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Protein

G1/S-specific cyclin CLN3

Gene

CLN3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G1/S (start) transition. CLN3 may be an upstream activator of the G1 cyclins which directly catalyze start.

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD
  • protein kinase binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division

Enzyme and pathway databases

BioCyciYEAST:G3O-28848-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
G1/S-specific cyclin CLN3
Gene namesi
Name:CLN3
Synonyms:DAF1, WHI1
Ordered Locus Names:YAL040C
ORF Names:FUN10
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome I

Organism-specific databases

SGDiS000000038 CLN3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804131 – 580G1/S-specific cyclin CLN3Add BLAST580

Proteomic databases

PaxDbiP13365
PRIDEiP13365

PTM databases

iPTMnetiP13365

Expressioni

Inductioni

Not significantly cell cycle regulated.

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi31725, 282 interactors
ComplexPortaliCPX-1700 CLN3-CDC28 kinase complex
DIPiDIP-1267N
IntActiP13365, 15 interactors
MINTiP13365
STRINGi4932.YAL040C

Structurei

3D structure databases

ProteinModelPortaliP13365
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

InParanoidiP13365
KOiK06646
OMAiMYCHTRL
OrthoDBiEOG092C4JRU

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

P13365-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAILKDTIIR YANARYATAS GTSTATAASV SAASCPNLPL LLQKRRAIAS
60 70 80 90 100
AKSKNPNLVK RELQAHHSAI SEYNNDQLDH YFRLSHTERP LYNLTNFNSQ
110 120 130 140 150
PQVNPKMRFL IFDFIMYCHT RLNLSTSTLF LTFTILDKYS SRFIIKSYNY
160 170 180 190 200
QLLSLTALWI SSKFWDSKNR MATLKVLQNL CCNQYSIKQF TTMEMHLFKS
210 220 230 240 250
LDWSICQSAT FDSYIDIFLF QSTSPLSPGV VLSAPLEAFI QQKLALLNNA
260 270 280 290 300
AGTAINKSSS SQGPSLNINE IKLGAIMLCE LASFNLELSF KYDRSLIALG
310 320 330 340 350
AINLIKLSLN YYNSNLWENI NLALEENCQD LDIKLSEISN TLLDIAMDQN
360 370 380 390 400
SFPSSFKSKY LNSNKTSLAK SLLDALQNYC IQLKLEEFYR SQELETMYNT
410 420 430 440 450
IFAQSFDSDS LTCVYSNATT PKSATVSSAA TDYFSDHTHL RRLTKDSISP
460 470 480 490 500
PFAFTPTSSS SSPSPFNSPY KTSSSMTTPD SASHHSHSGS FSSTQNSFKR
510 520 530 540 550
SLSIPQNSSI FWPSPLTPTT PSLMSNRKLL QNLSVRSKRL FPVRPMATAH
560 570 580
PCSAPTQLKK RSTSSVDCDF NDSSNLKKTR
Length:580
Mass (Da):64,991
Last modified:April 1, 1990 - v2
Checksum:iAF6950A7E68DB295
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23S → P in AAU09673 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13964 Genomic DNA Translation: CAA32143.1
M23359 Genomic DNA Translation: AAA34552.1
M23359 Genomic DNA Translation: AAA34551.1 Different termination.
U12980 Genomic DNA Translation: AAC04991.1
AY723756 Genomic DNA Translation: AAU09673.1
BK006935 Genomic DNA Translation: DAA06946.1
PIRiS14054
RefSeqiNP_009360.1, NM_001178185.1

Genome annotation databases

EnsemblFungiiYAL040C; YAL040C; YAL040C
GeneIDi851191
KEGGisce:YAL040C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13964 Genomic DNA Translation: CAA32143.1
M23359 Genomic DNA Translation: AAA34552.1
M23359 Genomic DNA Translation: AAA34551.1 Different termination.
U12980 Genomic DNA Translation: AAC04991.1
AY723756 Genomic DNA Translation: AAU09673.1
BK006935 Genomic DNA Translation: DAA06946.1
PIRiS14054
RefSeqiNP_009360.1, NM_001178185.1

3D structure databases

ProteinModelPortaliP13365
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31725, 282 interactors
ComplexPortaliCPX-1700 CLN3-CDC28 kinase complex
DIPiDIP-1267N
IntActiP13365, 15 interactors
MINTiP13365
STRINGi4932.YAL040C

PTM databases

iPTMnetiP13365

Proteomic databases

PaxDbiP13365
PRIDEiP13365

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYAL040C; YAL040C; YAL040C
GeneIDi851191
KEGGisce:YAL040C

Organism-specific databases

SGDiS000000038 CLN3

Phylogenomic databases

InParanoidiP13365
KOiK06646
OMAiMYCHTRL
OrthoDBiEOG092C4JRU

Enzyme and pathway databases

BioCyciYEAST:G3O-28848-MONOMER

Miscellaneous databases

PROiPR:P13365

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PfamiView protein in Pfam
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 1 hit
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCG13_YEAST
AccessioniPrimary (citable) accession number: P13365
Secondary accession number(s): D6VPH6, E9P940
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: April 1, 1990
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names
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Main funding by: National Institutes of Health

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