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Protein

Recombination endonuclease VII

Gene

49

Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cleaves DNA cruciform and Y-structures as well as heteroduplex loops. Resolves Holliday junctions, recognizes a broad spectrum of DNA substrates ranging from branched DNAs to single base mismatches.

Cofactori

Protein has several cofactor binding sites:
  • Ca2+Note: Binds 1 Ca2+ ion per subunit.
  • Zn2+Note: Binds 1 zinc ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi23Zinc1
Metal bindingi26Zinc1
Metal bindingi40Calcium1
Metal bindingi58Zinc1
Metal bindingi61Zinc1
Metal bindingi62Calcium1

GO - Molecular functioni

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.1.22.4 732

Names & Taxonomyi

Protein namesi
Recommended name:
Recombination endonuclease VII (EC:3.1.-.-)
Short name:
Endo VII
Alternative name(s):
Gene product 49
Short name:
gp49
Gene namesi
Name:49
OrganismiEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifieri10665 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000009087 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000033261 – 157Recombination endonuclease VIIAdd BLAST157

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

DIPiDIP-60245N

Structurei

Secondary structure

1157
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 18Combined sources13
Turni19 – 21Combined sources3
Turni24 – 26Combined sources3
Helixi34 – 36Combined sources3
Beta strandi37 – 41Combined sources5
Beta strandi45 – 47Combined sources3
Turni48 – 51Combined sources4
Beta strandi52 – 57Combined sources6
Helixi59 – 74Combined sources16
Beta strandi75 – 77Combined sources3
Helixi78 – 80Combined sources3
Helixi84 – 96Combined sources13
Helixi107 – 117Combined sources11
Helixi121 – 130Combined sources10
Beta strandi137 – 139Combined sources3
Helixi141 – 155Combined sources15

3D structure databases

ProteinModelPortaliP13340
SMRiP13340
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13340

Family & Domainsi

Phylogenomic databases

KOiK18960
OrthoDBiVOG090000ZV

Family and domain databases

Gene3Di3.40.1800.10, 1 hit
InterProiView protein in InterPro
IPR004211 Endonuclease_7
IPR038563 Endonuclease_7_sf
IPR036309 T4_recomb_endonuclease_dim_sf
IPR015208 T4_recomb_endonuclease_dimer
PfamiView protein in Pfam
PF09124 Endonuc-dimeris, 1 hit
PF02945 Endonuclease_7, 1 hit
SUPFAMiSSF68918 SSF68918, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform Long (identifier: P13340-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLTGKLYKE EKQKFYDAQN GKCLICQREL NPDVQANHLD HDHELNGPKA
60 70 80 90 100
GKVRGLLCNL CNAAEGQMKH KFNRSGLKGQ GVDYLEWLEN LLTYLKSDYT
110 120 130 140 150
QNNIHPNFVG DKSKEFSRLG KEEMMAEMLQ RGFEYNESDT KTQLIASFKK

QLRKSLK
Length:157
Mass (Da):18,144
Last modified:January 1, 1990 - v1
Checksum:i86233D2A7FC0F9A8
GO
Isoform Short (identifier: P13340-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.
     53-53: V → M

Show »
Length:105
Mass (Da):12,213
Checksum:iB2EDCD7FA9B65546
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0186781 – 52Missing in isoform Short. CuratedAdd BLAST52
Alternative sequenceiVSP_01898653V → M in isoform Short. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12629 Genomic DNA Translation: CAA31148.1
X12629 Genomic DNA Translation: CAA31149.1
Y00122 Genomic DNA Translation: CAA68307.1
AF158101 Genomic DNA Translation: AAD42477.1
AF158101 Genomic DNA Translation: AAD42687.2
PIRiS01906 ZNBPT9
RefSeqiNP_049692.1, NC_000866.4 [P13340-1]
NP_049693.2, NC_000866.4 [P13340-2]

Genome annotation databases

GeneIDi1258702
1258772
KEGGivg:1258702
vg:1258772

Keywords - Coding sequence diversityi

Alternative initiation

Entry informationi

Entry nameiEND7_BPT4
AccessioniPrimary (citable) accession number: P13340
Secondary accession number(s): Q38426, Q9T0V4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: March 28, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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