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UniProtKB - P13236 (CCL4_HUMAN)

Entry version 207 (07 Oct 2020)
Sequence version 1 (01 Jan 1990)
Previous versions | rss
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Protein

C-C motif chemokine 4

Gene

CCL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.3 Publications

Caution

Was originally thought to be a ligand for CCR8.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P13236

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-380108, Chemokine receptors bind chemokines
R-HSA-418594, G alpha (i) signalling events
R-HSA-6783783, Interleukin-10 signaling

SIGNOR Signaling Network Open Resource

More...SIGNORi		P13236

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C-C motif chemokine 4
Alternative name(s):
G-26 T-lymphocyte-secreted protein
HC21
Lymphocyte activation gene 1 protein
Short name:
LAG-1
MIP-1-beta(1-69)
Macrophage inflammatory protein 1-beta
Short name:
MIP-1-beta
PAT 744
Protein H400
SIS-gamma
Small-inducible cytokine A4
T-cell activation protein 2
Short name:
ACT-2
Cleaved into the following chain:
MIP-1-beta(3-69)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCL4
Synonyms:LAG1, MIP1B, SCYA4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000275302.1

Human Gene Nomenclature Database

More...HGNCi		HGNC:10630, CCL4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		182284, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P13236

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		388372
6351

Open Targets

More...OpenTargetsi		ENSG00000275302

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P13236, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCL4

Domain mapping of disease mutations (DMDM)

More...DMDMi		127080

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Add BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000516424 – 92C-C motif chemokine 4Add BLAST69
ChainiPRO_000000516526 – 92MIP-1-beta(3-69)Add BLAST67

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi34 ↔ 58By similarity
Disulfide bondi35 ↔ 74By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.

Keywords - PTMi

Disulfide bond

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P13236

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P13236

PeptideAtlas

More...PeptideAtlasi		P13236

PRoteomics IDEntifications database

More...PRIDEi		P13236

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		52904

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By mitogens.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000275302, Expressed in granulocyte and 180 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P13236, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P13236, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000275302, Group enriched (blood, lung, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112254, 24 interactors

Database of interacting proteins

More...DIPi		DIP-5840N

Protein interaction database and analysis system

More...IntActi		P13236, 26 interactors

Molecular INTeraction database

More...MINTi		P13236

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000482259

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P13236

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P13236, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

192
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P13236

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P13236

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intercrine beta (chemokine CC) family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S8M4, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214365

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_141716_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P13236

KEGG Orthology (KO)

More...KOi		K12964

Identification of Orthologs from Complete Genome Data

More...OMAi		VDYYDTN

Database of Orthologous Groups

More...OrthoDBi		1575018at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P13236

TreeFam database of animal gene trees

More...TreeFami		TF334888

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039809, Chemokine_b/g/d
IPR000827, Chemokine_CC_CS
IPR001811, Chemokine_IL8-like_dom
IPR036048, Interleukin_8-like_sf

The PANTHER Classification System

More...PANTHERi		PTHR12015, PTHR12015, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00048, IL8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00199, SCY, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54117, SSF54117, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00472, SMALL_CYTOKINES_CC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P13236-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLCVTVLSL LMLVAAFCSP ALSAPMGSDP PTACCFSYTA RKLPRNFVVD 
        60         70         80         90 
YYETSSLCSQ PAVVFQTKRS KQVCADPSES WVQEYVYDLE LN
Length:92
Mass (Da):10,212
Last modified:January 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF2EA7CF341B0E258
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7M4M2Q7M4M2_HUMAN
C-C motif chemokine 4
CCL4
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6T → C in AAA36752 (PubMed:2809212).Curated1
Sequence conflicti15A → S in AAB00790 (PubMed:1894635).Curated1
Sequence conflicti40 – 45ARKLPR → REASS in AAA36656 (PubMed:2521353).Curated6
Sequence conflicti56S → I in AAA36752 (PubMed:2809212).Curated1
Sequence conflicti70S → G in CAA37722 (PubMed:1894635).Curated1
Sequence conflicti70S → G in AAB00790 (PubMed:1894635).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04870212M → V. Corresponds to variant dbSNP:rs1049752Ensembl.1
Natural variantiVAR_04870320P → L. Corresponds to variant dbSNP:rs1130750Ensembl.1
Natural variantiVAR_05921180S → T2 PublicationsCorresponds to variant dbSNP:rs1719152Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J04130 mRNA Translation: AAA51576.1
M25316 mRNA Translation: AAA57256.1
M23502 mRNA Translation: AAA36656.1
X53683 mRNA Translation: CAA37723.1
X53682 Genomic DNA Translation: CAA37722.2 Sequence problems.
X16166 mRNA Translation: CAA34291.1
M69203, M69201, M69202 Genomic DNA Translation: AAB00790.1
AY766446 mRNA Translation: AAX07305.1
AY766459 Genomic DNA Translation: AAX07292.1
CR542119 mRNA Translation: CAG46916.1
AC003976 Genomic DNA No translation available.
BC104226 mRNA Translation: AAI04227.1
BC104227 mRNA Translation: AAI04228.1
BC107433 mRNA Translation: AAI07434.1
M57503 mRNA Translation: AAA36752.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS11308.1

Protein sequence database of the Protein Information Resource

More...PIRi		JH0319, A31767

NCBI Reference Sequences

More...RefSeqi		NP_002975.1, NM_002984.3
NP_996890.1, NM_207007.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000615863; ENSP00000482259; ENSG00000275302
ENST00000617322; ENSP00000480345; ENSG00000275824
ENST00000621600; ENSP00000478708; ENSG00000277943

Database of genes from NCBI RefSeq genomes

More...GeneIDi		388372
6351

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:388372
hsa:6351

UCSC genome browser

More...UCSCi		uc002hkw.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Macrophage inflammatory protein entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04130 mRNA Translation: AAA51576.1
M25316 mRNA Translation: AAA57256.1
M23502 mRNA Translation: AAA36656.1
X53683 mRNA Translation: CAA37723.1
X53682 Genomic DNA Translation: CAA37722.2 Sequence problems.
X16166 mRNA Translation: CAA34291.1
M69203, M69201, M69202 Genomic DNA Translation: AAB00790.1
AY766446 mRNA Translation: AAX07305.1
AY766459 Genomic DNA Translation: AAX07292.1
CR542119 mRNA Translation: CAG46916.1
AC003976 Genomic DNA No translation available.
BC104226 mRNA Translation: AAI04227.1
BC104227 mRNA Translation: AAI04228.1
BC107433 mRNA Translation: AAI07434.1
M57503 mRNA Translation: AAA36752.1
CCDSiCCDS11308.1
PIRiJH0319, A31767
RefSeqiNP_002975.1, NM_002984.3
NP_996890.1, NM_207007.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HUMNMR-A/B24-92[»]
1HUNNMR-A/B24-92[»]
1JE4NMR-A24-92[»]
2FFKNMR-B24-92[»]
2FINNMR-B24-92[»]
2X6LX-ray2.60A/B/C/D/E24-92[»]
3TN2X-ray1.60A24-91[»]
4RALX-ray3.15D/E24-92[»]
SMRiP13236
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112254, 24 interactors
DIPiDIP-5840N
IntActiP13236, 26 interactors
MINTiP13236
STRINGi9606.ENSP00000482259

Chemistry databases

BindingDBiP13236

Polymorphism and mutation databases

BioMutaiCCL4
DMDMi127080

Proteomic databases

MassIVEiP13236
PaxDbiP13236
PeptideAtlasiP13236
PRIDEiP13236
ProteomicsDBi52904

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		72629, 585 antibodies

The DNASU plasmid repository

More...DNASUi		388372
9560

Genome annotation databases

EnsembliENST00000615863; ENSP00000482259; ENSG00000275302
ENST00000617322; ENSP00000480345; ENSG00000275824
ENST00000621600; ENSP00000478708; ENSG00000277943
GeneIDi388372
6351
KEGGihsa:388372
hsa:6351
UCSCiuc002hkw.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		388372
6351
DisGeNETi388372
6351
EuPathDBiHostDB:ENSG00000275302.1

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCL4
HGNCiHGNC:10630, CCL4
HPAiENSG00000275302, Group enriched (blood, lung, lymphoid tissue)
MIMi182284, gene
neXtProtiNX_P13236
OpenTargetsiENSG00000275302

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S8M4, Eukaryota
GeneTreeiENSGT01000000214365
HOGENOMiCLU_141716_4_0_1
InParanoidiP13236
KOiK12964
OMAiVDYYDTN
OrthoDBi1575018at2759
PhylomeDBiP13236
TreeFamiTF334888

Enzyme and pathway databases

PathwayCommonsiP13236
ReactomeiR-HSA-380108, Chemokine receptors bind chemokines
R-HSA-418594, G alpha (i) signalling events
R-HSA-6783783, Interleukin-10 signaling
SIGNORiP13236

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		388372, 3 hits in 107 CRISPR screens
6351, 3 hits in 845 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCL4, human
EvolutionaryTraceiP13236

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CCL4
PharosiP13236, Tbio

Protein Ontology

More...PROi		PR:P13236
RNActiP13236, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000275302, Expressed in granulocyte and 180 other tissues
ExpressionAtlasiP13236, baseline and differential
GenevisibleiP13236, HS

Family and domain databases

InterProiView protein in InterPro
IPR039809, Chemokine_b/g/d
IPR000827, Chemokine_CC_CS
IPR001811, Chemokine_IL8-like_dom
IPR036048, Interleukin_8-like_sf
PANTHERiPTHR12015, PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048, IL8, 1 hit
SMARTiView protein in SMART
SM00199, SCY, 1 hit
SUPFAMiSSF54117, SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472, SMALL_CYTOKINES_CC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCL4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13236
Secondary accession number(s): P22617
, Q13704, Q3SXL8, Q6FGI8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: October 7, 2020
This is version 207 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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