UniProtKB - P13378 (HXD8_HUMAN)
Protein
Homeobox protein Hox-D8
Gene
HOXD8
Organism
Homo sapiens (Human)
Status
Functioni
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 197 – 256 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- anterior/posterior axis specification, embryo Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- skeletal system morphogenesis Source: Ensembl
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P13378 |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein Hox-D8Alternative name(s): Homeobox protein Hox-4E Homeobox protein Hox-5.4 |
Gene namesi | Name:HOXD8 Synonyms:HOX4E |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000175879.8 |
HGNCi | HGNC:5139, HOXD8 |
MIMi | 142985, gene |
neXtProti | NX_P13378 |
Subcellular locationi
Nucleus
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 3234 |
OpenTargetsi | ENSG00000175879 |
PharmGKBi | PA29413 |
Miscellaneous databases
Pharosi | P13378, Tbio |
Polymorphism and mutation databases
BioMutai | HOXD8 |
DMDMi | 13124737 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200216 | 1 – 290 | Homeobox protein Hox-D8Add BLAST | 290 |
Proteomic databases
jPOSTi | P13378 |
MassIVEi | P13378 |
MaxQBi | P13378 |
PaxDbi | P13378 |
PeptideAtlasi | P13378 |
PRIDEi | P13378 |
ProteomicsDBi | 30803 52907 [P13378-1] 52908 [P13378-2] |
PTM databases
iPTMneti | P13378 |
PhosphoSitePlusi | P13378 |
Expressioni
Gene expression databases
Bgeei | ENSG00000175879, Expressed in metanephros and 143 other tissues |
ExpressionAtlasi | P13378, baseline and differential |
Genevisiblei | P13378, HS |
Organism-specific databases
HPAi | ENSG00000175879, Tissue enhanced (ductus deferens, epididymis) |
Interactioni
Binary interactionsi
Hide detailsP13378
With | #Exp. | IntAct |
---|---|---|
BAIAP2 - isoform 6 [Q9UQB8-6] | 3 | EBI-7098661,EBI-9092016 |
LDLRAP1 [Q5SW96] | 3 | EBI-7098661,EBI-747813 |
NCK2 [O43639] | 3 | EBI-7098661,EBI-713635 |
Protein-protein interaction databases
BioGRIDi | 109474, 9 interactors |
IntActi | P13378, 8 interactors |
MINTi | P13378 |
STRINGi | 9606.ENSP00000315949 |
Miscellaneous databases
RNActi | P13378, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 15 – 23 | Poly-Ala | 9 | |
Compositional biasi | 45 – 50 | Poly-Ala | 6 | |
Compositional biasi | 109 – 123 | Poly-ProAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the Antp homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000161653 |
InParanoidi | P13378 |
OMAi | QEYFHPG |
OrthoDBi | 976319at2759 |
PhylomeDBi | P13378 |
TreeFami | TF316310 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001827, Homeobox_Antennapedia_CS IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00032, ANTENNAPEDIA, 1 hit PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P13378-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSYFVNPLY SKYKAAAAAA AAAGEAINPT YYDCHFAPEV GGRHAAAAAA
60 70 80 90 100
LQLYGNSAAG FPHAPPQAHA HPHPSPPPSG TGCGGREGRG QEYFHPGGGS
110 120 130 140 150
PAAAYQAAPP PPPHPPPPPP PPPCGGIACH GEPAKFYGYD NLQRQPIFTT
160 170 180 190 200
QQEAELVQYP DCKSSSGNIG EDPDHLNQSS SPSQMFPWMR PQAAPGRRRG
210 220 230 240 250
RQTYSRFQTL ELEKEFLFNP YLTRKRRIEV SHALALTERQ VKIWFQNRRM
260 270 280 290
KWKKENNKDK FPVSRQEVKD GETKKEAQEL EEDRAEGLTN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MSX5 | A0A0A0MSX5_HUMAN | Homeobox protein Hox-D8 | HOXD8 | 106 | Annotation score: | ||
A0A0A0MTF4 | A0A0A0MTF4_HUMAN | Homeobox protein Hox-D8 | HOXD8 | 186 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 39 | E → G in AAH90853 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 287 | G → A in CAA33529 (PubMed:2568311).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045862 | 1 – 184 | Missing in isoform 3. 1 PublicationAdd BLAST | 184 | |
Alternative sequenceiVSP_042856 | 193 | Missing in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_045863 | 252 – 290 | Missing in isoform 3. 1 PublicationAdd BLAST | 39 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY014304, AY014303 Genomic DNA Translation: AAG42152.1 AL520835 mRNA No translation available. AC009336 Genomic DNA No translation available. BC038709 mRNA Translation: AAH38709.1 BC090853 mRNA Translation: AAH90853.1 X15507 Genomic DNA Translation: CAA33529.1 |
CCDSi | CCDS2268.1 [P13378-1] CCDS56148.1 [P13378-2] |
PIRi | B32830 |
RefSeqi | NP_001186675.1, NM_001199746.1 [P13378-2] NP_062458.1, NM_019558.3 [P13378-1] |
Genome annotation databases
Ensembli | ENST00000313173; ENSP00000315949; ENSG00000175879 [P13378-1] ENST00000450510; ENSP00000409026; ENSG00000175879 [P13378-2] |
GeneIDi | 3234 |
KEGGi | hsa:3234 |
UCSCi | uc002uko.4, human [P13378-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY014304, AY014303 Genomic DNA Translation: AAG42152.1 AL520835 mRNA No translation available. AC009336 Genomic DNA No translation available. BC038709 mRNA Translation: AAH38709.1 BC090853 mRNA Translation: AAH90853.1 X15507 Genomic DNA Translation: CAA33529.1 |
CCDSi | CCDS2268.1 [P13378-1] CCDS56148.1 [P13378-2] |
PIRi | B32830 |
RefSeqi | NP_001186675.1, NM_001199746.1 [P13378-2] NP_062458.1, NM_019558.3 [P13378-1] |
3D structure databases
SMRi | P13378 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109474, 9 interactors |
IntActi | P13378, 8 interactors |
MINTi | P13378 |
STRINGi | 9606.ENSP00000315949 |
PTM databases
iPTMneti | P13378 |
PhosphoSitePlusi | P13378 |
Polymorphism and mutation databases
BioMutai | HOXD8 |
DMDMi | 13124737 |
Proteomic databases
jPOSTi | P13378 |
MassIVEi | P13378 |
MaxQBi | P13378 |
PaxDbi | P13378 |
PeptideAtlasi | P13378 |
PRIDEi | P13378 |
ProteomicsDBi | 30803 52907 [P13378-1] 52908 [P13378-2] |
Protocols and materials databases
Antibodypediai | 33911, 267 antibodies |
Genome annotation databases
Ensembli | ENST00000313173; ENSP00000315949; ENSG00000175879 [P13378-1] ENST00000450510; ENSP00000409026; ENSG00000175879 [P13378-2] |
GeneIDi | 3234 |
KEGGi | hsa:3234 |
UCSCi | uc002uko.4, human [P13378-1] |
Organism-specific databases
CTDi | 3234 |
DisGeNETi | 3234 |
EuPathDBi | HostDB:ENSG00000175879.8 |
GeneCardsi | HOXD8 |
HGNCi | HGNC:5139, HOXD8 |
HPAi | ENSG00000175879, Tissue enhanced (ductus deferens, epididymis) |
MIMi | 142985, gene |
neXtProti | NX_P13378 |
OpenTargetsi | ENSG00000175879 |
PharmGKBi | PA29413 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0489, Eukaryota |
GeneTreei | ENSGT00940000161653 |
InParanoidi | P13378 |
OMAi | QEYFHPG |
OrthoDBi | 976319at2759 |
PhylomeDBi | P13378 |
TreeFami | TF316310 |
Enzyme and pathway databases
PathwayCommonsi | P13378 |
Miscellaneous databases
BioGRID-ORCSi | 3234, 3 hits in 866 CRISPR screens |
GeneWikii | HOXD8 |
GenomeRNAii | 3234 |
Pharosi | P13378, Tbio |
PROi | PR:P13378 |
RNActi | P13378, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175879, Expressed in metanephros and 143 other tissues |
ExpressionAtlasi | P13378, baseline and differential |
Genevisiblei | P13378, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR001827, Homeobox_Antennapedia_CS IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00032, ANTENNAPEDIA, 1 hit PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HXD8_HUMAN | |
Accessioni | P13378Primary (citable) accession number: P13378 Secondary accession number(s): F8WBG7, Q5BL00, Q8IXZ1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | February 21, 2001 | |
Last modified: | December 2, 2020 | |
This is version 187 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Vertebrate homeotic Hox proteins
Nomenclature of vertebrate homeotic Hox proteins and list of entries