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Protein

Hisactophilin-1

Gene

hatA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as an intracellular pH sensor that links chemotactic signals to responses in the microfilament system of the cells by nucleating actin polymerization or stabilizing the filaments.

GO - Molecular functioni

  • actin filament binding Source: dictyBase
  • actin monomer binding Source: dictyBase
  • fatty acid binding Source: dictyBase
  • lipid binding Source: dictyBase
  • protein binding, bridging Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hisactophilin-1
Alternative name(s):
Histidine-rich actin-binding protein 1
Short name:
HS I
Gene namesi
Name:hatA
Synonyms:abpH
ORF Names:DDB_G0282141
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0282141 hatA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000839042 – 118Hisactophilin-1Add BLAST117

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Disulfide bond, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiP13231

PTM databases

iPTMnetiP13231

Interactioni

Subunit structurei

Homodimer or heterodimer of hatA and hatB, linked by a disulfide bond.

GO - Molecular functioni

Structurei

Secondary structure

1118
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP13231
SMRiP13231
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13231

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 461Add BLAST13
Repeati74 – 862Add BLAST13

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni8 – 109Contains several HHXH repeatsAdd BLAST102
Regioni34 – 862 X 13 AA approximate repeatsAdd BLAST53

Sequence similaritiesi

Belongs to the hisactophilin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiP13231
PhylomeDBiP13231

Family and domain databases

CDDicd00257 Fascin, 1 hit
InterProiView protein in InterPro
IPR008999 Actin-crosslinking
IPR022768 Fascin-domain
PfamiView protein in Pfam
PF06268 Fascin, 2 hits
SUPFAMiSSF50405 SSF50405, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13231-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNRAFKSHH GHFLSAEGEA VKTHHGHHDH HTHFHVENHG GKVALKTHCG
60 70 80 90 100
KYLSIGDHKQ VYLSHHLHGD HSLFHLEHHG GKVSIKGHHH HYISADHHGH
110
VSTKEHHDHD TTFEEIII
Length:118
Mass (Da):13,456
Last modified:January 23, 2007 - v3
Checksum:iB5B43F527B694716
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04472 mRNA Translation: AAA33218.1
AAFI02000045 Genomic DNA Translation: EAL66350.1
PIRiA31429
RefSeqiXP_640342.1, XM_635250.1

Genome annotation databases

EnsemblProtistsiEAL66350; EAL66350; DDB_G0282141
GeneIDi8623443
KEGGiddi:DDB_G0282141

Similar proteinsi

Entry informationi

Entry nameiHATA_DICDI
AccessioniPrimary (citable) accession number: P13231
Secondary accession number(s): Q54SW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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