UniProtKB - P13350 (CCNB1_XENLA)
Protein
G2/mitotic-specific cyclin-B1
Gene
ccnb1
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Essential for the control of the cell cycle at the G2/M (mitosis) transition.1 Publication
GO - Molecular functioni
- patched binding Source: BHF-UCL
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
Keywordsi
Molecular function | Cyclin |
Biological process | Cell cycle, Cell division, Mitosis |
Names & Taxonomyi
Protein namesi | Recommended name: G2/mitotic-specific cyclin-B1 |
Gene namesi | Name:ccnb1 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-5736929, ccnb1.2.S |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytoskeleton
- centrosome By similarity
Other locations
- Cytoplasm 1 Publication
Cytoskeleton
- microtubule organizing center Source: UniProtKB-SubCell
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080354 | 1 – 397 | G2/mitotic-specific cyclin-B1Add BLAST | 397 |
Expressioni
Developmental stagei
Accumulates steadily during G2 and is abruptly destroyed at mitosis.1 Publication
Interactioni
Subunit structurei
Interacts with the cdc2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. When not in a complex with cdc2, interacts with spdya.
Interacts with nap1l1.
Interacts with nanos1.
3 PublicationsGO - Molecular functioni
- patched binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 99081, 1 interactor |
ELMi | P13350 |
IntActi | P13350, 1 interactor |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 45 – 77 | Lys-richAdd BLAST | 33 |
Sequence similaritiesi
Phylogenomic databases
OMAi | YLVGQEV |
OrthoDBi | 993640at2759 |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
PIRSFi | PIRSF001771, Cyclin_A_B_D_E, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
i Sequence
Sequence statusi: Complete.
P13350-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLRVTRNML ANAENNVKTT LAGKRVVATK PGLRPRTALG DIGNKAEVKV
60 70 80 90 100
PTKKELKPAV KAAKKAKPVD KLLEPLKVIE ENVCPKPAQV EPSSPSPMET
110 120 130 140 150
SGCLPDELCQ AFSDVLIHVK DVDADDDGNP MLCSEYVKDI YAYLRSLEDA
160 170 180 190 200
QAVRQNYLHG QEVTGNMRAI LIDWLVQVQM KFRLLQETMF MTVGIIDRFL
210 220 230 240 250
QEHPVPKNQL QLVGVTAMFL AAKYEEMYPP EIGDFTFVTD HTYTKAQIRD
260 270 280 290 300
MEMKILRVLK FAIGRPLPLH FLRRASKIGE VTAEQHSLAK YLMELVMVDY
310 320 330 340 350
DMVHFTPSQI AAASSCLSLK ILNAGDWTPT LHHYMAYSEE DLVPVMQHMA
360 370 380 390
KNIIKVNKGL TKHLTVKNKY ASSKQMKIST IPQLRSDVVV EMARPLM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03166 mRNA Translation: AAA49696.1 BC088950 mRNA Translation: AAH88950.1 |
PIRi | A32370 |
RefSeqi | NP_001081266.1, NM_001087797.1 |
Genome annotation databases
GeneIDi | 397742 |
KEGGi | xla:397742 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J03166 mRNA Translation: AAA49696.1 BC088950 mRNA Translation: AAH88950.1 |
PIRi | A32370 |
RefSeqi | NP_001081266.1, NM_001087797.1 |
3D structure databases
SMRi | P13350 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 99081, 1 interactor |
ELMi | P13350 |
IntActi | P13350, 1 interactor |
Genome annotation databases
GeneIDi | 397742 |
KEGGi | xla:397742 |
Organism-specific databases
CTDi | 397742 |
Xenbasei | XB-GENE-5736929, ccnb1.2.S |
Phylogenomic databases
OMAi | YLVGQEV |
OrthoDBi | 993640at2759 |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
InterProi | View protein in InterPro IPR039361, Cyclin IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR004367, Cyclin_C-dom IPR006671, Cyclin_N |
PANTHERi | PTHR10177, PTHR10177, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
PIRSFi | PIRSF001771, Cyclin_A_B_D_E, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
PROSITEi | View protein in PROSITE PS00292, CYCLINS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCNB1_XENLA | |
Accessioni | P13350Primary (citable) accession number: P13350 Secondary accession number(s): Q5HZN2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | January 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |