UniProtKB - P13346 (FOSB_MOUSE)
Protein
Protein fosB
Gene
Fosb
Organism
Mus musculus (Mouse)
Status
Functioni
FosB interacts with Jun proteins enhancing their DNA binding activity.
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- double-stranded DNA binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- cellular response to calcium ion Source: MGI
- cellular response to hormone stimulus Source: Ensembl
- female pregnancy Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to cAMP Source: Ensembl
- response to corticosterone Source: Ensembl
- response to drug Source: Ensembl
- response to mechanical stimulus Source: Ensembl
- response to morphine Source: Ensembl
- response to progesterone Source: Ensembl
- transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Protein fosB |
Gene namesi | Name:Fosb |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95575, Fosb |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Other locations
- intracellular membrane-bounded organelle Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076477 | 1 – 338 | Protein fosBAdd BLAST | 338 |
Proteomic databases
MaxQBi | P13346 |
PaxDbi | P13346 |
PRIDEi | P13346 |
ProteomicsDBi | 271710 |
PTM databases
iPTMneti | P13346 |
PhosphoSitePlusi | P13346 |
Expressioni
Inductioni
By growth factors.
Gene expression databases
Bgeei | ENSMUSG00000003545, Expressed in epididymal fat pad and 121 other tissues |
Genevisiblei | P13346, MM |
Interactioni
Subunit structurei
Heterodimer.
By similarityProtein-protein interaction databases
BioGRIDi | 199727, 2 interactors |
DIPi | DIP-1067N |
IntActi | P13346, 1 interactor |
STRINGi | 10090.ENSMUSP00000003640 |
Miscellaneous databases
RNActi | P13346, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 155 – 218 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 157 – 182 | Basic motifPROSITE-ProRule annotationAdd BLAST | 26 | |
Regioni | 183 – 211 | Leucine-zipperPROSITE-ProRule annotationAdd BLAST | 29 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000160358 |
HOGENOMi | CLU_049742_0_0_1 |
InParanoidi | P13346 |
OrthoDBi | 1221590at2759 |
PhylomeDBi | P13346 |
TreeFami | TF326301 |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR004827, bZIP IPR029813, FosB |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF3, PTHR23351:SF3, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PRINTSi | PR00042, LEUZIPPRFOS |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
P13346-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFQAFPGDYD SGSRCSSSPS AESQYLSSVD SFGSPPTAAA SQECAGLGEM
60 70 80 90 100
PGSFVPTVTA ITTSQDLQWL VQPTLISSMA QSQGQPLASQ PPAVDPYDMP
110 120 130 140 150
GTSYSTPGLS AYSTGGASGS GGPSTSTTTS GPVSARPARA RPRRPREETL
160 170 180 190 200
TPEEEEKRRV RRERNKLAAA KCRNRRRELT DRLQAETDQL EEEKAELESE
210 220 230 240 250
IAELQKEKER LEFVLVAHKP GCKIPYEEGP GPGPLAEVRD LPGSTSAKED
260 270 280 290 300
GFGWLLPPPP PPPLPFQSSR DAPPNLTASL FTHSEVQVLG DPFPVVSPSY
310 320 330
TSSFVLTCPE VSAFAGAQRT SGSEQPSDPL NSPSLLAL
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A140LIE4 | A0A140LIE4_MOUSE | Protein fosB | Fosb | 237 | Annotation score: | ||
A0A140LHW0 | A0A140LHW0_MOUSE | Protein fosB | Fosb | 299 | Annotation score: | ||
A0A140LHS3 | A0A140LHS3_MOUSE | Protein fosB | Fosb | 201 | Annotation score: | ||
A0A140LJH0 | A0A140LJH0_MOUSE | Protein fosB | Fosb | 302 | Annotation score: | ||
A0A140LIT4 | A0A140LIT4_MOUSE | Protein fosB | Fosb | 263 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14897 mRNA Translation: CAA33026.1 AF093624 Genomic DNA Translation: AAD13196.1 |
CCDSi | CCDS20897.1 |
PIRi | S35477, TVMSFB |
RefSeqi | NP_032062.1, NM_008036.2 XP_006539606.1, XM_006539543.2 |
Genome annotation databases
Ensembli | ENSMUST00000003640; ENSMUSP00000003640; ENSMUSG00000003545 |
GeneIDi | 14282 |
KEGGi | mmu:14282 |
UCSCi | uc009flk.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14897 mRNA Translation: CAA33026.1 AF093624 Genomic DNA Translation: AAD13196.1 |
CCDSi | CCDS20897.1 |
PIRi | S35477, TVMSFB |
RefSeqi | NP_032062.1, NM_008036.2 XP_006539606.1, XM_006539543.2 |
3D structure databases
SMRi | P13346 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199727, 2 interactors |
DIPi | DIP-1067N |
IntActi | P13346, 1 interactor |
STRINGi | 10090.ENSMUSP00000003640 |
PTM databases
iPTMneti | P13346 |
PhosphoSitePlusi | P13346 |
Proteomic databases
MaxQBi | P13346 |
PaxDbi | P13346 |
PRIDEi | P13346 |
ProteomicsDBi | 271710 |
Protocols and materials databases
Antibodypediai | 4139, 530 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000003640; ENSMUSP00000003640; ENSMUSG00000003545 |
GeneIDi | 14282 |
KEGGi | mmu:14282 |
UCSCi | uc009flk.1, mouse |
Organism-specific databases
CTDi | 2354 |
MGIi | MGI:95575, Fosb |
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000160358 |
HOGENOMi | CLU_049742_0_0_1 |
InParanoidi | P13346 |
OrthoDBi | 1221590at2759 |
PhylomeDBi | P13346 |
TreeFami | TF326301 |
Miscellaneous databases
BioGRID-ORCSi | 14282, 0 hits in 52 CRISPR screens |
ChiTaRSi | Fosb, mouse |
PROi | PR:P13346 |
RNActi | P13346, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000003545, Expressed in epididymal fat pad and 121 other tissues |
Genevisiblei | P13346, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR004827, bZIP IPR029813, FosB |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF3, PTHR23351:SF3, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PRINTSi | PR00042, LEUZIPPRFOS |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FOSB_MOUSE | |
Accessioni | P13346Primary (citable) accession number: P13346 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | January 1, 1990 | |
Last modified: | April 7, 2021 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families