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Protein

Potassium channel toxin alpha-KTx 1.1

Gene
N/A
Organism
Leiurus quinquestriatus hebraeus (Yellow scorpion)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This toxin inhibits numerous potassium channels: shaker (Ki=227 nM), Kv1.2/KCNA2 (nanomolar range), Kv1.3/KCNA3 (nanomolar range), Kv1.5/KCNA5 (Kd>100 nM), Kv1.6/KCNA6 (Ki=22 nM), KCa1.1/KCNMA1 (IC50=5.9 nM). It blocks channel activity by a simple bimolecular inhibition process. It also exhibits pH-specific antimicrobial activities against bacteria (B.subtilis, E.coli and S.aureus) and the fungus C.albicans (PubMed:15118082).6 Publications

Miscellaneous

This toxin does not or very weakly inhibits Kv1.1/KCNA1, Kv2.1/KCNB1 (Ki>2 µM), Kv3.1/KCNC1 (Kd>1 µM), Kv11.1/KCNH2, KCa2.1/KCNN1 (IC50> 1 µM), KCa2.2/ KCNN2 (IC50> 1 µM), KCa2.3/ KCNN3 (IC50> 1 µM).5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei49Basic residue of the functional dyadBy similarity1
Sitei58Aromatic residue of the functional dyadBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Calcium-activated potassium channel impairing toxin, Fungicide, Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin, Voltage-gated potassium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel toxin alpha-KTx 1.1
Alternative name(s):
ChTX-Lq11 Publication
ChTx-a
Charybdotoxin1 Publication
Short name:
CTX1 Publication
Short name:
ChTX1 Publication
OrganismiLeiurus quinquestriatus hebraeus (Yellow scorpion)
Taxonomic identifieri6884 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeLeiurus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 223 PublicationsAdd BLAST22
ChainiPRO_000003530723 – 59Potassium channel toxin alpha-KTx 1.13 PublicationsAdd BLAST37

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23Pyrrolidone carboxylic acid2 Publications1
Disulfide bondi29 ↔ 507 Publications
Disulfide bondi35 ↔ 557 Publications
Disulfide bondi39 ↔ 577 Publications

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

Secondary structure

159
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP13487
SMRiP13487
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13487

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni48 – 55Interaction with Ca(2+)-activated K(+) channelsSequence analysis8

Domaini

Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta).1 Publication

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR036574 Scorpion_toxin-like_sf
IPR001947 Scorpion_toxinS_K_inh
PfamiView protein in Pfam
PF00451 Toxin_2, 1 hit
PRINTSiPR00286 CHARYBDTOXIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003586 Scorpion_toxinS, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS01138 SCORP_SHORT_TOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13487-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKILSVLLLA LIICSIVGWS EAQFTNVSCT TSKECWSVCQ RLHNTSRGKC

MNKKCRCYS
Length:59
Mass (Da):6,674
Last modified:November 21, 2003 - v4
Checksum:i379227EBBCB21947
GO

Sequence databases

PIRiA28202 A60963

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA28202 A60963

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BAHNMR-A24-59[»]
1CMRNMR-A29-59[»]
2A9HNMR-E24-59[»]
2CRDNMR-A24-59[»]
4JTAX-ray2.50Y23-59[»]
4JTCX-ray2.56Y23-59[»]
4JTDX-ray2.54Y23-59[»]
ProteinModelPortaliP13487
SMRiP13487
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP13487

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR036574 Scorpion_toxin-like_sf
IPR001947 Scorpion_toxinS_K_inh
PfamiView protein in Pfam
PF00451 Toxin_2, 1 hit
PRINTSiPR00286 CHARYBDTOXIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD003586 Scorpion_toxinS, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS01138 SCORP_SHORT_TOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKAX11_LEIQH
AccessioniPrimary (citable) accession number: P13487
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 21, 2003
Last modified: February 28, 2018
This is version 128 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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