ccnb1

Functionⁱ

Essential for the control of the cell cycle at the G2/M (mitosis) transition.1 Publication

GO - Molecular functionⁱ

patched binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 11331587

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell cycle Source: UniProtKB-KW
cell division Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cyclin
Biological process	Cell cycle, Cell division, Mitosis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: G2/mitotic-specific cyclin-B1
Gene namesⁱ	Name:ccnb1
Organismⁱ	Xenopus laevis (African clawed frog)
Taxonomic identifierⁱ	8355 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Organism-specific databases

Xenbaseⁱ	XB-GENE-5736929 ccnb1.2

Xenbaseⁱ

XB-GENE-5736929 ccnb1.2

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000080354	1 – 397	G2/mitotic-specific cyclin-B1Add BLAST		397

Expressionⁱ

Developmental stageⁱ

Accumulates steadily during G2 and is abruptly destroyed at mitosis.1 Publication

Interactionⁱ

Subunit structureⁱ

Interacts with the cdc2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. When not in a complex with cdc2, interacts with spdya. Interacts with nap1l1. Interacts with nanos1.3 Publications

GO - Molecular functionⁱ

patched binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 11331587

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	99081, 1 interactor
ELMⁱ	P13350
IntActⁱ	P13350, 1 interactor

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P13350
SMRⁱ	P13350
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	45 – 77	Lys-richAdd BLAST		33

Sequence similaritiesⁱ

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

HOVERGENⁱ	HBG061650
KEGG Orthology (KO) More...KOⁱ	K05868

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00043 CYCLIN, 2 hits
InterProⁱ	View protein in InterPro IPR039361 Cyclin IPR013763 Cyclin-like IPR036915 Cyclin-like_sf IPR004367 Cyclin_C-dom IPR006671 Cyclin_N
PANTHERⁱ	PTHR10177 PTHR10177, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02984 Cyclin_C, 1 hit PF00134 Cyclin_N, 1 hit
SMARTⁱ	View protein in SMART SM00385 CYCLIN, 2 hits SM01332 Cyclin_C, 1 hit
SUPFAMⁱ	SSF47954 SSF47954, 2 hits
PROSITEⁱ	View protein in PROSITE PS00292 CYCLINS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P13350-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLRVTRNML ANAENNVKTT LAGKRVVATK PGLRPRTALG DIGNKAEVKV 
        60         70         80         90        100
PTKKELKPAV KAAKKAKPVD KLLEPLKVIE ENVCPKPAQV EPSSPSPMET 
       110        120        130        140        150
SGCLPDELCQ AFSDVLIHVK DVDADDDGNP MLCSEYVKDI YAYLRSLEDA 
       160        170        180        190        200
QAVRQNYLHG QEVTGNMRAI LIDWLVQVQM KFRLLQETMF MTVGIIDRFL 
       210        220        230        240        250
QEHPVPKNQL QLVGVTAMFL AAKYEEMYPP EIGDFTFVTD HTYTKAQIRD 
       260        270        280        290        300
MEMKILRVLK FAIGRPLPLH FLRRASKIGE VTAEQHSLAK YLMELVMVDY 
       310        320        330        340        350
DMVHFTPSQI AAASSCLSLK ILNAGDWTPT LHHYMAYSEE DLVPVMQHMA 
       360        370        380        390 
KNIIKVNKGL TKHLTVKNKY ASSKQMKIST IPQLRSDVVV EMARPLM

Length:397

Mass (Da):44,673

Last modified:January 1, 1990 - v1

Checksum:ⁱFBDA648E1258D78F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J03166 mRNA Translation: AAA49696.1 BC088950 mRNA Translation: AAH88950.1
PIRⁱ	A32370
NCBI Reference Sequences More...RefSeqⁱ	NP_001081266.1, NM_001087797.1
UniGeneⁱ	Xl.21952

Genome annotation databases

GeneIDⁱ	397742
KEGGⁱ	xla:397742

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P13350	Uncharacterized protein		XENLA		397	UniRef100_P13350
Cyclin B1 beta (Fragment)		XENBO		19

Protein	Similar proteins		Species	Score	Length	Source
P13350	Uncharacterized protein		XENLA		397	UniRef90_P13350
Cyclin B1 beta (Fragment)		XENBO		19
Cyclin B1		XENTR		397
Cyclin B1		XENTR		397
Cyclin B1		XENTR		397
+2

Protein	Similar proteins		Species	Score	Length	Source
P13350	G2/mitotic-specific cyclin-B2		ANGJA		394	UniRef50_P13350
G2/mitotic-specific cyclin-B1		CARAU		397
G2/mitotic-specific cyclin-B2		XENLA		392
G2/mitotic-specific cyclin-B2		RANJA		392
G2/mitotic-specific cyclin-B1		ORYLA		404
+268

Entry informationⁱ

Entry nameⁱ	CCNB1_XENLA
Accessionⁱ	P13350Primary (citable) accession number: P13350 Secondary accession number(s): Q5HZN2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	January 1, 1990
	Last modified:	July 18, 2018
	This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB - P13350 (CCNB1_XENLA)

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G2/mitotic-specific cyclin-B1

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

Nucleus

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Nucleus

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Expressionⁱ

Developmental stageⁱ

Interactionⁱ

Subunit structureⁱ

GO - Molecular functionⁱ

Protein-protein interaction databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Compositional bias

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Entry informationⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P13350 (CCNB1_XENLA)

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G2/mitotic-specific cyclin-B1

ccnb1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Entry informationⁱ