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Protein

Immunoglobulin iota chain

Gene

Vpreb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation.

GO - Molecular functioni

  • signaling receptor activity Source: MGI

GO - Biological processi

  • B cell proliferation Source: MGI
  • cell morphogenesis Source: MGI
  • hemopoiesis Source: MGI
  • homeostasis of number of cells Source: MGI
  • immune response Source: MGI
  • immunoglobulin production Source: MGI
  • regulation of cell size Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin iota chain
Alternative name(s):
Protein VPreB1
CD_antigen: CD179a
Gene namesi
Name:Vpreb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:98936 Vpreb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001500120 – 142Immunoglobulin iota chainAdd BLAST123

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 115PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP13372
PRIDEiP13372

PTM databases

PhosphoSitePlusiP13372

Expressioni

Tissue specificityi

Only expressed by pre-B-cells.

Gene expression databases

BgeeiENSMUSG00000059305 Expressed in 25 organ(s), highest expression level in bone marrow
CleanExiMM_VPREB1
ExpressionAtlasiP13372 baseline and differential
GenevisibleiP13372 MM

Interactioni

Protein-protein interaction databases

BioGridi204532, 1 interactor
STRINGi10090.ENSMUSP00000074537

Structurei

3D structure databases

ProteinModelPortaliP13372
SMRiP13372
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 41Framework-1Add BLAST22
Regioni42 – 56Complementarity-determining-1Add BLAST15
Regioni57 – 70Framework-2Add BLAST14
Regioni71 – 81Complementarity-determining-2Add BLAST11
Regioni82 – 115Framework-3Add BLAST34

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IYZ1 Eukaryota
ENOG411181I LUCA
GeneTreeiENSGT00900000140867
HOGENOMiHOG000059537
HOVERGENiHBG018013
InParanoidiP13372
KOiK06553
OMAiWASSLFM
OrthoDBiEOG091G0XV9
PhylomeDBiP13372
TreeFamiTF352061

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13372-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWTSVLLML LAYLTGCGPQ PMVHQPPLAS SSLGATIRLS CTLSNDHNIG
60 70 80 90 100
IYSIYWYQQR PGHPPRFLLR YFSHSDKHQG PDIPPRFSGS KDTTRNLGYL
110 120 130 140
SISELQPEDE AVYYCAVGLR SQEKKRMERE WEGEKSYTDL GS
Length:142
Mass (Da):16,125
Last modified:January 1, 1990 - v1
Checksum:i2E18BF963A0F448C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05556 mRNA Translation: CAA29071.1
X05557 Genomic DNA Translation: CAA29072.1
CCDSiCCDS27989.1
PIRiA28344
RefSeqiNP_058678.1, NM_016982.2
UniGeneiMm.57574

Genome annotation databases

EnsembliENSMUST00000075017; ENSMUSP00000074537; ENSMUSG00000059305
GeneIDi22362
KEGGimmu:22362
UCSCiuc007yjg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05556 mRNA Translation: CAA29071.1
X05557 Genomic DNA Translation: CAA29072.1
CCDSiCCDS27989.1
PIRiA28344
RefSeqiNP_058678.1, NM_016982.2
UniGeneiMm.57574

3D structure databases

ProteinModelPortaliP13372
SMRiP13372
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204532, 1 interactor
STRINGi10090.ENSMUSP00000074537

PTM databases

PhosphoSitePlusiP13372

Proteomic databases

PaxDbiP13372
PRIDEiP13372

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075017; ENSMUSP00000074537; ENSMUSG00000059305
GeneIDi22362
KEGGimmu:22362
UCSCiuc007yjg.2 mouse

Organism-specific databases

CTDi7441
MGIiMGI:98936 Vpreb1

Phylogenomic databases

eggNOGiENOG410IYZ1 Eukaryota
ENOG411181I LUCA
GeneTreeiENSGT00900000140867
HOGENOMiHOG000059537
HOVERGENiHBG018013
InParanoidiP13372
KOiK06553
OMAiWASSLFM
OrthoDBiEOG091G0XV9
PhylomeDBiP13372
TreeFamiTF352061

Enzyme and pathway databases

ReactomeiR-MMU-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

PROiPR:P13372
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059305 Expressed in 25 organ(s), highest expression level in bone marrow
CleanExiMM_VPREB1
ExpressionAtlasiP13372 baseline and differential
GenevisibleiP13372 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVPRE1_MOUSE
AccessioniPrimary (citable) accession number: P13372
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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