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Protein

T-cell surface glycoprotein CD5

Gene

Cd5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a receptor in regulating T-cell proliferation.

GO - Molecular functioni

GO - Biological processi

  • apoptotic signaling pathway Source: MGI
  • T cell costimulation Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD5
Alternative name(s):
Lymphocyte antigen 1
Short name:
Ly-1
Short name:
Lyt-1
CD_antigen: CD5
Gene namesi
Name:Cd5
Synonyms:Ly-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:88340 Cd5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 371ExtracellularSequence analysisAdd BLAST347
Transmembranei372 – 401HelicalSequence analysisAdd BLAST30
Topological domaini402 – 494CytoplasmicSequence analysisAdd BLAST93

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
ChainiPRO_000003322324 – 494T-cell surface glycoprotein CD5Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 85PROSITE-ProRule annotation
Disulfide bondi59 ↔ 125PROSITE-ProRule annotation
Disulfide bondi80 ↔ 132PROSITE-ProRule annotation
Disulfide bondi106 ↔ 116PROSITE-ProRule annotation
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi201 ↔ 267PROSITE-ProRule annotation
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi244 ↔ 250PROSITE-ProRule annotation
Disulfide bondi285 ↔ 321PROSITE-ProRule annotation
Disulfide bondi301 ↔ 358PROSITE-ProRule annotation
Disulfide bondi316 ↔ 366PROSITE-ProRule annotation
Disulfide bondi341 ↔ 349PROSITE-ProRule annotation
Modified residuei438PhosphoserineBy similarity1
Modified residuei452PhosphotyrosineBy similarity1
Modified residuei459PhosphoserineBy similarity1
Modified residuei482PhosphoserineCombined sources1
Modified residuei484PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP13379
PaxDbiP13379
PeptideAtlasiP13379
PRIDEiP13379

PTM databases

iPTMnetiP13379
PhosphoSitePlusiP13379
SwissPalmiP13379

Expressioni

Gene expression databases

BgeeiENSMUSG00000024669 Expressed in 47 organ(s), highest expression level in thymus
CleanExiMM_CD5
ExpressionAtlasiP13379 baseline and differential
GenevisibleiP13379 MM

Interactioni

Subunit structurei

Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1.1 Publication

Binary interactionsi

Protein-protein interaction databases

IntActiP13379, 5 interactors
STRINGi10090.ENSMUSP00000025571

Structurei

3D structure databases

ProteinModelPortaliP13379
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 133SRCR 1PROSITE-ProRule annotationAdd BLAST100
Domaini159 – 268SRCR 2PROSITE-ProRule annotationAdd BLAST110
Domaini276 – 367SRCR 3PROSITE-ProRule annotationAdd BLAST92

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ3D Eukaryota
ENOG4111C54 LUCA
GeneTreeiENSGT00390000017536
HOGENOMiHOG000111490
HOVERGENiHBG005286
InParanoidiP13379
KOiK06455
OMAiMSFHRNH
OrthoDBiEOG091G0G5S
PhylomeDBiP13379
TreeFamiTF329295

Family and domain databases

Gene3Di3.10.250.10, 2 hits
InterProiView protein in InterPro
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR003566 Tcell_CD5
PfamiView protein in Pfam
PF00530 SRCR, 1 hit
PRINTSiPR00258 SPERACTRCPTR
PR01409 TCELLCD5
SMARTiView protein in SMART
SM00202 SR, 2 hits
SUPFAMiSSF56487 SSF56487, 2 hits
PROSITEiView protein in PROSITE
PS50287 SRCR_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13379-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSHEVLLAA TYLLGTLAAF CLGQSGRGGL DIQVMLSGSN SKCQGQVEIQ
60 70 80 90 100
MENKWKTVCS SSWRLSQDHS KNAQQASAVC KQLRCGDPLA LGPFPSLNRP
110 120 130 140 150
QNQVFCQGSP WSISNCNNTS SQDQCLPLSL ICLEPQRTTP PPTTTPPTTV
160 170 180 190 200
PEPTAPPRLQ LVPGHEGLRC TGVVEFYNGS WGGTILYKAK DRPLGLGNLI
210 220 230 240 250
CKSLQCGSFL THLSGTEAAG TPAPAELRDP RPLPIRWEAP NGSCVSLQQC
260 270 280 290 300
FQKTTAQEGG QALTVICSDF QPKVQSRLVG GSSVCEGIAE VRQRSQWEAL
310 320 330 340 350
CDSSAARGRG RWEELCREQQ CGDLISFHTV DADKTSPGFL CAQEKLSQCY
360 370 380 390 400
HLQKKKHCNK RVFVTCQDPN PAGLAPGTVA SIILTLVLLV VLLAMCGPLV
410 420 430 440 450
YKKLVKKFRQ KKQRQWIGPT GVNQNMSFHR SHTATVRSQV ENPTASHVDN
460 470 480 490
EYSQPPRNSH LSAYPALEGA LHRSSTQPDN SSDSDYDLQV AQRL
Length:494
Mass (Da):53,849
Last modified:January 1, 1990 - v1
Checksum:i1EBBBBFE2488C162
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15177 mRNA Translation: AAA39453.1
U09204 Genomic DNA Translation: AAC52187.1
CCDSiCCDS29586.1
PIRiA29079
RefSeqiNP_031676.3, NM_007650.3
UniGeneiMm.779

Genome annotation databases

EnsembliENSMUST00000025571; ENSMUSP00000025571; ENSMUSG00000024669
GeneIDi12507
KEGGimmu:12507
UCSCiuc008gqv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15177 mRNA Translation: AAA39453.1
U09204 Genomic DNA Translation: AAC52187.1
CCDSiCCDS29586.1
PIRiA29079
RefSeqiNP_031676.3, NM_007650.3
UniGeneiMm.779

3D structure databases

ProteinModelPortaliP13379
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP13379, 5 interactors
STRINGi10090.ENSMUSP00000025571

PTM databases

iPTMnetiP13379
PhosphoSitePlusiP13379
SwissPalmiP13379

Proteomic databases

EPDiP13379
PaxDbiP13379
PeptideAtlasiP13379
PRIDEiP13379

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025571; ENSMUSP00000025571; ENSMUSG00000024669
GeneIDi12507
KEGGimmu:12507
UCSCiuc008gqv.1 mouse

Organism-specific databases

CTDi921
MGIiMGI:88340 Cd5

Phylogenomic databases

eggNOGiENOG410IJ3D Eukaryota
ENOG4111C54 LUCA
GeneTreeiENSGT00390000017536
HOGENOMiHOG000111490
HOVERGENiHBG005286
InParanoidiP13379
KOiK06455
OMAiMSFHRNH
OrthoDBiEOG091G0G5S
PhylomeDBiP13379
TreeFamiTF329295

Miscellaneous databases

PROiPR:P13379
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024669 Expressed in 47 organ(s), highest expression level in thymus
CleanExiMM_CD5
ExpressionAtlasiP13379 baseline and differential
GenevisibleiP13379 MM

Family and domain databases

Gene3Di3.10.250.10, 2 hits
InterProiView protein in InterPro
IPR001190 SRCR
IPR017448 SRCR-like_dom
IPR036772 SRCR-like_dom_sf
IPR003566 Tcell_CD5
PfamiView protein in Pfam
PF00530 SRCR, 1 hit
PRINTSiPR00258 SPERACTRCPTR
PR01409 TCELLCD5
SMARTiView protein in SMART
SM00202 SR, 2 hits
SUPFAMiSSF56487 SSF56487, 2 hits
PROSITEiView protein in PROSITE
PS50287 SRCR_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCD5_MOUSE
AccessioniPrimary (citable) accession number: P13379
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 12, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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