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Protein

Troponin I, slow skeletal muscle

Gene

Tnni1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi106 – 117By similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

  • muscle contraction Source: GO_Central
  • regulation of muscle contraction Source: RGD

Keywordsi

Molecular functionActin-binding, Muscle protein
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin I, slow skeletal muscle
Alternative name(s):
Troponin I, slow-twitch isoform
Gene namesi
Name:Tnni1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621765 Tnni1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001861422 – 187Troponin I, slow skeletal muscleAdd BLAST186

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylprolineBy similarity1
Modified residuei58PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP13413
PRIDEiP13413

PTM databases

iPTMnetiP13413
PhosphoSitePlusiP13413

Interactioni

Subunit structurei

Binds to actin and tropomyosin.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012096

Structurei

3D structure databases

ProteinModelPortaliP13413
SMRiP13413
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 48Involved in binding TNCAdd BLAST47
Regioni97 – 118Involved in binding TNC and actinAdd BLAST22

Sequence similaritiesi

Belongs to the troponin I family.Curated

Phylogenomic databases

eggNOGiKOG3977 Eukaryota
ENOG410Y9IX LUCA
HOGENOMiHOG000293300
HOVERGENiHBG052737
InParanoidiP13413
KOiK10371
PhylomeDBiP13413

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR001978 Troponin
IPR038077 Troponin_sf
PfamiView protein in Pfam
PF00992 Troponin, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P13413-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEVERKSKI TASRKLMLKS LMLAKAKECW EQEHEEREAE KVRYLSERIP
60 70 80 90 100
TLQTRGLSLS ALQDLCRELH AKVEVVDEER YDIEAKCLHN TREIKDLKLK
110 120 130 140 150
VLDLRGKFKR PPLRRVRVSA DAMLRALLGS KHKVSMDLRA NLKSVKKEDT
160 170 180
EKERPVEVGD WRKNVEAMSG MEGRKKMFDA AKSPTLQ
Length:187
Mass (Da):21,724
Last modified:January 23, 2007 - v2
Checksum:i69A62A39D0F471D4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096MIZ5A0A096MIZ5_RAT
Troponin I, slow skeletal muscle
Tnni1
187Annotation score:
F1LMC6F1LMC6_RAT
Troponin I, slow skeletal muscle
Tnni1
187Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04993 mRNA Translation: AAA42295.1
PIRiB44786
RefSeqiNP_058880.1, NM_017184.1
UniGeneiRn.4035

Genome annotation databases

GeneIDi29388
KEGGirno:29388
UCSCiRGD:621765 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04993 mRNA Translation: AAA42295.1
PIRiB44786
RefSeqiNP_058880.1, NM_017184.1
UniGeneiRn.4035

3D structure databases

ProteinModelPortaliP13413
SMRiP13413
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012096

PTM databases

iPTMnetiP13413
PhosphoSitePlusiP13413

Proteomic databases

PaxDbiP13413
PRIDEiP13413

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29388
KEGGirno:29388
UCSCiRGD:621765 rat

Organism-specific databases

CTDi7135
RGDi621765 Tnni1

Phylogenomic databases

eggNOGiKOG3977 Eukaryota
ENOG410Y9IX LUCA
HOGENOMiHOG000293300
HOVERGENiHBG052737
InParanoidiP13413
KOiK10371
PhylomeDBiP13413

Miscellaneous databases

PROiPR:P13413

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR001978 Troponin
IPR038077 Troponin_sf
PfamiView protein in Pfam
PF00992 Troponin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTNNI1_RAT
AccessioniPrimary (citable) accession number: P13413
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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