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Protein

G2/mitotic-specific cyclin-B1

Gene

ccnb1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition.1 Publication

GO - Molecular functioni

  • patched binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-B1
Gene namesi
Name:ccnb1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-5736929 ccnb1.2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000803541 – 397G2/mitotic-specific cyclin-B1Add BLAST397

Expressioni

Developmental stagei

Accumulates steadily during G2 and is abruptly destroyed at mitosis.1 Publication

Interactioni

Subunit structurei

Interacts with the cdc2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. When not in a complex with cdc2, interacts with spdya. Interacts with nap1l1. Interacts with nanos1.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi99081, 1 interactor
ELMiP13350
IntActiP13350, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP13350
SMRiP13350
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi45 – 77Lys-richAdd BLAST33

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

HOVERGENiHBG061650
KOiK05868

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR039361 Cyclin
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PANTHERiPTHR10177 PTHR10177, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequencei

Sequence statusi: Complete.

P13350-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLRVTRNML ANAENNVKTT LAGKRVVATK PGLRPRTALG DIGNKAEVKV
60 70 80 90 100
PTKKELKPAV KAAKKAKPVD KLLEPLKVIE ENVCPKPAQV EPSSPSPMET
110 120 130 140 150
SGCLPDELCQ AFSDVLIHVK DVDADDDGNP MLCSEYVKDI YAYLRSLEDA
160 170 180 190 200
QAVRQNYLHG QEVTGNMRAI LIDWLVQVQM KFRLLQETMF MTVGIIDRFL
210 220 230 240 250
QEHPVPKNQL QLVGVTAMFL AAKYEEMYPP EIGDFTFVTD HTYTKAQIRD
260 270 280 290 300
MEMKILRVLK FAIGRPLPLH FLRRASKIGE VTAEQHSLAK YLMELVMVDY
310 320 330 340 350
DMVHFTPSQI AAASSCLSLK ILNAGDWTPT LHHYMAYSEE DLVPVMQHMA
360 370 380 390
KNIIKVNKGL TKHLTVKNKY ASSKQMKIST IPQLRSDVVV EMARPLM
Length:397
Mass (Da):44,673
Last modified:January 1, 1990 - v1
Checksum:iFBDA648E1258D78F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03166 mRNA Translation: AAA49696.1
BC088950 mRNA Translation: AAH88950.1
PIRiA32370
RefSeqiNP_001081266.1, NM_001087797.1
UniGeneiXl.21952

Genome annotation databases

GeneIDi397742
KEGGixla:397742

Similar proteinsi

Entry informationi

Entry nameiCCNB1_XENLA
AccessioniPrimary (citable) accession number: P13350
Secondary accession number(s): Q5HZN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: July 18, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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