CCL4

Functionⁱ

Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.3 Publications

Caution

Was originally thought to be a ligand for CCR8.1 Publication

GO - Molecular functionⁱ

CCR1 chemokine receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 7545673
CCR5 chemokine receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10383387
- 10679098
chemokine activity Source: GO_Central
cytokine activity
Source: ProtInc
Traceable author statementⁱ
- 2462251
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 20959807

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell adhesion
Source: ProtInc
Traceable author statementⁱ
- 10929056
cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 2521882
cellular response to interferon-gamma Source: GO_Central
cellular response to interleukin-1 Source: GO_Central
cellular response to tumor necrosis factor Source: GO_Central
chemokine-mediated signaling pathway Source: GO_Central
cytokine-mediated signaling pathway Source: Reactome
establishment or maintenance of cell polarity
Source: ProtInc
Traceable author statementⁱ
- 9759849
G-protein coupled receptor signaling pathway Source: GO_Central
immune response
Source: ProtInc
Traceable author statementⁱ
- 10929056
inflammatory response Source: GO_Central
monocyte chemotaxis Source: GO_Central
negative regulation by host of viral transcription
Source: UniProtKB
Inferred from direct assayⁱ
- 10841574
neutrophil chemotaxis Source: GO_Central
positive regulation of calcium ion transport
Source: UniProtKB
Inferred from direct assayⁱ
- 8699119
positive regulation of calcium-mediated signaling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 10679098
positive regulation of ERK1 and ERK2 cascade Source: GO_Central
positive regulation of GTPase activity Source: GO_Central
positive regulation of natural killer cell chemotaxis
Source: UniProtKB
Inferred from direct assayⁱ
- 7545673
response to toxic substance
Source: UniProtKB
Inferred from direct assayⁱ
- 10841574
response to virus
Source: ProtInc
Traceable author statementⁱ
- 9743377
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 10929056
- 9558100

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine
Biological process	Chemotaxis, Inflammatory response

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events R-HSA-6783783 Interleukin-10 signaling
SIGNORⁱ	P13236

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C-C motif chemokine 4 Alternative name(s): G-26 T-lymphocyte-secreted protein HC21 Lymphocyte activation gene 1 protein Short name: LAG-1 MIP-1-beta(1-69) Macrophage inflammatory protein 1-beta Short name: MIP-1-beta PAT 744 Protein H400 SIS-gamma Small-inducible cytokine A4 T-cell activation protein 2 Short name: ACT-2 Cleaved into the following chain: MIP-1-beta(3-69)
Gene namesⁱ	Name:CCL4 Synonyms:LAG1, MIP1B, SCYA4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000275302.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10630 CCL4
MIMⁱ	182284 gene
neXtProtⁱ	NX_P13236

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	388372 6351 9560
Open Targets More...OpenTargetsⁱ	ENSG00000275302
PharmGKBⁱ	PA35563

Polymorphism and mutation databases

BioMutaⁱ	CCL4
DMDMⁱ	127080

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 23	Add BLAST	23
ChainⁱPRO_0000005164	24 – 92	C-C motif chemokine 4Add BLAST	69
ChainⁱPRO_0000005165	26 – 92	MIP-1-beta(3-69)Add BLAST	67

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	34 ↔ 58	By similarity
Disulfide bondⁱ	35 ↔ 74	By similarity

Post-translational modificationⁱ

N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	P13236
PeptideAtlas More...PeptideAtlasⁱ	P13236
PRIDEⁱ	P13236
ProteomicsDBⁱ	52904

Expressionⁱ

Inductionⁱ

By mitogens.

Gene expression databases

Bgeeⁱ	ENSG00000275302 Expressed in 161 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_CCL4
ExpressionAtlasⁱ	P13236 baseline and differential
Genevisibleⁱ	P13236 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB007805

HPAⁱ

CAB007805

Interactionⁱ

Subunit structureⁱ

Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
itself		3	EBI-2873970,EBI-2873970
CCR5	P51681	2	EBI-6625160,EBI-489374
SLC30A2	Q9BRI3	5	EBI-2873970,EBI-8644112

GO - Molecular functionⁱ

CCR1 chemokine receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 7545673
CCR5 chemokine receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 10383387
- 10679098
chemokine activity Source: GO_Central
cytokine activity
Source: ProtInc
Traceable author statementⁱ
- 2462251
identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 20959807

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112254, 6 interactors
Database of interacting proteins More...DIPⁱ	DIP-5840N
IntActⁱ	P13236, 23 interactors
Molecular INTeraction database More...MINTⁱ	P13236
STRINGⁱ	9606.ENSP00000250151

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	26 – 28	Combined sources	3
Turnⁱ	30 – 32	Combined sources	3
Helixⁱ	45 – 47	Combined sources	3
Beta strandⁱ	48 – 53	Combined sources	6
Beta strandⁱ	58 – 60	Combined sources	3
Beta strandⁱ	63 – 67	Combined sources	5
Beta strandⁱ	68 – 70	Combined sources	3
Beta strandⁱ	72 – 75	Combined sources	4
Helixⁱ	80 – 90	Combined sources	11

Show more details

3D structure databases

ProteinModelPortalⁱ	P13236
SMRⁱ	P13236
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P13236

EvolutionaryTraceⁱ

P13236

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the intercrine beta (chemokine CC) family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J4I9 Eukaryota ENOG410YXJU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140870
HOGENOMⁱ	HOG000036685
HOVERGENⁱ	HBG017871
InParanoidⁱ	P13236
KEGG Orthology (KO) More...KOⁱ	K12964
OMAⁱ	RSKQVCA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G14Y2
PhylomeDBⁱ	P13236
TreeFamⁱ	TF334888

Family and domain databases

InterProⁱ	View protein in InterPro IPR000827 Chemokine_CC_CS IPR001811 Chemokine_IL8-like_dom IPR036048 Interleukin_8-like_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00048 IL8, 1 hit
SMARTⁱ	View protein in SMART SM00199 SCY, 1 hit
SUPFAMⁱ	SSF54117 SSF54117, 1 hit
PROSITEⁱ	View protein in PROSITE PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P13236-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKLCVTVLSL LMLVAAFCSP ALSAPMGSDP PTACCFSYTA RKLPRNFVVD 
        60         70         80         90 
YYETSSLCSQ PAVVFQTKRS KQVCADPSES WVQEYVYDLE LN

Length:92

Mass (Da):10,212

Last modified:January 1, 1990 - v1

Checksum:ⁱF2EA7CF341B0E258

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q7M4M2	Q7M4M2_HUMAN		C-C motif chemokine 4 C-C motif chemokine 4 (CC chemokine ligand 4d2) (Monocyte adherence-induced protein 5 alpha)	CCL4	52	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	6	T → C in AAA36752 (PubMed:2809212).Curated	1
Sequence conflictⁱ	15	A → S in AAB00790 (PubMed:1894635).Curated	1
Sequence conflictⁱ	40 – 45	ARKLPR → REASS in AAA36656 (PubMed:2521353).Curated	6
Sequence conflictⁱ	56	S → I in AAA36752 (PubMed:2809212).Curated	1
Sequence conflictⁱ	70	S → G in CAA37722 (PubMed:1894635).Curated	1
Sequence conflictⁱ	70	S → G in AAB00790 (PubMed:1894635).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_048702	12	M → V. Corresponds to variant dbSNP:rs1049752Ensembl.	1
Natural variantⁱVAR_048703	20	P → L. Corresponds to variant dbSNP:rs1130750Ensembl.	1
Natural variantⁱVAR_059211	80	S → T2 PublicationsCorresponds to variant dbSNP:rs1719152Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04130 mRNA Translation: AAA51576.1 M25316 mRNA Translation: AAA57256.1 M23502 mRNA Translation: AAA36656.1 X53683 mRNA Translation: CAA37723.1 X53682 Genomic DNA Translation: CAA37722.2 Sequence problems. X16166 mRNA Translation: CAA34291.1 M69203, M69201, M69202 Genomic DNA Translation: AAB00790.1 AY766446 mRNA Translation: AAX07305.1 AY766459 Genomic DNA Translation: AAX07292.1 CR542119 mRNA Translation: CAG46916.1 AC003976 Genomic DNA No translation available. BC104226 mRNA Translation: AAI04227.1 BC104227 mRNA Translation: AAI04228.1 BC107433 mRNA Translation: AAI07434.1 M57503 mRNA Translation: AAA36752.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11308.1
PIRⁱ	JH0319 A31767
NCBI Reference Sequences More...RefSeqⁱ	NP_002975.1, NM_002984.3 NP_996890.1, NM_207007.3
UniGeneⁱ	Hs.449862 Hs.515183 Hs.75703

Genome annotation databases

Ensemblⁱ	ENST00000615863; ENSP00000482259; ENSG00000275302 ENST00000617322; ENSP00000480345; ENSG00000275824 ENST00000621600; ENSP00000478708; ENSG00000277943
GeneIDⁱ	388372 6351
KEGGⁱ	hsa:388372 hsa:6351
UCSC genome browser More...UCSCⁱ	uc002hkw.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P13236	C-C motif chemokine 4-like		HUMAN		92	UniRef90_P13236
C-C motif chemokine 4		MACMU		92
C-C motif chemokine		PONAB		93
C-C motif chemokine		MACFA		92
C-C motif chemokine		CALJA		92
+39

Protein	Similar proteins		Species	Score	Length	Source
P13236	C-C motif chemokine 4-like		HUMAN		92	UniRef50_P13236
C-C motif chemokine 4		MACMU		92
C-C motif chemokine 3		BOVIN		93
C-C motif chemokine		PONAB		93
C-C motif chemokine		MACFA		92
+164

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Macrophage inflammatory protein entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J04130 mRNA Translation: AAA51576.1 M25316 mRNA Translation: AAA57256.1 M23502 mRNA Translation: AAA36656.1 X53683 mRNA Translation: CAA37723.1 X53682 Genomic DNA Translation: CAA37722.2 Sequence problems. X16166 mRNA Translation: CAA34291.1 M69203, M69201, M69202 Genomic DNA Translation: AAB00790.1 AY766446 mRNA Translation: AAX07305.1 AY766459 Genomic DNA Translation: AAX07292.1 CR542119 mRNA Translation: CAG46916.1 AC003976 Genomic DNA No translation available. BC104226 mRNA Translation: AAI04227.1 BC104227 mRNA Translation: AAI04228.1 BC107433 mRNA Translation: AAI07434.1 M57503 mRNA Translation: AAA36752.1
CCDSⁱ	CCDS11308.1
PIRⁱ	JH0319 A31767
RefSeqⁱ	NP_002975.1, NM_002984.3 NP_996890.1, NM_207007.3
UniGeneⁱ	Hs.449862 Hs.515183 Hs.75703

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1HUM	NMR	-	A/B	24-92	[»]
	1HUN	NMR	-	A/B	24-92	[»]
	1JE4	NMR	-	A	24-92	[»]
	2FFK	NMR	-	B	24-92	[»]
	2FIN	NMR	-	B	24-92	[»]
	2X6L	X-ray	2.60	A/B/C/D/E	24-92	[»]
	3TN2	X-ray	1.60	A	24-91	[»]
	4RAL	X-ray	3.15	D/E	24-92	[»]
ProteinModelPortalⁱ	P13236
SMRⁱ	P13236
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112254, 6 interactors
DIPⁱ	DIP-5840N
IntActⁱ	P13236, 23 interactors
MINTⁱ	P13236
STRINGⁱ	9606.ENSP00000250151

Polymorphism and mutation databases

BioMutaⁱ	CCL4
DMDMⁱ	127080

Proteomic databases

PaxDbⁱ	P13236
PeptideAtlasⁱ	P13236
PRIDEⁱ	P13236
ProteomicsDBⁱ	52904

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	388372 9560
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000615863; ENSP00000482259; ENSG00000275302 ENST00000617322; ENSP00000480345; ENSG00000275824 ENST00000621600; ENSP00000478708; ENSG00000277943
GeneIDⁱ	388372 6351
KEGGⁱ	hsa:388372 hsa:6351
UCSCⁱ	uc002hkw.3 human

Organism-specific databases

CTDⁱ	388372 6351
DisGeNETⁱ	388372 6351 9560
EuPathDBⁱ	HostDB:ENSG00000275302.1
GeneCardsⁱ	CCL4
HGNCⁱ	HGNC:10630 CCL4
HPAⁱ	CAB007805
MIMⁱ	182284 gene
neXtProtⁱ	NX_P13236
OpenTargetsⁱ	ENSG00000275302
PharmGKBⁱ	PA35563
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J4I9 Eukaryota ENOG410YXJU LUCA
GeneTreeⁱ	ENSGT00900000140870
HOGENOMⁱ	HOG000036685
HOVERGENⁱ	HBG017871
InParanoidⁱ	P13236
KOⁱ	K12964
OMAⁱ	RSKQVCA
OrthoDBⁱ	EOG091G14Y2
PhylomeDBⁱ	P13236
TreeFamⁱ	TF334888

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events R-HSA-6783783 Interleukin-10 signaling
SIGNORⁱ	P13236

Miscellaneous databases

ChiTaRSⁱ	CCL4 human
EvolutionaryTraceⁱ	P13236
GeneWikiⁱ	CCL4
Protein Ontology More...PROⁱ	PR:P13236
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000275302 Expressed in 161 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_CCL4
ExpressionAtlasⁱ	P13236 baseline and differential
Genevisibleⁱ	P13236 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000827 Chemokine_CC_CS IPR001811 Chemokine_IL8-like_dom IPR036048 Interleukin_8-like_sf
Pfamⁱ	View protein in Pfam PF00048 IL8, 1 hit
SMARTⁱ	View protein in SMART SM00199 SCY, 1 hit
SUPFAMⁱ	SSF54117 SSF54117, 1 hit
PROSITEⁱ	View protein in PROSITE PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCL4_HUMAN
Accessionⁱ	P13236Primary (citable) accession number: P13236 Secondary accession number(s): P22617 , Q13704, Q3SXL8, Q6FGI8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	January 1, 1990
	Last modified:	September 12, 2018
	This is version 190 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P13236 (CCL4_HUMAN)

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C-C motif chemokine 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ