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Protein

Homeobox protein MSX-1

Gene

Msx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis.2 Publications

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi172 – 231HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein MSX-1
Alternative name(s):
Homeobox protein Hox-7
Hox-7.1
Msh homeobox 1-like protein
Gene namesi
Name:Msx1
Synonyms:Hox7, Hox7.1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:97168 Msx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi15K → R: Abolishes sumoylation. 1 Publication1
Mutagenesisi53K → R: Sumoylated. 1 Publication1
Mutagenesisi72K → R: Sumoylated. 1 Publication1
Mutagenesisi125K → R: Sumoylated. 1 Publication1
Mutagenesisi133K → R: Abolishes sumoylation. 1 Publication1
Mutagenesisi139K → R: Sumoylated. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000490911 – 303Homeobox protein MSX-1Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki15Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Cross-linki133Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Post-translational modificationi

Sumoylated by PIAS1, desumoylated by SENP1.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP13297
PRIDEiP13297

PTM databases

iPTMnetiP13297
PhosphoSitePlusiP13297

Expressioni

Gene expression databases

BgeeiENSMUSG00000048450 Expressed in 378 organ(s), highest expression level in remnant of Rathke's pouch
CleanExiMM_MSX1
GenevisibleiP13297 MM

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201536, 12 interactors
IntActiP13297, 5 interactors
STRINGi10090.ENSMUSP00000058354

Structurei

Secondary structure

1303
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP13297
SMRiP13297
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13297

Family & Domainsi

Sequence similaritiesi

Belongs to the Msh homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0492 Eukaryota
ENOG410YT2J LUCA
GeneTreeiENSGT00920000148979
HOGENOMiHOG000231922
HOVERGENiHBG005205
InParanoidiP13297
KOiK09341
OMAiCMAPSIA
OrthoDBiEOG091G0P1V
PhylomeDBiP13297
TreeFamiTF350699

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P13297-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPAAAMTSL PLGVKVEDSA FAKPAGGGVG QAPGAAAATA TAMGTDEEGA
60 70 80 90 100
KPKVPASLLP FSVEALMADH RKPGAKESVL VASEGAQAAG GSVQHLGTRP
110 120 130 140 150
GSLGAPDAPS SPRPLGHFSV GGLLKLPEDA LVKAESPEKL DRTPWMQSPR
160 170 180 190 200
FSPPPARRLS PPACTLRKHK TNRKPRTPFT TAQLLALERK FRQKQYLSIA
210 220 230 240 250
ERAEFSSSLS LTETQVKIWF QNRRAKAKRL QEAELEKLKM AAKPMLPPAA
260 270 280 290 300
FGLSFPLGGP AAVAAAAGAS LYSASGPFQR AALPVAPVGL YTAHVGYSMY

HLT
Length:303
Mass (Da):31,672
Last modified:November 13, 2013 - v4
Checksum:i8E07FF038AEF0EDF
GO

Sequence cautioni

The sequence AAH16426 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA32871 differs from that shown. Reason: Frameshift at position 252.Curated
The sequence CAA32871 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti263 – 266Missing in CAA41944 (PubMed:1682128).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14759 mRNA Translation: CAA32871.1 Sequence problems.
X59251 mRNA Translation: CAA41944.1
AF308572 mRNA Translation: AAG32466.1
AC114671 Genomic DNA No translation available.
CH466524 Genomic DNA Translation: EDL37531.1
BC016426 mRNA Translation: AAH16426.1 Different initiation.
X14457 Genomic DNA Translation: CAA32626.1
M38575 Genomic DNA Translation: AAA37823.1
CCDSiCCDS19249.1
PIRiPS0411
S03636
S18813
RefSeqiNP_034965.2, NM_010835.2
UniGeneiMm.256509

Genome annotation databases

EnsembliENSMUST00000063116; ENSMUSP00000058354; ENSMUSG00000048450
GeneIDi17701
KEGGimmu:17701
UCSCiuc008xfw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14759 mRNA Translation: CAA32871.1 Sequence problems.
X59251 mRNA Translation: CAA41944.1
AF308572 mRNA Translation: AAG32466.1
AC114671 Genomic DNA No translation available.
CH466524 Genomic DNA Translation: EDL37531.1
BC016426 mRNA Translation: AAH16426.1 Different initiation.
X14457 Genomic DNA Translation: CAA32626.1
M38575 Genomic DNA Translation: AAA37823.1
CCDSiCCDS19249.1
PIRiPS0411
S03636
S18813
RefSeqiNP_034965.2, NM_010835.2
UniGeneiMm.256509

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IG7X-ray2.20A173-230[»]
ProteinModelPortaliP13297
SMRiP13297
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201536, 12 interactors
IntActiP13297, 5 interactors
STRINGi10090.ENSMUSP00000058354

PTM databases

iPTMnetiP13297
PhosphoSitePlusiP13297

Proteomic databases

PaxDbiP13297
PRIDEiP13297

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063116; ENSMUSP00000058354; ENSMUSG00000048450
GeneIDi17701
KEGGimmu:17701
UCSCiuc008xfw.1 mouse

Organism-specific databases

CTDi4487
MGIiMGI:97168 Msx1

Phylogenomic databases

eggNOGiKOG0492 Eukaryota
ENOG410YT2J LUCA
GeneTreeiENSGT00920000148979
HOGENOMiHOG000231922
HOVERGENiHBG005205
InParanoidiP13297
KOiK09341
OMAiCMAPSIA
OrthoDBiEOG091G0P1V
PhylomeDBiP13297
TreeFamiTF350699

Miscellaneous databases

EvolutionaryTraceiP13297
PROiPR:P13297
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000048450 Expressed in 378 organ(s), highest expression level in remnant of Rathke's pouch
CleanExiMM_MSX1
GenevisibleiP13297 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMSX1_MOUSE
AccessioniPrimary (citable) accession number: P13297
Secondary accession number(s): Q91W75, Q9ERF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 13, 2013
Last modified: September 12, 2018
This is version 182 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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