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UniProtKB - P13395 (SPTCA_DROME)

Entry version 212 (07 Apr 2021)
Sequence version 2 (20 Jun 2001)
Previous versions | rss
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Protein

Spectrin alpha chain

Gene

alpha-Spec

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. Essential for larval survival and development. Stabilizes cell to cell interactions that are critical for the maintenance of cell shape and subcellular organization within embryonic tissues. Lva and spectrin may form a Golgi-based scaffold that mediates interaction of Golgi bodies with microtubules and facilitates Golgi-derived membrane secretion required for the formation of furrows during cellularization.3 Publications

Miscellaneous

Its transcript shares the first untranslated exon with the dlt transcript, suggesting a common regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi2278 – 22891PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi2321 – 23322PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin capping, Actin-binding, Calmodulin-binding
Biological processCell shape
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-264870, Caspase-mediated cleavage of cytoskeletal proteins
R-DME-6798695, Neutrophil degranulation
R-DME-6807878, COPI-mediated anterograde transport

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P13395

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spectrin alpha chain
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:alpha-Spec
Synonyms:SPEC-A
ORF Names:CG1977
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0250789, alpha-Spec

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000734671 – 2415Spectrin alpha chainAdd BLAST2415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1032Phosphoserine1 Publication1
Modified residuei1034Phosphoserine2 Publications1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P13395

PRoteomics IDEntifications database

More...PRIDEi		P13395

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P13395

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

A substantial pool of maternal protein in the egg undergoes dynamic changes in distribution early in embryogenesis. In gastrulated embryo, the highest level of protein is found in the respiratory tract cells and the lowest in parts of the forming gut.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0250789, Expressed in eye disc (Drosophila) and 56 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P13395, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P13395, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Native spectrin molecule is a tetramer composed of two antiparallel heterodimers joined head to head so that each end of the native molecule includes the C-terminus of the alpha subunit and the N-terminus of the beta subunit.

Interacts with calmodulin in a calcium-dependent manner, interacts with F-actin and also interacts with Lva.

Interacts with Ten-m.

2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		63763, 46 interactors

Database of interacting proteins

More...DIPi		DIP-17516N

Protein interaction database and analysis system

More...IntActi		P13395, 2 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0305100

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12415
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P13395

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P13395

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati48 – 150Spectrin 1Sequence analysisAdd BLAST103
Repeati154 – 254Spectrin 2Sequence analysisAdd BLAST101
Repeati258 – 362Spectrin 3Sequence analysisAdd BLAST105
Repeati366 – 464Spectrin 4Sequence analysisAdd BLAST99
Repeati471 – 574Spectrin 5Sequence analysisAdd BLAST104
Repeati577 – 679Spectrin 6Sequence analysisAdd BLAST103
Repeati683 – 784Spectrin 7Sequence analysisAdd BLAST102
Repeati788 – 890Spectrin 8Sequence analysisAdd BLAST103
Repeati894 – 963Spectrin 9Sequence analysisAdd BLAST70
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini970 – 1029SH3PROSITE-ProRule annotationAdd BLAST60
Repeati1079 – 1177Spectrin 10Sequence analysisAdd BLAST99
Repeati1181 – 1284Spectrin 11Sequence analysisAdd BLAST104
Repeati1287 – 1391Spectrin 12Sequence analysisAdd BLAST105
Repeati1394 – 1496Spectrin 13Sequence analysisAdd BLAST103
Repeati1500 – 1604Spectrin 14Sequence analysisAdd BLAST105
Repeati1608 – 1710Spectrin 15Sequence analysisAdd BLAST103
Repeati1714 – 1816Spectrin 16Sequence analysisAdd BLAST103
Repeati1820 – 1921Spectrin 17Sequence analysisAdd BLAST102
Repeati1926 – 2028Spectrin 18Sequence analysisAdd BLAST103
Repeati2040 – 2141Spectrin 19Sequence analysisAdd BLAST102
Repeati2154 – 2252Spectrin 20Sequence analysisAdd BLAST99
Domaini2265 – 2300EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini2308 – 2343EF-hand 2PROSITE-ProRule annotationAdd BLAST36

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the spectrin family.Curated

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0040, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156662

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000847_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P13395

Identification of Orthologs from Complete Genome Data

More...OMAi		QQFNRTV

Database for complete collections of gene phylogenies

More...PhylomeDBi		P13395

Family and domain databases

Conserved Domains Database

More...CDDi		cd00051, EFh, 1 hit
cd11808, SH3_Alpha_Spectrin, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035825, Alpha_Spectrin_SH3
IPR011992, EF-hand-dom_pair
IPR014837, EF-hand_Ca_insen
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13499, EF-hand_7, 1 hit
PF08726, EFhand_Ca_insen, 1 hit
PF00018, SH3_1, 1 hit
PF00435, Spectrin, 20 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00054, EFh, 2 hits
SM00326, SH3, 1 hit
SM00150, SPEC, 20 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit
SSF50044, SSF50044, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P13395-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENFTPKEVK ILETVEDIQE RREQVLSRYN DFKIETRQKR EKLEDSRRFQ 
        60         70         80         90        100
YFKRDADELE SWIHEKLQAA SEESYRDPTN LQAKIQKHQA FEAEVSAHSN 
       110        120        130        140        150
AIVSLDNTGQ EMINQQHFAS ESIQVRLDEL HKLWELLLSR LAEKGLKLQQ 
       160        170        180        190        200
ALVLVQFLRQ CEEVMFWIKD KETFVTADEF GQDLEHVEVL QRKFDEFQKD 
       210        220        230        240        250
MASQEYRVTE VNQLADKLVQ DGHPERDTIT KRKEELNEAW QRLKQLAIVR 
       260        270        280        290        300
QEKLFGAHEI QRFNRDADET VAWIAEKDVV LSSDDYGRDL ASVQALQRKH 
       310        320        330        340        350
EGVERDLAAL EDKVSTLGAE AQRLCSIHAD HSDQIRDKQA EIANYWQSLT 
       360        370        380        390        400
TKARERKQKL DESYYLHRFL ADFRDLVSWI NGMKAIISAD ELAKDVAGAE 
       410        420        430        440        450
ALLERHQEHK GEIDAREDSF KLTTESGQKL LEREHYAAAE IQEKLAALEN 
       460        470        480        490        500
DKSSLLSLWE DRRILYEQCM DLQLFYRDTE QADTWMAKQE AFLANEDLGD 
       510        520        530        540        550
SLDSVEALIK KHEDFEKSLA AQEEKIKALD IFATKLIDGQ HYAADDVAQR 
       560        570        580        590        600
RQMLLARRAA LQEKSSKRRQ LLEDSNRYQQ FERDCDETKG WISEKLKFAT 
       610        620        630        640        650
DDSYLDPTNL NGKMQKHQNF EHELNANKSR IEDITNVGTE LIEKQHYAAD 
       660        670        680        690        700
QINTRMQEIV VLWETLVQAS DKKGTKLNEA CQQQQFNRTI EDIELWLSEI 
       710        720        730        740        750
EGQLLSEDHG KDLTSVQNLQ KKHALLEADV MAHQDRIESI KVAANKFIES 
       760        770        780        790        800
GHFDADNIRN KEGNLSARYA ALAAPMGERK QHLLDSLQVQ QLFRDLEDEA 
       810        820        830        840        850
AWIREKEPIA ASTNRGRDLI GVQNLIKKHQ AVLAEINNHE ARLLNVISSG 
       860        870        880        890        900
ENMLKDQPFA SDDIRQRLEA LQEQWNTLKE KSSQRKQDLD DSLQAHQYFA 
       910        920        930        940        950
DANEAESWMR EKEPIATGSD YGKDEDSSEA LLKKHEALVS DLEAFGNTIQ 
       960        970        980        990       1000
ALQEQAKNCR QQETPVVDIT GKECVVALYD YTEKSPREVS MKKGDVLTLL 
      1010       1020       1030       1040       1050
NSNNKDWWKV EVNDRQGFVP AAYIKKIDAG LSASQQNLVD NHSIAKRQNQ 
      1060       1070       1080       1090       1100
INSQYDNLLA LARERQNKLN ETVKAYVLVR EAADLAQWIR DKENHAQIAD 
      1110       1120       1130       1140       1150
VVGEDLEEVE VLQKKFDDFN DDLKANEVRL ANMNEIAVQL TSLGQTEAAL 
      1160       1170       1180       1190       1200
KIQTQMQDLN EKWNNLQTLT AEKASQLGSA HEVQRFHRDI DETKDWIAEK 
      1210       1220       1230       1240       1250
ANALNNDDLG KDLRSVQTLQ RKHEGVERDL AALRDKIRQL DETANRLMQS 
      1260       1270       1280       1290       1300
HPDTAEQTYA KQKEINEMWD QIITKSTARK EKLLDSYDLQ RFLSDYRDLL 
      1310       1320       1330       1340       1350
AWINSMMSLV TSDELANDVT GAEALIERHQ EHRTEIDARA GTFGAFEQFG 
      1360       1370       1380       1390       1400
NELLQANHYA SPEIKEKIED LAKAREDLEK AWTERRLQLE QNLDLQLYMR 
      1410       1420       1430       1440       1450
DCELAESWMS AREAFLNADD DANAGGNVEA LIKKHEDFDK AINGHEQKIA 
      1460       1470       1480       1490       1500
ALQTVADQLI AQNHYASNLV DEKRKQVLER WRHLKEGLIE KRSRLGDEQT 
      1510       1520       1530       1540       1550
LQQFSRDADE IENWIAEKLQ LATEESYKDP ANIQSKHQKH QAFEAELAAN 
      1560       1570       1580       1590       1600
ADRIQSVLAM GGNLIDKKQC SGSEDAVQKR LTQIADQWEY LTHKTTEKSL 
      1610       1620       1630       1640       1650
KLKEANKQRT YIAAVKDLDF WLGEVESLLT TEDSGKDLAS VQNLMKKHQL 
      1660       1670       1680       1690       1700
VEADIVAHED RIKDMNNQAD SLVESGQFDT AGIQEKRQSI NERYERICNL 
      1710       1720       1730       1740       1750
AAHRQARLNE ALTLHQFFRD IADEESWIKE KKLLVGSDDY GRDLTGVQNL 
      1760       1770       1780       1790       1800
KKKHKRLEAE LGSHEPAIQA VQEAGEKLMD VSNLGVPEIE QRLKALNQAW 
      1810       1820       1830       1840       1850
AELKNLAATR GQKLDESLTY QQFLAQVEEE EAWITEKQQL LSVEDYGDSM 
      1860       1870       1880       1890       1900
AAVQGLLKKH DAFETDFTAH KDRCSLICDQ GSELVEAKNH HGESIAQRCQ 
      1910       1920       1930       1940       1950
QLRLKLDNLS ALAARRKGAL LDNSAYLQFM WKADVVESWI DDKENYVRSD 
      1960       1970       1980       1990       2000
EFGRDLSTVQ TLLTKQETFD AGLNAFEQEG IHNITALKDQ LINASHAQSP 
      2010       2020       2030       2040       2050
AILKRHGDVI ARWQKLRDAS NTRKDRLLAM QEQFRQIEEL YLTFAKKASA 
      2060       2070       2080       2090       2100
FNSWFENAEE DLTDPVRCNS IEEIRALRDA HAQFQASLSS AEADFKALAA 
      2110       2120       2130       2140       2150
LDQKIKSFNV GPNPYTWFTM EALEETWRNL QKIIEERDGE LAKEAKRQEE 
      2160       2170       2180       2190       2200
NDKLRKEFAK HANLFHQWLT ETRTSMMEGS GSLEQQLEAL RVKATEVRAR 
      2210       2220       2230       2240       2250
RVDLKKIEEL GALLEEHLIL DNRYTEHSTV GLAQQWDQLD QLSMRMQHNL 
      2260       2270       2280       2290       2300
EQQIQARNHS GVSEDSLKEF SMMFKHFDKD KSGKLNHQEF KSCLRALGYD 
      2310       2320       2330       2340       2350
LPMVEEGQPD PEFEAILDVV DPNRDGYVSL QEYIAFMISK ETENVQSYEE 
      2360       2370       2380       2390       2400
IENAFRAITA ADRPYVTKEE LYCNLTKDMA DYCVQRMKPF SEPRSGQPIK 
      2410 
DALDYIDFTR TLFQN
Length:2,415
Mass (Da):278,303
Last modified:June 20, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF1F72FB990EB0A37
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PBI5M9PBI5_DROME
Alpha spectrin, isoform C
alpha-Spec 3A9, alfa-Spec, alpha, alpha spectrin, alpha-Sp
2,447Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PDQ0M9PDQ0_DROME
Alpha spectrin, isoform D
alpha-Spec 3A9, alfa-Spec, alpha, alpha spectrin, alpha-Sp
2,425Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PGV6M9PGV6_DROME
Alpha spectrin, isoform B
alpha-Spec 3A9, alfa-Spec, alpha, alpha spectrin, alpha-Sp
2,457Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL39886 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence ABA81823 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti110Q → D in AAB29441 (PubMed:8276898).Curated1
Sequence conflicti212N → I in ABA81823 (Ref. 4) Curated1
Sequence conflicti337D → G in ABA81823 (Ref. 4) Curated1
Sequence conflicti651Q → L in ABA81823 (Ref. 4) Curated1
Sequence conflicti1555Q → H in AAL39886 (PubMed:12537569).Curated1
Sequence conflicti1562G → E in ABA81823 (Ref. 4) Curated1
Sequence conflicti1668Q → R in AAA28907 (PubMed:2808524).Curated1
Sequence conflicti1908N → S in ABA81823 (Ref. 4) Curated1
Sequence conflicti2203D → G in ABA81823 (Ref. 4) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M26400 mRNA Translation: AAA28907.1
AE014296 Genomic DNA Translation: AAF47569.1
BT023889 mRNA Translation: ABA81823.1 Frameshift.
S67762 Genomic DNA Translation: AAB29441.2
S67765 Genomic DNA Translation: AAB29442.1
AY069741 mRNA Translation: AAL39886.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...PIRi		A33733

NCBI Reference Sequences

More...RefSeqi		NP_476739.1, NM_057391.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0072789; FBpp0072672; FBgn0250789

Database of genes from NCBI RefSeq genomes

More...GeneIDi		38231

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG1977

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26400 mRNA Translation: AAA28907.1
AE014296 Genomic DNA Translation: AAF47569.1
BT023889 mRNA Translation: ABA81823.1 Frameshift.
S67762 Genomic DNA Translation: AAB29441.2
S67765 Genomic DNA Translation: AAB29442.1
AY069741 mRNA Translation: AAL39886.1 Different initiation.
PIRiA33733
RefSeqiNP_476739.1, NM_057391.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2SPCX-ray1.80A/B1391-1497[»]
SMRiP13395
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi63763, 46 interactors
DIPiDIP-17516N
IntActiP13395, 2 interactors
STRINGi7227.FBpp0305100

PTM databases

iPTMnetiP13395

Proteomic databases

PaxDbiP13395
PRIDEiP13395

Genome annotation databases

EnsemblMetazoaiFBtr0072789; FBpp0072672; FBgn0250789
GeneIDi38231
KEGGidme:Dmel_CG1977

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		38231
FlyBaseiFBgn0250789, alpha-Spec

Phylogenomic databases

eggNOGiKOG0040, Eukaryota
GeneTreeiENSGT00940000156662
HOGENOMiCLU_000847_0_0_1
InParanoidiP13395
OMAiQQFNRTV
PhylomeDBiP13395

Enzyme and pathway databases

ReactomeiR-DME-264870, Caspase-mediated cleavage of cytoskeletal proteins
R-DME-6798695, Neutrophil degranulation
R-DME-6807878, COPI-mediated anterograde transport
SignaLinkiP13395

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		38231, 0 hits in 3 CRISPR screens
EvolutionaryTraceiP13395

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		38231

Protein Ontology

More...PROi		PR:P13395

Gene expression databases

BgeeiFBgn0250789, Expressed in eye disc (Drosophila) and 56 other tissues
ExpressionAtlasiP13395, baseline and differential
GenevisibleiP13395, DM

Family and domain databases

CDDicd00051, EFh, 1 hit
cd11808, SH3_Alpha_Spectrin, 1 hit
InterProiView protein in InterPro
IPR035825, Alpha_Spectrin_SH3
IPR011992, EF-hand-dom_pair
IPR014837, EF-hand_Ca_insen
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PfamiView protein in Pfam
PF13499, EF-hand_7, 1 hit
PF08726, EFhand_Ca_insen, 1 hit
PF00018, SH3_1, 1 hit
PF00435, Spectrin, 20 hits
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00054, EFh, 2 hits
SM00326, SH3, 1 hit
SM00150, SPEC, 20 hits
SUPFAMiSSF47473, SSF47473, 1 hit
SSF50044, SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPTCA_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13395
Secondary accession number(s): Q26340
, Q3KN50, Q8SZW7, Q9W085
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: June 20, 2001
Last modified: April 7, 2021
This is version 212 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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