Retinoblastoma-associated protein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• disordered domain specific binding Source: MGI
• enzyme binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • Ref.11

    "The arginine methyltransferase PRMT2 binds RB and regulates E2F function."
    Yoshimoto T., Boehm M., Olive M., Crook M.F., San H., Langenickel T., Nabel E.G.
    Exp. Cell Res. 312:2040-2053(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH PRMT2.
• identical protein binding Source: MGI
• importin-alpha family protein binding Source: MGI
• kinase binding Source: UniProtKB
• phosphoprotein binding Source: MGI
• RNA polymerase II activating transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "E2F-1 has dual roles depending on the cell cycle."
    Sahin F., Sladek T.L.
    Int J Biol Sci 6:116-128(2010) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: UniProtKBInferred from physical interactionⁱ
  • "The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A."
    Lavender P., Vandel L., Bannister A.J., Kouzarides T.
    Oncogene 14:2721-2728(1997) [PubMed] [Europe PMC] [Abstract]
• ubiquitin protein ligase binding Source: MGI

GO - Biological processⁱ

• aortic valve morphogenesis Source: BHF-UCL <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation."
    Freytsis M., Baugh L., Liu Z., Georgakoudi I., Hinds P.W., Black L.D., Huggins G.S.
    PLoS One 13:e0190623-e0190623(2018) [PubMed] [Europe PMC] [Abstract]
• cell cycle arrest Source: MGIInferred from mutant phenotypeⁱ
  • "Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency."
    Chen P.L., Liu F., Cai S., Lin X., Li A., Chen Y., Gu B., Lee E.Y., Lee W.H.
    Mol Cell Biol 25:3535-3542(2005) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell division Source: MGIInferred from mutant phenotypeⁱ
  • "The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear."
    Mantela J., Jiang Z., Ylikoski J., Fritzsch B., Zacksenhaus E., Pirvola U.
    Development 132:2377-2388(2005) [PubMed] [Europe PMC] [Abstract]
• cell morphogenesis involved in neuron differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation."
    Lee E.Y., Hu N., Yuan S.S., Cox L.A., Bradley A., Lee W.H., Herrup K.
    Genes Dev 8:2008-2021(1994) [PubMed] [Europe PMC] [Abstract]
• cellular response to xenobiotic stimulus Source: MGIInferred from mutant phenotypeⁱ
  • "RB tumor suppressive function in response to xenobiotic hepatocarcinogens."
    Reed C., Hutcheson J., Mayhew C.N., Witkiewicz A.K., Knudsen E.S.
    Am J Pathol 184:1853-1859(2014) [PubMed] [Europe PMC] [Abstract]
• chromatin organization Source: UniProtKB-KW
• digestive tract development Source: MGIInferred from mutant phenotypeⁱ
  • "pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development."
    Yang H.S., Hinds P.W.
    BMC Dev Biol 7:6-6(2007) [PubMed] [Europe PMC] [Abstract]
• enucleate erythrocyte differentiation Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages."
    Iavarone A., King E.R., Dai X.M., Leone G., Stanley E.R., Lasorella A.
    Nature 432:1040-1045(2004) [PubMed] [Europe PMC] [Abstract]
• G1/S transition of mitotic cell cycle Source: MGIInferred from mutant phenotypeⁱ
  • "Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiency."
    Chen P.L., Liu F., Cai S., Lin X., Li A., Chen Y., Gu B., Lee E.Y., Lee W.H.
    Mol Cell Biol 25:3535-3542(2005) [PubMed] [Europe PMC] [Abstract]
• glial cell apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice."
    Simpson M.T., MacLaurin J.G., Xu D., Ferguson K.L., Vanderluit J.L., Davoli M.A., Roy S., Nicholson D.W., Robertson G.S., Park D.S., Slack R.S.
    J Neurosci 21:7089-7098(2001) [PubMed] [Europe PMC] [Abstract]
• hepatocyte apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice."
    Simpson M.T., MacLaurin J.G., Xu D., Ferguson K.L., Vanderluit J.L., Davoli M.A., Roy S., Nicholson D.W., Robertson G.S., Park D.S., Slack R.S.
    J Neurosci 21:7089-7098(2001) [PubMed] [Europe PMC] [Abstract]
• maintenance of mitotic sister chromatid cohesion Source: MGI
• myoblast differentiation Source: UniProtKB
• negative regulation of apoptotic signaling pathway Source: MGI
• negative regulation of cell cycle Source: MGIInferred from mutant phenotypeⁱ
  • "Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry."
    Sage J., Miller A.L., Perez-Mancera P.A., Wysocki J.M., Jacks T.
    Nature 424:223-228(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell growth Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.4

    "A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity."
    Zacksenhaus E., Bremner R., Phillips R.A., Gallie B.L.
    Mol. Cell. Biol. 13:4588-4599(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, IDENTIFICATION OF THE NUCLEAR LOCALIZATION SIGNAL, MUTAGENESIS OF 733-LYS--PRO-769; 769-PRO--ILE-872; 853-LYS--ARG-869 AND 866-LYS--ARG-869, INTERACTION WITH ADENOVIRUS E1A PROTEIN AND SV40 LARGE T ANTIGEN (MICROBIAL INFECTION), INTERACTION WITH E2F1, PHOSPHORYLATION.
• negative regulation of cell population proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear."
    Mantela J., Jiang Z., Ylikoski J., Fritzsch B., Zacksenhaus E., Pirvola U.
    Development 132:2377-2388(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cold-induced thermogenesis Source: YuBioLabInferred from mutant phenotypeⁱ
  • "Haploinsufficiency of the retinoblastoma protein gene reduces diet-induced obesity, insulin resistance, and hepatosteatosis in mice."
    Mercader J., Ribot J., Murano I., Feddersen S., Cinti S., Madsen L., Kristiansen K., Bonet M.L., Palou A.
    Am J Physiol Endocrinol Metab 297:E184-93(2009) [PubMed] [Europe PMC] [Abstract]
• negative regulation of epithelial cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development."
    Yang H.S., Hinds P.W.
    BMC Dev Biol 7:6-6(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of G1/S transition of mitotic cell cycle Source: MGIInferred from mutant phenotypeⁱ
  • "Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation."
    Lee E.Y., Hu N., Yuan S.S., Cox L.A., Bradley A., Lee W.H., Herrup K.
    Genes Dev 8:2008-2021(1994) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: MGIInferred from mutant phenotypeⁱ
  • "Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells."
    Miles W.O., Korenjak M., Griffiths L.M., Dyer M.A., Provero P., Dyson N.J.
    EMBO J 33:2201-2215(2014) [PubMed] [Europe PMC] [Abstract]
• negative regulation of hepatocyte apoptotic process Source: MGI
• negative regulation of inflammatory response Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation."
    Freytsis M., Baugh L., Liu Z., Georgakoudi I., Hinds P.W., Black L.D., Huggins G.S.
    PLoS One 13:e0190623-e0190623(2018) [PubMed] [Europe PMC] [Abstract]
• negative regulation of mitotic cell cycle Source: MGIInferred from genetic interactionⁱ
  • "The cytostatic function of c-Abl is controlled by multiple nuclear localization signals and requires the p53 and Rb tumor suppressor gene products."
    Wen S.T., Jackson P.K., Van Etten R.A.
    EMBO J 15:1583-1595(1996) [PubMed] [Europe PMC] [Abstract]
• negative regulation of myofibroblast differentiation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation."
    Freytsis M., Baugh L., Liu Z., Georgakoudi I., Hinds P.W., Black L.D., Huggins G.S.
    PLoS One 13:e0190623-e0190623(2018) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein kinase activity Source: UniProtKB
• negative regulation of protein serine/threonine kinase activity Source: MGI
• negative regulation of smoothened signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • "pRb-mediated control of epithelial cell proliferation and Indian hedgehog expression in mouse intestinal development."
    Yang H.S., Hinds P.W.
    BMC Dev Biol 7:6-6(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of tau-protein kinase activity Source: MGI
• negative regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1."
    Hsu S.-I., Yang C.M., Sim K.G., Hentschel D.M., O'Leary E., Bonventre J.V.
    EMBO J. 20:2273-2285(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "Pax-2 interacts with RB and reverses its repression on the promoter of Rig-1, a Robo member."
    Yuan S.S., Yeh Y.T., Lee E.Y.
    Biochem Biophys Res Commun 296:1019-1025(2002) [PubMed] [Europe PMC] [Abstract]
  • "Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes."
    Beijersbergen R.L., Carlee L., Kerkhoven R.M., Bernards R.
    Genes Dev 9:1340-1353(1995) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription involved in G1/S transition of mitotic cell cycle Source: BHF-UCLInferred from genetic interactionⁱ
  • "E2F-1 has dual roles depending on the cell cycle."
    Sahin F., Sladek T.L.
    Int J Biol Sci 6:116-128(2010) [PubMed] [Europe PMC] [Abstract]
• neuron apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice."
    Simpson M.T., MacLaurin J.G., Xu D., Ferguson K.L., Vanderluit J.L., Davoli M.A., Roy S., Nicholson D.W., Robertson G.S., Park D.S., Slack R.S.
    J Neurosci 21:7089-7098(2001) [PubMed] [Europe PMC] [Abstract]
  • "Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation."
    Lee E.Y., Hu N., Yuan S.S., Cox L.A., Bradley A., Lee W.H., Herrup K.
    Genes Dev 8:2008-2021(1994) [PubMed] [Europe PMC] [Abstract]
• neuron differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation."
    Lee E.Y., Hu N., Yuan S.S., Cox L.A., Bradley A., Lee W.H., Herrup K.
    Genes Dev 8:2008-2021(1994) [PubMed] [Europe PMC] [Abstract]
• neuron maturation Source: MGIInferred from mutant phenotypeⁱ
  • "Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation."
    Lee E.Y., Hu N., Yuan S.S., Cox L.A., Bradley A., Lee W.H., Herrup K.
    Genes Dev 8:2008-2021(1994) [PubMed] [Europe PMC] [Abstract]
• neuron projection development Source: MGIInferred from mutant phenotypeⁱ
  • "Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation."
    Lee E.Y., Hu N., Yuan S.S., Cox L.A., Bradley A., Lee W.H., Herrup K.
    Genes Dev 8:2008-2021(1994) [PubMed] [Europe PMC] [Abstract]
• positive regulation of collagen fibril organization Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation."
    Freytsis M., Baugh L., Liu Z., Georgakoudi I., Hinds P.W., Black L.D., Huggins G.S.
    PLoS One 13:e0190623-e0190623(2018) [PubMed] [Europe PMC] [Abstract]
• positive regulation of extracellular matrix organization Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation."
    Freytsis M., Baugh L., Liu Z., Georgakoudi I., Hinds P.W., Black L.D., Huggins G.S.
    PLoS One 13:e0190623-e0190623(2018) [PubMed] [Europe PMC] [Abstract]
• positive regulation of macrophage differentiation Source: MGIInferred from genetic interactionⁱ
  • "Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages."
    Iavarone A., King E.R., Dai X.M., Leone G., Stanley E.R., Lasorella A.
    Nature 432:1040-1045(2004) [PubMed] [Europe PMC] [Abstract]
• positive regulation of mitotic metaphase/anaphase transition Source: MGI
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "Retinoblastoma and the related pocket protein p107 act as coactivators of NeuroD1 to enhance gene transcription."
    Batsche E., Moschopoulos P., Desroches J., Bilodeau S., Drouin J.
    J Biol Chem 280:16088-16095(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription regulatory region DNA binding Source: MGIInferred from sequence orthologyⁱ
  • "Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells."
    Miles W.O., Korenjak M., Griffiths L.M., Dyer M.A., Provero P., Dyson N.J.
    EMBO J 33:2201-2215(2014) [PubMed] [Europe PMC] [Abstract]
• protein localization to chromosome, centromeric region Source: MGI
• Ras protein signal transduction Source: Ensembl
• regulation of cell cycle Source: MGIInferred from mutant phenotypeⁱ
  • "Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice."
    Kalitsis P., Fowler K.J., Griffiths B., Earle E., Chow C.W., Jamsen K., Choo K.H.
    Genes Chromosomes Cancer 44:29-36(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of cell growth Source: MGIInferred from genetic interactionⁱ
  • "Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells."
    Miles W.O., Korenjak M., Griffiths L.M., Dyer M.A., Provero P., Dyson N.J.
    EMBO J 33:2201-2215(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of cohesin loading Source: MGI
• regulation of lipid kinase activity Source: UniProtKB
• regulation of mitotic cell cycle Source: MGI
• sister chromatid biorientation Source: MGI
• skeletal muscle cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation."
    Rajan S., Chu Pham Dang H., Djambazian H., Zuzan H., Fedyshyn Y., Ketela T., Moffat J., Hudson T.J., Sladek R.
    Physiol Genomics 44:183-197(2012) [PubMed] [Europe PMC] [Abstract]
• striated muscle cell differentiation Source: MGIInferred from genetic interactionⁱ
  • "Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression."
    Takahashi C., Contreras B., Bronson R.T., Loda M., Ewen M.E.
    Mol Cell Biol 24:10406-10415(2004) [PubMed] [Europe PMC] [Abstract]
• tissue homeostasis Source: MGIInferred from genetic interactionⁱ
  • "Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells."
    Miles W.O., Korenjak M., Griffiths L.M., Dyer M.A., Provero P., Dyson N.J.
    EMBO J 33:2201-2215(2014) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Keywords - Diseaseⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• disordered domain specific binding Source: MGI
• enzyme binding Source: UniProtKBInferred from physical interactionⁱ
  • Ref.11

    "The arginine methyltransferase PRMT2 binds RB and regulates E2F function."
    Yoshimoto T., Boehm M., Olive M., Crook M.F., San H., Langenickel T., Nabel E.G.
    Exp. Cell Res. 312:2040-2053(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: INTERACTION WITH PRMT2.
• identical protein binding Source: MGI
• importin-alpha family protein binding Source: MGI
• kinase binding Source: UniProtKB
• phosphoprotein binding Source: MGI
• RNA polymerase II activating transcription factor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "E2F-1 has dual roles depending on the cell cycle."
    Sahin F., Sladek T.L.
    Int J Biol Sci 6:116-128(2010) [PubMed] [Europe PMC] [Abstract]
• transcription factor binding Source: UniProtKBInferred from physical interactionⁱ
  • "The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A."
    Lavender P., Vandel L., Bannister A.J., Kouzarides T.
    Oncogene 14:2721-2728(1997) [PubMed] [Europe PMC] [Abstract]
• ubiquitin protein ligase binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MPPKAPRRAA AAEPPPPPPP PPREDDPAQD SGPEELPLAR LEFEEIEEPE 
        60         70         80         90        100
FIALCQKLKV PDHVRERAWL TWEKVSSVDG ILEGYIQKKK ELWGICIFIA 
       110        120        130        140        150
AVDLDEMPFT FTELQKSIET SVYKFFDLLK EIDTSTKVDN AMSRLLKKYN 
       160        170        180        190        200
VLCALYSKLE RTCELIYLTQ PSSALSTEIN SMLVLKISWI TFLLAKGEVL 
       210        220        230        240        250
QMEDDLVISF QLMLCVVDYF IKFSPPALLR EPYKTAAIPI NGSPRTPRRG 
       260        270        280        290        300
QNRSARIAKQ LENDTRIIEV LCKEHECNID EVKNVYFKNF IPFINSLGIV 
       310        320        330        340        350
SSNGLPEVES LSKRYEEVYL KNKDLDARLF LDHDKTLQTD PIDSFETERT 
       360        370        380        390        400
PRKNNPDEEA NVVTPHTPVR TVMNTIQQLM VILNSASDQP SENLISYFNN 
       410        420        430        440        450
CTVNPKENIL KRVKDVGHIF KEKFANAVGQ GCVDIGVQRY KLGVRLYYRV 
       460        470        480        490        500
MESMLKSEEE RLSIQNFSKL LNDNIFHMSL LACALEVVMA TYSRSTLQHL 
       510        520        530        540        550
DSGTDLSFPW ILNVLNLKAF DFYKVIESFI KVEANLTREM IKHLERCEHR 
       560        570        580        590        600
IMESLAWLSD SPLFDLIKQS KDGEGPDNLE PACPLSLPLQ GNHTAADMYL 
       610        620        630        640        650
SPLRSPKKRT STTRVNSAAN TETQAASAFH TQKPLKSTSL ALFYKKVYRL 
       660        670        680        690        700
AYLRLNTLCA RLLSDHPELE HIIWTLFQHT LQNEYELMRD RHLDQIMMCS 
       710        720        730        740        750
MYGICKVKNI DLKFKIIVTA YKDLPHAAQE TFKRVLIREE EFDSIIVFYN 
       760        770        780        790        800
SVFMQRLKTN ILQYASTRPP TLSPIPHIPR SPYKFSSSPL RIPGGNIYIS 
       810        820        830        840        850
PLKSPYKISE GLPTPTKMTP RSRILVSIGE SFGTSEKFQK INQMVCNSDR 
       860        870        880        890        900
VLKRSAEGGN PPKPLKKLRF DIEGADEADG SKHLPAESKF QQKLAEMTST 
       910        920 
RTRMQKQRMN ESKDVSNKEE K                                

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families