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Protein

Troponin I, fast skeletal muscle

Gene

Tnni2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi105 – 116By similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Muscle protein
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin I, fast skeletal muscle
Alternative name(s):
Troponin I, fast-twitch isoform
Gene namesi
Name:Tnni2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:105070 Tnni2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001861442 – 182Troponin I, fast skeletal muscleAdd BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineBy similarity1
Modified residuei12PhosphothreonineBy similarity1
Modified residuei118PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP13412
PaxDbiP13412
PRIDEiP13412

2D gel databases

SWISS-2DPAGEiP13412

PTM databases

iPTMnetiP13412
PhosphoSitePlusiP13412

Expressioni

Gene expression databases

BgeeiENSMUSG00000031097 Expressed in 143 organ(s), highest expression level in gastrocnemius
CleanExiMM_TNNI2
ExpressionAtlasiP13412 baseline and differential
GenevisibleiP13412 MM

Interactioni

Subunit structurei

Binds to actin and tropomyosin.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101591

Structurei

3D structure databases

ProteinModelPortaliP13412
SMRiP13412
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 48Involved in binding TNCAdd BLAST47
Regioni97 – 117Involved in binding TNC and actinAdd BLAST21

Sequence similaritiesi

Belongs to the troponin I family.Curated

Phylogenomic databases

eggNOGiKOG3977 Eukaryota
ENOG410Y9IX LUCA
GeneTreeiENSGT00390000002746
HOGENOMiHOG000293300
HOVERGENiHBG052737
InParanoidiP13412
KOiK12043
PhylomeDBiP13412
TreeFamiTF313374

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR001978 Troponin
IPR038077 Troponin_sf
PfamiView protein in Pfam
PF00992 Troponin, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P13412-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDEEKRNRA ITARRQHLKS VMLQIAATEL EKEESRRESE KENYLSEHCP
60 70 80 90 100
PLHIPGSMSE VQELCKQLHA KIDVAEEEKY DMEVKVQKSS KELEDMNQKL
110 120 130 140 150
FDLRGKFKRP PLRRVRMSAD AMLKALLGSK HKVCMDLRAN LKQVKKEDTE
160 170 180
KERDLRDVGD WRKNIEEKSG MEGRKKMFES ES
Length:182
Mass (Da):21,358
Last modified:January 23, 2007 - v2
Checksum:iB09B6657CC85F73C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A6J8A2A6J8_MOUSE
Troponin I, fast skeletal muscle
Tnni2
190Annotation score:
A2A6K0A2A6K0_MOUSE
Troponin I, fast skeletal muscle
Tnni2
135Annotation score:
A0A1B0GRY8A0A1B0GRY8_MOUSE
Troponin I, fast skeletal muscle
Tnni2
172Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04992 mRNA Translation: AAA40485.1
AL603651 Genomic DNA No translation available.
BC028515 mRNA Translation: AAH28515.1
CCDSiCCDS40192.1
PIRiA44786
RefSeqiNP_033431.1, NM_009405.2
XP_006508602.1, XM_006508539.3
UniGeneiMm.39469

Genome annotation databases

EnsembliENSMUST00000105971; ENSMUSP00000101591; ENSMUSG00000031097
ENSMUST00000149529; ENSMUSP00000122733; ENSMUSG00000031097
GeneIDi21953
KEGGimmu:21953
UCSCiuc033jdj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04992 mRNA Translation: AAA40485.1
AL603651 Genomic DNA No translation available.
BC028515 mRNA Translation: AAH28515.1
CCDSiCCDS40192.1
PIRiA44786
RefSeqiNP_033431.1, NM_009405.2
XP_006508602.1, XM_006508539.3
UniGeneiMm.39469

3D structure databases

ProteinModelPortaliP13412
SMRiP13412
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101591

PTM databases

iPTMnetiP13412
PhosphoSitePlusiP13412

2D gel databases

SWISS-2DPAGEiP13412

Proteomic databases

MaxQBiP13412
PaxDbiP13412
PRIDEiP13412

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105971; ENSMUSP00000101591; ENSMUSG00000031097
ENSMUST00000149529; ENSMUSP00000122733; ENSMUSG00000031097
GeneIDi21953
KEGGimmu:21953
UCSCiuc033jdj.1 mouse

Organism-specific databases

CTDi7136
MGIiMGI:105070 Tnni2

Phylogenomic databases

eggNOGiKOG3977 Eukaryota
ENOG410Y9IX LUCA
GeneTreeiENSGT00390000002746
HOGENOMiHOG000293300
HOVERGENiHBG052737
InParanoidiP13412
KOiK12043
PhylomeDBiP13412
TreeFamiTF313374

Enzyme and pathway databases

ReactomeiR-MMU-390522 Striated Muscle Contraction

Miscellaneous databases

ChiTaRSiTnni2 mouse
PROiPR:P13412
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031097 Expressed in 143 organ(s), highest expression level in gastrocnemius
CleanExiMM_TNNI2
ExpressionAtlasiP13412 baseline and differential
GenevisibleiP13412 MM

Family and domain databases

Gene3Di1.20.5.350, 1 hit
InterProiView protein in InterPro
IPR001978 Troponin
IPR038077 Troponin_sf
PfamiView protein in Pfam
PF00992 Troponin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTNNI2_MOUSE
AccessioniPrimary (citable) accession number: P13412
Secondary accession number(s): A2A6J9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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