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UniProtKB - P13208 (SRTX_ATREN)
Protein
Sarafotoxin
Gene
N/A
Organism
Atractaspis engaddensis (Israeli burrowing asp) (Israeli mole viper)
Status
Functioni
Vasoconstrictor activity. These toxins cause cardiac arrest probably as a result of coronary vasospasm.
1 PublicationVasoconstrictor activity. Causes cardiac arrest probably as a result of coronary vasospasm (By similarity).
Displays high agonistic activities towards endothelin-2 receptor (EDNRB) (displays affinity in the picomolar range) and endothelin-1 receptor (EDNRA) (lower affinities) (PubMed:21889567).
By similarity1 PublicationSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 90 | Endothelin-receptor binding siteBy similarity | 1 | |
Sitei | 130 | Endothelin-receptor binding siteBy similarity | 1 | |
Sitei | 170 | Endothelin-receptor binding siteBy similarity | 1 | |
Sitei | 210 | Endothelin-receptor binding siteBy similarity | 1 | |
Sitei | 250 | Endothelin-receptor binding siteBy similarity | 1 | |
Sitei | 290 | Endothelin-receptor binding siteBy similarity | 1 | |
Sitei | 330 | Endothelin-receptor binding siteBy similarity | 1 | |
Sitei | 370 | Endothelin-receptor binding siteBy similarity | 1 | |
Sitei | 410 | Endothelin-receptor binding siteBy similarity | 1 | |
Sitei | 450 | Endothelin-receptor binding siteBy similarity | 1 | |
Sitei | 490 | Endothelin-receptor binding siteBy similarity | 1 | |
Sitei | 530 | Endothelin-receptor binding siteBy similarity | 1 |
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- regulation of vasoconstriction Source: InterPro
- vasoconstriction Source: UniProtKB-KW
Keywordsi
Molecular function | Cardiotoxin, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasoconstrictor |
Names & Taxonomyi
Protein namesi | Recommended name: SarafotoxinCleaved into the following 5 chains: Alternative name(s): S6A Alternative name(s): S6C Alternative name(s): S6B Alternative name(s): S6E |
Organismi | Atractaspis engaddensis (Israeli burrowing asp) (Israeli mole viper) |
Taxonomic identifieri | 1343144 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Lamprophiidae › Atractaspidinae › Atractaspis |
Subcellular locationi
Extracellular region or secreted
- Secreted 2 Publications
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Toxic dosei
LD50 is 0.015 mg/kg by intravenous injection into mice.2 Publications
LD50 is 0.015 mg/kg by intravenous injection into mice.2 Publications
LD50 is 0.015 mg/kg by intravenous injection into mice.2 Publications
LD50 is 0.3 mg/kg by intravenous injection into mice.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 170 | W → WVNRN or WDEP: Drastic decrease in affinity for ET-B receptors (3 and 5-orders or magnitude for VNRN and DEP, respectively). 1 Publication | 1 | |
Mutagenesisi | 450 | W → WVNRN or DEP: Drastic decrease in affinity for ET-B receptors (3 and 5-orders or magnitude for VNRN and DEP, respectively). 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
PropeptideiPRO_0000008123 | 24 – 69 | Add BLAST | 46 | |
PeptideiPRO_0000008124 | 70 – 90 | Sarafotoxin-A, Ser-isoformAdd BLAST | 21 | |
PropeptideiPRO_0000008125 | 92 – 109 | Add BLAST | 18 | |
PeptideiPRO_0000008126 | 110 – 130 | Sarafotoxin-CAdd BLAST | 21 | |
PropeptideiPRO_0000008127 | 132 – 149 | Add BLAST | 18 | |
PeptideiPRO_0000008128 | 150 – 170 | Sarafotoxin-BAdd BLAST | 21 | |
PropeptideiPRO_0000008129 | 172 – 189 | Add BLAST | 18 | |
PeptideiPRO_0000008130 | 190 – 210 | Sarafotoxin-CAdd BLAST | 21 | |
PropeptideiPRO_0000008131 | 212 – 229 | Add BLAST | 18 | |
PeptideiPRO_0000008132 | 230 – 250 | Sarafotoxin-CAdd BLAST | 21 | |
PropeptideiPRO_0000008133 | 252 – 269 | Add BLAST | 18 | |
PeptideiPRO_0000008134 | 270 – 290 | Sarafotoxin-EAdd BLAST | 21 | |
PropeptideiPRO_0000008135 | 292 – 309 | Add BLAST | 18 | |
PeptideiPRO_0000008136 | 310 – 330 | Sarafotoxin-A, Ser-isoformAdd BLAST | 21 | |
PropeptideiPRO_0000008137 | 332 – 349 | Add BLAST | 18 | |
PeptideiPRO_0000008138 | 350 – 370 | Sarafotoxin-CAdd BLAST | 21 | |
PropeptideiPRO_0000008139 | 372 – 389 | Add BLAST | 18 | |
PeptideiPRO_0000008140 | 390 – 410 | Sarafotoxin-CAdd BLAST | 21 | |
PropeptideiPRO_0000008141 | 412 – 429 | Add BLAST | 18 | |
PeptideiPRO_0000008142 | 430 – 450 | Sarafotoxin-BAdd BLAST | 21 | |
PropeptideiPRO_0000008143 | 452 – 469 | Add BLAST | 18 | |
PeptideiPRO_0000008144 | 470 – 490 | Sarafotoxin-A, Ser-isoformAdd BLAST | 21 | |
PropeptideiPRO_0000008145 | 492 – 509 | Add BLAST | 18 | |
PeptideiPRO_0000008146 | 510 – 530 | Sarafotoxin-A, Thr-isoformAdd BLAST | 21 | |
PropeptideiPRO_0000008147 | 532 – 543 | Add BLAST | 12 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 70 ↔ 84 | By similarity | ||
Disulfide bondi | 72 ↔ 80 | By similarity | ||
Disulfide bondi | 110 ↔ 124 | By similarity | ||
Disulfide bondi | 112 ↔ 120 | By similarity | ||
Disulfide bondi | 150 ↔ 164 | 1 Publication | ||
Disulfide bondi | 152 ↔ 160 | 1 Publication | ||
Disulfide bondi | 190 ↔ 204 | By similarity | ||
Disulfide bondi | 192 ↔ 200 | By similarity | ||
Disulfide bondi | 230 ↔ 244 | By similarity | ||
Disulfide bondi | 232 ↔ 240 | By similarity | ||
Disulfide bondi | 270 ↔ 284 | By similarity | ||
Disulfide bondi | 272 ↔ 280 | By similarity | ||
Disulfide bondi | 310 ↔ 324 | By similarity | ||
Disulfide bondi | 312 ↔ 320 | By similarity | ||
Disulfide bondi | 350 ↔ 364 | By similarity | ||
Disulfide bondi | 352 ↔ 360 | By similarity | ||
Disulfide bondi | 390 ↔ 404 | By similarity | ||
Disulfide bondi | 392 ↔ 400 | By similarity | ||
Disulfide bondi | 430 ↔ 444 | 1 Publication | ||
Disulfide bondi | 432 ↔ 440 | 1 Publication | ||
Disulfide bondi | 470 ↔ 484 | By similarity | ||
Disulfide bondi | 472 ↔ 480 | By similarity | ||
Disulfide bondi | 510 ↔ 524 | By similarity | ||
Disulfide bondi | 512 ↔ 520 | By similarity |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.2 Publications
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P13208 |
SMRi | P13208 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P13208 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 51 – 90 | 1Add BLAST | 40 | |
Repeati | 91 – 130 | 2Add BLAST | 40 | |
Repeati | 131 – 170 | 3Add BLAST | 40 | |
Repeati | 171 – 210 | 4Add BLAST | 40 | |
Repeati | 211 – 250 | 5Add BLAST | 40 | |
Repeati | 251 – 290 | 6Add BLAST | 40 | |
Repeati | 291 – 330 | 7Add BLAST | 40 | |
Repeati | 331 – 370 | 8Add BLAST | 40 | |
Repeati | 371 – 410 | 9Add BLAST | 40 | |
Repeati | 411 – 450 | 10Add BLAST | 40 | |
Repeati | 451 – 490 | 11Add BLAST | 40 | |
Repeati | 491 – 530 | 12Add BLAST | 40 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 45 – 65 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 51 – 530 | 12 X 40 AA tandem repeatsAdd BLAST | 480 |
Sequence similaritiesi
Belongs to the endothelin/sarafotoxin family.Curated
Keywords - Domaini
Repeat, SignalFamily and domain databases
InterProi | View protein in InterPro IPR020475, Endothelin IPR019764, Endothelin_toxin_CS IPR001928, Endothln-like_toxin |
PANTHERi | PTHR13874, PTHR13874, 12 hits |
Pfami | View protein in Pfam PF00322, Endothelin, 12 hits |
SMARTi | View protein in SMART SM00272, END, 12 hits |
PROSITEi | View protein in PROSITE PS00270, ENDOTHELIN, 12 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P13208-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALLPRLAAG GLLLLLALAA LEGKPAPSAL SQLLEKRSED QAAAGRIIDG
60 70 80 90 100
GDTKQAARDP SPQRNVEPLC SCKDMSDKEC LNFCHQDVIW RDTKQAARDP
110 120 130 140 150
SPQRNVEPLC TCNDMTDEEC LNFCHQDVIW RDTKQAARDP SPQRNVEPLC
160 170 180 190 200
SCKDMTDKEC LYFCHQDVIW RDTKQAARDP SPQRNVEPLC TCNDMTDEEC
210 220 230 240 250
LNFCHQDVIW RDTKQAARDP SPQRNVEPLC TCNDMTDEEC LNFCHQDVIW
260 270 280 290 300
RDTKQAARDP SPQRNVEPLC TCKDMTDKEC LYFCHQGIIW RDTKQAARDP
310 320 330 340 350
SPQRNVEPLC SCKDMSDKEC LNFCHQDVIW RDTKQAARDP SPQRNVEPLC
360 370 380 390 400
TCNDMTDEEC LNFCHQDVIW RDTKQAARDP SPQRNVEPLC TCNDMTDEEC
410 420 430 440 450
LNFCHQDVIW RDTKQAARDP SPQRNVEPLC SCKDMTDKEC LYFCHQDVIW
460 470 480 490 500
RDTKQAARDP SPQRNVEPLC SCKDMSDKEC LNFCHQDVIW RDTKQAARDP
510 520 530 540
SPQRNVEPLC SCKDMTDKEC LNFCHQDVIW KNADTSANPE FLG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L07528 mRNA Translation: AAA48515.1 D13322 Genomic DNA Translation: BAA02579.2 |
PIRi | A46601 |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L07528 mRNA Translation: AAA48515.1 D13322 Genomic DNA Translation: BAA02579.2 |
PIRi | A46601 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1SRB | NMR | - | A | 430-450 | [»] | |
6LRY | X-ray | 3.00 | B | 430-450 | [»] | |
AlphaFoldDBi | P13208 | |||||
SMRi | P13208 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P13208 |
Family and domain databases
InterProi | View protein in InterPro IPR020475, Endothelin IPR019764, Endothelin_toxin_CS IPR001928, Endothln-like_toxin |
PANTHERi | PTHR13874, PTHR13874, 12 hits |
Pfami | View protein in Pfam PF00322, Endothelin, 12 hits |
SMARTi | View protein in SMART SM00272, END, 12 hits |
PROSITEi | View protein in PROSITE PS00270, ENDOTHELIN, 12 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SRTX_ATREN | |
Accessioni | P13208Primary (citable) accession number: P13208 Secondary accession number(s): P13209, P13210 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | February 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 120 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families