LAMP2

Functionⁱ

Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).By similarity6 Publications

Isoform LAMP-2C: Modulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of exogenous and membrane-derived antigens by MHCII.1 Publication

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 22641697
protein domain specific binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

autophagosome maturation Source: UniProtKB
cellular response to starvation Source: UniProtKB
chaperone-mediated autophagy
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 8662539
lysosomal protein catabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24880125
muscle cell cellular homeostasis Source: Ensembl
negative regulation of protein homooligomerization
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 26203154
neutrophil degranulation Source: Reactome
platelet degranulation Source: Reactome
protein import
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 20176123
protein stabilization Source: UniProtKB
protein targeting Source: UniProtKB
protein targeting to lysosome involved in chaperone-mediated autophagy
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 27628032
regulation of protein stability
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 26212789

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Autophagy

Biological process

Autophagy

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-114608 Platelet degranulation
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

TCDBⁱ	9.A.16.1.2 the lysosomal protein import (lpi) family

TCDBⁱ

9.A.16.1.2 the lysosomal protein import (lpi) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lysosome-associated membrane glycoprotein 2 Short name: LAMP-2 Short name: Lysosome-associated membrane protein 2 Alternative name(s): CD107 antigen-like family member B LGP-961 Publication CD_antigen: CD107b
Gene namesⁱ	Name:LAMP2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000005893.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6501 LAMP2
MIMⁱ	309060 gene
neXtProtⁱ	NX_P13473

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	29 – 375	LumenalSequence analysisAdd BLAST	347
Transmembraneⁱ	376 – 399	HelicalPROSITE-ProRule annotationAdd BLAST	24
Topological domainⁱ	400 – 410	CytoplasmicPROSITE-ProRule annotationAdd BLAST	11

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasmic vesicle, Endosome, Lysosome, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Danon disease (DAND)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionDAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_026230	321	W → R in DAND. 2 PublicationsCorresponds to variant dbSNP:rs104894859EnsemblClinVar.		1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	401 – 404	KHHH → AAAA: Impairs binding and subsequent lysosomal degradation of target proteins, such as GAPDH. 1 Publication		4

Keywords - Diseaseⁱ

Disease mutation, Glycogen storage disease

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3920
MalaCards human disease database More...MalaCardsⁱ	LAMP2
MIMⁱ	300257 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000005893
Orphanetⁱ	34587 Glycogen storage disease due to LAMP-2 deficiency
PharmGKBⁱ	PA30285

Polymorphism and mutation databases

BioMutaⁱ	LAMP2
DMDMⁱ	1708854

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 28	3 PublicationsAdd BLAST		28
ChainⁱPRO_0000017110	29 – 410	Lysosome-associated membrane glycoprotein 2Add BLAST		382

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	32	N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication	1
Glycosylationⁱ	38	N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication	1
Disulfide bondⁱ	41 ↔ 79	PROSITE-ProRule annotation
Glycosylationⁱ	49	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	58	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	75	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	101	N-linked (GlcNAc...) asparagine3 Publications	1
Glycosylationⁱ	123	N-linked (GlcNAc...) asparagine2 Publications	1
Disulfide bondⁱ	153 ↔ 189	PROSITE-ProRule annotation
Glycosylationⁱ	179	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	195	O-linked (GalNAc...) serine1 Publication	1
Glycosylationⁱ	196	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	200	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	203	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	204	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	207	O-linked (GalNAc...) serine; partial1 Publication	1
Glycosylationⁱ	209	O-linked (GalNAc...) threonine; partial1 Publication	1
Glycosylationⁱ	210	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	211	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	213	O-linked (GalNAc...) threonine; partial1 Publication	1
Glycosylationⁱ	229	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	232 ↔ 265	PROSITE-ProRule annotation
Glycosylationⁱ	242	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	257	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	275	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	300	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	307	N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication	1
Glycosylationⁱ	317	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	331 ↔ 368	PROSITE-ProRule annotation
Glycosylationⁱ	356	N-linked (GlcNAc...) asparagine1 Publication	1

Post-translational modificationⁱ

O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.6 Publications

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P13473
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P13473
PeptideAtlas More...PeptideAtlasⁱ	P13473
PRIDEⁱ	P13473
ProteomicsDBⁱ	52910 52911 [P13473-2] 52912 [P13473-3]

PTM databases

GlyConnectⁱ	356
iPTMnetⁱ	P13473
PhosphoSitePlusⁱ	P13473
SwissPalmⁱ	P13473
UniCarbKBⁱ	P13473

Miscellaneous databases

PMAP-CutDBⁱ	P13473

PMAP-CutDBⁱ

P13473

Expressionⁱ

Tissue specificityⁱ

Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle (PubMed:7488019, PubMed:26856698). Isoform LAMP-2B is detected in spleen, thymus, prostate, testis, small intestine, colon, skeletal muscle, brain, placenta, lung, kidney, ovary and pancreas and liver (PubMed:7488019, PubMed:26856698). Isoform LAMP-2C is detected in small intestine, colon, heart, brain, skeletal muscle, and at lower levels in kidney and placenta (PubMed:26856698).2 Publications

Inductionⁱ

In peripheral blood B cells isoform LAMP-2A, LAMP-2B and LAMP-2C are up-regulated in response to treatments that stimulate immune responses via the Toll-like receptors TLR7 or TLR9.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000005893 Expressed in 236 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_LAMP2
ExpressionAtlasⁱ	P13473 baseline and differential
Genevisibleⁱ	P13473 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB005272 HPA029100

HPAⁱ

CAB005272
HPA029100

Interactionⁱ

Subunit structureⁱ

Monomer (PubMed:18644871, PubMed:25342746). Homodimer (PubMed:25342746). Homotrimer (PubMed:25342746). Forms large homooligomers (PubMed:18644871). Interacts (via its cytoplasmic region) with HSPA8 (PubMed:25342746). Interacts with HSP90 in the lysosome lumen; this enhances LAMP2 stability (By similarity). Interacts with MLLT11 (PubMed:24880125).By similarity3 Publications

GO - Molecular functionⁱ

enzyme binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 22641697
protein domain specific binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110114, 96 interactors
IntActⁱ	P13473, 17 interactors
Molecular INTeraction database More...MINTⁱ	P13473

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Beta strandⁱ	374 – 377	Combined sources		4
Helixⁱ	380 – 400	Combined sources		21

Show more details

3D structure databases

ProteinModelPortalⁱ	P13473
SMRⁱ	P13473
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	29 – 192	First lumenal domainAdd BLAST	164
Regionⁱ	193 – 228	HingeAdd BLAST	36
Regionⁱ	229 – 375	Second lumenal domainAdd BLAST	147
Regionⁱ	401 – 404	Important for binding and subsequent lysosomal degradation of target proteins1 Publication	4

Sequence similaritiesⁱ

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063068
HOGENOMⁱ	HOG000230942
HOVERGENⁱ	HBG052303
InParanoidⁱ	P13473
KEGG Orthology (KO) More...KOⁱ	K06528
OMAⁱ	PIIHTTV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09EV
PhylomeDBⁱ	P13473
TreeFamⁱ	TF316339

Family and domain databases

InterProⁱ	View protein in InterPro IPR018134 LAMP_CS IPR002000 Lysosome-assoc_membr_glycop
PANTHERⁱ	PTHR11506 PTHR11506, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01299 Lamp, 1 hit
PRINTSⁱ	PR00336 LYSASSOCTDMP
PROSITEⁱ	View protein in PROSITE PS00310 LAMP_1, 1 hit PS00311 LAMP_2, 1 hit PS51407 LAMP_3, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform LAMP-2A (identifier: P13473-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVCFRLFPVP GSGLVLVCLV LGAVRSYALE LNLTDSENAT CLYAKWQMNF 
        60         70         80         90        100
TVRYETTNKT YKTVTISDHG TVTYNGSICG DDQNGPKIAV QFGPGFSWIA 
       110        120        130        140        150
NFTKAASTYS IDSVSFSYNT GDNTTFPDAE DKGILTVDEL LAIRIPLNDL 
       160        170        180        190        200
FRCNSLSTLE KNDVVQHYWD VLVQAFVQNG TVSTNEFLCD KDKTSTVAPT 
       210        220        230        240        250
IHTTVPSPTT TPTPKEKPEA GTYSVNNGND TCLLATMGLQ LNITQDKVAS 
       260        270        280        290        300
VININPNTTH STGSCRSHTA LLRLNSSTIK YLDFVFAVKN ENRFYLKEVN 
       310        320        330        340        350
ISMYLVNGSV FSIANNNLSY WDAPLGSSYM CNKEQTVSVS GAFQINTFDL 
       360        370        380        390        400
RVQPFNVTQG KYSTAQDCSA DDDNFLVPIA VGAALAGVLI LVLLAYFIGL 
       410
KHHHAGYEQF

Length:410

Mass (Da):44,961

Last modified:October 1, 1996 - v2

Checksum:ⁱ9E08E3B62D58F454

GO

Isoform LAMP-2B (identifier: P13473-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
367-410: DCSADDDNFL...KHHHAGYEQF → ECSLDDDTIL...RKSYAGYQTL

« Hide

        10         20         30         40         50
MVCFRLFPVP GSGLVLVCLV LGAVRSYALE LNLTDSENAT CLYAKWQMNF 
        60         70         80         90        100
TVRYETTNKT YKTVTISDHG TVTYNGSICG DDQNGPKIAV QFGPGFSWIA 
       110        120        130        140        150
NFTKAASTYS IDSVSFSYNT GDNTTFPDAE DKGILTVDEL LAIRIPLNDL 
       160        170        180        190        200
FRCNSLSTLE KNDVVQHYWD VLVQAFVQNG TVSTNEFLCD KDKTSTVAPT 
       210        220        230        240        250
IHTTVPSPTT TPTPKEKPEA GTYSVNNGND TCLLATMGLQ LNITQDKVAS 
       260        270        280        290        300
VININPNTTH STGSCRSHTA LLRLNSSTIK YLDFVFAVKN ENRFYLKEVN 
       310        320        330        340        350
ISMYLVNGSV FSIANNNLSY WDAPLGSSYM CNKEQTVSVS GAFQINTFDL 
       360        370        380        390        400
RVQPFNVTQG KYSTAQECSL DDDTILIPII VGAGLSGLII VIVIAYVIGR 
       410
RKSYAGYQTL

Show »

Length:410

Mass (Da):44,956

Checksum:ⁱ70B523369D40DEFA

GO

Isoform LAMP-2C (identifier: P13473-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
366-410: QDCSADDDNF...KHHHAGYEQF → EECSADSDLN...RKSRTGYQSV

« Hide

        10         20         30         40         50
MVCFRLFPVP GSGLVLVCLV LGAVRSYALE LNLTDSENAT CLYAKWQMNF 
        60         70         80         90        100
TVRYETTNKT YKTVTISDHG TVTYNGSICG DDQNGPKIAV QFGPGFSWIA 
       110        120        130        140        150
NFTKAASTYS IDSVSFSYNT GDNTTFPDAE DKGILTVDEL LAIRIPLNDL 
       160        170        180        190        200
FRCNSLSTLE KNDVVQHYWD VLVQAFVQNG TVSTNEFLCD KDKTSTVAPT 
       210        220        230        240        250
IHTTVPSPTT TPTPKEKPEA GTYSVNNGND TCLLATMGLQ LNITQDKVAS 
       260        270        280        290        300
VININPNTTH STGSCRSHTA LLRLNSSTIK YLDFVFAVKN ENRFYLKEVN 
       310        320        330        340        350
ISMYLVNGSV FSIANNNLSY WDAPLGSSYM CNKEQTVSVS GAFQINTFDL 
       360        370        380        390        400
RVQPFNVTQG KYSTAEECSA DSDLNFLIPV AVGVALGFLI IVVFISYMIG 
       410 
RRKSRTGYQS V

Show »

Length:411

Mass (Da):45,170

Checksum:ⁱB37AAC83BA1C3B1B

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H0YCG2	H0YCG2_HUMAN		Lysosome-associated membrane glycop... Lysosome-associated membrane glycoprotein 2	LAMP2	258	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	8 – 13	PVPGSG → RFRSGLR no nucleotide entry (PubMed:8407947).Curated	6
Sequence conflictⁱ	53	R → G no nucleotide entry (PubMed:8407947).Curated	1
Sequence conflictⁱ	68	D → V in AAB41647 (PubMed:8517882).Curated	1
Sequence conflictⁱ	111	I → N in AAB41647 (PubMed:8517882).Curated	1
Sequence conflictⁱ	143	I → Y in AAB41647 (PubMed:8517882).Curated	1
Sequence conflictⁱ	220	A → P in AAB41647 (PubMed:8517882).Curated	1
Sequence conflictⁱ	234	L → R in AAB41647 (PubMed:8517882).Curated	1
Sequence conflictⁱ	263 – 269	GSCRSHT → AAAVSH no nucleotide entry (PubMed:8407947).Curated	7
Sequence conflictⁱ	322 – 326	DAPLG → MPP in AAA60383 (PubMed:3198605).Curated	5

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_011992	256	P → H. Corresponds to variant dbSNP:rs1043878Ensembl.		1
Natural variantⁱVAR_026230	321	W → R in DAND. 2 PublicationsCorresponds to variant dbSNP:rs104894859EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042519	366 – 410	QDCSA…GYEQF → EECSADSDLNFLIPVAVGVA LGFLIIVVFISYMIGRRKSR TGYQSV in isoform LAMP-2C. 1 PublicationAdd BLAST		45
Alternative sequenceⁱVSP_003044	367 – 410	DCSAD…GYEQF → ECSLDDDTILIPIIVGAGLS GLIIVIVIAYVIGRRKSYAG YQTL in isoform LAMP-2B. 3 PublicationsAdd BLAST		44

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04183 mRNA Translation: AAA60383.1 L09717 L09716 Genomic DNA Translation: AAB41647.1 X77196 mRNA Translation: CAA54416.1 S79873 mRNA Translation: AAB35426.1 U36336 mRNA Translation: AAA91149.1 AY561849 mRNA Translation: AAS67876.1 AK291090 mRNA Translation: BAF83779.1 AC002476 Genomic DNA Translation: AAB67313.1 AC002476 Genomic DNA Translation: AAB67314.1 CH471107 Genomic DNA Translation: EAX11881.1 CH471107 Genomic DNA Translation: EAX11882.1 CH471107 Genomic DNA Translation: EAX11883.1 CH471107 Genomic DNA Translation: EAX11884.1 BC002965 mRNA Translation: AAH02965.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14599.1 [P13473-1] CCDS14600.1 [P13473-2] CCDS48159.1 [P13473-3]
PIRⁱ	JC2414 B31959 JC4317
NCBI Reference Sequences More...RefSeqⁱ	NP_001116078.1, NM_001122606.1 [P13473-3] NP_002285.1, NM_002294.2 [P13473-1] NP_054701.1, NM_013995.2 [P13473-2]
UniGeneⁱ	Hs.496684

Genome annotation databases

Ensemblⁱ	ENST00000200639; ENSP00000200639; ENSG00000005893 [P13473-1] ENST00000371335; ENSP00000360386; ENSG00000005893 [P13473-2] ENST00000434600; ENSP00000408411; ENSG00000005893 [P13473-3]
GeneIDⁱ	3920
KEGGⁱ	hsa:3920
UCSC genome browser More...UCSCⁱ	uc004ess.5 human [P13473-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P13473	Lysosome-associated membrane glycoprotein 2 isoform A		MACMU		410	UniRef90_P13473
Brain cDNA, clone: QtrA-12874, similar to human lysosomal-associated membrane protein 2 (LAMP2),transcript variant LAMP2A		MACFA		410
Uncharacterized protein		MACNE		410
LAMP2 isoform 2		PANTR		410
Uncharacterized protein		PANPA		410
+11
P13473-2	cDNA FLJ58780, highly similar to Homo sapiens lysosomal-associated membrane protein 2 (LAMP2), transcript variant LAMP2B, mRNA		HUMAN		363	UniRef90_P13473-2
Lysosomal associated membrane protein 2		MACMU		410
Uncharacterized protein		MACFA		410
LAMP2 isoform 4		PANTR		410
Uncharacterized protein		PANPA		410
+20
P13473-3	Lysosomal-associated membrane protein 2 (Fragment)		HUMAN		61	UniRef90_P13473-3
Lysosomal associated membrane protein 2		CALJA		411
LAMP2 isoform 1		PANTR		411
Uncharacterized protein		PANPA		411
Lysosomal associated membrane protein 2		MACFA		411
+24

Protein	Similar proteins		Species	Score	Length	Source
P13473	Lysosome-associated membrane glycoprotein 2		CHICK		425	UniRef50_P13473
Uncharacterized protein		NOMLE		410
Lysosome-associated membrane glycoprotein 2 isoform A		MACMU		410
Brain cDNA, clone: QtrA-12874, similar to human lysosomal-associated membrane protein 2 (LAMP2),transcript variant LAMP2A		MACFA		410
Uncharacterized protein		MACNE		410
+294

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04183 mRNA Translation: AAA60383.1 L09717 L09716 Genomic DNA Translation: AAB41647.1 X77196 mRNA Translation: CAA54416.1 S79873 mRNA Translation: AAB35426.1 U36336 mRNA Translation: AAA91149.1 AY561849 mRNA Translation: AAS67876.1 AK291090 mRNA Translation: BAF83779.1 AC002476 Genomic DNA Translation: AAB67313.1 AC002476 Genomic DNA Translation: AAB67314.1 CH471107 Genomic DNA Translation: EAX11881.1 CH471107 Genomic DNA Translation: EAX11882.1 CH471107 Genomic DNA Translation: EAX11883.1 CH471107 Genomic DNA Translation: EAX11884.1 BC002965 mRNA Translation: AAH02965.1
CCDSⁱ	CCDS14599.1 [P13473-1] CCDS14600.1 [P13473-2] CCDS48159.1 [P13473-3]
PIRⁱ	JC2414 B31959 JC4317
RefSeqⁱ	NP_001116078.1, NM_001122606.1 [P13473-3] NP_002285.1, NM_002294.2 [P13473-1] NP_054701.1, NM_013995.2 [P13473-2]
UniGeneⁱ	Hs.496684

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2MOF	NMR	-	A	369-410	[»]
	2MOM	NMR	-	A/B/C	369-410	[»]
ProteinModelPortalⁱ	P13473
SMRⁱ	P13473
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110114, 96 interactors
IntActⁱ	P13473, 17 interactors
MINTⁱ	P13473

Protein family/group databases

TCDBⁱ	9.A.16.1.2 the lysosomal protein import (lpi) family

TCDBⁱ

9.A.16.1.2 the lysosomal protein import (lpi) family

PTM databases

GlyConnectⁱ	356
iPTMnetⁱ	P13473
PhosphoSitePlusⁱ	P13473
SwissPalmⁱ	P13473
UniCarbKBⁱ	P13473

Polymorphism and mutation databases

BioMutaⁱ	LAMP2
DMDMⁱ	1708854

Proteomic databases

EPDⁱ	P13473
MaxQBⁱ	P13473
PeptideAtlasⁱ	P13473
PRIDEⁱ	P13473
ProteomicsDBⁱ	52910 52911 [P13473-2] 52912 [P13473-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3920
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000200639; ENSP00000200639; ENSG00000005893 [P13473-1] ENST00000371335; ENSP00000360386; ENSG00000005893 [P13473-2] ENST00000434600; ENSP00000408411; ENSG00000005893 [P13473-3]
GeneIDⁱ	3920
KEGGⁱ	hsa:3920
UCSCⁱ	uc004ess.5 human [P13473-1]

Organism-specific databases

CTDⁱ	3920
DisGeNETⁱ	3920
EuPathDBⁱ	HostDB:ENSG00000005893.15
GeneCardsⁱ	LAMP2
HGNCⁱ	HGNC:6501 LAMP2
HPAⁱ	CAB005272 HPA029100
MalaCardsⁱ	LAMP2
MIMⁱ	300257 phenotype 309060 gene
neXtProtⁱ	NX_P13473
OpenTargetsⁱ	ENSG00000005893
Orphanetⁱ	34587 Glycogen storage disease due to LAMP-2 deficiency
PharmGKBⁱ	PA30285
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00530000063068
HOGENOMⁱ	HOG000230942
HOVERGENⁱ	HBG052303
InParanoidⁱ	P13473
KOⁱ	K06528
OMAⁱ	PIIHTTV
OrthoDBⁱ	EOG091G09EV
PhylomeDBⁱ	P13473
TreeFamⁱ	TF316339

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-6798695 Neutrophil degranulation

Reactomeⁱ

R-HSA-114608 Platelet degranulation
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSⁱ	LAMP2 human
GeneWikiⁱ	LAMP2
GenomeRNAiⁱ	3920
PMAP-CutDBⁱ	P13473
Protein Ontology More...PROⁱ	PR:P13473
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000005893 Expressed in 236 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_LAMP2
ExpressionAtlasⁱ	P13473 baseline and differential
Genevisibleⁱ	P13473 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR018134 LAMP_CS IPR002000 Lysosome-assoc_membr_glycop
PANTHERⁱ	PTHR11506 PTHR11506, 1 hit
Pfamⁱ	View protein in Pfam PF01299 Lamp, 1 hit
PRINTSⁱ	PR00336 LYSASSOCTDMP
PROSITEⁱ	View protein in PROSITE PS00310 LAMP_1, 1 hit PS00311 LAMP_2, 1 hit PS51407 LAMP_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LAMP2_HUMAN
Accessionⁱ	P13473Primary (citable) accession number: P13473 Secondary accession number(s): A8K4X5 Q9UD93
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	October 1, 1996
	Last modified:	October 10, 2018
	This is version 198 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P13473 (LAMP2_HUMAN)

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Lysosome-associated membrane glycoprotein 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

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Keywords - PTMi

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Gene expression databases

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Keywords - Coding sequence diversityi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ