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UniProtKB - P13473 (LAMP2_HUMAN)

Entry version 215 (07 Oct 2020)
Sequence version 2 (01 Oct 1996)
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Protein

Lysosome-associated membrane glycoprotein 2

Gene

LAMP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).By similarity6 Publications
Modulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of exogenous and membrane-derived antigens by MHCII.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P13473

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608, Platelet degranulation
R-HSA-6798695, Neutrophil degranulation
R-HSA-9613829, Chaperone Mediated Autophagy

SIGNOR Signaling Network Open Resource

More...SIGNORi		P13473

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.16.1.2, the lysosomal protein import (lpi) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 2
Short name:
LAMP-2
Short name:
Lysosome-associated membrane protein 2
Alternative name(s):
CD107 antigen-like family member B
LGP-961 Publication
CD_antigen: CD107b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000005893.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:6501, LAMP2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		309060, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P13473

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 375LumenalSequence analysisAdd BLAST347
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei376 – 399HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini400 – 410CytoplasmicPROSITE-ProRule annotationAdd BLAST11

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Danon disease (DAND)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionDAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026230321W → R in DAND. 2 PublicationsCorresponds to variant dbSNP:rs104894859EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi401 – 404KHHH → AAAA: Impairs binding and subsequent lysosomal degradation of target proteins, such as GAPDH. 1 Publication4

Keywords - Diseasei

Disease mutation, Glycogen storage disease

Organism-specific databases

DisGeNET

More...DisGeNETi		3920

MalaCards human disease database

More...MalaCardsi		LAMP2
MIMi300257, phenotype

Open Targets

More...OpenTargetsi		ENSG00000005893

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		34587, Glycogen storage disease due to LAMP-2 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30285

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P13473, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LAMP2

Domain mapping of disease mutations (DMDM)

More...DMDMi		1708854

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 283 PublicationsAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001711029 – 410Lysosome-associated membrane glycoprotein 2Add BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi32N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication1
Glycosylationi38N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi41 ↔ 79PROSITE-ProRule annotation
Glycosylationi49N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi58N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi75N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi101N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi123N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi153 ↔ 189PROSITE-ProRule annotation
Glycosylationi179N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi195O-linked (GalNAc...) serine1 Publication1
Glycosylationi196O-linked (GalNAc...) threonine1 Publication1
Glycosylationi200O-linked (GalNAc...) threonine1 Publication1
Glycosylationi203O-linked (GalNAc...) threonine1 Publication1
Glycosylationi204O-linked (GalNAc...) threonine1 Publication1
Glycosylationi207O-linked (GalNAc...) serine; partial1 Publication1
Glycosylationi209O-linked (GalNAc...) threonine; partial1 Publication1
Glycosylationi210O-linked (GalNAc...) threonine1 Publication1
Glycosylationi211O-linked (GalNAc...) threonine1 Publication1
Glycosylationi213O-linked (GalNAc...) threonine; partial1 Publication1
Glycosylationi229N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi232 ↔ 265PROSITE-ProRule annotation
Glycosylationi242N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi257N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi275N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi300N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi307N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication1
Glycosylationi317N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi331 ↔ 368PROSITE-ProRule annotation
Glycosylationi356N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.6 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1494
CPTAC-689

Encyclopedia of Proteome Dynamics

More...EPDi		P13473

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P13473

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P13473

MaxQB - The MaxQuant DataBase

More...MaxQBi		P13473

PeptideAtlas

More...PeptideAtlasi		P13473

PRoteomics IDEntifications database

More...PRIDEi		P13473

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52910 [P13473-1]
52911 [P13473-2]
52912 [P13473-3]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		356, 115 N-Linked glycans (13 sites), 3 O-Linked glycans

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P13473, 27 sites, 24 N-linked glycans (6 sites), 2 O-linked glycans (9 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P13473

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P13473

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P13473

UniCarbKB; an annotated and curated database of glycan structures

More...UniCarbKBi		P13473

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle (PubMed:7488019, PubMed:26856698). Isoform LAMP-2B is detected in spleen, thymus, prostate, testis, small intestine, colon, skeletal muscle, brain, placenta, lung, kidney, ovary and pancreas and liver (PubMed:7488019, PubMed:26856698). Isoform LAMP-2C is detected in small intestine, colon, heart, brain, skeletal muscle, and at lower levels in kidney and placenta (PubMed:26856698).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In peripheral blood B cells isoform LAMP-2A, LAMP-2B and LAMP-2C are up-regulated in response to treatments that stimulate immune responses via the Toll-like receptors TLR7 or TLR9.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000005893, Expressed in corpus callosum and 248 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P13473, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P13473, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000005893, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:18644871, PubMed:25342746). Homodimer (PubMed:25342746). Homotrimer (PubMed:25342746). Forms large homooligomers (PubMed:18644871).

Interacts (via its cytoplasmic region) with HSPA8 (PubMed:25342746).

Interacts with HSP90 in the lysosome lumen; this enhances LAMP2 stability (By similarity).

Interacts with MLLT11 (PubMed:24880125).

By similarity3 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110114, 115 interactors

Protein interaction database and analysis system

More...IntActi		P13473, 61 interactors

Molecular INTeraction database

More...MINTi		P13473

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000408411

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P13473, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1410
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P13473

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P13473

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni29 – 192First lumenal domainAdd BLAST164
Regioni193 – 228HingeAdd BLAST36
Regioni229 – 375Second lumenal domainAdd BLAST147
Regioni401 – 404Important for binding and subsequent lysosomal degradation of target proteins1 Publication4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4818, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182899

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_055379_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P13473

KEGG Orthology (KO)

More...KOi		K06528

Identification of Orthologs from Complete Genome Data

More...OMAi		TGSCHPQ

Database of Orthologous Groups

More...OrthoDBi		1042920at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P13473

TreeFam database of animal gene trees

More...TreeFami		TF316339

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018134, LAMP_CS
IPR002000, Lysosome-assoc_membr_glycop

The PANTHER Classification System

More...PANTHERi		PTHR11506, PTHR11506, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01299, Lamp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00336, LYSASSOCTDMP

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00310, LAMP_1, 1 hit
PS00311, LAMP_2, 1 hit
PS51407, LAMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform LAMP-2A (identifier: P13473-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVCFRLFPVP GSGLVLVCLV LGAVRSYALE LNLTDSENAT CLYAKWQMNF 
        60         70         80         90        100
TVRYETTNKT YKTVTISDHG TVTYNGSICG DDQNGPKIAV QFGPGFSWIA 
       110        120        130        140        150
NFTKAASTYS IDSVSFSYNT GDNTTFPDAE DKGILTVDEL LAIRIPLNDL 
       160        170        180        190        200
FRCNSLSTLE KNDVVQHYWD VLVQAFVQNG TVSTNEFLCD KDKTSTVAPT 
       210        220        230        240        250
IHTTVPSPTT TPTPKEKPEA GTYSVNNGND TCLLATMGLQ LNITQDKVAS 
       260        270        280        290        300
VININPNTTH STGSCRSHTA LLRLNSSTIK YLDFVFAVKN ENRFYLKEVN 
       310        320        330        340        350
ISMYLVNGSV FSIANNNLSY WDAPLGSSYM CNKEQTVSVS GAFQINTFDL 
       360        370        380        390        400
RVQPFNVTQG KYSTAQDCSA DDDNFLVPIA VGAALAGVLI LVLLAYFIGL 
       410
KHHHAGYEQF
Length:410
Mass (Da):44,961
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E08E3B62D58F454
GO
Isoform LAMP-2B (identifier: P13473-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     367-410: DCSADDDNFL...KHHHAGYEQF → ECSLDDDTIL...RKSYAGYQTL

Show »
Length:410
Mass (Da):44,956
Checksum:i70B523369D40DEFA
GO
Isoform LAMP-2C (identifier: P13473-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     366-410: QDCSADDDNF...KHHHAGYEQF → EECSADSDLN...RKSRTGYQSV

Show »
Length:411
Mass (Da):45,170
Checksum:iB37AAC83BA1C3B1B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCG2H0YCG2_HUMAN
Lysosome-associated membrane glycop...
LAMP2
258Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8 – 13PVPGSG → RFRSGLR no nucleotide entry (PubMed:8407947).Curated6
Sequence conflicti53R → G no nucleotide entry (PubMed:8407947).Curated1
Sequence conflicti68D → V in AAB41647 (PubMed:8517882).Curated1
Sequence conflicti111I → N in AAB41647 (PubMed:8517882).Curated1
Sequence conflicti143I → Y in AAB41647 (PubMed:8517882).Curated1
Sequence conflicti220A → P in AAB41647 (PubMed:8517882).Curated1
Sequence conflicti234L → R in AAB41647 (PubMed:8517882).Curated1
Sequence conflicti263 – 269GSCRSHT → AAAVSH no nucleotide entry (PubMed:8407947).Curated7
Sequence conflicti322 – 326DAPLG → MPP in AAA60383 (PubMed:3198605).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011992256P → H. Corresponds to variant dbSNP:rs1043878Ensembl.1
Natural variantiVAR_026230321W → R in DAND. 2 PublicationsCorresponds to variant dbSNP:rs104894859EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042519366 – 410QDCSA…GYEQF → EECSADSDLNFLIPVAVGVA LGFLIIVVFISYMIGRRKSR TGYQSV in isoform LAMP-2C. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_003044367 – 410DCSAD…GYEQF → ECSLDDDTILIPIIVGAGLS GLIIVIVIAYVIGRRKSYAG YQTL in isoform LAMP-2B. 3 PublicationsAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J04183 mRNA Translation: AAA60383.1
L09717 L09716 Genomic DNA Translation: AAB41647.1
X77196 mRNA Translation: CAA54416.1
S79873 mRNA Translation: AAB35426.1
U36336 mRNA Translation: AAA91149.1
AY561849 mRNA Translation: AAS67876.1
AK291090 mRNA Translation: BAF83779.1
AC002476 Genomic DNA Translation: AAB67313.1
AC002476 Genomic DNA Translation: AAB67314.1
CH471107 Genomic DNA Translation: EAX11881.1
CH471107 Genomic DNA Translation: EAX11882.1
CH471107 Genomic DNA Translation: EAX11883.1
CH471107 Genomic DNA Translation: EAX11884.1
BC002965 mRNA Translation: AAH02965.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14599.1 [P13473-1]
CCDS14600.1 [P13473-2]
CCDS48159.1 [P13473-3]

Protein sequence database of the Protein Information Resource

More...PIRi		JC2414, B31959
JC4317

NCBI Reference Sequences

More...RefSeqi		NP_001116078.1, NM_001122606.1 [P13473-3]
NP_002285.1, NM_002294.2 [P13473-1]
NP_054701.1, NM_013995.2 [P13473-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000200639; ENSP00000200639; ENSG00000005893 [P13473-1]
ENST00000371335; ENSP00000360386; ENSG00000005893 [P13473-2]
ENST00000434600; ENSP00000408411; ENSG00000005893 [P13473-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3920

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3920

UCSC genome browser

More...UCSCi		uc004ess.5, human [P13473-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04183 mRNA Translation: AAA60383.1
L09717 L09716 Genomic DNA Translation: AAB41647.1
X77196 mRNA Translation: CAA54416.1
S79873 mRNA Translation: AAB35426.1
U36336 mRNA Translation: AAA91149.1
AY561849 mRNA Translation: AAS67876.1
AK291090 mRNA Translation: BAF83779.1
AC002476 Genomic DNA Translation: AAB67313.1
AC002476 Genomic DNA Translation: AAB67314.1
CH471107 Genomic DNA Translation: EAX11881.1
CH471107 Genomic DNA Translation: EAX11882.1
CH471107 Genomic DNA Translation: EAX11883.1
CH471107 Genomic DNA Translation: EAX11884.1
BC002965 mRNA Translation: AAH02965.1
CCDSiCCDS14599.1 [P13473-1]
CCDS14600.1 [P13473-2]
CCDS48159.1 [P13473-3]
PIRiJC2414, B31959
JC4317
RefSeqiNP_001116078.1, NM_001122606.1 [P13473-3]
NP_002285.1, NM_002294.2 [P13473-1]
NP_054701.1, NM_013995.2 [P13473-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MOFNMR-A369-410[»]
2MOMNMR-A/B/C369-410[»]
BMRBiP13473
SMRiP13473
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110114, 115 interactors
IntActiP13473, 61 interactors
MINTiP13473
STRINGi9606.ENSP00000408411

Protein family/group databases

TCDBi9.A.16.1.2, the lysosomal protein import (lpi) family

PTM databases

GlyConnecti356, 115 N-Linked glycans (13 sites), 3 O-Linked glycans
GlyGeniP13473, 27 sites, 24 N-linked glycans (6 sites), 2 O-linked glycans (9 sites)
iPTMnetiP13473
PhosphoSitePlusiP13473
SwissPalmiP13473
UniCarbKBiP13473

Polymorphism and mutation databases

BioMutaiLAMP2
DMDMi1708854

Proteomic databases

CPTACiCPTAC-1494
CPTAC-689
EPDiP13473
jPOSTiP13473
MassIVEiP13473
MaxQBiP13473
PeptideAtlasiP13473
PRIDEiP13473
ProteomicsDBi52910 [P13473-1]
52911 [P13473-2]
52912 [P13473-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3938, 1253 antibodies

The DNASU plasmid repository

More...DNASUi		3920

Genome annotation databases

EnsembliENST00000200639; ENSP00000200639; ENSG00000005893 [P13473-1]
ENST00000371335; ENSP00000360386; ENSG00000005893 [P13473-2]
ENST00000434600; ENSP00000408411; ENSG00000005893 [P13473-3]
GeneIDi3920
KEGGihsa:3920
UCSCiuc004ess.5, human [P13473-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3920
DisGeNETi3920
EuPathDBiHostDB:ENSG00000005893.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		LAMP2
HGNCiHGNC:6501, LAMP2
HPAiENSG00000005893, Low tissue specificity
MalaCardsiLAMP2
MIMi300257, phenotype
309060, gene
neXtProtiNX_P13473
OpenTargetsiENSG00000005893
Orphaneti34587, Glycogen storage disease due to LAMP-2 deficiency
PharmGKBiPA30285

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4818, Eukaryota
GeneTreeiENSGT00950000182899
HOGENOMiCLU_055379_2_0_1
InParanoidiP13473
KOiK06528
OMAiTGSCHPQ
OrthoDBi1042920at2759
PhylomeDBiP13473
TreeFamiTF316339

Enzyme and pathway databases

PathwayCommonsiP13473
ReactomeiR-HSA-114608, Platelet degranulation
R-HSA-6798695, Neutrophil degranulation
R-HSA-9613829, Chaperone Mediated Autophagy
SIGNORiP13473

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3920, 3 hits in 500 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LAMP2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		LAMP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3920
PharosiP13473, Tbio

Protein Ontology

More...PROi		PR:P13473
RNActiP13473, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000005893, Expressed in corpus callosum and 248 other tissues
ExpressionAtlasiP13473, baseline and differential
GenevisibleiP13473, HS

Family and domain databases

InterProiView protein in InterPro
IPR018134, LAMP_CS
IPR002000, Lysosome-assoc_membr_glycop
PANTHERiPTHR11506, PTHR11506, 1 hit
PfamiView protein in Pfam
PF01299, Lamp, 1 hit
PRINTSiPR00336, LYSASSOCTDMP
PROSITEiView protein in PROSITE
PS00310, LAMP_1, 1 hit
PS00311, LAMP_2, 1 hit
PS51407, LAMP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13473
Secondary accession number(s): A8K4X5
, D3DTF0, Q16641, Q6Q3G8, Q96J30, Q99534, Q9UD93
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 1, 1996
Last modified: October 7, 2020
This is version 215 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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