Homeobox protein MSX-1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cis-regulatory region binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Coordinately Co-opted Multiple Transposable Elements Constitute an Enhancer for wnt5a Expression in the Mammalian Secondary Palate."
    Nishihara H., Kobayashi N., Kimura-Yoshida C., Yan K., Bormuth O., Ding Q., Nakanishi A., Sasaki T., Hirakawa M., Sumiyama K., Furuta Y., Tarabykin V., Matsuo I., Okada N.
    PLoS Genet. 12:e1006380-e1006380(2016) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • "Msx1 and Msx2 promote meiosis initiation."
    Le Bouffant R., Souquet B., Duval N., Duquenne C., Herve R., Frydman N., Robert B., Habert R., Livera G.
    Development 138:5393-5402(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • "Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43."
    Boogerd K.J., Wong L.Y., Christoffels V.M., Klarenbeek M., Ruijter J.M., Moorman A.F., Barnett P.
    Cardiovasc. Res. 78:485-493(2008) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SBInferred from direct assayⁱ
  • "Comparison of MSX-1 and MSX-2 suggests a molecular basis for functional redundancy."
    Catron K.M., Wang H., Hu G., Shen M.M., Abate-Shen C.
    Mech. Dev. 55:185-199(1996) [PubMed] [Europe PMC] [Abstract]
• p53 binding Source: MGI
• RNA polymerase II regulatory region sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis."
    Lee H., Habas R., Abate-Shen C.
    Science 304:1675-1678(2004) [PubMed] [Europe PMC] [Abstract]
  • "Murine homeobox-containing gene, Msx-1: analysis of genomic organization, promoter structure, and potential autoregulatory cis-acting elements."
    Kuzuoka M., Takahashi T., Guron C., Raghow R.
    Genomics 21:85-91(1994) [PubMed] [Europe PMC] [Abstract]
  • "Msx1 is present in thyrotropic cells and binds to a consensus site on the glycoprotein hormone alpha-subunit promoter."
    Sarapura V.D., Strouth H.L., Gordon D.F., Wood W.M., Ridgway E.C.
    Mol. Endocrinol. 11:1782-1794(1997) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "Rapid identification of homeodomain binding sites in the Wnt-5a gene using an immunoprecipitation strategy."
    Iler N., Abate-Shen C.
    Biochem. Biophys. Res. Commun. 227:257-265(1996) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• activation of meiosis Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Msx1 and Msx2 promote meiosis initiation."
    Le Bouffant R., Souquet B., Duval N., Duquenne C., Herve R., Frydman N., Robert B., Habert R., Livera G.
    Development 138:5393-5402(2011) [PubMed] [Europe PMC] [Abstract]
• anterior/posterior pattern specification Source: MGIInferred from genetic interactionⁱ
  • "Msx1 and Msx2 in limb mesenchyme modulate digit number and identity."
    Bensoussan-Trigano V., Lallemand Y., Saint Cloment C., Robert B.
    Dev. Dyn. 240:1190-1202(2011) [PubMed] [Europe PMC] [Abstract]
• BMP signaling pathway Source: MGIInferred from direct assayⁱ
  • "FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism."
    Cho A., Ko H.W., Eggenschwiler J.T.
    Dev. Biol. 321:27-39(2008) [PubMed] [Europe PMC] [Abstract]
• BMP signaling pathway involved in heart development Source: MGIInferred from genetic interactionⁱ
  • "Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium."
    Chen Y.H., Ishii M., Sucov H.M., Maxson R.E. Jr.
    BMC Dev. Biol. 8:75-75(2008) [PubMed] [Europe PMC] [Abstract]
• bone morphogenesis Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Msx1 is a regulator of bone formation during development and postnatal growth: in vivo investigations in a transgenic mouse model."
    Orestes-Cardoso S., Nefussi J.R., Lezot F., Oboeuf M., Pereira M., Mesbah M., Robert B., Berdal A.
    Connect. Tissue Res. 43:153-160(2002) [PubMed] [Europe PMC] [Abstract]
  • "Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation."
    Levi G., Mantero S., Barbieri O., Cantatore D., Paleari L., Beverdam A., Genova F., Robert B., Merlo G.R.
    Mech. Dev. 123:3-16(2006) [PubMed] [Europe PMC] [Abstract]
• cartilage development Source: MGI
• cartilage morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Msx1 is a regulator of bone formation during development and postnatal growth: in vivo investigations in a transgenic mouse model."
    Orestes-Cardoso S., Nefussi J.R., Lezot F., Oboeuf M., Pereira M., Mesbah M., Robert B., Berdal A.
    Connect. Tissue Res. 43:153-160(2002) [PubMed] [Europe PMC] [Abstract]
• cell morphogenesis Source: MGI
• cellular response to nicotine Source: Ensembl
• embryonic digit morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Msx1 and Msx2 in limb mesenchyme modulate digit number and identity."
    Bensoussan-Trigano V., Lallemand Y., Saint Cloment C., Robert B.
    Dev. Dyn. 240:1190-1202(2011) [PubMed] [Europe PMC] [Abstract]
• embryonic forelimb morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Msx1 and Msx2 in limb mesenchyme modulate digit number and identity."
    Bensoussan-Trigano V., Lallemand Y., Saint Cloment C., Robert B.
    Dev. Dyn. 240:1190-1202(2011) [PubMed] [Europe PMC] [Abstract]
• embryonic hindlimb morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Msx1 and Msx2 in limb mesenchyme modulate digit number and identity."
    Bensoussan-Trigano V., Lallemand Y., Saint Cloment C., Robert B.
    Dev. Dyn. 240:1190-1202(2011) [PubMed] [Europe PMC] [Abstract]
• embryonic limb morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development."
    Lallemand Y., Nicola M.A., Ramos C., Bach A., Cloment C.S., Robert B.
    Development 132:3003-3014(2005) [PubMed] [Europe PMC] [Abstract]
  • "Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb."
    Lallemand Y., Bensoussan V., Cloment C.S., Robert B.
    Dev. Biol. 331:189-198(2009) [PubMed] [Europe PMC] [Abstract]
• embryonic morphogenesis Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• embryonic nail plate morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "A nonsense mutation in MSX1 causes Witkop syndrome."
    Jumlongras D., Bei M., Stimson J.M., Wang W.-F., DePalma S.R., Seidman C.E., Felbor U., Maas R., Seidman J.G., Olsen B.R.
    Am. J. Hum. Genet. 69:67-74(2001) [PubMed] [Europe PMC] [Abstract]
• epithelial to mesenchymal transition Source: UniProtKBInferred from mutant phenotypeⁱ
  • "BMP4 rescues a non-cell-autonomous function of Msx1 in tooth development."
    Bei M., Kratochwil K., Maas R.L.
    Development 127:4711-4718(2000) [PubMed] [Europe PMC] [Abstract]
• epithelial to mesenchymal transition involved in endocardial cushion formation Source: MGIInferred from genetic interactionⁱ
  • "Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium."
    Chen Y.H., Ishii M., Sucov H.M., Maxson R.E. Jr.
    BMC Dev. Biol. 8:75-75(2008) [PubMed] [Europe PMC] [Abstract]
• face morphogenesis Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "A nonsense mutation in MSX1 causes Witkop syndrome."
    Jumlongras D., Bei M., Stimson J.M., Wang W.-F., DePalma S.R., Seidman C.E., Felbor U., Maas R., Seidman J.G., Olsen B.R.
    Am. J. Hum. Genet. 69:67-74(2001) [PubMed] [Europe PMC] [Abstract]
• forebrain development Source: MGIInferred from mutant phenotypeⁱ
  • "Msx1 disruption leads to diencephalon defects and hydrocephalus."
    Ramos C., Fernandez-Llebrez P., Bach A., Robert B., Soriano E.
    Dev. Dyn. 230:446-460(2004) [PubMed] [Europe PMC] [Abstract]
  • "Msx1-deficient mice fail to form prosomere 1 derivatives, subcommissural organ, and posterior commissure and develop hydrocephalus."
    Fernandez-Llebrez P., Grondona J.M., Perez J., Lopez-Aranda M.F., Estivill-Torrus G., Llebrez-Zayas P.F., Soriano E., Ramos C., Lallemand Y., Bach A., Robert B.
    J. Neuropathol. Exp. Neurol. 63:574-586(2004) [PubMed] [Europe PMC] [Abstract]
• heart development Source: MGIInferred from genetic interactionⁱ
  • "Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract."
    Chen Y.H., Ishii M., Sun J., Sucov H.M., Maxson R.E. Jr.
    Dev. Biol. 308:421-437(2007) [PubMed] [Europe PMC] [Abstract]
• heart morphogenesis Source: MGIInferred from genetic interactionⁱ
  • "Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract."
    Chen Y.H., Ishii M., Sun J., Sucov H.M., Maxson R.E. Jr.
    Dev. Biol. 308:421-437(2007) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • "Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract."
    Chen Y.H., Ishii M., Sun J., Sucov H.M., Maxson R.E. Jr.
    Dev. Biol. 308:421-437(2007) [PubMed] [Europe PMC] [Abstract]
• mammary gland epithelium development Source: MGIInferred from genetic interactionⁱ
  • "Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation."
    Satokata I., Ma L., Ohshima H., Bei M., Woo I., Nishizawa K., Maeda T., Takano Y., Uchiyama M., Heaney S., Peters H., Tang Z., Maxson R., Maas R.
    Nat. Genet. 24:391-395(2000) [PubMed] [Europe PMC] [Abstract]
• mesenchymal cell proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "BMP4 rescues a non-cell-autonomous function of Msx1 in tooth development."
    Bei M., Kratochwil K., Maas R.L.
    Development 127:4711-4718(2000) [PubMed] [Europe PMC] [Abstract]
• midbrain development Source: MGIInferred from mutant phenotypeⁱ
  • "Msx1 disruption leads to diencephalon defects and hydrocephalus."
    Ramos C., Fernandez-Llebrez P., Bach A., Robert B., Soriano E.
    Dev. Dyn. 230:446-460(2004) [PubMed] [Europe PMC] [Abstract]
• middle ear morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation."
    Levi G., Mantero S., Barbieri O., Cantatore D., Paleari L., Beverdam A., Genova F., Robert B., Merlo G.R.
    Mech. Dev. 123:3-16(2006) [PubMed] [Europe PMC] [Abstract]
• muscle organ development Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis."
    Lee H., Habas R., Abate-Shen C.
    Science 304:1675-1678(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: MGIInferred from genetic interactionⁱ
  • "Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract."
    Chen Y.H., Ishii M., Sun J., Sucov H.M., Maxson R.E. Jr.
    Dev. Biol. 308:421-437(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell growth Source: MGI
• negative regulation of cell population proliferation Source: MGIInferred from genetic interactionⁱ
  • "Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract."
    Chen Y.H., Ishii M., Sun J., Sucov H.M., Maxson R.E. Jr.
    Dev. Biol. 308:421-437(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA binding Source: MGIInferred from direct assayⁱ
  • "Bone morphogenetic protein-induced MSX1 and MSX2 inhibit myocardin-dependent smooth muscle gene transcription."
    Hayashi K., Nakamura S., Nishida W., Sobue K.
    Mol. Cell. Biol. 26:9456-9470(2006) [PubMed] [Europe PMC] [Abstract]
• negative regulation of striated muscle cell differentiation Source: MGIInferred from direct assayⁱ
  • "YB1/p32, a nuclear Y-box binding protein 1, is a novel regulator of myoblast differentiation that interacts with Msx1 homeoprotein."
    Song Y.J., Lee H.
    Exp. Cell Res. 316:517-529(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • "MSX1 cooperates with histone H1b for inhibition of transcription and myogenesis."
    Lee H., Habas R., Abate-Shen C.
    Science 304:1675-1678(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: NTNU_SBInferred from direct assayⁱ
  • "Comparison of MSX-1 and MSX-2 suggests a molecular basis for functional redundancy."
    Catron K.M., Wang H., Hu G., Shen M.M., Abate-Shen C.
    Mech. Dev. 55:185-199(1996) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription regulatory region DNA binding Source: MGIInferred from genetic interactionⁱ
  • "Protein complex formation between Msx1 and Lhx2 homeoproteins is incompatible with DNA binding activity."
    Bendall A.J., Rincon-Limas D.E., Botas J., Abate-Shen C.
    Differentiation 63:151-157(1998) [PubMed] [Europe PMC] [Abstract]
• odontogenesis Source: UniProtKBInferred from mutant phenotypeⁱ
  • "BMP4 rescues a non-cell-autonomous function of Msx1 in tooth development."
    Bei M., Kratochwil K., Maas R.L.
    Development 127:4711-4718(2000) [PubMed] [Europe PMC] [Abstract]
• odontogenesis of dentin-containing tooth Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "A nonsense mutation in MSX1 causes Witkop syndrome."
    Jumlongras D., Bei M., Stimson J.M., Wang W.-F., DePalma S.R., Seidman C.E., Felbor U., Maas R., Seidman J.G., Olsen B.R.
    Am. J. Hum. Genet. 69:67-74(2001) [PubMed] [Europe PMC] [Abstract]
• pituitary gland development Source: Ensembl
• positive regulation of BMP signaling pathway Source: MGIInferred from genetic interactionⁱ
  • "Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium."
    Chen Y.H., Ishii M., Sucov H.M., Maxson R.E. Jr.
    BMC Dev. Biol. 8:75-75(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator Source: MGI
• positive regulation of mesenchymal cell apoptotic process Source: MGIInferred from genetic interactionⁱ
  • "Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb."
    Lallemand Y., Bensoussan V., Cloment C.S., Robert B.
    Dev. Biol. 331:189-198(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from mutant phenotypeⁱ
  • "Msx1 controls inductive signaling in mammalian tooth morphogenesis."
    Chen Y., Bei M., Woo I., Satokata I., Maas R.
    Development 122:3035-3044(1996) [PubMed] [Europe PMC] [Abstract]
• protein localization to nucleus Source: MGI
• protein stabilization Source: MGI
• regulation of odontogenesis Source: MGIInferred from genetic interactionⁱ
  • "Genetic interactions between Pax9 and Msx1 regulate lip development and several stages of tooth morphogenesis."
    Nakatomi M., Wang X.P., Key D., Lund J.J., Turbe-Doan A., Kist R., Aw A., Chen Y., Maas R.L., Peters H.
    Dev. Biol. 340:438-449(2010) [PubMed] [Europe PMC] [Abstract]
• roof of mouth development Source: MGIInferred from mutant phenotypeⁱ
  • "Msx1 and Dlx5 act independently in development of craniofacial skeleton, but converge on the regulation of Bmp signaling in palate formation."
    Levi G., Mantero S., Barbieri O., Cantatore D., Paleari L., Beverdam A., Genova F., Robert B., Merlo G.R.
    Mech. Dev. 123:3-16(2006) [PubMed] [Europe PMC] [Abstract]
• signal transduction involved in regulation of gene expression Source: MGIInferred from genetic interactionⁱ
  • "Msx1 and Msx2 in limb mesenchyme modulate digit number and identity."
    Bensoussan-Trigano V., Lallemand Y., Saint Cloment C., Robert B.
    Dev. Dyn. 240:1190-1202(2011) [PubMed] [Europe PMC] [Abstract]
• stem cell differentiation Source: MGIInferred from genetic interactionⁱ
  • "Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development."
    Han J., Ishii M., Bringas P. Jr., Maas R.L., Maxson R.E. Jr., Chai Y.
    Mech. Dev. 124:729-745(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• p53 binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MAPAAAMTSL PLGVKVEDSA FAKPAGGGVG QAPGAAAATA TAMGTDEEGA 
        60         70         80         90        100
KPKVPASLLP FSVEALMADH RKPGAKESVL VASEGAQAAG GSVQHLGTRP 
       110        120        130        140        150
GSLGAPDAPS SPRPLGHFSV GGLLKLPEDA LVKAESPEKL DRTPWMQSPR 
       160        170        180        190        200
FSPPPARRLS PPACTLRKHK TNRKPRTPFT TAQLLALERK FRQKQYLSIA 
       210        220        230        240        250
ERAEFSSSLS LTETQVKIWF QNRRAKAKRL QEAELEKLKM AAKPMLPPAA 
       260        270        280        290        300
FGLSFPLGGP AAVAAAAGAS LYSASGPFQR AALPVAPVGL YTAHVGYSMY 

HLT                                                    

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families
3. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot