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Protein

Nuclease SbcCD subunit C

Gene

sbcC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi37 – 44ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Exonuclease, Hydrolase, Nuclease
Biological processDNA recombination, DNA replication
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG10927-MONOMER
MetaCyc:EG10927-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclease SbcCD subunit C
Gene namesi
Name:sbcC
Synonyms:rmuA
Ordered Locus Names:b0397, JW0387
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10927 sbcC

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001058641 – 1048Nuclease SbcCD subunit CAdd BLAST1048

Proteomic databases

PaxDbiP13458
PRIDEiP13458

Interactioni

Subunit structurei

Heterodimer of SbcC and SbcD.

Binary interactionsi

WithEntry#Exp.IntActNotes
ynbCP760923EBI-546919,EBI-544837

Protein-protein interaction databases

BioGridi4259821, 33 interactors
DIPiDIP-342N
IntActiP13458, 6 interactors
STRINGi316385.ECDH10B_0353

Structurei

3D structure databases

ProteinModelPortaliP13458
SMRiP13458
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili191 – 402Sequence analysisAdd BLAST212
Coiled coili438 – 502Sequence analysisAdd BLAST65
Coiled coili528 – 648Sequence analysisAdd BLAST121
Coiled coili671 – 695Sequence analysisAdd BLAST25
Coiled coili770 – 880Sequence analysisAdd BLAST111

Sequence similaritiesi

Belongs to the SMC family. SbcC subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG4105EYH Bacteria
COG0419 LUCA
HOGENOMiHOG000280831
InParanoidiP13458
KOiK03546
PhylomeDBiP13458

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR038729 Rad50/SbcC_AAA
IPR027050 SbcC-like
IPR004592 SbcC_gammaproteobac_type
PANTHERiPTHR32114 PTHR32114, 1 hit
PfamiView protein in Pfam
PF13476 AAA_23, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00618 sbcc, 1 hit

Sequencei

Sequence statusi: Complete.

P13458-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKILSLRLKN LNSLKGEWKI DFTREPFASN GLFAITGPTG AGKTTLLDAI
60 70 80 90 100
CLALYHETPR LSNVSQSQND LMTRDTAECL AEVEFEVKGE AYRAFWSQNR
110 120 130 140 150
ARNQPDGNLQ VPRVELARCA DGKILADKVK DKLELTATLT GLDYGRFTRS
160 170 180 190 200
MLLSQGQFAA FLNAKPKERA ELLEELTGTE IYGQISAMVF EQHKSARTEL
210 220 230 240 250
EKLQAQASGV TLLTPEQVQS LTASLQVLTD EEKQLITAQQ QEQQSLNWLT
260 270 280 290 300
RQDELQQEAS RRQQALQQAL AEEEKAQPQL AALSLAQPAR NLRPHWERIA
310 320 330 340 350
EHSAALAHIR QQIEEVNTRL QSTMALRASI RHHAAKQSAE LQQQQQSLNT
360 370 380 390 400
WLQEHDRFRQ WNNEPAGWRA QFSQQTSDRE HLRQWQQQLT HAEQKLNALA
410 420 430 440 450
AITLTLTADE VATALAQHAE QRPLRQHLVA LHGQIVPQQK RLAQLQVAIQ
460 470 480 490 500
NVTQEQTQRN AALNEMRQRY KEKTQQLADV KTICEQEARI KTLEAQRAQL
510 520 530 540 550
QAGQPCPLCG STSHPAVEAY QALEPGVNQS RLLALENEVK KLGEEGATLR
560 570 580 590 600
GQLDAITKQL QRDENEAQSL RQDEQALTQQ WQAVTASLNI TLQPLDDIQP
610 620 630 640 650
WLDAQDEHER QLRLLSQRHE LQGQIAAHNQ QIIQYQQQIE QRQQLLLTTL
660 670 680 690 700
TGYALTLPQE DEEESWLATR QQEAQSWQQR QNELTALQNR IQQLTPILET
710 720 730 740 750
LPQSDELPHC EETVVLENWR QVHEQCLALH SQQQTLQQQD VLAAQSLQKA
760 770 780 790 800
QAQFDTALQA SVFDDQQAFL AALMDEQTLT QLEQLKQNLE NQRRQAQTLV
810 820 830 840 850
TQTAETLAQH QQHRPDDGLA LTVTVEQIQQ ELAQTHQKLR ENTTSQGEIR
860 870 880 890 900
QQLKQDADNR QQQQTLMQQI AQMTQQVEDW GYLNSLIGSK EGDKFRKFAQ
910 920 930 940 950
GLTLDNLVHL ANQQLTRLHG RYLLQRKASE ALEVEVVDTW QADAVRDTRT
960 970 980 990 1000
LSGGESFLVS LALALALSDL VSHKTRIDSL FLDEGFGTLD SETLDTALDA
1010 1020 1030 1040
LDALNASGKT IGVISHVEAM KERIPVQIKV KKINGLGYSK LESTFAVK
Length:1,048
Mass (Da):118,721
Last modified:January 1, 1990 - v1
Checksum:iBF873BC3386F98C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15981 Genomic DNA Translation: CAA34104.1
U73857 Genomic DNA Translation: AAB18121.1
U00096 Genomic DNA Translation: AAC73500.1
AP009048 Genomic DNA Translation: BAE76177.1
M64787 Genomic DNA Translation: AAA23473.1
PIRiJS0350 BVECSC
RefSeqiNP_414931.1, NC_000913.3
WP_000698951.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73500; AAC73500; b0397
BAE76177; BAE76177; BAE76177
GeneIDi949076
KEGGiecj:JW0387
eco:b0397
PATRICifig|1411691.4.peg.1882

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15981 Genomic DNA Translation: CAA34104.1
U73857 Genomic DNA Translation: AAB18121.1
U00096 Genomic DNA Translation: AAC73500.1
AP009048 Genomic DNA Translation: BAE76177.1
M64787 Genomic DNA Translation: AAA23473.1
PIRiJS0350 BVECSC
RefSeqiNP_414931.1, NC_000913.3
WP_000698951.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP13458
SMRiP13458
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259821, 33 interactors
DIPiDIP-342N
IntActiP13458, 6 interactors
STRINGi316385.ECDH10B_0353

Proteomic databases

PaxDbiP13458
PRIDEiP13458

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73500; AAC73500; b0397
BAE76177; BAE76177; BAE76177
GeneIDi949076
KEGGiecj:JW0387
eco:b0397
PATRICifig|1411691.4.peg.1882

Organism-specific databases

EchoBASEiEB0920
EcoGeneiEG10927 sbcC

Phylogenomic databases

eggNOGiENOG4105EYH Bacteria
COG0419 LUCA
HOGENOMiHOG000280831
InParanoidiP13458
KOiK03546
PhylomeDBiP13458

Enzyme and pathway databases

BioCyciEcoCyc:EG10927-MONOMER
MetaCyc:EG10927-MONOMER

Miscellaneous databases

PROiPR:P13458

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR038729 Rad50/SbcC_AAA
IPR027050 SbcC-like
IPR004592 SbcC_gammaproteobac_type
PANTHERiPTHR32114 PTHR32114, 1 hit
PfamiView protein in Pfam
PF13476 AAA_23, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR00618 sbcc, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSBCC_ECOLI
AccessioniPrimary (citable) accession number: P13458
Secondary accession number(s): Q2MC29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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