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Entry version 180 (29 Sep 2021)
Sequence version 2 (05 Oct 2010)
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Protein

DNA-directed RNA polymerase, mitochondrial

Gene

RPO41

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei945By similarity1
Active sitei1014By similarity1
Active sitei1189By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase, mitochondrial (EC:2.7.7.6)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPO41
Ordered Locus Names:YFL036W
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VI

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000001858, RPO41

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YFL036W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase, Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – ?Mitochondrion
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000031078? – 1351DNA-directed RNA polymerase, mitochondrial

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P13433

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P13433

PRoteomics IDEntifications database

More...
PRIDEi
P13433

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
31110, 275 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3146, Mitochondrial DNA-directed RNA polymerase complex

Database of interacting proteins

More...
DIPi
DIP-2431N

Protein interaction database and analysis system

More...
IntActi
P13433, 7 interactors

Molecular INTeraction database

More...
MINTi
P13433

STRING: functional protein association networks

More...
STRINGi
4932.YFL036W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P13433, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11351
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Small Angle Scattering Biological Data Bank

More...
SASBDBi
P13433

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P13433

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1038, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008060

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003364_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P13433

Identification of Orthologs from Complete Genome Data

More...
OMAi
TIACMLK

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1320.10, 1 hit
1.10.287.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024075, DNA-dir_RNA_pol_helix_hairp_sf
IPR002092, DNA-dir_Rpol_phage-type
IPR043502, DNA/RNA_pol_sf
IPR037159, RNA_POL_N_sf
IPR029262, RPOL_N

The PANTHER Classification System

More...
PANTHERi
PTHR10102, PTHR10102, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00940, RNA_pol, 1 hit
PF14700, RPOL_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01311, RPOL_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00900, RNA_POL_PHAGE_1, 1 hit
PS00489, RNA_POL_PHAGE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P13433-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRPAYKSLV KTSLLQRRLI SSKGSKLFKP SPDSTSTILI SEDPLVTGSS
60 70 80 90 100
PTSSTTSGII SSNDFPLFNK NRKDAKSSIS YQWKNPSELE FDPFNKSHAS
110 120 130 140 150
AVTSMTRTRD VMQLWSLLEA CLQSNLMKRA FSILESLYLV PEHKQRFIED
160 170 180 190 200
YNMYLNSFSK NDPNFPILKM NEKLTNDLET SFKDVNYNDK TLAIMIHHAL
210 220 230 240 250
NFHSTTSSML LKPIISAYLK MSVNGIREIF SCLDILTISD LNILMNDLKV
260 270 280 290 300
ITPSQLPNSV RPILESLTLS PTPVNNIENE EGLNKVEAEN DSKLHKASNA
310 320 330 340 350
SSDSIKKPSL DPLREVSFHG STEVLSKDAE KLIAVDTIGM RVIRHTLLGL
360 370 380 390 400
SLTPEQKEQI SKFKFDANDN VLKMKPTKND DNNNSINFFE IYNSLPTLEE
410 420 430 440 450
KKAFESALNI FNQDRQKVLE NRATEAARER WKHDFEEAKA RGDISIEKNL
460 470 480 490 500
NVKLWKWYNE MLPLVKEEIN HCRSLLSEKL SDKKGLNKVD TNRLGYGPYL
510 520 530 540 550
TLIDPGKMCV ITILELLKLN STGGVIEGMR TARAVISVGK AIEMEFRSEQ
560 570 580 590 600
VLKSESQAFR DVNKKSPEFK KLVQNAKSVF RSSQIEQSKI LWPQSIRARI
610 620 630 640 650
GSVLISMLIQ VAKVSVQGVD PVTKAKVHGE APAFAHGYQY HNGSKLGVLK
660 670 680 690 700
IHKTLIRQLN GERLIASVQP QLLPMLVEPK PWVNWRSGGY HYTQSTLLRT
710 720 730 740 750
KDSPEQVAYL KAASDNGDID RVYDGLNVLG RTPWTVNRKV FDVVSQVWNK
760 770 780 790 800
GEGFLDIPGA QDEMVLPPAP PKNSDPSILR AWKLQVKTIA NKFSSDRSNR
810 820 830 840 850
CDTNYKLEIA RAFLGEKLYF PHNLDFRGRA YPLSPHFNHL GNDMSRGLLI
860 870 880 890 900
FWHGKKLGPS GLKWLKIHLS NLFGFDKLPL KDRVAFTESH LQDIKDSAEN
910 920 930 940 950
PLTGDRWWTT ADKPWQALAT CFELNEVMKM DNPEEFISHQ PVHQDGTCNG
960 970 980 990 1000
LQHYAALGGD VEGATQVNLV PSDKPQDVYA HVARLVQKRL EIAAEKGDEN
1010 1020 1030 1040 1050
AKILKDKITR KVVKQTVMTN VYGVTYVGAT FQIAKQLSPI FDDRKESLDF
1060 1070 1080 1090 1100
SKYLTKHVFS AIRELFHSAH LIQDWLGESA KRISKSIRLD VDEKSFKNGN
1110 1120 1130 1140 1150
KPDFMSSVIW TTPLGLPIVQ PYREESKKQV ETNLQTVFIS DPFAVNPVNA
1160 1170 1180 1190 1200
RRQKAGLPPN FIHSLDASHM LLSAAECGKQ GLDFASVHDS YWTHASDIDT
1210 1220 1230 1240 1250
MNVVLREQFI KLHEVDLVLR LKEEFDQRYK NYVKIGKLKR STDLAQKIIR
1260 1270 1280 1290 1300
IRKDLSRKLG RSTTLADEIY FEKKRQELLN SPLIEDRNVG EKMVTTVSLF
1310 1320 1330 1340 1350
EDITDLDALE LENGGDENSG MSVLLPLRLP EIPPKGDFDV TVLRNSQYFF

S
Length:1,351
Mass (Da):153,047
Last modified:October 5, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70A055CB71DB223E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti485G → S in AAA35007 (PubMed:3308116).Curated1
Sequence conflicti900 – 901NP → KS in AAA35007 (PubMed:3308116).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M17539 Genomic DNA Translation: AAA35007.1
D50617 Genomic DNA Translation: BAA09203.1
BK006940 Genomic DNA Translation: DAA12404.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S56218

NCBI Reference Sequences

More...
RefSeqi
NP_116617.1, NM_001179930.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YFL036W_mRNA; YFL036W; YFL036W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
850507

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YFL036W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17539 Genomic DNA Translation: AAA35007.1
D50617 Genomic DNA Translation: BAA09203.1
BK006940 Genomic DNA Translation: DAA12404.1
PIRiS56218
RefSeqiNP_116617.1, NM_001179930.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6YMVelectron microscopy3.10A100-1351[»]
6YMWelectron microscopy3.71A100-1351[»]
SASBDBiP13433
SMRiP13433
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi31110, 275 interactors
ComplexPortaliCPX-3146, Mitochondrial DNA-directed RNA polymerase complex
DIPiDIP-2431N
IntActiP13433, 7 interactors
MINTiP13433
STRINGi4932.YFL036W

Proteomic databases

MaxQBiP13433
PaxDbiP13433
PRIDEiP13433

Genome annotation databases

EnsemblFungiiYFL036W_mRNA; YFL036W; YFL036W
GeneIDi850507
KEGGisce:YFL036W

Organism-specific databases

SGDiS000001858, RPO41
VEuPathDBiFungiDB:YFL036W

Phylogenomic databases

eggNOGiKOG1038, Eukaryota
GeneTreeiENSGT00390000008060
HOGENOMiCLU_003364_1_0_1
InParanoidiP13433
OMAiTIACMLK

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P13433
RNActiP13433, protein

Family and domain databases

Gene3Di1.10.1320.10, 1 hit
1.10.287.260, 1 hit
InterProiView protein in InterPro
IPR024075, DNA-dir_RNA_pol_helix_hairp_sf
IPR002092, DNA-dir_Rpol_phage-type
IPR043502, DNA/RNA_pol_sf
IPR037159, RNA_POL_N_sf
IPR029262, RPOL_N
PANTHERiPTHR10102, PTHR10102, 1 hit
PfamiView protein in Pfam
PF00940, RNA_pol, 1 hit
PF14700, RPOL_N, 1 hit
SMARTiView protein in SMART
SM01311, RPOL_N, 1 hit
SUPFAMiSSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS00900, RNA_POL_PHAGE_1, 1 hit
PS00489, RNA_POL_PHAGE_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPOM_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13433
Secondary accession number(s): D6VTJ4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 5, 2010
Last modified: September 29, 2021
This is version 180 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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