Q10

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNases via a large protein interaction surface on its interior side.3 Publications

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4308 Eukaryota
ENOG410ZBX3 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000161492

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000140402

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG001059

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P13489

KEGG Orthology (KO)

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KOi
K16634

Identification of Orthologs from Complete Genome Data

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OMAi
LWLWDCD

Database of Orthologous Groups

More...
OrthoDBi
710473at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P13489

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13516 LRR_6, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00367 LRR_CC, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

P13489-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLDIQSLDI QCEELSDARW AELLPLLQQC QVVRLDDCGL TEARCKDISS
60 70 80 90 100
ALRVNPALAE LNLRSNELGD VGVHCVLQGL QTPSCKIQKL SLQNCCLTGA
110 120 130 140 150
GCGVLSSTLR TLPTLQELHL SDNLLGDAGL QLLCEGLLDP QCRLEKLQLE
160 170 180 190 200
YCSLSAASCE PLASVLRAKP DFKELTVSNN DINEAGVRVL CQGLKDSPCQ
210 220 230 240 250
LEALKLESCG VTSDNCRDLC GIVASKASLR ELALGSNKLG DVGMAELCPG
260 270 280 290 300
LLHPSSRLRT LWIWECGITA KGCGDLCRVL RAKESLKELS LAGNELGDEG
310 320 330 340 350
ARLLCETLLE PGCQLESLWV KSCSFTAACC SHFSSVLAQN RFLLELQISN
360 370 380 390 400
NRLEDAGVRE LCQGLGQPGS VLRVLWLADC DVSDSSCSSL AATLLANHSL
410 420 430 440 450
RELDLSNNCL GDAGILQLVE SVRQPGCLLE QLVLYDIYWS EEMEDRLQAL
460
EKDKPSLRVI S
Length:461
Mass (Da):49,973
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E88CDAC95BAE5B3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PLZ3E9PLZ3_HUMAN
Ribonuclease inhibitor
RNH1
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIK5E9PIK5_HUMAN
Ribonuclease inhibitor
RNH1
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCR7H0YCR7_HUMAN
Ribonuclease inhibitor
RNH1
285Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMJ3E9PMJ3_HUMAN
Ribonuclease inhibitor
RNH1
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIM9E9PIM9_HUMAN
Ribonuclease inhibitor
RNH1
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMN0E9PMN0_HUMAN
Ribonuclease inhibitor
RNH1
168Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMA9E9PMA9_HUMAN
Ribonuclease inhibitor
RNH1
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMI1E9PMI1_HUMAN
Ribonuclease inhibitor
RNH1
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PR82E9PR82_HUMAN
Ribonuclease inhibitor
RNH1
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YXC4A0A0J9YXC4_HUMAN
Ribonuclease inhibitor
RNH1
8Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti188R → H in AAH03506 (PubMed:15489334).Curated1
Sequence conflicti359R → A in AAL60586 (PubMed:14515218).Curated1
Sequence conflicti365L → P in AAL60586 (PubMed:14515218).Curated1
Sequence conflicti423 – 424RQ → SE in CAA32151 (PubMed:3243277).Curated2
Sequence conflicti423 – 424RQ → SE in AAA60249 (PubMed:3243277).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_014726170P → L. Corresponds to variant dbSNP:rs17585Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M22414 mRNA Translation: AAA59130.1
M36717 mRNA Translation: AAA60249.1
X13973 mRNA Translation: CAA32151.1
AY071904 mRNA Translation: AAL60586.1
AL161967 mRNA Translation: CAB82310.1
BC000677 mRNA Translation: AAH00677.1
BC003506 mRNA Translation: AAH03506.1
BC011186 mRNA Translation: AAH11186.1
BC011500 mRNA Translation: AAH11500.1
BC014629 mRNA Translation: AAH14629.1
BC024037 mRNA Translation: AAH24037.1
BC047730 mRNA Translation: AAH47730.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7697.1

Protein sequence database of the Protein Information Resource

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PIRi
A31858

NCBI Reference Sequences

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RefSeqi
NP_002930.2, NM_002939.3
NP_976317.1, NM_203383.1
NP_976318.1, NM_203384.1
NP_976319.1, NM_203385.1
NP_976320.1, NM_203386.2
NP_976321.1, NM_203387.2
NP_976322.1, NM_203388.2
NP_976323.1, NM_203389.2
XP_011518557.1, XM_011520255.1
XP_011518559.1, XM_011520257.2
XP_011518560.1, XM_011520258.2
XP_011518561.1, XM_011520259.2
XP_011518562.1, XM_011520260.2
XP_011518563.1, XM_011520261.2
XP_011518564.1, XM_011520262.2
XP_011518565.1, XM_011520263.1
XP_016873595.1, XM_017018106.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.530687

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000354420; ENSP00000346402; ENSG00000023191
ENST00000356187; ENSP00000348515; ENSG00000023191
ENST00000397604; ENSP00000380729; ENSG00000023191
ENST00000397614; ENSP00000380738; ENSG00000023191
ENST00000397615; ENSP00000380739; ENSG00000023191
ENST00000438658; ENSP00000416589; ENSG00000023191
ENST00000533410; ENSP00000435594; ENSG00000023191
ENST00000534797; ENSP00000433999; ENSG00000023191
ENST00000612988; ENSP00000479004; ENSG00000276230
ENST00000617351; ENSP00000484572; ENSG00000276230
ENST00000618184; ENSP00000478664; ENSG00000276230
ENST00000619599; ENSP00000479966; ENSG00000276230
ENST00000621211; ENSP00000480036; ENSG00000276230
ENST00000632527; ENSP00000487940; ENSG00000276230
ENST00000632954; ENSP00000487753; ENSG00000276230
ENST00000633287; ENSP00000488734; ENSG00000276230

Database of genes from NCBI RefSeq genomes

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GeneIDi
6050

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6050

UCSC genome browser

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UCSCi
uc001lpk.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22414 mRNA Translation: AAA59130.1
M36717 mRNA Translation: AAA60249.1
X13973 mRNA Translation: CAA32151.1
AY071904 mRNA Translation: AAL60586.1
AL161967 mRNA Translation: CAB82310.1
BC000677 mRNA Translation: AAH00677.1
BC003506 mRNA Translation: AAH03506.1
BC011186 mRNA Translation: AAH11186.1
BC011500 mRNA Translation: AAH11500.1
BC014629 mRNA Translation: AAH14629.1
BC024037 mRNA Translation: AAH24037.1
BC047730 mRNA Translation: AAH47730.1
CCDSiCCDS7697.1
PIRiA31858
RefSeqiNP_002930.2, NM_002939.3
NP_976317.1, NM_203383.1
NP_976318.1, NM_203384.1
NP_976319.1, NM_203385.1
NP_976320.1, NM_203386.2
NP_976321.1, NM_203387.2
NP_976322.1, NM_203388.2
NP_976323.1, NM_203389.2
XP_011518557.1, XM_011520255.1
XP_011518559.1, XM_011520257.2
XP_011518560.1, XM_011520258.2
XP_011518561.1, XM_011520259.2
XP_011518562.1, XM_011520260.2
XP_011518563.1, XM_011520261.2
XP_011518564.1, XM_011520262.2
XP_011518565.1, XM_011520263.1
XP_016873595.1, XM_017018106.1
UniGeneiHs.530687

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A4YX-ray2.00A/D2-461[»]
1Z7XX-ray1.95W/Y1-461[»]
2BEXX-ray1.99A/B2-461[»]
2Q4GX-ray1.95W/Y1-461[»]
ProteinModelPortaliP13489
SMRiP13489
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111977, 73 interactors
CORUMiP13489
IntActiP13489, 33 interactors
MINTiP13489
STRINGi9606.ENSP00000346402

PTM databases

iPTMnetiP13489
PhosphoSitePlusiP13489
SwissPalmiP13489

Polymorphism and mutation databases

BioMutaiRNH1
DMDMi132573

2D gel databases

REPRODUCTION-2DPAGEiIPI00550069

Proteomic databases

EPDiP13489
jPOSTiP13489
MaxQBiP13489
PaxDbiP13489
PeptideAtlasiP13489
PRIDEiP13489
ProteomicsDBi52913

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354420; ENSP00000346402; ENSG00000023191
ENST00000356187; ENSP00000348515; ENSG00000023191
ENST00000397604; ENSP00000380729; ENSG00000023191
ENST00000397614; ENSP00000380738; ENSG00000023191
ENST00000397615; ENSP00000380739; ENSG00000023191
ENST00000438658; ENSP00000416589; ENSG00000023191
ENST00000533410; ENSP00000435594; ENSG00000023191
ENST00000534797; ENSP00000433999; ENSG00000023191
ENST00000612988; ENSP00000479004; ENSG00000276230
ENST00000617351; ENSP00000484572; ENSG00000276230
ENST00000618184; ENSP00000478664; ENSG00000276230
ENST00000619599; ENSP00000479966; ENSG00000276230
ENST00000621211; ENSP00000480036; ENSG00000276230
ENST00000632527; ENSP00000487940; ENSG00000276230
ENST00000632954; ENSP00000487753; ENSG00000276230
ENST00000633287; ENSP00000488734; ENSG00000276230
GeneIDi6050
KEGGihsa:6050
UCSCiuc001lpk.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6050
DisGeNETi6050
EuPathDBiHostDB:ENSG00000023191.16

GeneCards: human genes, protein and diseases

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GeneCardsi
RNH1
HGNCiHGNC:10074 RNH1
HPAiHPA039223
HPA040781
MIMi173320 gene
neXtProtiNX_P13489
OpenTargetsiENSG00000023191
PharmGKBiPA34447

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4308 Eukaryota
ENOG410ZBX3 LUCA
GeneTreeiENSGT00940000161492
HOGENOMiHOG000140402
HOVERGENiHBG001059
InParanoidiP13489
KOiK16634
OMAiLWLWDCD
OrthoDBi710473at2759
PhylomeDBiP13489

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RNH1 human
EvolutionaryTraceiP13489

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RNH1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6050

Protein Ontology

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PROi
PR:P13489

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000023191 Expressed in 231 organ(s), highest expression level in skin of leg
CleanExiHS_RNH1
ExpressionAtlasiP13489 baseline and differential
GenevisibleiP13489 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13516 LRR_6, 6 hits
SMARTiView protein in SMART
SM00367 LRR_CC, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRINI_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13489
Secondary accession number(s): Q8IZK8
, Q96FD7, Q9BQ80, Q9UDK6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: January 16, 2019
This is version 207 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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