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Protein

Cytochrome b-c1 complex subunit 8

Gene

UQCRQ

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-BTA-611105 Respiratory electron transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 8
Alternative name(s):
Complex III subunit 8
Complex III subunit VIII
Ubiquinol-cytochrome c reductase complex 9.5 kDa protein
Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C
Gene namesi
Name:UQCRQ
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Organism-specific databases

VGNCiVGNC:36697 UQCRQ

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001935432 – 82Cytochrome b-c1 complex subunit 8Add BLAST81

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33N6-acetyllysine; alternateBy similarity1
Modified residuei33N6-succinyllysine; alternateBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP13271
PRIDEiP13271

Expressioni

Gene expression databases

BgeeiENSBTAG00000009479 Expressed in 9 organ(s), highest expression level in adult mammalian kidney

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

CORUMiP13271
DIPiDIP-38971N
IntActiP13271, 2 interactors
STRINGi9913.ENSBTAP00000040860

Structurei

Secondary structure

182
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP13271
SMRiP13271
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13271

Family & Domainsi

Sequence similaritiesi

Belongs to the UQCRQ/QCR8 family.Curated

Phylogenomic databases

eggNOGiKOG4116 Eukaryota
ENOG41123BH LUCA
GeneTreeiENSGT00390000004029
HOGENOMiHOG000205681
HOVERGENiHBG001468
InParanoidiP13271
KOiK00418
OMAiCILRVAP
OrthoDBiEOG091G13Z0
TreeFamiTF300281

Family and domain databases

Gene3Di1.20.5.210, 1 hit
InterProiView protein in InterPro
IPR004205 Cyt_bc1_su8
IPR036642 Cyt_bc1_su8_sf
PANTHERiPTHR12119 PTHR12119, 1 hit
PfamiView protein in Pfam
PF02939 UcrQ, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD331499 UcrQ, 1 hit
SUPFAMiSSF81508 SSF81508, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13271-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRQFGHLTR VRHVITYSLS PFEQRAFPHY FSKGIPNVLR RTRACILRVA
60 70 80
PPFVAFYLVY TWGTQEFEKS KRKNPAAYEN DR
Length:82
Mass (Da):9,720
Last modified:January 23, 2007 - v3
Checksum:i38D7E52051EB7FFA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62W → C AA sequence (PubMed:3009231).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06665 mRNA Translation: AAB03845.1
BC103110 mRNA Translation: AAI03111.1
PIRiA24864
RefSeqiNP_777230.1, NM_174805.2
UniGeneiBt.49658

Genome annotation databases

EnsembliENSBTAT00000043278; ENSBTAP00000040860; ENSBTAG00000009479
GeneIDi286885
KEGGibta:286885

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06665 mRNA Translation: AAB03845.1
BC103110 mRNA Translation: AAI03111.1
PIRiA24864
RefSeqiNP_777230.1, NM_174805.2
UniGeneiBt.49658

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BCCX-ray3.16G2-82[»]
1BE3X-ray3.00G2-82[»]
1BGYX-ray3.00G/S2-82[»]
1L0LX-ray2.35G2-82[»]
1L0NX-ray2.60G2-82[»]
1NTKX-ray2.60G2-82[»]
1NTMX-ray2.40G2-82[»]
1NTZX-ray2.60G2-82[»]
1NU1X-ray3.20G2-82[»]
1PP9X-ray2.10G/T2-82[»]
1PPJX-ray2.10G/T2-82[»]
1QCRX-ray2.70G2-71[»]
1SQBX-ray2.69G2-82[»]
1SQPX-ray2.70G2-82[»]
1SQQX-ray3.00G2-82[»]
1SQVX-ray2.85G2-82[»]
1SQXX-ray2.60G2-82[»]
2A06X-ray2.10G/T2-82[»]
2BCCX-ray3.50G2-82[»]
2FYUX-ray2.26G2-82[»]
2YBBelectron microscopy19.00G/g2-82[»]
3BCCX-ray3.70G2-82[»]
4D6TX-ray3.57G/T1-82[»]
4D6UX-ray4.09G/T1-82[»]
5GPNelectron microscopy5.40G/S2-82[»]
5KLVX-ray2.65G2-81[»]
5LUFelectron microscopy9.10g/s2-82[»]
5NMIX-ray3.50G/T1-82[»]
5OKDX-ray3.10G1-82[»]
6FO0electron microscopy4.10G/T1-82[»]
6FO2electron microscopy4.40G/T1-82[»]
6FO6electron microscopy4.10G/T1-82[»]
ProteinModelPortaliP13271
SMRiP13271
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP13271
DIPiDIP-38971N
IntActiP13271, 2 interactors
STRINGi9913.ENSBTAP00000040860

Proteomic databases

PaxDbiP13271
PRIDEiP13271

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000043278; ENSBTAP00000040860; ENSBTAG00000009479
GeneIDi286885
KEGGibta:286885

Organism-specific databases

CTDi27089
VGNCiVGNC:36697 UQCRQ

Phylogenomic databases

eggNOGiKOG4116 Eukaryota
ENOG41123BH LUCA
GeneTreeiENSGT00390000004029
HOGENOMiHOG000205681
HOVERGENiHBG001468
InParanoidiP13271
KOiK00418
OMAiCILRVAP
OrthoDBiEOG091G13Z0
TreeFamiTF300281

Enzyme and pathway databases

ReactomeiR-BTA-611105 Respiratory electron transport

Miscellaneous databases

EvolutionaryTraceiP13271

Gene expression databases

BgeeiENSBTAG00000009479 Expressed in 9 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

Gene3Di1.20.5.210, 1 hit
InterProiView protein in InterPro
IPR004205 Cyt_bc1_su8
IPR036642 Cyt_bc1_su8_sf
PANTHERiPTHR12119 PTHR12119, 1 hit
PfamiView protein in Pfam
PF02939 UcrQ, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD331499 UcrQ, 1 hit
SUPFAMiSSF81508 SSF81508, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQCR8_BOVIN
AccessioniPrimary (citable) accession number: P13271
Secondary accession number(s): Q3ZBT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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