UniProtKB - P13346 (FOSB_MOUSE)

BLAST

>sp|P13346|FOSB_MOUSE Protein fosB OS=Mus musculus OX=10090 GN=Fosb PE=2 SV=1
MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTA
ITTSQDLQWLVQPTLISSMAQSQGQPLASQPPAVDPYDMPGTSYSTPGLSAYSTGGASGS
GGPSTSTTTSGPVSARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELT
DRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRD
LPGSTSAKEDGFGWLLPPPPPPPLPFQSSRDAPPNLTASLFTHSEVQVLGDPFPVVSPSY
TSSFVLTCPEVSAFAGAQRTSGSEQPSDPLNSPSLLAL

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History
Entry version 147 (07 Nov 2018)
Sequence version 1 (01 Jan 1990)
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Protein

Protein fosB

Gene

Fosb

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

FosB interacts with Jun proteins enhancing their DNA binding activity.

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from direct assayⁱ
- 12220541
DNA-binding transcription factor activity Source: MGI
double-stranded DNA binding Source: MGI
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 12525489
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 12525489
sequence-specific DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to calcium ion
Source: MGI
Inferred from direct assayⁱ
- 19303854
cellular response to hormone stimulus Source: Ensembl
female pregnancy Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 12525489
response to cAMP Source: Ensembl
response to corticosterone Source: Ensembl
response to mechanical stimulus Source: Ensembl
response to morphine Source: Ensembl
response to progesterone Source: Ensembl
transcription by RNA polymerase II Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein fosB
Gene namesⁱ	Name:Fosb
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:95575 Fosb

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076477	1 – 338	Protein fosBAdd BLAST		338

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P13346
PaxDbⁱ	P13346
PRIDEⁱ	P13346

PTM databases

iPTMnetⁱ	P13346
PhosphoSitePlusⁱ	P13346

Expressionⁱ

Inductionⁱ

By growth factors.

Gene expression databases

Bgeeⁱ	ENSMUSG00000003545 Expressed in 96 organ(s), highest expression level in epididymal fat pad
CleanExⁱ	MM_FOSB
ExpressionAtlasⁱ	P13346 baseline and differential
Genevisibleⁱ	P13346 MM

Interactionⁱ

Subunit structureⁱ

Heterodimer.By similarity

Protein-protein interaction databases

BioGridⁱ	199727, 2 interactors
CORUMⁱ	P13346
Database of interacting proteins More...DIPⁱ	DIP-1067N
IntActⁱ	P13346, 1 interactor
STRINGⁱ	10090.ENSMUSP00000003640

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P13346
SMRⁱ	P13346
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	155 – 218	bZIPPROSITE-ProRule annotationAdd BLAST		64

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	157 – 182	Basic motifPROSITE-ProRule annotationAdd BLAST		26
Regionⁱ	183 – 211	Leucine-zipperPROSITE-ProRule annotationAdd BLAST		29

Sequence similaritiesⁱ

Belongs to the bZIP family. Fos subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG1414 Eukaryota ENOG4111CH5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110541
HOGENOMⁱ	HOG000234334
HOVERGENⁱ	HBG005743
InParanoidⁱ	P13346
KEGG Orthology (KO) More...KOⁱ	K09029
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GGW
PhylomeDBⁱ	P13346
TreeFamⁱ	TF326301

Family and domain databases

InterProⁱ	View protein in InterPro IPR000837 AP-1 IPR004827 bZIP IPR029813 FosB
PANTHERⁱ	PTHR23351 PTHR23351, 1 hit PTHR23351:SF3 PTHR23351:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
PRINTSⁱ	PR00042 LEUZIPPRFOS
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

P13346-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM 
        60         70         80         90        100
PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPAVDPYDMP 
       110        120        130        140        150
GTSYSTPGLS AYSTGGASGS GGPSTSTTTS GPVSARPARA RPRRPREETL 
       160        170        180        190        200
TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE 
       210        220        230        240        250
IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD LPGSTSAKED 
       260        270        280        290        300
GFGWLLPPPP PPPLPFQSSR DAPPNLTASL FTHSEVQVLG DPFPVVSPSY 
       310        320        330 
TSSFVLTCPE VSAFAGAQRT SGSEQPSDPL NSPSLLAL

Length:338

Mass (Da):35,977

Last modified:January 1, 1990 - v1

Checksum:ⁱE9D031A4BEAE48EC

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A140LIE4	A0A140LIE4_MOUSE	Protein fosB Protein fosB	Fosb	237	Annotation score:
A0A140LHW0	A0A140LHW0_MOUSE	Protein fosB Protein fosB	Fosb	299	Annotation score:
A0A140LHS3	A0A140LHS3_MOUSE	Protein fosB Protein fosB	Fosb	201	Annotation score:
A0A140LJH0	A0A140LJH0_MOUSE	Protein fosB Protein fosB	Fosb	302	Annotation score:
A0A140LIT4	A0A140LIT4_MOUSE	Protein fosB Protein fosB	Fosb	263	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14897 mRNA Translation: CAA33026.1 AF093624 Genomic DNA Translation: AAD13196.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS20897.1
PIRⁱ	S35477 TVMSFB
NCBI Reference Sequences More...RefSeqⁱ	NP_032062.1, NM_008036.2 XP_006539606.1, XM_006539543.2
UniGeneⁱ	Mm.248335

Genome annotation databases

Ensemblⁱ	ENSMUST00000003640; ENSMUSP00000003640; ENSMUSG00000003545
GeneIDⁱ	14282
KEGGⁱ	mmu:14282
UCSC genome browser More...UCSCⁱ	uc009flk.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P13346	FBJ osteosarcoma oncogene B		MOUSE		338	UniRef100_P13346
Osteosarcoma oncoprotein B FosB (Fragment)		MOUSE		125
Protein fosB		MOUSE		237
Osteosarcoma oncoprotein B FosB (Fragment)		MOUSE		149

Protein	Similar proteins		Species	Score	Length	Source
P13346	Protein fosB	)	HUMAN		338	UniRef90_P53539
Protein fosB		CANLF		338
FBJ murine osteosarcoma viral oncogene homolog B		PANTR		338
FOSB isoform 6		PONAB		338
Uncharacterized protein		PANPA		338
+154

Protein	Similar proteins		Species	Score	Length	Source
P13346	Protein fosB	)	HUMAN		338	UniRef50_P53539
Protein fosB		CANLF		338
FBJ murine osteosarcoma viral oncogene homolog B		PANTR		338
FOSB isoform 6		PONAB		338
Uncharacterized protein		PANPA		338
+202

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14897 mRNA Translation: CAA33026.1 AF093624 Genomic DNA Translation: AAD13196.1
CCDSⁱ	CCDS20897.1
PIRⁱ	S35477 TVMSFB
RefSeqⁱ	NP_032062.1, NM_008036.2 XP_006539606.1, XM_006539543.2
UniGeneⁱ	Mm.248335

3D structure databases

ProteinModelPortalⁱ	P13346
SMRⁱ	P13346
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199727, 2 interactors
CORUMⁱ	P13346
DIPⁱ	DIP-1067N
IntActⁱ	P13346, 1 interactor
STRINGⁱ	10090.ENSMUSP00000003640

PTM databases

iPTMnetⁱ	P13346
PhosphoSitePlusⁱ	P13346

Proteomic databases

MaxQBⁱ	P13346
PaxDbⁱ	P13346
PRIDEⁱ	P13346

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000003640; ENSMUSP00000003640; ENSMUSG00000003545
GeneIDⁱ	14282
KEGGⁱ	mmu:14282
UCSCⁱ	uc009flk.1 mouse

Organism-specific databases

CTDⁱ	2354
MGIⁱ	MGI:95575 Fosb

Phylogenomic databases

eggNOGⁱ	KOG1414 Eukaryota ENOG4111CH5 LUCA
GeneTreeⁱ	ENSGT00730000110541
HOGENOMⁱ	HOG000234334
HOVERGENⁱ	HBG005743
InParanoidⁱ	P13346
KOⁱ	K09029
OrthoDBⁱ	EOG091G0GGW
PhylomeDBⁱ	P13346
TreeFamⁱ	TF326301

Miscellaneous databases

ChiTaRSⁱ	Fosb mouse
Protein Ontology More...PROⁱ	PR:P13346
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000003545 Expressed in 96 organ(s), highest expression level in epididymal fat pad
CleanExⁱ	MM_FOSB
ExpressionAtlasⁱ	P13346 baseline and differential
Genevisibleⁱ	P13346 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000837 AP-1 IPR004827 bZIP IPR029813 FosB
PANTHERⁱ	PTHR23351 PTHR23351, 1 hit PTHR23351:SF3 PTHR23351:SF3, 1 hit
Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
PRINTSⁱ	PR00042 LEUZIPPRFOS
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FOSB_MOUSE
Accessionⁱ	P13346Primary (citable) accession number: P13346
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	January 1, 1990
	Last modified:	November 7, 2018
	This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P13346 (FOSB_MOUSE)

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Protein fosB

Fosb

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ