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Protein

Homeobox protein Hox-D8

Gene

HOXD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi197 – 256HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D8
Alternative name(s):
Homeobox protein Hox-4E
Homeobox protein Hox-5.4
Gene namesi
Name:HOXD8
Synonyms:HOX4E
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000175879.8
HGNCiHGNC:5139 HOXD8
MIMi142985 gene
neXtProtiNX_P13378

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3234
OpenTargetsiENSG00000175879
PharmGKBiPA29413

Polymorphism and mutation databases

BioMutaiHOXD8
DMDMi13124737

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002002161 – 290Homeobox protein Hox-D8Add BLAST290

Proteomic databases

MaxQBiP13378
PaxDbiP13378
PeptideAtlasiP13378
PRIDEiP13378
ProteomicsDBi52907
52908 [P13378-2]

PTM databases

iPTMnetiP13378
PhosphoSitePlusiP13378

Expressioni

Gene expression databases

BgeeiENSG00000175879 Expressed in 129 organ(s), highest expression level in metanephros
CleanExiHS_HOXD8
ExpressionAtlasiP13378 baseline and differential
GenevisibleiP13378 HS

Interactioni

Protein-protein interaction databases

BioGridi109474, 6 interactors
IntActiP13378, 8 interactors
MINTiP13378
STRINGi9606.ENSP00000315949

Structurei

3D structure databases

ProteinModelPortaliP13378
SMRiP13378
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 23Poly-Ala9
Compositional biasi45 – 50Poly-Ala6
Compositional biasi109 – 123Poly-ProAdd BLAST15

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP13378
KOiK09308
OMAiQEYFHPG
OrthoDBiEOG091G09XD
PhylomeDBiP13378
TreeFamiTF316310

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P13378-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSYFVNPLY SKYKAAAAAA AAAGEAINPT YYDCHFAPEV GGRHAAAAAA
60 70 80 90 100
LQLYGNSAAG FPHAPPQAHA HPHPSPPPSG TGCGGREGRG QEYFHPGGGS
110 120 130 140 150
PAAAYQAAPP PPPHPPPPPP PPPCGGIACH GEPAKFYGYD NLQRQPIFTT
160 170 180 190 200
QQEAELVQYP DCKSSSGNIG EDPDHLNQSS SPSQMFPWMR PQAAPGRRRG
210 220 230 240 250
RQTYSRFQTL ELEKEFLFNP YLTRKRRIEV SHALALTERQ VKIWFQNRRM
260 270 280 290
KWKKENNKDK FPVSRQEVKD GETKKEAQEL EEDRAEGLTN
Length:290
Mass (Da):31,911
Last modified:February 21, 2001 - v2
Checksum:i75FF95A73E2AA85F
GO
Isoform 2 (identifier: P13378-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-193: Missing.

Note: No experimental confirmation available.
Show »
Length:289
Mass (Da):31,840
Checksum:i4C2621085174B447
GO
Isoform 3 (identifier: P13378-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.
     252-290: Missing.

Note: No experimental confirmation available.
Show »
Length:67
Mass (Da):8,354
Checksum:iBBA9151D54C57E6D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSX5A0A0A0MSX5_HUMAN
Homeobox protein Hox-D8
HOXD8
106Annotation score:
A0A0A0MTF4A0A0A0MTF4_HUMAN
Homeobox protein Hox-D8
HOXD8
186Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39E → G in AAH90853 (PubMed:15489334).Curated1
Sequence conflicti287G → A in CAA33529 (PubMed:2568311).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0458621 – 184Missing in isoform 3. 1 PublicationAdd BLAST184
Alternative sequenceiVSP_042856193Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_045863252 – 290Missing in isoform 3. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014304, AY014303 Genomic DNA Translation: AAG42152.1
AL520835 mRNA No translation available.
AC009336 Genomic DNA No translation available.
BC038709 mRNA Translation: AAH38709.1
BC090853 mRNA Translation: AAH90853.1
X15507 Genomic DNA Translation: CAA33529.1
CCDSiCCDS2268.1 [P13378-1]
CCDS56148.1 [P13378-2]
PIRiB32830
RefSeqiNP_001186675.1, NM_001199746.1 [P13378-2]
NP_062458.1, NM_019558.3 [P13378-1]
UniGeneiHs.301963
Hs.700870

Genome annotation databases

EnsembliENST00000313173; ENSP00000315949; ENSG00000175879 [P13378-1]
ENST00000450510; ENSP00000409026; ENSG00000175879 [P13378-2]
GeneIDi3234
KEGGihsa:3234
UCSCiuc002uko.4 human [P13378-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014304, AY014303 Genomic DNA Translation: AAG42152.1
AL520835 mRNA No translation available.
AC009336 Genomic DNA No translation available.
BC038709 mRNA Translation: AAH38709.1
BC090853 mRNA Translation: AAH90853.1
X15507 Genomic DNA Translation: CAA33529.1
CCDSiCCDS2268.1 [P13378-1]
CCDS56148.1 [P13378-2]
PIRiB32830
RefSeqiNP_001186675.1, NM_001199746.1 [P13378-2]
NP_062458.1, NM_019558.3 [P13378-1]
UniGeneiHs.301963
Hs.700870

3D structure databases

ProteinModelPortaliP13378
SMRiP13378
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109474, 6 interactors
IntActiP13378, 8 interactors
MINTiP13378
STRINGi9606.ENSP00000315949

PTM databases

iPTMnetiP13378
PhosphoSitePlusiP13378

Polymorphism and mutation databases

BioMutaiHOXD8
DMDMi13124737

Proteomic databases

MaxQBiP13378
PaxDbiP13378
PeptideAtlasiP13378
PRIDEiP13378
ProteomicsDBi52907
52908 [P13378-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313173; ENSP00000315949; ENSG00000175879 [P13378-1]
ENST00000450510; ENSP00000409026; ENSG00000175879 [P13378-2]
GeneIDi3234
KEGGihsa:3234
UCSCiuc002uko.4 human [P13378-1]

Organism-specific databases

CTDi3234
DisGeNETi3234
EuPathDBiHostDB:ENSG00000175879.8
GeneCardsiHOXD8
HGNCiHGNC:5139 HOXD8
MIMi142985 gene
neXtProtiNX_P13378
OpenTargetsiENSG00000175879
PharmGKBiPA29413
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000143983
HOGENOMiHOG000231181
HOVERGENiHBG016849
InParanoidiP13378
KOiK09308
OMAiQEYFHPG
OrthoDBiEOG091G09XD
PhylomeDBiP13378
TreeFamiTF316310

Miscellaneous databases

GeneWikiiHOXD8
GenomeRNAii3234
PROiPR:P13378
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175879 Expressed in 129 organ(s), highest expression level in metanephros
CleanExiHS_HOXD8
ExpressionAtlasiP13378 baseline and differential
GenevisibleiP13378 HS

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXD8_HUMAN
AccessioniPrimary (citable) accession number: P13378
Secondary accession number(s): F8WBG7, Q5BL00, Q8IXZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 21, 2001
Last modified: November 7, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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