Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Uridine 5'-monophosphate synthase

Gene

Umps

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.
Orotidine 5'-phosphate = UMP + CO2.

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 1 and 2 of the subpathway that synthesizes UMP from orotate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Uridine 5'-monophosphate synthase (Umps)
  2. Uridine 5'-monophosphate synthase (Umps)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei314For OMPdecase activityBy similarity1
Active sitei317For OMPdecase activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Glycosyltransferase, Lyase, Multifunctional enzyme, Transferase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

ReactomeiR-MMU-500753 Pyrimidine biosynthesis
UniPathwayi
UPA00070;UER00119

UPA00070;UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Including the following 2 domains:
Orotate phosphoribosyltransferase (EC:2.4.2.10)
Short name:
OPRTase
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMPdecase
Gene namesi
Name:Umps
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1298388 Umps

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001396501 – 481Uridine 5'-monophosphate synthaseAdd BLAST481

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP13439
PaxDbiP13439
PeptideAtlasiP13439
PRIDEiP13439

PTM databases

iPTMnetiP13439
PhosphoSitePlusiP13439
SwissPalmiP13439

Expressioni

Gene expression databases

BgeeiENSMUSG00000022814 Expressed in 268 organ(s), highest expression level in primitive streak
CleanExiMM_UMPS
ExpressionAtlasiP13439 baseline and differential
GenevisibleiP13439 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204442, 2 interactors
IntActiP13439, 3 interactors
MINTiP13439
STRINGi10090.ENSMUSP00000023510

Structurei

3D structure databases

ProteinModelPortaliP13439
SMRiP13439
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 214OPRTaseAdd BLAST214
Regioni215 – 220Domain linker6
Regioni221 – 481OMPdecaseAdd BLAST261

Sequence similaritiesi

In the N-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.Curated
In the C-terminal section; belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG1377 Eukaryota
COG0284 LUCA
COG0461 LUCA
GeneTreeiENSGT00390000001856
HOVERGENiHBG000870
InParanoidiP13439
KOiK13421
OMAiEQGGKDK
OrthoDBiEOG091G06JT
PhylomeDBiP13439
TreeFamiTF314694

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01208 PyrE, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR018089 OMPdecase_AS
IPR001754 OMPdeCOase_dom
IPR023031 OPRT
IPR004467 Or_phspho_trans_dom
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
PF00156 Pribosyltran, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
SSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR00336 pyrE, 1 hit
TIGR01740 pyrF, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit
PS00103 PUR_PYR_PR_TRANSFER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P13439-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVASQALGP LVTELYDVQA FKFGSFVLKS GLSSPVYIDL RGIVSRPRLL
60 70 80 90 100
SQVADILFQT AKNAGISFDS VCGVPYTALP LATVICSANH IPMLIRRKET
110 120 130 140 150
KDYGTKRLVE GEINPGQTCL VIEDVVTSGA SVLETVEVLQ KEGLKVTDAI
160 170 180 190 200
VLLDREQGGK DKLQAQGIRL HAVCTLSQML EILQQQEKID ADMVGRVKRF
210 220 230 240 250
IQENVFSAAN HNGLPPPEKK ACKELSFGAR AELPGTHPLA SKLLRLMQKK
260 270 280 290 300
ETNLCLSADV SEARELLQLA DALGPSICML KTHVDILNDF TLDVMEELTA
310 320 330 340 350
LAKRHEFLIF EDRKFADIGN TVKKQYESGT FKIASWADIV NAHVVPGSGV
360 370 380 390 400
VKGLQEVGLP LHRACLLIAE MSSAGSLATG NYTKAAVGMA EEHCEFVIGF
410 420 430 440 450
ISGSRVSMKP EFLHLTPGVQ LETGGDHLGQ QYNSPQEVIG KRGSDVIIVG
460 470 480
RGILAAANRL EAAEMYRKAA WEAYLSRLAV Q
Length:481
Mass (Da):52,292
Last modified:June 6, 2002 - v3
Checksum:i761C7EF7960C9C59
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RJ62D6RJ62_MOUSE
Uridine 5'-monophosphate synthase
Umps
57Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003887 mRNA Translation: AAH03887.1
M29395 mRNA Translation: AAA39859.1
CCDSiCCDS28136.1
PIRiA25323 DCMSOP
RefSeqiNP_033497.1, NM_009471.3
UniGeneiMm.13145
Mm.466951

Genome annotation databases

EnsembliENSMUST00000023510; ENSMUSP00000023510; ENSMUSG00000022814
GeneIDi22247
KEGGimmu:22247
UCSCiuc007zap.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC003887 mRNA Translation: AAH03887.1
M29395 mRNA Translation: AAA39859.1
CCDSiCCDS28136.1
PIRiA25323 DCMSOP
RefSeqiNP_033497.1, NM_009471.3
UniGeneiMm.13145
Mm.466951

3D structure databases

ProteinModelPortaliP13439
SMRiP13439
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204442, 2 interactors
IntActiP13439, 3 interactors
MINTiP13439
STRINGi10090.ENSMUSP00000023510

PTM databases

iPTMnetiP13439
PhosphoSitePlusiP13439
SwissPalmiP13439

Proteomic databases

EPDiP13439
PaxDbiP13439
PeptideAtlasiP13439
PRIDEiP13439

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023510; ENSMUSP00000023510; ENSMUSG00000022814
GeneIDi22247
KEGGimmu:22247
UCSCiuc007zap.1 mouse

Organism-specific databases

CTDi7372
MGIiMGI:1298388 Umps

Phylogenomic databases

eggNOGiKOG1377 Eukaryota
COG0284 LUCA
COG0461 LUCA
GeneTreeiENSGT00390000001856
HOVERGENiHBG000870
InParanoidiP13439
KOiK13421
OMAiEQGGKDK
OrthoDBiEOG091G06JT
PhylomeDBiP13439
TreeFamiTF314694

Enzyme and pathway databases

UniPathwayi
UPA00070;UER00119

UPA00070;UER00120

ReactomeiR-MMU-500753 Pyrimidine biosynthesis

Miscellaneous databases

PROiPR:P13439
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022814 Expressed in 268 organ(s), highest expression level in primitive streak
CleanExiMM_UMPS
ExpressionAtlasiP13439 baseline and differential
GenevisibleiP13439 MM

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01208 PyrE, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR018089 OMPdecase_AS
IPR001754 OMPdeCOase_dom
IPR023031 OPRT
IPR004467 Or_phspho_trans_dom
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
PF00156 Pribosyltran, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
SSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR00336 pyrE, 1 hit
TIGR01740 pyrF, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit
PS00103 PUR_PYR_PR_TRANSFER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUMPS_MOUSE
AccessioniPrimary (citable) accession number: P13439
Secondary accession number(s): Q99L26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: June 6, 2002
Last modified: November 7, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again