Homeobox protein MSX-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 15192231
  • 7916326
  • 9369446
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • 22071108
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SBInferred from direct assayⁱ
  • 8861098
• enhancer binding Source: MGIInferred from direct assayⁱ
  • 27741242
• p53 binding Source: MGI
• RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 8861098
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • 8858134
• transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • 18285513

GO - Biological processⁱ

• activation of meiosis Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 22071108
• anterior/posterior pattern specification Source: MGIInferred from genetic interactionⁱ
  • 21465616
• BMP signaling pathway Source: MGIInferred from direct assayⁱ
  • 18590716
• BMP signaling pathway involved in heart development Source: MGIInferred from genetic interactionⁱ
  • 18667074
• bone morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 12489152
  • 16330189
• cartilage development Source: MGI
• cartilage morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 12489152
• cell morphogenesis Source: MGI
• cellular response to nicotine Source: Ensembl
• embryonic digit morphogenesis Source: MGIInferred from genetic interactionⁱ
  • 21465616
• embryonic forelimb morphogenesis Source: MGIInferred from genetic interactionⁱ
  • 21465616
• embryonic hindlimb morphogenesis Source: MGIInferred from genetic interactionⁱ
  • 21465616
• embryonic limb morphogenesis Source: MGIInferred from genetic interactionⁱ
  • 15930102
  • 19422820
• embryonic nail plate morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 11369996
• epithelial to mesenchymal transition Source: UniProtKBInferred from mutant phenotypeⁱ
  • 11023873
• epithelial to mesenchymal transition involved in endocardial cushion formation Source: MGIInferred from genetic interactionⁱ
  • 18667074
• face morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 11369996
• forebrain development Source: MGIInferred from mutant phenotypeⁱ
  • 15188430
  • 15217086
• heart development Source: MGIInferred from genetic interactionⁱ
  • 17601530
• heart morphogenesis Source: MGIInferred from genetic interactionⁱ
  • 17601530
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • 17601530
• mammary gland epithelium development Source: MGIInferred from genetic interactionⁱ
  • 10742104
• mesenchymal cell proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • 11023873
• midbrain development Source: MGIInferred from mutant phenotypeⁱ
  • 15188430
• middle ear morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 16330189
• muscle organ development Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 15192231
• negative regulation of apoptotic process Source: MGIInferred from genetic interactionⁱ
  • 17601530
• negative regulation of cell growth Source: MGI
• negative regulation of cell proliferation Source: MGIInferred from genetic interactionⁱ
  • 17601530
• negative regulation of DNA binding Source: MGIInferred from direct assayⁱ
  • 17030628
• negative regulation of striated muscle cell differentiation Source: MGIInferred from direct assayⁱ
  • 20004191
• negative regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • 15192231
• negative regulation of transcription by RNA polymerase II Source: NTNU_SBInferred from direct assayⁱ
  • 8861098
• negative regulation of transcription regulatory region DNA binding Source: MGIInferred from genetic interactionⁱ
  • 9697309
• odontogenesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • 11023873
• odontogenesis of dentin-containing tooth Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 11369996
• pituitary gland development Source: Ensembl
• positive regulation of BMP signaling pathway Source: MGIInferred from genetic interactionⁱ
  • 18667074
• positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator Source: MGI
• positive regulation of mesenchymal cell apoptotic process Source: MGIInferred from genetic interactionⁱ
  • 19422820
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from mutant phenotypeⁱ
  • 8898217
• protein localization to nucleus Source: MGI
• protein stabilization Source: MGI
• regulation of odontogenesis Source: MGIInferred from genetic interactionⁱ
  • 20123092
• roof of mouth development Source: MGIInferred from mutant phenotypeⁱ
  • 16330189
• signal transduction involved in regulation of gene expression Source: MGIInferred from genetic interactionⁱ
  • 21465616
• stem cell differentiation Source: MGIInferred from genetic interactionⁱ
  • 17693062

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• p53 binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAPAAAMTSL PLGVKVEDSA FAKPAGGGVG QAPGAAAATA TAMGTDEEGA 
        60         70         80         90        100
KPKVPASLLP FSVEALMADH RKPGAKESVL VASEGAQAAG GSVQHLGTRP 
       110        120        130        140        150
GSLGAPDAPS SPRPLGHFSV GGLLKLPEDA LVKAESPEKL DRTPWMQSPR 
       160        170        180        190        200
FSPPPARRLS PPACTLRKHK TNRKPRTPFT TAQLLALERK FRQKQYLSIA 
       210        220        230        240        250
ERAEFSSSLS LTETQVKIWF QNRRAKAKRL QEAELEKLKM AAKPMLPPAA 
       260        270        280        290        300
FGLSFPLGGP AAVAAAAGAS LYSASGPFQR AALPVAPVGL YTAHVGYSMY 

HLT                                                    

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references