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UniProtKB - P13360 (GLAS_DROME)
Protein
Protein glass
Gene
gl
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Transcription factor required for gene expression specific to photoreceptor cells.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 437 – 459 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 465 – 487 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 493 – 515 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 521 – 543 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 549 – 571 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: FlyBase
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- circadian temperature homeostasis Source: FlyBase
- compound eye morphogenesis Source: FlyBase
- compound eye photoreceptor cell differentiation Source: FlyBase
- compound eye photoreceptor fate commitment Source: FlyBase
- entrainment of circadian clock Source: FlyBase
- entrainment of circadian clock by photoperiod Source: FlyBase
- photoreceptor cell differentiation Source: FlyBase
- positive regulation of transcription by RNA polymerase II Source: FlyBase
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to red light Source: FlyBase
- ring gland development Source: FlyBase
- sensory perception of sound Source: FlyBase
- visual perception Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Biological process | Sensory transduction, Transcription, Transcription regulation, Vision |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
SignaLinki | P13360 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein glass |
Gene namesi | Name:gl ORF Names:CG7672 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0004618, gl |
VEuPathDBi | VectorBase:FBgn0004618 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000046939 | 1 – 604 | Protein glassAdd BLAST | 604 |
Proteomic databases
PaxDbi | P13360 |
Expressioni
Gene expression databases
Bgeei | FBgn0004618, Expressed in eye disc (Drosophila) and 25 other tissues |
ExpressionAtlasi | P13360, baseline and differential |
Genevisiblei | P13360, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 67226, 23 interactors |
IntActi | P13360, 4 interactors |
STRINGi | 7227.FBpp0083005 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 111 – 139 | DisorderedSequence analysisAdd BLAST | 29 | |
Regioni | 199 – 237 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 359 – 400 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 414 – 434 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 566 – 604 | DisorderedSequence analysisAdd BLAST | 39 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 369 – 383 | Polar residuesSequence analysisAdd BLAST | 15 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 437 – 459 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 465 – 487 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 493 – 515 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 521 – 543 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 549 – 571 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
InParanoidi | P13360 |
OMAi | DMKPNLC |
PhylomeDBi | P13360 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform A (identifier: P13360-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGLLYKGSKL LNTILDSLED QEGGAMYISC DVSNGGPVEP ETGYVPNNPL
60 70 80 90 100
FGLALDSPQQ ECAASCVGCL SCQGSTALPI SSLTSSDFDC GGCFDPTIGV
110 120 130 140 150
GVGIGGGHIQ ISTTPPASSG NGSSNNGAGG GSSGNHGYWS TDEMASTFPG
160 170 180 190 200
LPPLDIDPLP SLFPFSPCGA SYNFAAGNPH QAASLSYTVH PHQMLISPNS
210 220 230 240 250
HNHGQMHSQH QQHQHQQSQV QASHVGNSLL QSSGGNNIGS NGSAGGVANA
260 270 280 290 300
ASCYYETSAG TAAPPPPPAA AMYPSMSVNV SMNMTMHHGY GAGDAGGVPM
310 320 330 340 350
QCSQMNWTPP SNSTSAAAAA AAVNVLYPPL LSPGHYPASA TYSFTADFRA
360 370 380 390 400
PAPTGLGALP PLTVGEKESP SPPANSSLAG YYPTGVGNQG YTPPHKSPTS
410 420 430 440 450
YQAAALGLSL SAFEDEEDSN EDLDGDEGSS GGEMKPNLCR LCGKTYARPS
460 470 480 490 500
TLKTHLRTHS GERPYRCPDC NKSFSQAANL TAHVRTHTGQ KPFRCPICDR
510 520 530 540 550
RFSQSSSVTT HMRTHSGERP YRCSSCKKSF SDSSTLTKHL RIHSGEKPYQ
560 570 580 590 600
CKLCLLRFSQ SGNLNRHMRV HGNNNSSNGS NGATGVGGES STGSGVGGGN
SLLT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4KGX3 | A0A0B4KGX3_DROME | Glass, isoform C | gl Dmel\CG7672, E(sina)5, Gl, Gla, gla | 679 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 60 | Q → E in CAA33450 (PubMed:2770860).Curated | 1 | |
Sequence conflicti | 361 | P → S cDNA (PubMed:2770860).Curated | 1 | |
Sequence conflicti | 362 | L → M in CAA33450 (PubMed:2770860).Curated | 1 | |
Sequence conflicti | 377 | S → T cDNA (PubMed:2770860).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_009352 | 558 – 604 | Missing in isoform B. 1 PublicationAdd BLAST | 47 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15400 Genomic DNA Translation: CAA33450.1 AE014297 Genomic DNA Translation: AAF55543.1 AE014297 Genomic DNA Translation: AAF55544.2 AY060322 mRNA Translation: AAL25361.1 |
PIRi | S05447 |
RefSeqi | NP_476854.1, NM_057506.3 [P13360-1] NP_732330.1, NM_169807.4 [P13360-2] |
Genome annotation databases
EnsemblMetazoai | FBtr0083584; FBpp0083005; FBgn0004618 [P13360-1] FBtr0083585; FBpp0083006; FBgn0004618 [P13360-2] |
GeneIDi | 42210 |
KEGGi | dme:Dmel_CG7672 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X15400 Genomic DNA Translation: CAA33450.1 AE014297 Genomic DNA Translation: AAF55543.1 AE014297 Genomic DNA Translation: AAF55544.2 AY060322 mRNA Translation: AAL25361.1 |
PIRi | S05447 |
RefSeqi | NP_476854.1, NM_057506.3 [P13360-1] NP_732330.1, NM_169807.4 [P13360-2] |
3D structure databases
SMRi | P13360 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 67226, 23 interactors |
IntActi | P13360, 4 interactors |
STRINGi | 7227.FBpp0083005 |
Proteomic databases
PaxDbi | P13360 |
Genome annotation databases
EnsemblMetazoai | FBtr0083584; FBpp0083005; FBgn0004618 [P13360-1] FBtr0083585; FBpp0083006; FBgn0004618 [P13360-2] |
GeneIDi | 42210 |
KEGGi | dme:Dmel_CG7672 |
Organism-specific databases
CTDi | 42210 |
FlyBasei | FBgn0004618, gl |
VEuPathDBi | VectorBase:FBgn0004618 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
InParanoidi | P13360 |
OMAi | DMKPNLC |
PhylomeDBi | P13360 |
Enzyme and pathway databases
SignaLinki | P13360 |
Miscellaneous databases
BioGRID-ORCSi | 42210, 0 hits in 3 CRISPR screens |
GenomeRNAii | 42210 |
PROi | PR:P13360 |
Gene expression databases
Bgeei | FBgn0004618, Expressed in eye disc (Drosophila) and 25 other tissues |
ExpressionAtlasi | P13360, baseline and differential |
Genevisiblei | P13360, DM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | GLAS_DROME | |
Accessioni | P13360Primary (citable) accession number: P13360 Secondary accession number(s): Q95T58, Q9VE83, Q9VE84 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | February 2, 2004 | |
Last modified: | February 23, 2022 | |
This is version 186 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase