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UniProtKB - P13378 (HXD8_HUMAN)

Entry version 187 (02 Dec 2020)
Sequence version 2 (21 Feb 2001)
Previous versions | rss
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Protein

Homeobox protein Hox-D8

Gene

HOXD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi197 – 256HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P13378

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein Hox-D8
Alternative name(s):
Homeobox protein Hox-4E
Homeobox protein Hox-5.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HOXD8
Synonyms:HOX4E
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000175879.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:5139, HOXD8

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		142985, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P13378

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3234

Open Targets

More...OpenTargetsi		ENSG00000175879

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29413

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P13378, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HOXD8

Domain mapping of disease mutations (DMDM)

More...DMDMi		13124737

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002002161 – 290Homeobox protein Hox-D8Add BLAST290

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P13378

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P13378

MaxQB - The MaxQuant DataBase

More...MaxQBi		P13378

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P13378

PeptideAtlas

More...PeptideAtlasi		P13378

PRoteomics IDEntifications database

More...PRIDEi		P13378

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		30803
52907 [P13378-1]
52908 [P13378-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P13378

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P13378

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000175879, Expressed in metanephros and 143 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P13378, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P13378, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000175879, Tissue enhanced (ductus deferens, epididymis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109474, 9 interactors

Protein interaction database and analysis system

More...IntActi		P13378, 8 interactors

Molecular INTeraction database

More...MINTi		P13378

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000315949

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P13378, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P13378

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 23Poly-Ala9
Compositional biasi45 – 50Poly-Ala6
Compositional biasi109 – 123Poly-ProAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0489, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161653

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P13378

Identification of Orthologs from Complete Genome Data

More...OMAi		QEYFHPG

Database of Orthologous Groups

More...OrthoDBi		976319at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P13378

TreeFam database of animal gene trees

More...TreeFami		TF316310

Family and domain databases

Conserved Domains Database

More...CDDi		cd00086, homeodomain, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009057, Homeobox-like_sf
IPR001827, Homeobox_Antennapedia_CS
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR020479, Homeobox_metazoa

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00046, Homeodomain, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00024, HOMEOBOX

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00389, HOX, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46689, SSF46689, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00032, ANTENNAPEDIA, 1 hit
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P13378-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSYFVNPLY SKYKAAAAAA AAAGEAINPT YYDCHFAPEV GGRHAAAAAA 
        60         70         80         90        100
LQLYGNSAAG FPHAPPQAHA HPHPSPPPSG TGCGGREGRG QEYFHPGGGS 
       110        120        130        140        150
PAAAYQAAPP PPPHPPPPPP PPPCGGIACH GEPAKFYGYD NLQRQPIFTT 
       160        170        180        190        200
QQEAELVQYP DCKSSSGNIG EDPDHLNQSS SPSQMFPWMR PQAAPGRRRG 
       210        220        230        240        250
RQTYSRFQTL ELEKEFLFNP YLTRKRRIEV SHALALTERQ VKIWFQNRRM 
       260        270        280        290
KWKKENNKDK FPVSRQEVKD GETKKEAQEL EEDRAEGLTN
Length:290
Mass (Da):31,911
Last modified:February 21, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i75FF95A73E2AA85F
GO
Isoform 2 (identifier: P13378-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-193: Missing.

Show »
Length:289
Mass (Da):31,840
Checksum:i4C2621085174B447
GO
Isoform 3 (identifier: P13378-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-184: Missing.
     252-290: Missing.

Show »
Length:67
Mass (Da):8,354
Checksum:iBBA9151D54C57E6D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MSX5A0A0A0MSX5_HUMAN
Homeobox protein Hox-D8
HOXD8
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTF4A0A0A0MTF4_HUMAN
Homeobox protein Hox-D8
HOXD8
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti39E → G in AAH90853 (PubMed:15489334).Curated1
Sequence conflicti287G → A in CAA33529 (PubMed:2568311).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0458621 – 184Missing in isoform 3. 1 PublicationAdd BLAST184
Alternative sequenceiVSP_042856193Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_045863252 – 290Missing in isoform 3. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY014304, AY014303 Genomic DNA Translation: AAG42152.1
AL520835 mRNA No translation available.
AC009336 Genomic DNA No translation available.
BC038709 mRNA Translation: AAH38709.1
BC090853 mRNA Translation: AAH90853.1
X15507 Genomic DNA Translation: CAA33529.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2268.1 [P13378-1]
CCDS56148.1 [P13378-2]

Protein sequence database of the Protein Information Resource

More...PIRi		B32830

NCBI Reference Sequences

More...RefSeqi		NP_001186675.1, NM_001199746.1 [P13378-2]
NP_062458.1, NM_019558.3 [P13378-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000313173; ENSP00000315949; ENSG00000175879 [P13378-1]
ENST00000450510; ENSP00000409026; ENSG00000175879 [P13378-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3234

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3234

UCSC genome browser

More...UCSCi		uc002uko.4, human [P13378-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY014304, AY014303 Genomic DNA Translation: AAG42152.1
AL520835 mRNA No translation available.
AC009336 Genomic DNA No translation available.
BC038709 mRNA Translation: AAH38709.1
BC090853 mRNA Translation: AAH90853.1
X15507 Genomic DNA Translation: CAA33529.1
CCDSiCCDS2268.1 [P13378-1]
CCDS56148.1 [P13378-2]
PIRiB32830
RefSeqiNP_001186675.1, NM_001199746.1 [P13378-2]
NP_062458.1, NM_019558.3 [P13378-1]

3D structure databases

SMRiP13378
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi109474, 9 interactors
IntActiP13378, 8 interactors
MINTiP13378
STRINGi9606.ENSP00000315949

PTM databases

iPTMnetiP13378
PhosphoSitePlusiP13378

Polymorphism and mutation databases

BioMutaiHOXD8
DMDMi13124737

Proteomic databases

jPOSTiP13378
MassIVEiP13378
MaxQBiP13378
PaxDbiP13378
PeptideAtlasiP13378
PRIDEiP13378
ProteomicsDBi30803
52907 [P13378-1]
52908 [P13378-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33911, 267 antibodies

Genome annotation databases

EnsembliENST00000313173; ENSP00000315949; ENSG00000175879 [P13378-1]
ENST00000450510; ENSP00000409026; ENSG00000175879 [P13378-2]
GeneIDi3234
KEGGihsa:3234
UCSCiuc002uko.4, human [P13378-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3234
DisGeNETi3234
EuPathDBiHostDB:ENSG00000175879.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		HOXD8
HGNCiHGNC:5139, HOXD8
HPAiENSG00000175879, Tissue enhanced (ductus deferens, epididymis)
MIMi142985, gene
neXtProtiNX_P13378
OpenTargetsiENSG00000175879
PharmGKBiPA29413

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0489, Eukaryota
GeneTreeiENSGT00940000161653
InParanoidiP13378
OMAiQEYFHPG
OrthoDBi976319at2759
PhylomeDBiP13378
TreeFamiTF316310

Enzyme and pathway databases

PathwayCommonsiP13378

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3234, 3 hits in 866 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HOXD8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3234
PharosiP13378, Tbio

Protein Ontology

More...PROi		PR:P13378
RNActiP13378, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000175879, Expressed in metanephros and 143 other tissues
ExpressionAtlasiP13378, baseline and differential
GenevisibleiP13378, HS

Family and domain databases

CDDicd00086, homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR001827, Homeobox_Antennapedia_CS
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR020479, Homeobox_metazoa
PfamiView protein in Pfam
PF00046, Homeodomain, 1 hit
PRINTSiPR00024, HOMEOBOX
SMARTiView protein in SMART
SM00389, HOX, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032, ANTENNAPEDIA, 1 hit
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHXD8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13378
Secondary accession number(s): F8WBG7, Q5BL00, Q8IXZ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: February 21, 2001
Last modified: December 2, 2020
This is version 187 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
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