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UniProtKB - P13473 (LAMP2_HUMAN)
Protein
Lysosome-associated membrane glycoprotein 2
Gene
LAMP2
Organism
Homo sapiens (Human)
Status
Functioni
Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032).
Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125).
Plays a role in lysosomal protein degradation in response to starvation (By similarity).
Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032).
Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032).
Required for normal degradation of the contents of autophagosomes (PubMed:27628032).
Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820).
Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).
By similarity6 PublicationsModulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of exogenous and membrane-derived antigens by MHCII.
1 Publication(Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.
1 PublicationGO - Molecular functioni
- enzyme binding Source: UniProtKB
GO - Biological processi
- autophagosome maturation Source: UniProtKB
- cellular response to starvation Source: UniProtKB
- chaperone-mediated autophagy Source: ParkinsonsUK-UCL
- establishment of protein localization to organelle Source: GO_Central
- lysosomal protein catabolic process Source: UniProtKB
- negative regulation of protein-containing complex assembly Source: ParkinsonsUK-UCL
- protein import Source: ParkinsonsUK-UCL
- protein stabilization Source: CAFA
- protein targeting Source: UniProtKB
- protein targeting to lysosome involved in chaperone-mediated autophagy Source: UniProtKB
- regulation of protein stability Source: ParkinsonsUK-UCL
Keywordsi
| Biological process | Autophagy |
Enzyme and pathway databases
| PathwayCommonsi | P13473 |
| Reactomei | R-HSA-114608, Platelet degranulation R-HSA-6798695, Neutrophil degranulation R-HSA-9613829, Chaperone Mediated Autophagy |
| SIGNORi | P13473 |
Protein family/group databases
| TCDBi | 9.A.16.1.2, the lysosomal protein import (lpi) family |
Names & Taxonomyi
| Protein namesi | Recommended name: Lysosome-associated membrane glycoprotein 2Short name: LAMP-2 Short name: Lysosome-associated membrane protein 2 Alternative name(s): CD107 antigen-like family member B LGP-961 Publication CD_antigen: CD107b |
| Gene namesi | Name:LAMP2 |
| Organismi | Homo sapiens (Human) |
| Taxonomic identifieri | 9606 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
| Proteomesi |
|
Organism-specific databases
| HGNCi | HGNC:6501, LAMP2 |
| MIMi | 309060, gene |
| neXtProti | NX_P13473 |
| VEuPathDBi | HostDB:ENSG00000005893 |
Subcellular locationi
Endosome
- Endosome membrane 1 Publication; Single-pass type I membrane protein PROSITE-ProRule annotation1 Publication
Lysosome
- Lysosome membrane PROSITE-ProRule annotation4 Publications; Single-pass type I membrane protein PROSITE-ProRule annotation1 Publication
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein PROSITE-ProRule annotation1 Publication
Other locations
- autophagosome membrane By similarity
Note: This protein shuttles between lysosomes, endosomes, and the plasma membrane.
Endosome
- late endosome Source: MGI
- late endosome membrane Source: MGI
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular space Source: UniProtKB
Golgi apparatus
- trans-Golgi network Source: ParkinsonsUK-UCL
Lysosome
- autolysosome Source: MGI
- azurophil granule membrane Source: Reactome
- chaperone-mediated autophagy translocation complex Source: ParkinsonsUK-UCL
- lysosomal lumen Source: ParkinsonsUK-UCL
- lysosomal matrix Source: Ensembl
- lysosomal membrane Source: MGI
- lysosome Source: UniProtKB
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- ficolin-1-rich granule membrane Source: Reactome
- integral component of autophagosome membrane Source: GO_Central
- membrane Source: MGI
- membrane raft Source: Ensembl
- perinuclear region of cytoplasm Source: ParkinsonsUK-UCL
- platelet dense granule membrane Source: MGI
Topology
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Topological domaini | 29 – 375 | LumenalSequence analysisAdd BLAST | 347 | |
| Transmembranei | 376 – 399 | HelicalPROSITE-ProRule annotationAdd BLAST | 24 | |
| Topological domaini | 400 – 410 | CytoplasmicPROSITE-ProRule annotationAdd BLAST | 11 |
Keywords - Cellular componenti
Cell membrane, Cytoplasmic vesicle, Endosome, Lysosome, MembranePathology & Biotechi
Involvement in diseasei
Danon disease (DAND)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionDAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes.
Related information in OMIM| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_026230 | 321 | W → R in DAND. 2 PublicationsCorresponds to variant dbSNP:rs104894859EnsemblClinVar. | 1 |
Mutagenesis
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Mutagenesisi | 401 – 404 | KHHH → AAAA: Impairs binding and subsequent lysosomal degradation of target proteins, such as GAPDH. 1 Publication | 4 |
Keywords - Diseasei
Disease variant, Glycogen storage diseaseOrganism-specific databases
| DisGeNETi | 3920 |
| GeneReviewsi | LAMP2 |
| MalaCardsi | LAMP2 |
| MIMi | 300257, phenotype |
| OpenTargetsi | ENSG00000005893 |
| Orphaneti | 34587, Glycogen storage disease due to LAMP-2 deficiency |
| PharmGKBi | PA30285 |
Miscellaneous databases
| Pharosi | P13473, Tbio |
Genetic variation databases
| BioMutai | LAMP2 |
| DMDMi | 1708854 |
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Signal peptidei | 1 – 28 | 3 PublicationsAdd BLAST | 28 | |
| ChainiPRO_0000017110 | 29 – 410 | Lysosome-associated membrane glycoprotein 2Add BLAST | 382 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Glycosylationi | 32 | N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication | 1 | |
| Glycosylationi | 38 | N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication | 1 | |
| Disulfide bondi | 41 ↔ 79 | PROSITE-ProRule annotation | ||
| Glycosylationi | 49 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
| Glycosylationi | 58 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
| Glycosylationi | 75 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
| Glycosylationi | 101 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
| Glycosylationi | 123 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
| Disulfide bondi | 153 ↔ 189 | PROSITE-ProRule annotation | ||
| Glycosylationi | 179 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
| Glycosylationi | 195 | O-linked (GalNAc...) serine1 Publication | 1 | |
| Glycosylationi | 196 | O-linked (GalNAc...) threonine1 Publication | 1 | |
| Glycosylationi | 200 | O-linked (GalNAc...) threonine1 Publication | 1 | |
| Glycosylationi | 203 | O-linked (GalNAc...) threonine1 Publication | 1 | |
| Glycosylationi | 204 | O-linked (GalNAc...) threonine1 Publication | 1 | |
| Glycosylationi | 207 | O-linked (GalNAc...) serine; partial1 Publication | 1 | |
| Glycosylationi | 209 | O-linked (GalNAc...) threonine; partial1 Publication | 1 | |
| Glycosylationi | 210 | O-linked (GalNAc...) threonine1 Publication | 1 | |
| Glycosylationi | 211 | O-linked (GalNAc...) threonine1 Publication | 1 | |
| Glycosylationi | 213 | O-linked (GalNAc...) threonine; partial1 Publication | 1 | |
| Glycosylationi | 229 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
| Disulfide bondi | 232 ↔ 265 | PROSITE-ProRule annotation | ||
| Glycosylationi | 242 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
| Glycosylationi | 257 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
| Glycosylationi | 275 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
| Glycosylationi | 300 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
| Glycosylationi | 307 | N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication | 1 | |
| Glycosylationi | 317 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
| Disulfide bondi | 331 ↔ 368 | PROSITE-ProRule annotation | ||
| Glycosylationi | 356 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Post-translational modificationi
O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.6 Publications
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
| CPTACi | CPTAC-1494 CPTAC-689 |
| EPDi | P13473 |
| jPOSTi | P13473 |
| MassIVEi | P13473 |
| MaxQBi | P13473 |
| PeptideAtlasi | P13473 |
| PRIDEi | P13473 |
| ProteomicsDBi | 52910 [P13473-1] 52911 [P13473-2] 52912 [P13473-3] |
PTM databases
| GlyConnecti | 356, 115 N-Linked glycans (12 sites), 3 O-Linked glycans |
| GlyGeni | P13473, 28 sites, 138 N-linked glycans (13 sites), 3 O-linked glycans (10 sites) |
| iPTMneti | P13473 |
| PhosphoSitePlusi | P13473 |
| SwissPalmi | P13473 |
Expressioni
Tissue specificityi
Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle (PubMed:7488019, PubMed:26856698). Isoform LAMP-2B is detected in spleen, thymus, prostate, testis, small intestine, colon, skeletal muscle, brain, placenta, lung, kidney, ovary and pancreas and liver (PubMed:7488019, PubMed:26856698). Isoform LAMP-2C is detected in small intestine, colon, heart, brain, skeletal muscle, and at lower levels in kidney and placenta (PubMed:26856698).2 Publications
Inductioni
In peripheral blood B cells isoform LAMP-2A, LAMP-2B and LAMP-2C are up-regulated in response to treatments that stimulate immune responses via the Toll-like receptors TLR7 or TLR9.1 Publication
Gene expression databases
| Bgeei | ENSG00000005893, Expressed in corpus callosum and 249 other tissues |
| ExpressionAtlasi | P13473, baseline and differential |
| Genevisiblei | P13473, HS |
Organism-specific databases
| HPAi | ENSG00000005893, Low tissue specificity |
Interactioni
Subunit structurei
Monomer (PubMed:18644871, PubMed:25342746). Homodimer (PubMed:25342746). Homotrimer (PubMed:25342746). Forms large homooligomers (PubMed:18644871).
Interacts (via its cytoplasmic region) with HSPA8 (PubMed:25342746).
Interacts with HSP90 in the lysosome lumen; this enhances LAMP2 stability (By similarity).
Interacts with MLLT11 (PubMed:24880125).
Interacts with ABCB9 (PubMed:22641697).
Interacts with FURIN (PubMed:32295904).
By similarity5 Publications(Microbial infection) Interacts with mumps virus protein F; this interaction promotes protein F cleavage by FURIN.
1 PublicationBinary interactionsi
Isoform LAMP-2B [P13473-2]
GO - Molecular functioni
- enzyme binding Source: UniProtKB
Protein-protein interaction databases
| BioGRIDi | 110114, 126 interactors |
| IntActi | P13473, 304 interactors |
| MINTi | P13473 |
| STRINGi | 9606.ENSP00000408411 |
Miscellaneous databases
| RNActi | P13473, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
| BMRBi | P13473 |
| SMRi | P13473 |
| ModBasei | Search... |
| PDBe-KBi | Search... |
Family & Domainsi
Region
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Regioni | 29 – 192 | First lumenal domainAdd BLAST | 164 | |
| Regioni | 193 – 228 | HingeAdd BLAST | 36 | |
| Regioni | 199 – 221 | DisorderedSequence analysisAdd BLAST | 23 | |
| Regioni | 229 – 375 | Second lumenal domainAdd BLAST | 147 | |
| Regioni | 401 – 404 | Important for binding and subsequent lysosomal degradation of target proteins1 Publication | 4 |
Sequence similaritiesi
Belongs to the LAMP family.PROSITE-ProRule annotation
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
| eggNOGi | KOG4818, Eukaryota |
| GeneTreei | ENSGT00950000182899 |
| HOGENOMi | CLU_055379_2_0_1 |
| InParanoidi | P13473 |
| OMAi | MATGYES |
| OrthoDBi | 1042920at2759 |
| PhylomeDBi | P13473 |
| TreeFami | TF316339 |
Family and domain databases
| InterProi | View protein in InterPro IPR018134, LAMP_CS IPR002000, Lysosome-assoc_membr_glycop |
| PANTHERi | PTHR11506, PTHR11506, 1 hit |
| Pfami | View protein in Pfam PF01299, Lamp, 1 hit |
| PRINTSi | PR00336, LYSASSOCTDMP |
| PROSITEi | View protein in PROSITE PS00310, LAMP_1, 1 hit PS00311, LAMP_2, 1 hit PS51407, LAMP_3, 1 hit |
Sequences (3+)i
Sequence statusi: Complete.
Sequence processingi: The displayed sequence is further processed into a mature form.
This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform LAMP-2A (identifier: P13473-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MVCFRLFPVP GSGLVLVCLV LGAVRSYALE LNLTDSENAT CLYAKWQMNF
60 70 80 90 100
TVRYETTNKT YKTVTISDHG TVTYNGSICG DDQNGPKIAV QFGPGFSWIA
110 120 130 140 150
NFTKAASTYS IDSVSFSYNT GDNTTFPDAE DKGILTVDEL LAIRIPLNDL
160 170 180 190 200
FRCNSLSTLE KNDVVQHYWD VLVQAFVQNG TVSTNEFLCD KDKTSTVAPT
210 220 230 240 250
IHTTVPSPTT TPTPKEKPEA GTYSVNNGND TCLLATMGLQ LNITQDKVAS
260 270 280 290 300
VININPNTTH STGSCRSHTA LLRLNSSTIK YLDFVFAVKN ENRFYLKEVN
310 320 330 340 350
ISMYLVNGSV FSIANNNLSY WDAPLGSSYM CNKEQTVSVS GAFQINTFDL
360 370 380 390 400
RVQPFNVTQG KYSTAQDCSA DDDNFLVPIA VGAALAGVLI LVLLAYFIGL
410
KHHHAGYEQF
Isoform LAMP-2B (identifier: P13473-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
367-410: DCSADDDNFL...KHHHAGYEQF → ECSLDDDTIL...RKSYAGYQTL
Isoform LAMP-2C (identifier: P13473-3) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
366-410: QDCSADDDNF...KHHHAGYEQF → EECSADSDLN...RKSRTGYQSV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket| H0YCG2 | H0YCG2_HUMAN | Lysosome-associated membrane glycop... | LAMP2 | 258 | Annotation score: |
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Sequence conflicti | 8 – 13 | PVPGSG → RFRSGLR no nucleotide entry (PubMed:8407947).Curated | 6 | |
| Sequence conflicti | 53 | R → G no nucleotide entry (PubMed:8407947).Curated | 1 | |
| Sequence conflicti | 68 | D → V in AAB41647 (PubMed:8517882).Curated | 1 | |
| Sequence conflicti | 111 | I → N in AAB41647 (PubMed:8517882).Curated | 1 | |
| Sequence conflicti | 143 | I → Y in AAB41647 (PubMed:8517882).Curated | 1 | |
| Sequence conflicti | 220 | A → P in AAB41647 (PubMed:8517882).Curated | 1 | |
| Sequence conflicti | 234 | L → R in AAB41647 (PubMed:8517882).Curated | 1 | |
| Sequence conflicti | 263 – 269 | GSCRSHT → AAAVSH no nucleotide entry (PubMed:8407947).Curated | 7 | |
| Sequence conflicti | 322 – 326 | DAPLG → MPP in AAA60383 (PubMed:3198605).Curated | 5 |
Natural variant
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_011992 | 256 | P → H. Corresponds to variant dbSNP:rs1043878Ensembl. | 1 | |
| Natural variantiVAR_026230 | 321 | W → R in DAND. 2 PublicationsCorresponds to variant dbSNP:rs104894859EnsemblClinVar. | 1 |
Alternative sequence
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Alternative sequenceiVSP_042519 | 366 – 410 | QDCSA…GYEQF → EECSADSDLNFLIPVAVGVA LGFLIIVVFISYMIGRRKSR TGYQSV in isoform LAMP-2C. 1 PublicationAdd BLAST | 45 | |
| Alternative sequenceiVSP_003044 | 367 – 410 | DCSAD…GYEQF → ECSLDDDTILIPIIVGAGLS GLIIVIVIAYVIGRRKSYAG YQTL in isoform LAMP-2B. 3 PublicationsAdd BLAST | 44 |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04183 mRNA Translation: AAA60383.1 L09717 , L09709, L09710, L09711, L09712, L09713, L09714, L09715, L09716 Genomic DNA Translation: AAB41647.1 X77196 mRNA Translation: CAA54416.1 S79873 mRNA Translation: AAB35426.1 U36336 mRNA Translation: AAA91149.1 AY561849 mRNA Translation: AAS67876.1 AK291090 mRNA Translation: BAF83779.1 AC002476 Genomic DNA Translation: AAB67313.1 AC002476 Genomic DNA Translation: AAB67314.1 CH471107 Genomic DNA Translation: EAX11881.1 CH471107 Genomic DNA Translation: EAX11882.1 CH471107 Genomic DNA Translation: EAX11883.1 CH471107 Genomic DNA Translation: EAX11884.1 BC002965 mRNA Translation: AAH02965.1 |
| CCDSi | CCDS14599.1 [P13473-1] CCDS14600.1 [P13473-2] CCDS48159.1 [P13473-3] |
| PIRi | JC2414, B31959 JC4317 |
| RefSeqi | NP_001116078.1, NM_001122606.1 [P13473-3] NP_002285.1, NM_002294.2 [P13473-1] NP_054701.1, NM_013995.2 [P13473-2] |
Genome annotation databases
| Ensembli | ENST00000200639; ENSP00000200639; ENSG00000005893 [P13473-1] ENST00000371335; ENSP00000360386; ENSG00000005893 [P13473-2] ENST00000434600; ENSP00000408411; ENSG00000005893 [P13473-3] |
| GeneIDi | 3920 |
| KEGGi | hsa:3920 |
| UCSCi | uc004ess.5, human [P13473-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04183 mRNA Translation: AAA60383.1 L09717 , L09709, L09710, L09711, L09712, L09713, L09714, L09715, L09716 Genomic DNA Translation: AAB41647.1 X77196 mRNA Translation: CAA54416.1 S79873 mRNA Translation: AAB35426.1 U36336 mRNA Translation: AAA91149.1 AY561849 mRNA Translation: AAS67876.1 AK291090 mRNA Translation: BAF83779.1 AC002476 Genomic DNA Translation: AAB67313.1 AC002476 Genomic DNA Translation: AAB67314.1 CH471107 Genomic DNA Translation: EAX11881.1 CH471107 Genomic DNA Translation: EAX11882.1 CH471107 Genomic DNA Translation: EAX11883.1 CH471107 Genomic DNA Translation: EAX11884.1 BC002965 mRNA Translation: AAH02965.1 |
| CCDSi | CCDS14599.1 [P13473-1] CCDS14600.1 [P13473-2] CCDS48159.1 [P13473-3] |
| PIRi | JC2414, B31959 JC4317 |
| RefSeqi | NP_001116078.1, NM_001122606.1 [P13473-3] NP_002285.1, NM_002294.2 [P13473-1] NP_054701.1, NM_013995.2 [P13473-2] |
3D structure databases
| Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
| 2MOF | NMR | - | A | 369-410 | [»] | |
| 2MOM | NMR | - | A/B/C | 369-410 | [»] | |
| BMRBi | P13473 | |||||
| SMRi | P13473 | |||||
| ModBasei | Search... | |||||
| PDBe-KBi | Search... | |||||
Protein-protein interaction databases
| BioGRIDi | 110114, 126 interactors |
| IntActi | P13473, 304 interactors |
| MINTi | P13473 |
| STRINGi | 9606.ENSP00000408411 |
Protein family/group databases
| TCDBi | 9.A.16.1.2, the lysosomal protein import (lpi) family |
PTM databases
| GlyConnecti | 356, 115 N-Linked glycans (12 sites), 3 O-Linked glycans |
| GlyGeni | P13473, 28 sites, 138 N-linked glycans (13 sites), 3 O-linked glycans (10 sites) |
| iPTMneti | P13473 |
| PhosphoSitePlusi | P13473 |
| SwissPalmi | P13473 |
Genetic variation databases
| BioMutai | LAMP2 |
| DMDMi | 1708854 |
Proteomic databases
| CPTACi | CPTAC-1494 CPTAC-689 |
| EPDi | P13473 |
| jPOSTi | P13473 |
| MassIVEi | P13473 |
| MaxQBi | P13473 |
| PeptideAtlasi | P13473 |
| PRIDEi | P13473 |
| ProteomicsDBi | 52910 [P13473-1] 52911 [P13473-2] 52912 [P13473-3] |
Protocols and materials databases
| Antibodypediai | 3938, 1304 antibodies |
| DNASUi | 3920 |
Genome annotation databases
| Ensembli | ENST00000200639; ENSP00000200639; ENSG00000005893 [P13473-1] ENST00000371335; ENSP00000360386; ENSG00000005893 [P13473-2] ENST00000434600; ENSP00000408411; ENSG00000005893 [P13473-3] |
| GeneIDi | 3920 |
| KEGGi | hsa:3920 |
| UCSCi | uc004ess.5, human [P13473-1] |
Organism-specific databases
| CTDi | 3920 |
| DisGeNETi | 3920 |
| GeneCardsi | LAMP2 |
| GeneReviewsi | LAMP2 |
| HGNCi | HGNC:6501, LAMP2 |
| HPAi | ENSG00000005893, Low tissue specificity |
| MalaCardsi | LAMP2 |
| MIMi | 300257, phenotype 309060, gene |
| neXtProti | NX_P13473 |
| OpenTargetsi | ENSG00000005893 |
| Orphaneti | 34587, Glycogen storage disease due to LAMP-2 deficiency |
| PharmGKBi | PA30285 |
| VEuPathDBi | HostDB:ENSG00000005893 |
| GenAtlasi | Search... |
Phylogenomic databases
| eggNOGi | KOG4818, Eukaryota |
| GeneTreei | ENSGT00950000182899 |
| HOGENOMi | CLU_055379_2_0_1 |
| InParanoidi | P13473 |
| OMAi | MATGYES |
| OrthoDBi | 1042920at2759 |
| PhylomeDBi | P13473 |
| TreeFami | TF316339 |
Enzyme and pathway databases
| PathwayCommonsi | P13473 |
| Reactomei | R-HSA-114608, Platelet degranulation R-HSA-6798695, Neutrophil degranulation R-HSA-9613829, Chaperone Mediated Autophagy |
| SIGNORi | P13473 |
Miscellaneous databases
| BioGRID-ORCSi | 3920, 6 hits in 646 CRISPR screens |
| ChiTaRSi | LAMP2, human |
| GeneWikii | LAMP2 |
| GenomeRNAii | 3920 |
| Pharosi | P13473, Tbio |
| PROi | PR:P13473 |
| RNActi | P13473, protein |
| SOURCEi | Search... |
Gene expression databases
| Bgeei | ENSG00000005893, Expressed in corpus callosum and 249 other tissues |
| ExpressionAtlasi | P13473, baseline and differential |
| Genevisiblei | P13473, HS |
Family and domain databases
| InterProi | View protein in InterPro IPR018134, LAMP_CS IPR002000, Lysosome-assoc_membr_glycop |
| PANTHERi | PTHR11506, PTHR11506, 1 hit |
| Pfami | View protein in Pfam PF01299, Lamp, 1 hit |
| PRINTSi | PR00336, LYSASSOCTDMP |
| PROSITEi | View protein in PROSITE PS00310, LAMP_1, 1 hit PS00311, LAMP_2, 1 hit PS51407, LAMP_3, 1 hit |
| MobiDBi | Search... |
Entry informationi
| Entry namei | LAMP2_HUMAN | |
| Accessioni | P13473Primary (citable) accession number: P13473 Secondary accession number(s): A8K4X5 Q9UD93 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
| Last sequence update: | October 1, 1996 | |
| Last modified: | September 29, 2021 | |
| This is version 220 of the entry and version 2 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families
