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Protein

Endoribonuclease RegB

Gene

regB

Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential to the early nucleolytic processing of a number of T4 messenger RNAs. Specifically cleaves after the GG dinucleotide GGAG within consensus 5'-GGAGRAYARAA-3' (R is a purine and Y is a pyrimidine) sequences found mainly in translation initiation sites.2 Publications

Activity regulationi

Activity is stimulated 10- to 100-fold by host ribosomal protein S1, which also helps confer substrate choice.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
Endoribonuclease RegB (EC:3.1.-.-)
Alternative name(s):
Gp61.9
Gene namesi
Name:regB
Synonyms:61.9
OrganismiEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifieri10665 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000009087 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001649731 – 153Endoribonuclease RegBAdd BLAST153

Structurei

Secondary structure

1153
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP13312
SMRiP13312
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13312

Family & Domainsi

Phylogenomic databases

OrthoDBiVOG090000Y3

Family and domain databases

InterProiView protein in InterPro
IPR019653 T4_endoribonuclease_RegB
PfamiView protein in Pfam
PF10715 REGB_T4, 1 hit

Sequencei

Sequence statusi: Complete.

P13312-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTINTEVFIR RNKLRRHFES EFRQINNEIR EASKAAGVSS FHLKYSQHLL
60 70 80 90 100
DRAIQREIDE TYVFELFHKI KDHVLEVNEF LSMPPRPDID EDFIDGVEYR
110 120 130 140 150
PGRLEITDGN LWLGFTVCKP NEKFKDPSLQ CRMAIINSRR LPGKASKAVI

KTQ
Length:153
Mass (Da):17,977
Last modified:January 1, 1990 - v1
Checksum:iD61494E883F4C9D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04567 Genomic DNA Translation: CAA28227.1
AF158101 Genomic DNA Translation: AAD42652.1
RefSeqiNP_049726.1, NC_000866.4

Genome annotation databases

GeneIDi1258703
KEGGivg:1258703

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04567 Genomic DNA Translation: CAA28227.1
AF158101 Genomic DNA Translation: AAD42652.1
RefSeqiNP_049726.1, NC_000866.4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HX6NMR-A1-153[»]
ProteinModelPortaliP13312
SMRiP13312
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1258703
KEGGivg:1258703

Phylogenomic databases

OrthoDBiVOG090000Y3

Miscellaneous databases

EvolutionaryTraceiP13312

Family and domain databases

InterProiView protein in InterPro
IPR019653 T4_endoribonuclease_RegB
PfamiView protein in Pfam
PF10715 REGB_T4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiREGB_BPT4
AccessioniPrimary (citable) accession number: P13312
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: September 12, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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