UniProtKB - P13297 (MSX1_MOUSE)
Protein
Homeobox protein MSX-1
Gene
Msx1
Organism
Mus musculus (Mouse)
Status
Functioni
Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis.2 Publications
Caution
It is uncertain whether Met-1 or Met-7 is the initiator.Curated
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 172 – 231 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- cis-regulatory region sequence-specific DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SB
- p53 binding Source: MGI
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- activation of meiosis Source: MGI
- anterior/posterior pattern specification Source: MGI
- BMP signaling pathway Source: MGI
- BMP signaling pathway involved in heart development Source: MGI
- bone morphogenesis Source: MGI
- cartilage development Source: MGI
- cartilage morphogenesis Source: MGI
- cell morphogenesis Source: MGI
- cellular response to nicotine Source: Ensembl
- embryonic digit morphogenesis Source: MGI
- embryonic forelimb morphogenesis Source: MGI
- embryonic hindlimb morphogenesis Source: MGI
- embryonic limb morphogenesis Source: MGI
- embryonic morphogenesis Source: GO_Central
- embryonic nail plate morphogenesis Source: BHF-UCL
- epithelial to mesenchymal transition Source: UniProtKB
- epithelial to mesenchymal transition involved in endocardial cushion formation Source: MGI
- face morphogenesis Source: BHF-UCL
- forebrain development Source: MGI
- heart development Source: MGI
- heart morphogenesis Source: MGI
- in utero embryonic development Source: MGI
- mammary gland epithelium development Source: MGI
- mesenchymal cell proliferation Source: UniProtKB
- midbrain development Source: MGI
- middle ear morphogenesis Source: MGI
- muscle organ development Source: MGI
- negative regulation of apoptotic process Source: MGI
- negative regulation of cell growth Source: MGI
- negative regulation of cell population proliferation Source: MGI
- negative regulation of DNA binding Source: MGI
- negative regulation of striated muscle cell differentiation Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: NTNU_SB
- negative regulation of transcription regulatory region DNA binding Source: MGI
- odontogenesis Source: UniProtKB
- odontogenesis of dentin-containing tooth Source: BHF-UCL
- pituitary gland development Source: Ensembl
- positive regulation of BMP signaling pathway Source: MGI
- positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator Source: MGI
- positive regulation of mesenchymal cell apoptotic process Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- protein localization to nucleus Source: MGI
- protein stabilization Source: MGI
- regulation of odontogenesis Source: MGI
- roof of mouth development Source: MGI
- signal transduction involved in regulation of gene expression Source: MGI
- stem cell differentiation Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein MSX-1Alternative name(s): Homeobox protein Hox-7 Hox-7.1 Msh homeobox 1-like protein |
Gene namesi | Name:Msx1 Synonyms:Hox7, Hox7.1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97168, Msx1 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 15 | K → R: Abolishes sumoylation. 1 Publication | 1 | |
Mutagenesisi | 53 | K → R: Sumoylated. 1 Publication | 1 | |
Mutagenesisi | 72 | K → R: Sumoylated. 1 Publication | 1 | |
Mutagenesisi | 125 | K → R: Sumoylated. 1 Publication | 1 | |
Mutagenesisi | 133 | K → R: Abolishes sumoylation. 1 Publication | 1 | |
Mutagenesisi | 139 | K → R: Sumoylated. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000049091 | 1 – 303 | Homeobox protein MSX-1Add BLAST | 303 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 15 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) | ||
Cross-linki | 133 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) |
Post-translational modificationi
Sumoylated by PIAS1, desumoylated by SENP1.1 Publication
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
PaxDbi | P13297 |
PRIDEi | P13297 |
PTM databases
iPTMneti | P13297 |
PhosphoSitePlusi | P13297 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000048450, Expressed in remnant of Rathke's pouch and 393 other tissues |
Genevisiblei | P13297, MM |
Interactioni
Binary interactionsi
Hide detailsGO - Molecular functioni
- p53 binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 201536, 12 interactors |
IntActi | P13297, 5 interactors |
STRINGi | 10090.ENSMUSP00000058354 |
Miscellaneous databases
RNActi | P13297, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P13297 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P13297 |
Family & Domainsi
Sequence similaritiesi
Belongs to the Msh homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0492, Eukaryota |
GeneTreei | ENSGT00940000161623 |
HOGENOMi | CLU_072675_1_0_1 |
InParanoidi | P13297 |
OMAi | KQERTPW |
OrthoDBi | 1226077at2759 |
PhylomeDBi | P13297 |
TreeFami | TF350699 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P13297-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPAAAMTSL PLGVKVEDSA FAKPAGGGVG QAPGAAAATA TAMGTDEEGA
60 70 80 90 100
KPKVPASLLP FSVEALMADH RKPGAKESVL VASEGAQAAG GSVQHLGTRP
110 120 130 140 150
GSLGAPDAPS SPRPLGHFSV GGLLKLPEDA LVKAESPEKL DRTPWMQSPR
160 170 180 190 200
FSPPPARRLS PPACTLRKHK TNRKPRTPFT TAQLLALERK FRQKQYLSIA
210 220 230 240 250
ERAEFSSSLS LTETQVKIWF QNRRAKAKRL QEAELEKLKM AAKPMLPPAA
260 270 280 290 300
FGLSFPLGGP AAVAAAAGAS LYSASGPFQR AALPVAPVGL YTAHVGYSMY
HLT
Sequence cautioni
The sequence AAH16426 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA32871 differs from that shown. Reason: Frameshift.Curated
The sequence CAA32871 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 263 – 266 | Missing in CAA41944 (PubMed:1682128).Curated | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14759 mRNA Translation: CAA32871.1 Sequence problems. X59251 mRNA Translation: CAA41944.1 AF308572 mRNA Translation: AAG32466.1 AC114671 Genomic DNA No translation available. CH466524 Genomic DNA Translation: EDL37531.1 BC016426 mRNA Translation: AAH16426.1 Different initiation. X14457 Genomic DNA Translation: CAA32626.1 M38575 Genomic DNA Translation: AAA37823.1 |
CCDSi | CCDS19249.1 |
PIRi | PS0411 S03636 S18813 |
RefSeqi | NP_034965.2, NM_010835.2 |
Genome annotation databases
Ensembli | ENSMUST00000063116; ENSMUSP00000058354; ENSMUSG00000048450 |
GeneIDi | 17701 |
KEGGi | mmu:17701 |
UCSCi | uc008xfw.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X14759 mRNA Translation: CAA32871.1 Sequence problems. X59251 mRNA Translation: CAA41944.1 AF308572 mRNA Translation: AAG32466.1 AC114671 Genomic DNA No translation available. CH466524 Genomic DNA Translation: EDL37531.1 BC016426 mRNA Translation: AAH16426.1 Different initiation. X14457 Genomic DNA Translation: CAA32626.1 M38575 Genomic DNA Translation: AAA37823.1 |
CCDSi | CCDS19249.1 |
PIRi | PS0411 S03636 S18813 |
RefSeqi | NP_034965.2, NM_010835.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1IG7 | X-ray | 2.20 | A | 173-230 | [»] | |
SMRi | P13297 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 201536, 12 interactors |
IntActi | P13297, 5 interactors |
STRINGi | 10090.ENSMUSP00000058354 |
PTM databases
iPTMneti | P13297 |
PhosphoSitePlusi | P13297 |
Proteomic databases
PaxDbi | P13297 |
PRIDEi | P13297 |
Protocols and materials databases
Antibodypediai | 9270, 370 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000063116; ENSMUSP00000058354; ENSMUSG00000048450 |
GeneIDi | 17701 |
KEGGi | mmu:17701 |
UCSCi | uc008xfw.1, mouse |
Organism-specific databases
CTDi | 4487 |
MGIi | MGI:97168, Msx1 |
Phylogenomic databases
eggNOGi | KOG0492, Eukaryota |
GeneTreei | ENSGT00940000161623 |
HOGENOMi | CLU_072675_1_0_1 |
InParanoidi | P13297 |
OMAi | KQERTPW |
OrthoDBi | 1226077at2759 |
PhylomeDBi | P13297 |
TreeFami | TF350699 |
Miscellaneous databases
BioGRID-ORCSi | 17701, 0 hits in 17 CRISPR screens |
EvolutionaryTracei | P13297 |
PROi | PR:P13297 |
RNActi | P13297, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000048450, Expressed in remnant of Rathke's pouch and 393 other tissues |
Genevisiblei | P13297, MM |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MSX1_MOUSE | |
Accessioni | P13297Primary (citable) accession number: P13297 Secondary accession number(s): Q91W75, Q9ERF6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | November 13, 2013 | |
Last modified: | December 2, 2020 | |
This is version 197 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families