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Protein

Gamma-interferon-inducible lysosomal thiol reductase

Gene

IFI30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity). Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity).By similarity

Miscellaneous

Both precursor form and mature form have thiol reductase activity.

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Kinetic parameters shown are for mature enzyme.
  1. KM=1200 µM for F(ab')2 fragment when denatured1 Publication
  2. KM=10 µM for F(ab')2 fragment1 Publication

    pH dependencei

    Optimum pH is 4-5.1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • oxidoreductase activity, acting on a sulfur group of donors Source: UniProtKB

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    Biological processImmunity

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-2132295 MHC class II antigen presentation
    R-HSA-877300 Interferon gamma signaling

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Gamma-interferon-inducible lysosomal thiol reductase (EC:1.8.-.-2 Publications)
    Alternative name(s):
    Gamma-interferon-inducible protein IP-30
    Legumaturain
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:IFI30
    Synonyms:GILT, IP30
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000216490.3

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:5398 IFI30

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    604664 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P13284

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Lysosome, Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi72C → S: Abolishes reducing activity, does not affect dimerization. Abolishes reducing activity; when associated with S-75. 2 Publications1
    Mutagenesisi75C → S: Abolishes reducing activity, does not affect dimerization. Abolishes reducing activity; when associated with S-72. 2 Publications1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    10437

    Open Targets

    More...
    OpenTargetsi
    ENSG00000216490

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA29644

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    IFI30

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    327478582

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002132827 – 57Removed in mature form1 PublicationAdd BLAST31
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002132958 – 232Gamma-interferon-inducible lysosomal thiol reductaseAdd BLAST175
    PropeptideiPRO_0000021330233 – 250Removed in mature form1 PublicationAdd BLAST18

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi72 ↔ 75Redox-active2 Publications
    Glycosylationi95N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    N-glycosylated. Sugar chains contain mannose-6-phosphate.2 Publications
    Synthesized as a 35 kDa precursor which is then processed into the mature 30 kDa form via cleavage of N-terminal and C-terminal propeptides. Processing of the precursor is mediated by multiple lysosomal proteases.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    P13284

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    P13284

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P13284

    PeptideAtlas

    More...
    PeptideAtlasi
    P13284

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P13284

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    52905

    PTM databases

    GlyConnect protein glycosylation platform

    More...
    GlyConnecti
    1262

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P13284

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P13284

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Expressed constitutively in antigen-presenting cells and induced by IFN-gamma in other cell types.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000216490 Expressed in 98 organ(s), highest expression level in blood

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_IFI30

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P13284 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P13284 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA026650

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Dimer; disulfide-linked.2 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    115704, 43 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    P13284, 8 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000384886

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    P13284

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the GILT family.Curated

    Keywords - Domaini

    Redox-active center, Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3160 Eukaryota
    ENOG4111IDT LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000010450

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000238423

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG005837

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P13284

    KEGG Orthology (KO)

    More...
    KOi
    K08059

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    ITEQVYP

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G0IMC

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P13284

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF315141

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR004911 Interferon-induced_GILT

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR13234 PTHR13234, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF03227 GILT, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    P13284-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MTLSPLLLFL PPLLLLLDVP TAAVQASPLQ ALDFFGNGPP VNYKTGNLYL
    60 70 80 90 100
    RGPLKKSNAP LVNVTLYYEA LCGGCRAFLI RELFPTWLLV MEILNVTLVP
    110 120 130 140 150
    YGNAQEQNVS GRWEFKCQHG EEECKFNKVE ACVLDELDME LAFLTIVCME
    160 170 180 190 200
    EFEDMERSLP LCLQLYAPGL SPDTIMECAM GDRGMQLMHA NAQRTDALQP
    210 220 230 240 250
    PHEYVPWVTV NGKPLEDQTQ LLTLVCQLYQ GKKPDVCPSS TSSLRSVCFK
    Length:250
    Mass (Da):27,964
    Last modified:April 5, 2011 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i54B4950E3788CD5A
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    M0QZG3M0QZG3_HUMAN
    Gamma-interferon-inducible lysosoma...
    IFI30
    105Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAA36105 differs from that shown. Chimeric cDNA. N-terminal sequence identical to a region of chromosome 11.Curated
    The sequence AAA36105 differs from that shown. Reason: Frameshift at positions 146 and 174.Curated
    The sequence AAA36105 differs from that shown. Reason: Erroneous termination at position 251. Translated as stop.Curated
    The sequence AAF04618 differs from that shown. Chimeric cDNA. N-terminal sequence identical to a region of chromosome 11.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti76R → Q in AAH31020 (PubMed:15489334).Curated1
    Sequence conflicti98L → S in AAA36105 (PubMed:3136170).Curated1
    Sequence conflicti119H → L in AAA36105 (PubMed:3136170).Curated1
    Sequence conflicti148C → WHG in AAA36105 (PubMed:3136170).Curated1
    Sequence conflicti223T → A in BAC98466 (Ref. 3) Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    J03909 mRNA Translation: AAA36105.1 Sequence problems.
    AF097362 mRNA Translation: AAF04618.1 Sequence problems.
    AB049659 mRNA Translation: BAC98466.1
    AC007192 Genomic DNA No translation available.
    AC093080 Genomic DNA No translation available.
    AC068499 Genomic DNA No translation available.
    CH471106 Genomic DNA Translation: EAW84662.1
    BC021136 mRNA Translation: AAH21136.1
    BC031020 mRNA Translation: AAH31020.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS46015.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A43708

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_006323.2, NM_006332.4

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.14623

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000407280; ENSP00000384886; ENSG00000216490

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    10437

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:10437

    UCSC genome browser

    More...
    UCSCi
    uc002nic.3 human

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    J03909 mRNA Translation: AAA36105.1 Sequence problems.
    AF097362 mRNA Translation: AAF04618.1 Sequence problems.
    AB049659 mRNA Translation: BAC98466.1
    AC007192 Genomic DNA No translation available.
    AC093080 Genomic DNA No translation available.
    AC068499 Genomic DNA No translation available.
    CH471106 Genomic DNA Translation: EAW84662.1
    BC021136 mRNA Translation: AAH21136.1
    BC031020 mRNA Translation: AAH31020.1
    CCDSiCCDS46015.1
    PIRiA43708
    RefSeqiNP_006323.2, NM_006332.4
    UniGeneiHs.14623

    3D structure databases

    ProteinModelPortaliP13284
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi115704, 43 interactors
    IntActiP13284, 8 interactors
    STRINGi9606.ENSP00000384886

    PTM databases

    GlyConnecti1262
    iPTMnetiP13284
    PhosphoSitePlusiP13284

    Polymorphism and mutation databases

    BioMutaiIFI30
    DMDMi327478582

    Proteomic databases

    EPDiP13284
    MaxQBiP13284
    PaxDbiP13284
    PeptideAtlasiP13284
    PRIDEiP13284
    ProteomicsDBi52905

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    10437
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000407280; ENSP00000384886; ENSG00000216490
    GeneIDi10437
    KEGGihsa:10437
    UCSCiuc002nic.3 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    10437
    DisGeNETi10437
    EuPathDBiHostDB:ENSG00000216490.3

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    IFI30
    HGNCiHGNC:5398 IFI30
    HPAiHPA026650
    MIMi604664 gene
    neXtProtiNX_P13284
    OpenTargetsiENSG00000216490
    PharmGKBiPA29644

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3160 Eukaryota
    ENOG4111IDT LUCA
    GeneTreeiENSGT00390000010450
    HOGENOMiHOG000238423
    HOVERGENiHBG005837
    InParanoidiP13284
    KOiK08059
    OMAiITEQVYP
    OrthoDBiEOG091G0IMC
    PhylomeDBiP13284
    TreeFamiTF315141

    Enzyme and pathway databases

    ReactomeiR-HSA-2132295 MHC class II antigen presentation
    R-HSA-877300 Interferon gamma signaling

    Miscellaneous databases

    The Gene Wiki collection of pages on human genes and proteins

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    GeneWikii
    IFI30

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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    GenomeRNAii
    10437

    Protein Ontology

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    PROi
    PR:P13284

    The Stanford Online Universal Resource for Clones and ESTs

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    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000216490 Expressed in 98 organ(s), highest expression level in blood
    CleanExiHS_IFI30
    ExpressionAtlasiP13284 baseline and differential
    GenevisibleiP13284 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR004911 Interferon-induced_GILT
    PANTHERiPTHR13234 PTHR13234, 1 hit
    PfamiView protein in Pfam
    PF03227 GILT, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGILT_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13284
    Secondary accession number(s): Q76MF9
    , Q8NEI4, Q8WU77, Q9UL08
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
    Last sequence update: April 5, 2011
    Last modified: December 5, 2018
    This is version 144 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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