TDGF1

Functionⁱ

GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated TDGF1 acts as a Nodal coreceptor in cis. Shedding of TDGF1 by TMEM8A modulates Nodal signaling by allowing soluble TDGF1 to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953).2 Publications

GO - Molecular functionⁱ

growth factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12925698
signaling receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11909953

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPK activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9013573
anterior/posterior axis specification, embryo Source: UniProtKB
cell differentiation
Source: UniProtKB
Traceable author statementⁱ
- 11857442
cell migration involved in sprouting angiogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17720976
cellular response to epidermal growth factor stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 17720976
cellular response to fibroblast growth factor stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 17720976
cellular response to hepatocyte growth factor stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 17720976
cellular response to interferon-gamma
Source: UniProtKB
Inferred from direct assayⁱ
- 17720976
cellular response to interleukin-6
Source: UniProtKB
Inferred from direct assayⁱ
- 17720976
cellular response to tumor necrosis factor
Source: UniProtKB
Inferred from direct assayⁱ
- 17720976
embryo development ending in birth or egg hatching
Source: UniProtKB
Traceable author statementⁱ
- 11857442
heart development
Source: UniProtKB
Inferred from direct assayⁱ
- 9576836
mammary gland development
Source: UniProtKB
Traceable author statementⁱ
- 11857442
morphogenesis of a branching structure
Source: UniProtKB
Traceable author statementⁱ
- 10070255
negative regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 10493495
peptidyl-serine phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 10493495
positive regulation of cell migration
Source: UniProtKB
Inferred from direct assayⁱ
- 12649175
positive regulation of cell proliferation
Source: MGI
Inferred from direct assayⁱ
- 8006041
positive regulation of endothelial cell migration
Source: UniProtKB
Inferred from direct assayⁱ
- 17720976
positive regulation of peptidyl-tyrosine phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 10493495
regulation of signal transduction
Source: UniProtKB
Inferred from direct assayⁱ
- 12649175
somatic stem cell population maintenance Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor

Molecular function

Growth factor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1181150 Signaling by NODAL R-HSA-1433617 Regulation of signaling by NODAL R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
SIGNORⁱ	P13385

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Teratocarcinoma-derived growth factor 1 Alternative name(s): Cripto-1 growth factor Short name: CRGF Epidermal growth factor-like cripto protein CR1
Gene namesⁱ	Name:TDGF1 Synonyms:CRIPTO
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000241186.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11701 TDGF1
MIMⁱ	187395 gene+phenotype
neXtProtⁱ	NX_P13385

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	188	Y → YVVVVV: Alters the localization and decreases the biological activity. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6997
MalaCards human disease database More...MalaCardsⁱ	TDGF1
MIMⁱ	187395 gene+phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000241186
Orphanetⁱ	93925 Alobar holoprosencephaly 93924 Lobar holoprosencephaly 280200 Microform holoprosencephaly 93926 Midline interhemispheric variant of holoprosencephaly 220386 Semilobar holoprosencephaly 280195 Septopreoptic holoprosencephaly
PharmGKBⁱ	PA36420

Chemistry databases

ChEMBLⁱ	CHEMBL3713025

ChEMBLⁱ

CHEMBL3713025

Polymorphism and mutation databases

BioMutaⁱ	TDGF1
DMDMⁱ	117473

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 30	1 PublicationAdd BLAST	30
ChainⁱPRO_0000007503	31 – 150	Teratocarcinoma-derived growth factor 1Add BLAST	120
PropeptideⁱPRO_0000395410	151 – 188	Removed in mature formAdd BLAST	38

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	79	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	82 ↔ 89	PROSITE-ProRule annotation
Disulfide bondⁱ	83 ↔ 95	PROSITE-ProRule annotation
Disulfide bondⁱ	97 ↔ 106	PROSITE-ProRule annotation
Disulfide bondⁱ	115 ↔ 133	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	128 ↔ 149	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	131 ↔ 140	PROSITE-ProRule annotation1 Publication
Lipidationⁱ	150	GPI-anchor amidated aspartate1 Publication	1

Post-translational modificationⁱ

The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, it is processed by GPI processing phospholipase A2 (TMEM8A), removing an acyl-chain at the sn-2 position of GPI and releasing TDGF1 as a lysophosphatidylinositol-bearing form, which is further cleaved by phospholipase D (GPLD1) into a soluble form.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDⁱ	P13385
PaxDbⁱ	P13385
PeptideAtlas More...PeptideAtlasⁱ	P13385
PRIDEⁱ	P13385
ProteomicsDBⁱ	52909

Expressionⁱ

Tissue specificityⁱ

Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000241186
CleanExⁱ	HS_TDGF1
ExpressionAtlasⁱ	P13385 baseline and differential
Genevisibleⁱ	P13385 HS

Interactionⁱ

Subunit structureⁱ

Interacts with the activin type-1 receptor ACVR1B.1 Publication

GO - Molecular functionⁱ

growth factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12925698
signaling receptor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11909953

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112856, 31 interactors
IntActⁱ	P13385, 9 interactors
Molecular INTeraction database More...MINTⁱ	P13385
STRINGⁱ	9606.ENSP00000296145

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P13385
SMRⁱ	P13385
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	78 – 107	EGF-likePROSITE-ProRule annotationAdd BLAST		30

Sequence similaritiesⁱ

Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.Curated

Keywords - Domainⁱ

EGF-like domain, Signal

Phylogenomic databases

eggNOGⁱ	KOG1217 Eukaryota ENOG410XP6K LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063804
HOGENOMⁱ	HOG000145523
HOVERGENⁱ	HBG054705
InParanoidⁱ	P13385
OMAⁱ	NCEHDVR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RA4
PhylomeDBⁱ	P13385
TreeFamⁱ	TF333187

Family and domain databases

InterProⁱ	View protein in InterPro IPR017047 Cripto_growth_factor IPR019011 Cryptic/Cripto_CFC-dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom
PANTHERⁱ	PTHR14949:SF26 PTHR14949:SF26, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09443 CFC, 1 hit
PIRSFⁱ	PIRSF036301 Cripto_growth_factor, 1 hit
PROSITEⁱ	View protein in PROSITE PS00022 EGF_1, 1 hit PS50026 EGF_3, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P13385-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDCRKMARFS YSVIWIMAIS KVFELGLVAG LGHQEFARPS RGYLAFRDDS 
        60         70         80         90        100
IWPQEEPAIR PRSSQRVPPM GIQHSKELNR TCCLNGGTCM LGSFCACPPS 
       110        120        130        140        150
FYGRNCEHDV RKENCGSVPH DTWLPKKCSL CKCWHGQLRC FPQAFLPGCD 
       160        170        180 
GLVMDEHLVA SRTPELPPSA RTTTFMLVGI CLSIQSYY

Length:188

Mass (Da):21,169

Last modified:January 1, 1990 - v1

Checksum:ⁱAEE8727D0F27D886

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_024262	22	V → A2 PublicationsCorresponds to variant dbSNP:rs11130097Ensembl.	1
Natural variantⁱVAR_021903	43	Y → D. Corresponds to variant dbSNP:rs2293025Ensembl.	1
Natural variantⁱVAR_048975	111	R → G. Corresponds to variant dbSNP:rs34501971Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14253 mRNA Translation: CAA32467.1 M96955 Genomic DNA Translation: AAA61134.1 AC104304 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64773.1 BC022393 mRNA Translation: AAH22393.1 BC067844 mRNA Translation: AAH67844.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2742.1
PIRⁱ	B39787 A30362
NCBI Reference Sequences More...RefSeqⁱ	NP_001167607.1, NM_001174136.1 NP_003203.1, NM_003212.3
UniGeneⁱ	Hs.385870

Genome annotation databases

Ensemblⁱ	ENST00000296145; ENSP00000296145; ENSG00000241186
GeneIDⁱ	6997
KEGGⁱ	hsa:6997
UCSC genome browser More...UCSCⁱ	uc003cpv.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P13385	Growth factor		HUMAN		172
Growth factor		PANTR		188
Growth factor		PANPA		188
Growth factor		NOMLE		188
Growth factor		GORGO		188
+34

Protein	Similar proteins		Species	Score	Length
P13385	Teratocarcinoma-derived growth factor	)	MOUSE		171
UPI000A316000		MUSCR		171
UPI000A3125F7		MUSPA		171
UPI0003C906E4		TUPCH		183
UPI00027FB10C		SAIBB		186
+121

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14253 mRNA Translation: CAA32467.1 M96955 Genomic DNA Translation: AAA61134.1 AC104304 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64773.1 BC022393 mRNA Translation: AAH22393.1 BC067844 mRNA Translation: AAH67844.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2742.1
PIRⁱ	B39787 A30362
NCBI Reference Sequences More...RefSeqⁱ	NP_001167607.1, NM_001174136.1 NP_003203.1, NM_003212.3
UniGeneⁱ	Hs.385870

3D structure databases

ProteinModelPortalⁱ	P13385
SMRⁱ	P13385
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112856, 31 interactors
IntActⁱ	P13385, 9 interactors
Molecular INTeraction database More...MINTⁱ	P13385
STRINGⁱ	9606.ENSP00000296145

Chemistry databases

ChEMBLⁱ	CHEMBL3713025

ChEMBLⁱ

CHEMBL3713025

Polymorphism and mutation databases

BioMutaⁱ	TDGF1
DMDMⁱ	117473

Proteomic databases

EPDⁱ	P13385
PaxDbⁱ	P13385
PeptideAtlas More...PeptideAtlasⁱ	P13385
PRIDEⁱ	P13385
ProteomicsDBⁱ	52909

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6997
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000296145; ENSP00000296145; ENSG00000241186
GeneIDⁱ	6997
KEGGⁱ	hsa:6997
UCSC genome browser More...UCSCⁱ	uc003cpv.4 human

Organism-specific databases

CTDⁱ	6997
DisGeNET More...DisGeNETⁱ	6997
EuPathDBⁱ	HostDB:ENSG00000241186.7
GeneCardsⁱ	TDGF1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11701 TDGF1
MalaCards human disease database More...MalaCardsⁱ	TDGF1
MIMⁱ	187395 gene+phenotype
neXtProtⁱ	NX_P13385
Open Targets More...OpenTargetsⁱ	ENSG00000241186
Orphanetⁱ	93925 Alobar holoprosencephaly 93924 Lobar holoprosencephaly 280200 Microform holoprosencephaly 93926 Midline interhemispheric variant of holoprosencephaly 220386 Semilobar holoprosencephaly 280195 Septopreoptic holoprosencephaly
PharmGKBⁱ	PA36420
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1217 Eukaryota ENOG410XP6K LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063804
HOGENOMⁱ	HOG000145523
HOVERGENⁱ	HBG054705
InParanoidⁱ	P13385
OMAⁱ	NCEHDVR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RA4
PhylomeDBⁱ	P13385
TreeFamⁱ	TF333187

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1181150 Signaling by NODAL R-HSA-1433617 Regulation of signaling by NODAL R-HSA-2892247 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
SIGNORⁱ	P13385

Miscellaneous databases

ChiTaRSⁱ	TDGF1 human
GeneWikiⁱ	Teratocarcinoma-derived_growth_factor_1
GenomeRNAiⁱ	6997
Protein Ontology More...PROⁱ	PR:P13385
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000241186
CleanExⁱ	HS_TDGF1
ExpressionAtlasⁱ	P13385 baseline and differential
Genevisibleⁱ	P13385 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR017047 Cripto_growth_factor IPR019011 Cryptic/Cripto_CFC-dom IPR013032 EGF-like_CS IPR000742 EGF-like_dom
PANTHERⁱ	PTHR14949:SF26 PTHR14949:SF26, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09443 CFC, 1 hit
PIRSFⁱ	PIRSF036301 Cripto_growth_factor, 1 hit
PROSITEⁱ	View protein in PROSITE PS00022 EGF_1, 1 hit PS50026 EGF_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TDGF1_HUMAN
Accessionⁱ	P13385Primary (citable) accession number: P13385 Secondary accession number(s): Q8TCC1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	January 1, 1990
	Last modified:	July 18, 2018
	This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P13385 (TDGF1_HUMAN)

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Teratocarcinoma-derived growth factor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Plasma membrane

Extracellular region or secreted

Plasma Membrane

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ