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Entry version 220 (29 Sep 2021)
Sequence version 2 (01 Oct 1996)
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Protein

Lysosome-associated membrane glycoprotein 2

Gene

LAMP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032).

Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125).

Plays a role in lysosomal protein degradation in response to starvation (By similarity).

Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032).

Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032).

Required for normal degradation of the contents of autophagosomes (PubMed:27628032).

Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820).

Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).

By similarity6 Publications

Modulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of exogenous and membrane-derived antigens by MHCII.

1 Publication

(Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P13473

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-114608, Platelet degranulation
R-HSA-6798695, Neutrophil degranulation
R-HSA-9613829, Chaperone Mediated Autophagy

SIGNOR Signaling Network Open Resource

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SIGNORi
P13473

Protein family/group databases

Transport Classification Database

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TCDBi
9.A.16.1.2, the lysosomal protein import (lpi) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 2
Short name:
LAMP-2
Short name:
Lysosome-associated membrane protein 2
Alternative name(s):
CD107 antigen-like family member B
LGP-961 Publication
CD_antigen: CD107b
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LAMP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:6501, LAMP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
309060, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P13473

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000005893

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 375LumenalSequence analysisAdd BLAST347
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei376 – 399HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini400 – 410CytoplasmicPROSITE-ProRule annotationAdd BLAST11

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Danon disease (DAND)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionDAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_026230321W → R in DAND. 2 PublicationsCorresponds to variant dbSNP:rs104894859EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi401 – 404KHHH → AAAA: Impairs binding and subsequent lysosomal degradation of target proteins, such as GAPDH. 1 Publication4

Keywords - Diseasei

Disease variant, Glycogen storage disease

Organism-specific databases

DisGeNET

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DisGeNETi
3920

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
LAMP2

MalaCards human disease database

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MalaCardsi
LAMP2
MIMi300257, phenotype

Open Targets

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OpenTargetsi
ENSG00000005893

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
34587, Glycogen storage disease due to LAMP-2 deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA30285

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
P13473, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
LAMP2

Domain mapping of disease mutations (DMDM)

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DMDMi
1708854

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 283 PublicationsAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001711029 – 410Lysosome-associated membrane glycoprotein 2Add BLAST382

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi32N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication1
Glycosylationi38N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi41 ↔ 79PROSITE-ProRule annotation
Glycosylationi49N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi58N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi75N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi101N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi123N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi153 ↔ 189PROSITE-ProRule annotation
Glycosylationi179N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi195O-linked (GalNAc...) serine1 Publication1
Glycosylationi196O-linked (GalNAc...) threonine1 Publication1
Glycosylationi200O-linked (GalNAc...) threonine1 Publication1
Glycosylationi203O-linked (GalNAc...) threonine1 Publication1
Glycosylationi204O-linked (GalNAc...) threonine1 Publication1
Glycosylationi207O-linked (GalNAc...) serine; partial1 Publication1
Glycosylationi209O-linked (GalNAc...) threonine; partial1 Publication1
Glycosylationi210O-linked (GalNAc...) threonine1 Publication1
Glycosylationi211O-linked (GalNAc...) threonine1 Publication1
Glycosylationi213O-linked (GalNAc...) threonine; partial1 Publication1
Glycosylationi229N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi232 ↔ 265PROSITE-ProRule annotation
Glycosylationi242N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi257N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi275N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi300N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi307N-linked (GlcNAc...) (polylactosaminoglycan) asparagine1 Publication1
Glycosylationi317N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi331 ↔ 368PROSITE-ProRule annotation
Glycosylationi356N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.6 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

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CPTACi
CPTAC-1494
CPTAC-689

Encyclopedia of Proteome Dynamics

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EPDi
P13473

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P13473

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P13473

MaxQB - The MaxQuant DataBase

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MaxQBi
P13473

PeptideAtlas

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PeptideAtlasi
P13473

PRoteomics IDEntifications database

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PRIDEi
P13473

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
52910 [P13473-1]
52911 [P13473-2]
52912 [P13473-3]

PTM databases

GlyConnect protein glycosylation platform

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GlyConnecti
356, 115 N-Linked glycans (12 sites), 3 O-Linked glycans

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
P13473, 28 sites, 138 N-linked glycans (13 sites), 3 O-linked glycans (10 sites)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P13473

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P13473

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P13473

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle (PubMed:7488019, PubMed:26856698). Isoform LAMP-2B is detected in spleen, thymus, prostate, testis, small intestine, colon, skeletal muscle, brain, placenta, lung, kidney, ovary and pancreas and liver (PubMed:7488019, PubMed:26856698). Isoform LAMP-2C is detected in small intestine, colon, heart, brain, skeletal muscle, and at lower levels in kidney and placenta (PubMed:26856698).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

In peripheral blood B cells isoform LAMP-2A, LAMP-2B and LAMP-2C are up-regulated in response to treatments that stimulate immune responses via the Toll-like receptors TLR7 or TLR9.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000005893, Expressed in corpus callosum and 249 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P13473, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P13473, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000005893, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:18644871, PubMed:25342746). Homodimer (PubMed:25342746). Homotrimer (PubMed:25342746). Forms large homooligomers (PubMed:18644871).

Interacts (via its cytoplasmic region) with HSPA8 (PubMed:25342746).

Interacts with HSP90 in the lysosome lumen; this enhances LAMP2 stability (By similarity).

Interacts with MLLT11 (PubMed:24880125).

Interacts with ABCB9 (PubMed:22641697).

Interacts with FURIN (PubMed:32295904).

By similarity5 Publications

(Microbial infection) Interacts with mumps virus protein F; this interaction promotes protein F cleavage by FURIN.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Isoform LAMP-2B [P13473-2]
With#Exp.IntAct
ABCG1 - isoform 6 [P45844-6]3EBI-21591415,EBI-25873349
ABHD12B - isoform 2 [Q7Z5M8-2]3EBI-21591415,EBI-21854797
ACTL7B [Q9Y614]3EBI-21591415,EBI-25835070
ADAL - isoform 2 [Q6DHV7-2]3EBI-21591415,EBI-18899653
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-21591415,EBI-10173507
AK8 [Q96MA6]3EBI-21591415,EBI-8466265
AKR1C8P [Q5T2L2]3EBI-21591415,EBI-22006248
ALKBH3 - isoform 2 [Q96Q83-2]3EBI-21591415,EBI-9089544
AMDHD2 - isoform 2 [Q9Y303-2]3EBI-21591415,EBI-12323557
ANKEF1 [Q9NU02]3EBI-21591415,EBI-8464238
ANXA4 [Q6LES2]3EBI-21591415,EBI-10250835
APOA1 [P02647]3EBI-21591415,EBI-701692
APOH [P02749]3EBI-21591415,EBI-2114682
ARFIP2 [P53365]3EBI-21591415,EBI-638194
ARL6IP4 - isoform 4 [Q66PJ3-4]3EBI-21591415,EBI-5280499
ASCL4 [Q6XD76]3EBI-21591415,EBI-10254793
ATF4 [P18848]3EBI-21591415,EBI-492498
ATG10 [Q9H0Y0]3EBI-21591415,EBI-1048913
ATG12 [C1IDX9]3EBI-21591415,EBI-25836940
ATP5MG [O75964]3EBI-21591415,EBI-1044001
BAAT [Q14032]3EBI-21591415,EBI-8994378
BCAT1 - isoform 4 [P54687-4]3EBI-21591415,EBI-25834445
BCHE [P06276]3EBI-21591415,EBI-7936069
BRWD1 - isoform D [Q9NSI6-4]3EBI-21591415,EBI-10693038
BSND [Q8WZ55]3EBI-21591415,EBI-7996695
BTBD9 - isoform 2 [Q96Q07-2]3EBI-21591415,EBI-22006737
C11orf54 - isoform 3 [Q9H0W9-3]3EBI-21591415,EBI-12108466
C12orf4 [Q9NQ89]3EBI-21591415,EBI-11090973
C1D [Q13901]3EBI-21591415,EBI-3844053
C3orf36 [Q3SXR2]3EBI-21591415,EBI-18036948
C4orf33 [Q8N1A6]3EBI-21591415,EBI-10264911
CAPN2 [P17655]3EBI-21591415,EBI-1028956
CAPN3 - isoform IV [P20807-4]3EBI-21591415,EBI-11532021
CASP6 [P55212]3EBI-21591415,EBI-718729
CBWD3 [Q5JTY5]3EBI-21591415,EBI-723434
CBX4 - isoform 2 [O00257-3]3EBI-21591415,EBI-4392727
CCNC [P24863]3EBI-21591415,EBI-395261
CCNL1 - isoform 3 [Q9UK58-5]3EBI-21591415,EBI-25873837
CD209 - isoform 10 [Q9NNX6-10]3EBI-21591415,EBI-12300031
CD4 [P01730]3EBI-21591415,EBI-353826
CDC23 [Q9UJX2]3EBI-21591415,EBI-396137
CDKN2C [P42773]3EBI-21591415,EBI-711290
CDS2 [O95674]3EBI-21591415,EBI-3913685
CETN3 [O15182]3EBI-21591415,EBI-712959
CHMP7 [Q8WUX9]3EBI-21591415,EBI-749253
CIAO2B [Q9Y3D0]3EBI-21591415,EBI-744045
CIART [Q8N365]3EBI-21591415,EBI-10265133
CIDEB [Q9UHD4]3EBI-21591415,EBI-7062247
CITED1 [Q99966]3EBI-21591415,EBI-2624951
CLTA - isoform Non-brain [P09496-2]3EBI-21591415,EBI-4401010
CNST - isoform 3 [Q6PJW8-3]3EBI-21591415,EBI-25836090
COA7 [Q96BR5]3EBI-21591415,EBI-6269632
COL2A1 - isoform 1 [P02458-1]3EBI-21591415,EBI-12375799
COQ8A [Q8NI60]3EBI-21591415,EBI-745535
CRCT1 [Q9UGL9]3EBI-21591415,EBI-713677
CRYBB3 [P26998]3EBI-21591415,EBI-1965681
CTNNB1 [P35222]3EBI-21591415,EBI-491549
CYBRD1 [Q53TN4]3EBI-21591415,EBI-8637742
CYP2C8 [P10632]3EBI-21591415,EBI-2951522
DCAF7 [P61962]3EBI-21591415,EBI-359808
DHRS1 [Q96LJ7]3EBI-21591415,EBI-746300
DLX3 [O60479]3EBI-21591415,EBI-3908248
DNAJA3 - isoform 3 [Q96EY1-3]3EBI-21591415,EBI-11526226
DNAJC1 [Q96KC8]3EBI-21591415,EBI-296550
DPF1 - isoform 2 [Q92782-2]3EBI-21591415,EBI-23669343
DPYSL5 [Q9BPU6]3EBI-21591415,EBI-724653
EEF1DP3 [Q658K8]3EBI-21591415,EBI-10248874
EIF3F [O00303]3EBI-21591415,EBI-711990
EIF3I [Q13347]3EBI-21591415,EBI-354047
ELL2 [O00472]3EBI-21591415,EBI-395274
EML1 [O00423]3EBI-21591415,EBI-751327
EPM2A - isoform 6 [O95278-6]3EBI-21591415,EBI-25836908
ESRP1 - isoform 3 [Q6NXG1-3]3EBI-21591415,EBI-21567429
F12 [P00748]3EBI-21591415,EBI-6378830
FAM135B - isoform 4 [Q49AJ0-4]3EBI-21591415,EBI-25835236
FAM167A [Q96KS9]3EBI-21591415,EBI-10290462
FAM177A1 - isoform 2 [Q8N128-2]3EBI-21591415,EBI-12201693
FAM9A [Q8IZU1]3EBI-21591415,EBI-8468186
FASTKD2 [Q9NYY8]3EBI-21591415,EBI-1055752
FGA - isoform 2 [P02671-2]3EBI-21591415,EBI-9640259
FGD5 [Q6ZNL6]3EBI-21591415,EBI-7962481
FGF21 [Q9NSA1]3EBI-21591415,EBI-3909329
FLT3LG - isoform 3 [P49771-3]3EBI-21591415,EBI-25872794
FOXD4L6 [Q3SYB3]3EBI-21591415,EBI-6425864
FUT6 [Q6P7E6]3EBI-21591415,EBI-25872807
FYN [P06241]3EBI-21591415,EBI-515315
GABPB1 - isoform 3 [Q06547-3]3EBI-21591415,EBI-9088619
GHITM [Q9H3K2]3EBI-21591415,EBI-2868909
GIMAP1 [Q8WWP7]3EBI-21591415,EBI-11991950
GLYR1 - isoform 4 [Q49A26-4]3EBI-21591415,EBI-12143817
GNB4 [Q9HAV0]3EBI-21591415,EBI-358539
GTF2H1 [P32780]3EBI-21591415,EBI-715539
H2AP [O75409]3EBI-21591415,EBI-6447217
H3-5 [Q6NXT2]3EBI-21591415,EBI-2868501
H3C12 [P68431]3EBI-21591415,EBI-79722
HAUS8 [Q9BT25]3EBI-21591415,EBI-2558143
HELLS - isoform 6 [Q9NRZ9-6]3EBI-21591415,EBI-12003732
HSPBAP1 - isoform 2 [Q96EW2-2]3EBI-21591415,EBI-25835621
IQCF1 - isoform 2 [Q8N6M8-2]3EBI-21591415,EBI-21771049
JADE3 [Q92613]3EBI-21591415,EBI-10278909
JMJD7 [P0C870]3EBI-21591415,EBI-9090173
JPT1 [Q9UK76]3EBI-21591415,EBI-720411
KCTD17 [Q8N5Z5]3EBI-21591415,EBI-743960
KLHDC4 - isoform 2 [Q8TBB5-2]3EBI-21591415,EBI-21838933
KLHL3 [Q9UH77]3EBI-21591415,EBI-8524663
KLHL36 - isoform 2 [Q8N4N3-2]3EBI-21591415,EBI-10973851
KRT222 [Q8N1A0]3EBI-21591415,EBI-8473062
LGALS9C [Q6DKI2]3EBI-21591415,EBI-9088829
LHX5 [Q9H2C1]3EBI-21591415,EBI-25835523
LINC00518 [Q8N0U6]3EBI-21591415,EBI-10264791
LIPT1 [Q9Y234]3EBI-21591415,EBI-727376
LITAF [Q99732]3EBI-21591415,EBI-725647
LONRF2 [Q1L5Z9]3EBI-21591415,EBI-2510853
LOXL4 [Q96JB6]3EBI-21591415,EBI-749562
LRRC56 [Q8IYG6]3EBI-21591415,EBI-14752528
LY9 [Q5VYH9]3EBI-21591415,EBI-25872860
LYNX1 - isoform 2 [P0DP58-2]3EBI-21591415,EBI-21916939
MAGEA8 [P43361]3EBI-21591415,EBI-10182930
MAGEB18 [Q96M61]3EBI-21591415,EBI-741835
MAL2 [Q969L2]3EBI-21591415,EBI-944295
MAOB [P27338]3EBI-21591415,EBI-3911344
MCFD2 [Q8NI22]3EBI-21591415,EBI-2689785
METTL15 - isoform 4 [A6NJ78-4]3EBI-21591415,EBI-10174029
MLST8 [A0A0A0MR05]3EBI-21591415,EBI-25835557
MPI - isoform 2 [P34949-2]3EBI-21591415,EBI-21823432
MRI1 [Q9BV20]3EBI-21591415,EBI-747381
MRM1 - isoform 2 [Q6IN84-2]3EBI-21591415,EBI-25835707
MUC15 [Q8N387]3EBI-21591415,EBI-17937277
MYBPHL [A2RUH7]3EBI-21591415,EBI-9088235
MYC [P01106]3EBI-21591415,EBI-447544
NAA60 [Q9H7X0]3EBI-21591415,EBI-12260336
NAB2 - isoform 2 [Q15742-2]3EBI-21591415,EBI-25834665
NAGK - isoform 2 [Q9UJ70-2]3EBI-21591415,EBI-11526455
NCBP2AS2 [Q69YL0]3EBI-21591415,EBI-10986258
NFYB [P25208]3EBI-21591415,EBI-389728
NPEPL1 - isoform 5 [Q8NDH3-5]3EBI-21591415,EBI-12329915
NPFF - isoform 2 [O15130-2]3EBI-21591415,EBI-25840002
NUDT1 - isoform p18 [P36639-4]3EBI-21591415,EBI-25834643
NUP37 [Q8NFH4]3EBI-21591415,EBI-2563158
NUP43 [Q8NFH3]3EBI-21591415,EBI-1059321
NUP54 [Q7Z3B4]3EBI-21591415,EBI-741048
OGFOD2 - isoform 2 [Q6N063-2]3EBI-21591415,EBI-22006224
OTUD7B - isoform 2 [Q6GQQ9-2]3EBI-21591415,EBI-25830200
PCYT2 [Q99447]3EBI-21591415,EBI-750317
PDE4A - isoform 4 [P27815-4]3EBI-21591415,EBI-12080840
PEDS1 [A5PLL7]3EBI-21591415,EBI-11337896
PHF23 [Q9BUL5]3EBI-21591415,EBI-722852
PITPNA [Q00169]3EBI-21591415,EBI-1042490
PITPNB [P48739]3EBI-21591415,EBI-1047143
PLEKHG4 - isoform 2 [Q58EX7-2]3EBI-21591415,EBI-21503705
PLIN3 [O60664]3EBI-21591415,EBI-725795
POLA2 [Q14181]3EBI-21591415,EBI-712752
POLR1D [P0DPB6]3EBI-21591415,EBI-359498
POLR2I [P36954]3EBI-21591415,EBI-395202
PPARA [Q07869]3EBI-21591415,EBI-78615
PPP1R11 [O60927]3EBI-21591415,EBI-1048104
PPP1R21 - isoform 5 [Q6ZMI0-5]3EBI-21591415,EBI-25835994
PROCA1 - isoform 2 [Q8NCQ7-2]3EBI-21591415,EBI-25836043
PRPH2 [P23942]3EBI-21591415,EBI-25836834
PTGDS [P41222]3EBI-21591415,EBI-948821
PTPN4 [P29074]3EBI-21591415,EBI-710431
RAB2B - isoform 2 [Q8WUD1-2]3EBI-21591415,EBI-25835884
RABGAP1L - isoform 9 [Q5R372-9]3EBI-21591415,EBI-10699389
RANGRF - isoform 3 [Q9HD47-3]3EBI-21591415,EBI-9089733
RBBP4 [Q09028]3EBI-21591415,EBI-620823
RBM39 [Q14498]3EBI-21591415,EBI-395290
REEP6 - isoform 2 [Q96HR9-2]3EBI-21591415,EBI-14065960
RELA [Q04206]3EBI-21591415,EBI-73886
RGR - isoform 3 [P47804-3]3EBI-21591415,EBI-25834767
RHEB [Q15382]4EBI-21591415,EBI-1055287
RIC8A - isoform 4 [Q9NPQ8-4]3EBI-21591415,EBI-9091816
RING1 [Q06587]3EBI-21591415,EBI-752313
RNF10 [Q8N5U6]3EBI-21591415,EBI-714023
RSRC1 [Q96IZ7]3EBI-21591415,EBI-712189
RUSC1-AS1 [Q66K80]3EBI-21591415,EBI-10248967
SCAMP1 [O15126]3EBI-21591415,EBI-954338
SCP2 - isoform 3 [P22307-3]3EBI-21591415,EBI-25834804
SDF4 [Q9BRK5]3EBI-21591415,EBI-1389808
SEMA4G - isoform 3 [Q9NTN9-3]3EBI-21591415,EBI-9089805
SERPINA3 [P01011]3EBI-21591415,EBI-296557
SFXN3 [A0A1P0AYU5]3EBI-21591415,EBI-14193895
SH3GLB2 [Q9NR46]3EBI-21591415,EBI-749607
SHCBP1L [Q9BZQ2]3EBI-21591415,EBI-10818532
SHOX2 - isoform 3 [O60902-3]3EBI-21591415,EBI-9092164
SLC25A20 [O43772]3EBI-21591415,EBI-727085
SLFN12 [Q8IYM2]3EBI-21591415,EBI-2822550
SMG6 [Q86US8]3EBI-21591415,EBI-3232100
SMIM12 [Q96EX1]3EBI-21591415,EBI-2874543
SNCA [P37840]3EBI-21591415,EBI-985879
SNF8 [Q96H20]3EBI-21591415,EBI-747719
SPART [Q8N0X7]3EBI-21591415,EBI-2643803
SPATS1 [Q496A3]3EBI-21591415,EBI-3923692
SPHK1 - isoform 2 [Q9NYA1-2]3EBI-21591415,EBI-12512419
SPIN2B [Q9BPZ2]3EBI-21591415,EBI-21726245
SPRY4 [Q9C004]3EBI-21591415,EBI-354861
SPSB1 [Q96BD6]3EBI-21591415,EBI-2659201
SUCNR1 [Q9BXA5]3EBI-21591415,EBI-17962797
SYMPK - isoform 2 [Q92797-2]3EBI-21591415,EBI-21560407
SYNCRIP - isoform 4 [O60506-4]3EBI-21591415,EBI-11123832
SYP [P08247]3EBI-21591415,EBI-9071725
SYT16 [Q17RD7]3EBI-21591415,EBI-10238936
TBX6 [O95947]3EBI-21591415,EBI-2824328
TCAP [O15273]3EBI-21591415,EBI-954089
TEN1 [Q86WV5]3EBI-21591415,EBI-2562799
TERF1 - isoform 2 [P54274-2]3EBI-21591415,EBI-711018
TGM1 [P22735]3EBI-21591415,EBI-2562368
TGM5 [O43548]3EBI-21591415,EBI-12027348
THEG [Q9P2T0]3EBI-21591415,EBI-751020
TIGAR [Q9NQ88]3EBI-21591415,EBI-3920747
TIMM23 [O14925]3EBI-21591415,EBI-1047996
TMEM115 [Q12893]3EBI-21591415,EBI-8633987
TMEM171 - isoform 2 [Q8WVE6-2]3EBI-21591415,EBI-25874374
TMEM176B [Q3YBM2]3EBI-21591415,EBI-2821479
tmp_locus_54 [Q53NU3]3EBI-21591415,EBI-10242677
TOMM22 [Q9NS69]3EBI-21591415,EBI-1047508
TP53 [P04637]3EBI-21591415,EBI-366083
TP53BP1 [Q12888]3EBI-21591415,EBI-396540
TRAF5 [O00463]3EBI-21591415,EBI-523498
TRIM23 [P36406]3EBI-21591415,EBI-740098
TRIM5 - isoform Gamma [Q9C035-3]3EBI-21591415,EBI-12840050
TRIM69 - isoform 2 [Q86WT6-2]3EBI-21591415,EBI-11525489
TTYH1 - isoform 4 [Q9H313-4]3EBI-21591415,EBI-17671298
TUBA1C [Q9BQE3]3EBI-21591415,EBI-1103245
UBE2A [P49459]3EBI-21591415,EBI-2339348
UBE2G1 [P62253]3EBI-21591415,EBI-2340619
UCHL1 [P09936]3EBI-21591415,EBI-714860
VPS54 - isoform 4 [Q9P1Q0-4]3EBI-21591415,EBI-25835297
WBP1L [Q9NX94]3EBI-21591415,EBI-10316321
WBP2NL [Q6ICG8]3EBI-21591415,EBI-17769315
WDR31 - isoform 2 [Q8NA23-2]3EBI-21591415,EBI-25835937
WDR77 [Q9BQA1]3EBI-21591415,EBI-1237307
WNT7A [O00755]3EBI-21591415,EBI-727198
YIF1A [O95070]3EBI-21591415,EBI-2799703
ZBTB8OS - isoform 2 [Q8IWT0-2]3EBI-21591415,EBI-12956041
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-21591415,EBI-14104088
ZNF248 [Q05CR2]3EBI-21591415,EBI-25835471
ZNF333 - isoform 2 [Q96JL9-2]3EBI-21591415,EBI-25835852
ZNF597 [Q96LX8]3EBI-21591415,EBI-9091553
ZNF829 - isoform 3 [Q3KNS6-3]3EBI-21591415,EBI-18036029
A0A384MDV83EBI-21591415,EBI-25834468
B7Z3E83EBI-21591415,EBI-25831617
Q86V283EBI-21591415,EBI-10259496

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
110114, 126 interactors

Protein interaction database and analysis system

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IntActi
P13473, 304 interactors

Molecular INTeraction database

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MINTi
P13473

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000408411

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P13473, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1410
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
P13473

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P13473

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni29 – 192First lumenal domainAdd BLAST164
Regioni193 – 228HingeAdd BLAST36
Regioni199 – 221DisorderedSequence analysisAdd BLAST23
Regioni229 – 375Second lumenal domainAdd BLAST147
Regioni401 – 404Important for binding and subsequent lysosomal degradation of target proteins1 Publication4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4818, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00950000182899

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_055379_2_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P13473

Identification of Orthologs from Complete Genome Data

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OMAi
MATGYES

Database of Orthologous Groups

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OrthoDBi
1042920at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P13473

TreeFam database of animal gene trees

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TreeFami
TF316339

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR018134, LAMP_CS
IPR002000, Lysosome-assoc_membr_glycop

The PANTHER Classification System

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PANTHERi
PTHR11506, PTHR11506, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01299, Lamp, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00336, LYSASSOCTDMP

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00310, LAMP_1, 1 hit
PS00311, LAMP_2, 1 hit
PS51407, LAMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform LAMP-2A (identifier: P13473-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVCFRLFPVP GSGLVLVCLV LGAVRSYALE LNLTDSENAT CLYAKWQMNF
60 70 80 90 100
TVRYETTNKT YKTVTISDHG TVTYNGSICG DDQNGPKIAV QFGPGFSWIA
110 120 130 140 150
NFTKAASTYS IDSVSFSYNT GDNTTFPDAE DKGILTVDEL LAIRIPLNDL
160 170 180 190 200
FRCNSLSTLE KNDVVQHYWD VLVQAFVQNG TVSTNEFLCD KDKTSTVAPT
210 220 230 240 250
IHTTVPSPTT TPTPKEKPEA GTYSVNNGND TCLLATMGLQ LNITQDKVAS
260 270 280 290 300
VININPNTTH STGSCRSHTA LLRLNSSTIK YLDFVFAVKN ENRFYLKEVN
310 320 330 340 350
ISMYLVNGSV FSIANNNLSY WDAPLGSSYM CNKEQTVSVS GAFQINTFDL
360 370 380 390 400
RVQPFNVTQG KYSTAQDCSA DDDNFLVPIA VGAALAGVLI LVLLAYFIGL
410
KHHHAGYEQF
Length:410
Mass (Da):44,961
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E08E3B62D58F454
GO
Isoform LAMP-2B (identifier: P13473-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     367-410: DCSADDDNFL...KHHHAGYEQF → ECSLDDDTIL...RKSYAGYQTL

Show »
Length:410
Mass (Da):44,956
Checksum:i70B523369D40DEFA
GO
Isoform LAMP-2C (identifier: P13473-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     366-410: QDCSADDDNF...KHHHAGYEQF → EECSADSDLN...RKSRTGYQSV

Show »
Length:411
Mass (Da):45,170
Checksum:iB37AAC83BA1C3B1B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCG2H0YCG2_HUMAN
Lysosome-associated membrane glycop...
LAMP2
258Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti8 – 13PVPGSG → RFRSGLR no nucleotide entry (PubMed:8407947).Curated6
Sequence conflicti53R → G no nucleotide entry (PubMed:8407947).Curated1
Sequence conflicti68D → V in AAB41647 (PubMed:8517882).Curated1
Sequence conflicti111I → N in AAB41647 (PubMed:8517882).Curated1
Sequence conflicti143I → Y in AAB41647 (PubMed:8517882).Curated1
Sequence conflicti220A → P in AAB41647 (PubMed:8517882).Curated1
Sequence conflicti234L → R in AAB41647 (PubMed:8517882).Curated1
Sequence conflicti263 – 269GSCRSHT → AAAVSH no nucleotide entry (PubMed:8407947).Curated7
Sequence conflicti322 – 326DAPLG → MPP in AAA60383 (PubMed:3198605).Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011992256P → H. Corresponds to variant dbSNP:rs1043878Ensembl.1
Natural variantiVAR_026230321W → R in DAND. 2 PublicationsCorresponds to variant dbSNP:rs104894859EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042519366 – 410QDCSA…GYEQF → EECSADSDLNFLIPVAVGVA LGFLIIVVFISYMIGRRKSR TGYQSV in isoform LAMP-2C. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_003044367 – 410DCSAD…GYEQF → ECSLDDDTILIPIIVGAGLS GLIIVIVIAYVIGRRKSYAG YQTL in isoform LAMP-2B. 3 PublicationsAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
J04183 mRNA Translation: AAA60383.1
L09717 L09716 Genomic DNA Translation: AAB41647.1
X77196 mRNA Translation: CAA54416.1
S79873 mRNA Translation: AAB35426.1
U36336 mRNA Translation: AAA91149.1
AY561849 mRNA Translation: AAS67876.1
AK291090 mRNA Translation: BAF83779.1
AC002476 Genomic DNA Translation: AAB67313.1
AC002476 Genomic DNA Translation: AAB67314.1
CH471107 Genomic DNA Translation: EAX11881.1
CH471107 Genomic DNA Translation: EAX11882.1
CH471107 Genomic DNA Translation: EAX11883.1
CH471107 Genomic DNA Translation: EAX11884.1
BC002965 mRNA Translation: AAH02965.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14599.1 [P13473-1]
CCDS14600.1 [P13473-2]
CCDS48159.1 [P13473-3]

Protein sequence database of the Protein Information Resource

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PIRi
JC2414, B31959
JC4317

NCBI Reference Sequences

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RefSeqi
NP_001116078.1, NM_001122606.1 [P13473-3]
NP_002285.1, NM_002294.2 [P13473-1]
NP_054701.1, NM_013995.2 [P13473-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000200639; ENSP00000200639; ENSG00000005893 [P13473-1]
ENST00000371335; ENSP00000360386; ENSG00000005893 [P13473-2]
ENST00000434600; ENSP00000408411; ENSG00000005893 [P13473-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3920

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3920

UCSC genome browser

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UCSCi
uc004ess.5, human [P13473-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04183 mRNA Translation: AAA60383.1
L09717 L09716 Genomic DNA Translation: AAB41647.1
X77196 mRNA Translation: CAA54416.1
S79873 mRNA Translation: AAB35426.1
U36336 mRNA Translation: AAA91149.1
AY561849 mRNA Translation: AAS67876.1
AK291090 mRNA Translation: BAF83779.1
AC002476 Genomic DNA Translation: AAB67313.1
AC002476 Genomic DNA Translation: AAB67314.1
CH471107 Genomic DNA Translation: EAX11881.1
CH471107 Genomic DNA Translation: EAX11882.1
CH471107 Genomic DNA Translation: EAX11883.1
CH471107 Genomic DNA Translation: EAX11884.1
BC002965 mRNA Translation: AAH02965.1
CCDSiCCDS14599.1 [P13473-1]
CCDS14600.1 [P13473-2]
CCDS48159.1 [P13473-3]
PIRiJC2414, B31959
JC4317
RefSeqiNP_001116078.1, NM_001122606.1 [P13473-3]
NP_002285.1, NM_002294.2 [P13473-1]
NP_054701.1, NM_013995.2 [P13473-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MOFNMR-A369-410[»]
2MOMNMR-A/B/C369-410[»]
BMRBiP13473
SMRiP13473
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110114, 126 interactors
IntActiP13473, 304 interactors
MINTiP13473
STRINGi9606.ENSP00000408411

Protein family/group databases

TCDBi9.A.16.1.2, the lysosomal protein import (lpi) family

PTM databases

GlyConnecti356, 115 N-Linked glycans (12 sites), 3 O-Linked glycans
GlyGeniP13473, 28 sites, 138 N-linked glycans (13 sites), 3 O-linked glycans (10 sites)
iPTMnetiP13473
PhosphoSitePlusiP13473
SwissPalmiP13473

Genetic variation databases

BioMutaiLAMP2
DMDMi1708854

Proteomic databases

CPTACiCPTAC-1494
CPTAC-689
EPDiP13473
jPOSTiP13473
MassIVEiP13473
MaxQBiP13473
PeptideAtlasiP13473
PRIDEiP13473
ProteomicsDBi52910 [P13473-1]
52911 [P13473-2]
52912 [P13473-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
3938, 1304 antibodies

The DNASU plasmid repository

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DNASUi
3920

Genome annotation databases

EnsembliENST00000200639; ENSP00000200639; ENSG00000005893 [P13473-1]
ENST00000371335; ENSP00000360386; ENSG00000005893 [P13473-2]
ENST00000434600; ENSP00000408411; ENSG00000005893 [P13473-3]
GeneIDi3920
KEGGihsa:3920
UCSCiuc004ess.5, human [P13473-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3920
DisGeNETi3920

GeneCards: human genes, protein and diseases

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GeneCardsi
LAMP2
GeneReviewsiLAMP2
HGNCiHGNC:6501, LAMP2
HPAiENSG00000005893, Low tissue specificity
MalaCardsiLAMP2
MIMi300257, phenotype
309060, gene
neXtProtiNX_P13473
OpenTargetsiENSG00000005893
Orphaneti34587, Glycogen storage disease due to LAMP-2 deficiency
PharmGKBiPA30285
VEuPathDBiHostDB:ENSG00000005893

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4818, Eukaryota
GeneTreeiENSGT00950000182899
HOGENOMiCLU_055379_2_0_1
InParanoidiP13473
OMAiMATGYES
OrthoDBi1042920at2759
PhylomeDBiP13473
TreeFamiTF316339

Enzyme and pathway databases

PathwayCommonsiP13473
ReactomeiR-HSA-114608, Platelet degranulation
R-HSA-6798695, Neutrophil degranulation
R-HSA-9613829, Chaperone Mediated Autophagy
SIGNORiP13473

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3920, 6 hits in 646 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LAMP2, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
LAMP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3920
PharosiP13473, Tbio

Protein Ontology

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PROi
PR:P13473
RNActiP13473, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000005893, Expressed in corpus callosum and 249 other tissues
ExpressionAtlasiP13473, baseline and differential
GenevisibleiP13473, HS

Family and domain databases

InterProiView protein in InterPro
IPR018134, LAMP_CS
IPR002000, Lysosome-assoc_membr_glycop
PANTHERiPTHR11506, PTHR11506, 1 hit
PfamiView protein in Pfam
PF01299, Lamp, 1 hit
PRINTSiPR00336, LYSASSOCTDMP
PROSITEiView protein in PROSITE
PS00310, LAMP_1, 1 hit
PS00311, LAMP_2, 1 hit
PS51407, LAMP_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAMP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13473
Secondary accession number(s): A8K4X5
, D3DTF0, Q16641, Q6Q3G8, Q96J30, Q99534, Q9UD93
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 1, 1996
Last modified: September 29, 2021
This is version 220 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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