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Protein

Tail sheath protein

Gene

18

Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Structural component of the bacteriophage tail which consists of a contractile sheath, a tube and a baseplate. The central cylindrical segment of the tail consists of a rigid tube, composed of multiple copies of gp19, surrounded by the outer contractile sheath assembled from gp18 subunits. A total of 138 copies of gp18 arranged into 23 hexameric rings constitutes the sheath. During infection, contraction of the sheath drives the central tube through the host outer membrane, creating a channel for DNA ejection from the capsid into the host cell.1 Publication

GO - Biological processi

Keywordsi

Molecular functionViral contractile tail ejection system
Biological process

Protein family/group databases

TCDBi1.K.1.1.1 the gp27/5 t4-baseplate (t4-bp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Tail sheath protein
Short name:
TSP
Alternative name(s):
Gene product 18
Short name:
gp18
Gene namesi
Name:18
OrganismiEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifieri10665 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000009087 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • virion Source: CACAO
  • virus tail, sheath Source: UniProtKB

Keywords - Cellular componenti

Viral tail protein, Viral tail sheath protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved; by host
ChainiPRO_00001650072 – 659Tail sheath proteinAdd BLAST658

Proteomic databases

PRIDEiP13332

Interactioni

Subunit structurei

Hexamer.

Structurei

Secondary structure

1659
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiP13332
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13332

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi172 – 176Ser-rich5

Sequence similaritiesi

Phylogenomic databases

KOiK21531
OrthoDBiVOG0900003X

Family and domain databases

InterProiView protein in InterPro
IPR035326 Phage_sheath_beta
IPR035089 Phage_sheath_subtilisin
IPR020287 Tail_sheath_C
PfamiView protein in Pfam
PF04984 Phage_sheath_1, 1 hit
PF17482 Phage_sheath_1C, 1 hit
PF17481 Phage_sheath_1N, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13332-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLLSPGIEL KETTVQSTVV NNSTGTAALA GKFQWGPAFQ IKQVTNEVDL
60 70 80 90 100
VNTFGQPTAE TADYFMSAMN FLQYGNDLRV VRAVDRDTAK NSSPIAGNID
110 120 130 140 150
YTISTPGSNY AVGDKITVKY VSDDIETEGK ITEVDADGKI KKINIPTGKN
160 170 180 190 200
YAKAKEVGEY PTLGSNWTAE ISSSSSGLAA VITLGKIITD SGILLAEIEN
210 220 230 240 250
AEAAMTAVDF QANLKKYGIP GVVALYPGEL GDKIEIEIVS KADYAKGASA
260 270 280 290 300
LLPIYPGGGT RASTAKAVFG YGPQTDSQYA IIVRRNDAIV QSVVLSTKRG
310 320 330 340 350
EKDIYDSNIY IDDFFAKGGS EYIFATAQNW PEGFSGILTL SGGLSSNAEV
360 370 380 390 400
TAGDLMEAWD FFADRESVDV QLFIAGSCAG ESLETASTVQ KHVVSIGDAR
410 420 430 440 450
QDCLVLCSPP RETVVGIPVT RAVDNLVNWR TAAGSYTDNN FNISSTYAAI
460 470 480 490 500
DGNHKYQYDK YNDVNRWVPL AADIAGLCAR TDNVSQTWMS PAGYNRGQIL
510 520 530 540 550
NVIKLAIETR QAQRDRLYQE AINPVTGTGG DGYVLYGDKT ATSVPSPFDR
560 570 580 590 600
INVRRLFNML KTNIGRSSKY RLFELNNAFT RSSFRTETAQ YLQGNKALGG
610 620 630 640 650
IYEYRVVCDT TNNTPSVIDR NEFVATFYIQ PARSINYITL NFVATATGAD

FDELTGLAG
Length:659
Mass (Da):71,331
Last modified:January 23, 2007 - v5
Checksum:i5E5974F5BF799816
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100D → E in AAA32541 (PubMed:2964531).Curated1
Sequence conflicti148 – 151GKNY → AKII in AAA32541 (PubMed:2964531).Curated4
Sequence conflicti301E → G in AAA32541 (PubMed:2964531).Curated1
Sequence conflicti399A → V in AAA32541 (PubMed:2964531).Curated1
Sequence conflicti454H → Y in AAA32541 (PubMed:2964531).Curated1
Sequence conflicti595N → I in AAA32541 (PubMed:2964531).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19085 Genomic DNA Translation: AAA32541.1
AF158101 Genomic DNA Translation: AAD42423.1
PIRiA60885
JF0021 GKBPT4
RefSeqiNP_049780.1, NC_000866.4

Genome annotation databases

GeneIDi1258597
KEGGivg:1258597

Similar proteinsi

Entry informationi

Entry nameiTSP_BPT4
AccessioniPrimary (citable) accession number: P13332
Secondary accession number(s): Q9T0U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 100 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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