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Protein

Intron-associated endonuclease 1

Gene

ITEVIR

Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This endonuclease is specific to the thymidylate synthase (td) gene splice junction and is involved in intron homing.

Cofactori

GO - Molecular functioni

  • bacterial-type RNA polymerase transcriptional repressor activity, metal ion regulated sequence-specific DNA binding Source: CAFA
  • DNA binding Source: CAFA
  • endonuclease activity Source: CAFA
  • sequence-specific DNA binding Source: CAFA
  • zinc ion binding Source: CAFA

GO - Biological processi

  • intron homing Source: UniProtKB-KW
  • negative regulation of transcription, DNA-templated Source: CAFA
  • nucleic acid phosphodiester bond hydrolysis Source: CAFA

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processIntron homing
LigandMagnesium

Protein family/group databases

MoonProtiP13299
REBASEi2625 I-TevI

Names & Taxonomyi

Protein namesi
Recommended name:
Intron-associated endonuclease 1 (EC:3.1.-.-)
Alternative name(s):
I-TevI
IRF protein
Gene namesi
Name:ITEVIR
OrganismiEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifieri10665 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000009087 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • transcriptional repressor complex Source: CAFA

Pathology & Biotechi

Chemistry databases

DrugBankiDB04272 Citric Acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001927921 – 245Intron-associated endonuclease 1Add BLAST245

Proteomic databases

PRIDEiP13299

Structurei

Secondary structure

1245
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 10Combined sources7
Turni11 – 13Combined sources3
Beta strandi16 – 23Combined sources8
Helixi24 – 37Combined sources14
Helixi43 – 52Combined sources10
Beta strandi56 – 63Combined sources8
Helixi68 – 81Combined sources14
Turni82 – 86Combined sources5
Beta strandi87 – 89Combined sources3
Beta strandi154 – 156Combined sources3
Turni165 – 167Combined sources3
Helixi172 – 174Combined sources3
Turni176 – 179Combined sources4
Helixi184 – 194Combined sources11
Beta strandi205 – 207Combined sources3
Beta strandi210 – 214Combined sources5
Helixi215 – 222Combined sources8
Helixi226 – 234Combined sources9
Beta strandi240 – 242Combined sources3

3D structure databases

ProteinModelPortaliP13299
SMRiP13299
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13299

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 88GIY-YIGPROSITE-ProRule annotationAdd BLAST88

Sequence similaritiesi

To endonucleases of group I introns of fungi and phage.Curated

Phylogenomic databases

OrthoDBiVOG090000LF

Family and domain databases

Gene3Di3.40.1440.10, 1 hit
InterProiView protein in InterPro
IPR000305 GIY-YIG_endonuc
IPR035901 GIY-YIG_endonuc_sf
IPR006350 Intron_endoG1
IPR003611 NUMOD3
PfamiView protein in Pfam
PF01541 GIY-YIG, 1 hit
PF07460 NUMOD3, 2 hits
SMARTiView protein in SMART
SM00465 GIYc, 1 hit
SM00496 IENR2, 2 hits
SUPFAMiSSF82771 SSF82771, 1 hit
TIGRFAMsiTIGR01453 grpIintron_endo, 1 hit
PROSITEiView protein in PROSITE
PS50164 GIY_YIG, 1 hit

Sequencei

Sequence statusi: Complete.

P13299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSGIYQIKN TLNNKVYVGS AKDFEKRWKR HFKDLEKGCH SSIKLQRSFN
60 70 80 90 100
KHGNVFECSI LEEIPYEKDL IIERENFWIK ELNSKINGYN IADATFGDTC
110 120 130 140 150
STHPLKEEII KKRSETVKAK MLKLGPDGRK ALYSKPGSKN GRWNPETHKF
160 170 180 190 200
CKCGVRIQTS AYTCSKCRNR SGENNSFFNH KHSDITKSKI SEKMKGKKPS
210 220 230 240
NIKKISCDGV IFDCAADAAR HFKISSGLVT YRVKSDKWNW FYINA
Length:245
Mass (Da):28,232
Last modified:July 15, 1999 - v2
Checksum:i29DF2ACF08ECD64C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12742 Genomic DNA Translation: AAC12817.1
AF158101 Genomic DNA Translation: AAD42521.3
PIRiT10130
RefSeqiNP_049849.3, NC_000866.4

Genome annotation databases

GeneIDi1258722
KEGGivg:1258722

Similar proteinsi

Entry informationi

Entry nameiTEV1_BPT4
AccessioniPrimary (citable) accession number: P13299
Secondary accession number(s): Q9T0T3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 15, 1999
Last modified: October 25, 2017
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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