UniProtKB - P13378 (HXD8_HUMAN)

BLAST

>sp|P13378|HXD8_HUMAN Homeobox protein Hox-D8 OS=Homo sapiens OX=9606 GN=HOXD8 PE=2 SV=2
MSSYFVNPLYSKYKAAAAAAAAAGEAINPTYYDCHFAPEVGGRHAAAAAALQLYGNSAAG
FPHAPPQAHAHPHPSPPPSGTGCGGREGRGQEYFHPGGGSPAAAYQAAPPPPPHPPPPPP
PPPCGGIACHGEPAKFYGYDNLQRQPIFTTQQEAELVQYPDCKSSSGNIGEDPDHLNQSS
SPSQMFPWMRPQAAPGRRRGRQTYSRFQTLELEKEFLFNPYLTRKRRIEVSHALALTERQ
VKIWFQNRRMKWKKENNKDKFPVSRQEVKDGETKKEAQELEEDRAEGLTN

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History
Entry version 174 (07 Nov 2018)
Sequence version 2 (21 Feb 2001)
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Protein

Homeobox protein Hox-D8

Gene

HOXD8

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	197 – 256	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 1756725
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
RNA polymerase II regulatory region sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 1756725

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterior/posterior axis specification, embryo
Source: UniProtKB
Non-traceable author statementⁱ
- 2568311
negative regulation of transcription by RNA polymerase II Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 1756725
skeletal system morphogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein Hox-D8 Alternative name(s): Homeobox protein Hox-4E Homeobox protein Hox-5.4
Gene namesⁱ	Name:HOXD8 Synonyms:HOX4E
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000175879.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5139 HOXD8
MIMⁱ	142985 gene
neXtProtⁱ	NX_P13378

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3234
Open Targets More...OpenTargetsⁱ	ENSG00000175879
PharmGKBⁱ	PA29413

Polymorphism and mutation databases

BioMutaⁱ	HOXD8
DMDMⁱ	13124737

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000200216	1 – 290	Homeobox protein Hox-D8Add BLAST		290

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P13378
PaxDbⁱ	P13378
PeptideAtlas More...PeptideAtlasⁱ	P13378
PRIDEⁱ	P13378
ProteomicsDBⁱ	52907 52908 [P13378-2]

PTM databases

iPTMnetⁱ	P13378
PhosphoSitePlusⁱ	P13378

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000175879 Expressed in 129 organ(s), highest expression level in metanephros
CleanExⁱ	HS_HOXD8
ExpressionAtlasⁱ	P13378 baseline and differential
Genevisibleⁱ	P13378 HS

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	109474, 6 interactors
IntActⁱ	P13378, 8 interactors
Molecular INTeraction database More...MINTⁱ	P13378
STRINGⁱ	9606.ENSP00000315949

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P13378
SMRⁱ	P13378
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	15 – 23	Poly-Ala	9
Compositional biasⁱ	45 – 50	Poly-Ala	6
Compositional biasⁱ	109 – 123	Poly-ProAdd BLAST	15

Sequence similaritiesⁱ

Belongs to the Antp homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143983
HOGENOMⁱ	HOG000231181
HOVERGENⁱ	HBG016849
InParanoidⁱ	P13378
KEGG Orthology (KO) More...KOⁱ	K09308
OMAⁱ	QEYFHPG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09XD
PhylomeDBⁱ	P13378
TreeFamⁱ	TF316310

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR001827 Homeobox_Antennapedia_CS IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00032 ANTENNAPEDIA, 1 hit PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P13378-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSYFVNPLY SKYKAAAAAA AAAGEAINPT YYDCHFAPEV GGRHAAAAAA 
        60         70         80         90        100
LQLYGNSAAG FPHAPPQAHA HPHPSPPPSG TGCGGREGRG QEYFHPGGGS 
       110        120        130        140        150
PAAAYQAAPP PPPHPPPPPP PPPCGGIACH GEPAKFYGYD NLQRQPIFTT 
       160        170        180        190        200
QQEAELVQYP DCKSSSGNIG EDPDHLNQSS SPSQMFPWMR PQAAPGRRRG 
       210        220        230        240        250
RQTYSRFQTL ELEKEFLFNP YLTRKRRIEV SHALALTERQ VKIWFQNRRM 
       260        270        280        290
KWKKENNKDK FPVSRQEVKD GETKKEAQEL EEDRAEGLTN

Length:290

Mass (Da):31,911

Last modified:February 21, 2001 - v2

Checksum:ⁱ75FF95A73E2AA85F

Isoform 2 (identifier: P13378-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
193-193: Missing.

« Hide

        10         20         30         40         50
MSSYFVNPLY SKYKAAAAAA AAAGEAINPT YYDCHFAPEV GGRHAAAAAA 
        60         70         80         90        100
LQLYGNSAAG FPHAPPQAHA HPHPSPPPSG TGCGGREGRG QEYFHPGGGS 
       110        120        130        140        150
PAAAYQAAPP PPPHPPPPPP PPPCGGIACH GEPAKFYGYD NLQRQPIFTT 
       160        170        180        190        200
QQEAELVQYP DCKSSSGNIG EDPDHLNQSS SPSQMFPWMR PQAPGRRRGR 
       210        220        230        240        250
QTYSRFQTLE LEKEFLFNPY LTRKRRIEVS HALALTERQV KIWFQNRRMK 
       260        270        280 
WKKENNKDKF PVSRQEVKDG ETKKEAQELE EDRAEGLTN

Note: No experimental confirmation available.

Show »

Length:289

Mass (Da):31,840

Checksum:ⁱ4C2621085174B447

Isoform 3 (identifier: P13378-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-184: Missing.
252-290: Missing.

« Hide

        10         20         30         40         50
MFPWMRPQAA PGRRRGRQTY SRFQTLELEK EFLFNPYLTR KRRIEVSHAL 
        60 
ALTERQVKIW FQNRRMK

Note: No experimental confirmation available.

Show »

Length:67

Mass (Da):8,354

Checksum:ⁱBBA9151D54C57E6D

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0A0MSX5	A0A0A0MSX5_HUMAN	Homeobox protein Hox-D8 Homeobox protein Hox-D8	HOXD8	106	Annotation score:
A0A0A0MTF4	A0A0A0MTF4_HUMAN	Homeobox protein Hox-D8 Homeobox protein Hox-D8	HOXD8	186	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	39	E → G in AAH90853 (PubMed:15489334).Curated		1
Sequence conflictⁱ	287	G → A in CAA33529 (PubMed:2568311).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_045862	1 – 184	Missing in isoform 3. 1 PublicationAdd BLAST	184
Alternative sequenceⁱVSP_042856	193	Missing in isoform 2. 1 Publication	1
Alternative sequenceⁱVSP_045863	252 – 290	Missing in isoform 3. 1 PublicationAdd BLAST	39

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY014304, AY014303 Genomic DNA Translation: AAG42152.1 AL520835 mRNA No translation available. AC009336 Genomic DNA No translation available. BC038709 mRNA Translation: AAH38709.1 BC090853 mRNA Translation: AAH90853.1 X15507 Genomic DNA Translation: CAA33529.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2268.1 [P13378-1] CCDS56148.1 [P13378-2]
PIRⁱ	B32830
NCBI Reference Sequences More...RefSeqⁱ	NP_001186675.1, NM_001199746.1 [P13378-2] NP_062458.1, NM_019558.3 [P13378-1]
UniGeneⁱ	Hs.301963 Hs.700870

Genome annotation databases

Ensemblⁱ	ENST00000313173; ENSP00000315949; ENSG00000175879 [P13378-1] ENST00000450510; ENSP00000409026; ENSG00000175879 [P13378-2]
GeneIDⁱ	3234
KEGGⁱ	hsa:3234
UCSC genome browser More...UCSCⁱ	uc002uko.4 human [P13378-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P13378	HOXD8 (Fragment)		PANPA		97	UniRef100_P13378
Homeobox protein Hox-D8		HUMAN		106
HOXD8 isoform 1		PANTR		106
Uncharacterized protein		PANPA		106
P13378-3	Homeobox protein Hox-D8		PTEAL		451	UniRef100_L5K057

Protein	Similar proteins		Species	Score	Length	Source
P13378	Homeobox protein Hox-D8		PANTR		290	UniRef90_P13378
Homeobox protein Hox-D8		MOUSE		289
HOXD8 (Fragment)		PANPA		97
Homeobox protein Hox-D8		HUMAN		106
HOXD8 isoform 2		PONAB		297
+65
P13378-3	Homeobox protein Hox-D8		PTEAL		451	UniRef90_L5K057

Protein	Similar proteins		Species	Score	Length	Source
P13378	Homeobox protein Hox-D8		PANTR		290	UniRef50_P13378
Homeobox protein Hox-D8		MOUSE		289
HOXD8 (Fragment)		PANPA		97
Homeobox protein Hox-D8		HUMAN		106
HOXD8 isoform 2		PONAB		297
+163
P13378-3	Homeobox protein Hox-D8		PTEAL		451	UniRef50_L5K057
Uncharacterized protein		HORVV		444
Transmembrane protein 127		PTEAL		554
UPI0007685A33		PTEAL		229

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY014304, AY014303 Genomic DNA Translation: AAG42152.1 AL520835 mRNA No translation available. AC009336 Genomic DNA No translation available. BC038709 mRNA Translation: AAH38709.1 BC090853 mRNA Translation: AAH90853.1 X15507 Genomic DNA Translation: CAA33529.1
CCDSⁱ	CCDS2268.1 [P13378-1] CCDS56148.1 [P13378-2]
PIRⁱ	B32830
RefSeqⁱ	NP_001186675.1, NM_001199746.1 [P13378-2] NP_062458.1, NM_019558.3 [P13378-1]
UniGeneⁱ	Hs.301963 Hs.700870

3D structure databases

ProteinModelPortalⁱ	P13378
SMRⁱ	P13378
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109474, 6 interactors
IntActⁱ	P13378, 8 interactors
MINTⁱ	P13378
STRINGⁱ	9606.ENSP00000315949

PTM databases

iPTMnetⁱ	P13378
PhosphoSitePlusⁱ	P13378

Polymorphism and mutation databases

BioMutaⁱ	HOXD8
DMDMⁱ	13124737

Proteomic databases

MaxQBⁱ	P13378
PaxDbⁱ	P13378
PeptideAtlasⁱ	P13378
PRIDEⁱ	P13378
ProteomicsDBⁱ	52907 52908 [P13378-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000313173; ENSP00000315949; ENSG00000175879 [P13378-1] ENST00000450510; ENSP00000409026; ENSG00000175879 [P13378-2]
GeneIDⁱ	3234
KEGGⁱ	hsa:3234
UCSCⁱ	uc002uko.4 human [P13378-1]

Organism-specific databases

CTDⁱ	3234
DisGeNETⁱ	3234
EuPathDBⁱ	HostDB:ENSG00000175879.8
GeneCardsⁱ	HOXD8
HGNCⁱ	HGNC:5139 HOXD8
MIMⁱ	142985 gene
neXtProtⁱ	NX_P13378
OpenTargetsⁱ	ENSG00000175879
PharmGKBⁱ	PA29413
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
GeneTreeⁱ	ENSGT00910000143983
HOGENOMⁱ	HOG000231181
HOVERGENⁱ	HBG016849
InParanoidⁱ	P13378
KOⁱ	K09308
OMAⁱ	QEYFHPG
OrthoDBⁱ	EOG091G09XD
PhylomeDBⁱ	P13378
TreeFamⁱ	TF316310

Miscellaneous databases

GeneWikiⁱ	HOXD8
GenomeRNAiⁱ	3234
Protein Ontology More...PROⁱ	PR:P13378
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000175879 Expressed in 129 organ(s), highest expression level in metanephros
CleanExⁱ	HS_HOXD8
ExpressionAtlasⁱ	P13378 baseline and differential
Genevisibleⁱ	P13378 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR001827 Homeobox_Antennapedia_CS IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00032 ANTENNAPEDIA, 1 hit PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HXD8_HUMAN
Accessionⁱ	P13378Primary (citable) accession number: P13378 Secondary accession number(s): F8WBG7, Q5BL00, Q8IXZ1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	February 21, 2001
	Last modified:	November 7, 2018
	This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - P13378 (HXD8_HUMAN)

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Homeobox protein Hox-D8

HOXD8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ