UniProtKB - P13208 (SRTX_ATREN)

BLAST

>sp|P13208|SRTX_ATREN Sarafotoxin OS=Atractaspis engaddensis OX=1343144 PE=1 SV=2
MALLPRLAAGGLLLLLALAALEGKPAPSALSQLLEKRSEDQAAAGRIIDGGDTKQAARDP
SPQRNVEPLCSCKDMSDKECLNFCHQDVIWRDTKQAARDPSPQRNVEPLCTCNDMTDEEC
LNFCHQDVIWRDTKQAARDPSPQRNVEPLCSCKDMTDKECLYFCHQDVIWRDTKQAARDP
SPQRNVEPLCTCNDMTDEECLNFCHQDVIWRDTKQAARDPSPQRNVEPLCTCNDMTDEEC
LNFCHQDVIWRDTKQAARDPSPQRNVEPLCTCKDMTDKECLYFCHQGIIWRDTKQAARDP
SPQRNVEPLCSCKDMSDKECLNFCHQDVIWRDTKQAARDPSPQRNVEPLCTCNDMTDEEC
LNFCHQDVIWRDTKQAARDPSPQRNVEPLCTCNDMTDEECLNFCHQDVIWRDTKQAARDP
SPQRNVEPLCSCKDMTDKECLYFCHQDVIWRDTKQAARDPSPQRNVEPLCSCKDMSDKEC
LNFCHQDVIWRDTKQAARDPSPQRNVEPLCSCKDMTDKECLNFCHQDVIWKNADTSANPE
FLG

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History
Entry version 108 (22 Nov 2017)
Sequence version 2 (01 Feb 1994)
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Protein

Sarafotoxin

Gene

N/A

Organism

Atractaspis engaddensis (Israeli burrowing asp) (Israeli mole viper)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Vasoconstrictor activity. These toxins cause cardiac arrest probably as a result of coronary vasospasm.1 Publication

Sarafotoxin-B: vasoconstrictor activity. Causes cardiac arrest probably as a result of coronary vasospasm (By similarity). Displays high agonistic activities towards endothelin-2 receptor (EDNRB) (displays affinity in the picomolar range) and endothelin-1 receptor (EDNRA) (lower affinities) (PubMed:21889567).By similarity1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	90	Endothelin-receptor binding siteBy similarity	1
Siteⁱ	130	Endothelin-receptor binding siteBy similarity	1
Siteⁱ	170	Endothelin-receptor binding siteBy similarity	1
Siteⁱ	210	Endothelin-receptor binding siteBy similarity	1
Siteⁱ	250	Endothelin-receptor binding siteBy similarity	1
Siteⁱ	290	Endothelin-receptor binding siteBy similarity	1
Siteⁱ	330	Endothelin-receptor binding siteBy similarity	1
Siteⁱ	370	Endothelin-receptor binding siteBy similarity	1
Siteⁱ	410	Endothelin-receptor binding siteBy similarity	1
Siteⁱ	450	Endothelin-receptor binding siteBy similarity	1
Siteⁱ	490	Endothelin-receptor binding siteBy similarity	1
Siteⁱ	530	Endothelin-receptor binding siteBy similarity	1

GO - Molecular functionⁱ

toxin activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of vasoconstriction Source: InterPro
vasoconstriction Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cardiotoxin, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasoconstrictor

Molecular function

Cardiotoxin, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasoconstrictor

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Sarafotoxin Cleaved into the following 5 chains: Sarafotoxin-A, Ser-isoform Short name: SRTX-A Short name: Sarafotoxin-A Alternative name(s): S6A Sarafotoxin-C Short name: SRTX-C Alternative name(s): S6C Sarafotoxin-B Short name: SRTX-B Alternative name(s): S6B Sarafotoxin-E Short name: SRTX-E Alternative name(s): S6E Sarafotoxin-A, Thr-isoform
Organismⁱ	Atractaspis engaddensis (Israeli burrowing asp) (Israeli mole viper)
Taxonomic identifierⁱ	1343144 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Sauropsida › Sauria › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Serpentes › Colubroidea › Lamprophiidae › Atractaspidinae › Atractaspis

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Toxic doseⁱ

Sarafotoxin-A and sarafotoxin-B: LD₅₀ is 0.015 mg/kg by intravenous injection into mice.2 Publications

Sarafotoxin-C: LD₅₀ is 0.3 mg/kg by intravenous injection into mice.1 Publication

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	170	W → WVNRN or WDEP: Drastic decrease in affinity for ET-B receptors (3 and 5-orders or magnitude for VNRN and DEP, respectively). 1 Publication		1
Mutagenesisⁱ	450	W → WVNRN or DEP: Drastic decrease in affinity for ET-B receptors (3 and 5-orders or magnitude for VNRN and DEP, respectively). 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST	23
PropeptideⁱPRO_0000008123	24 – 69	Add BLAST	46
PeptideⁱPRO_0000008124	70 – 90	Sarafotoxin-A, Ser-isoformAdd BLAST	21
PropeptideⁱPRO_0000008125	92 – 109	Add BLAST	18
PeptideⁱPRO_0000008126	110 – 130	Sarafotoxin-CAdd BLAST	21
PropeptideⁱPRO_0000008127	132 – 149	Add BLAST	18
PeptideⁱPRO_0000008128	150 – 170	Sarafotoxin-BAdd BLAST	21
PropeptideⁱPRO_0000008129	172 – 189	Add BLAST	18
PeptideⁱPRO_0000008130	190 – 210	Sarafotoxin-CAdd BLAST	21
PropeptideⁱPRO_0000008131	212 – 229	Add BLAST	18
PeptideⁱPRO_0000008132	230 – 250	Sarafotoxin-CAdd BLAST	21
PropeptideⁱPRO_0000008133	252 – 269	Add BLAST	18
PeptideⁱPRO_0000008134	270 – 290	Sarafotoxin-EAdd BLAST	21
PropeptideⁱPRO_0000008135	292 – 309	Add BLAST	18
PeptideⁱPRO_0000008136	310 – 330	Sarafotoxin-A, Ser-isoformAdd BLAST	21
PropeptideⁱPRO_0000008137	332 – 349	Add BLAST	18
PeptideⁱPRO_0000008138	350 – 370	Sarafotoxin-CAdd BLAST	21
PropeptideⁱPRO_0000008139	372 – 389	Add BLAST	18
PeptideⁱPRO_0000008140	390 – 410	Sarafotoxin-CAdd BLAST	21
PropeptideⁱPRO_0000008141	412 – 429	Add BLAST	18
PeptideⁱPRO_0000008142	430 – 450	Sarafotoxin-BAdd BLAST	21
PropeptideⁱPRO_0000008143	452 – 469	Add BLAST	18
PeptideⁱPRO_0000008144	470 – 490	Sarafotoxin-A, Ser-isoformAdd BLAST	21
PropeptideⁱPRO_0000008145	492 – 509	Add BLAST	18
PeptideⁱPRO_0000008146	510 – 530	Sarafotoxin-A, Thr-isoformAdd BLAST	21
PropeptideⁱPRO_0000008147	532 – 543	Add BLAST	12

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	70 ↔ 84	By similarity
Disulfide bondⁱ	72 ↔ 80	By similarity
Disulfide bondⁱ	110 ↔ 124	By similarity
Disulfide bondⁱ	112 ↔ 120	By similarity
Disulfide bondⁱ	150 ↔ 164	1 Publication
Disulfide bondⁱ	152 ↔ 160	1 Publication
Disulfide bondⁱ	190 ↔ 204	By similarity
Disulfide bondⁱ	192 ↔ 200	By similarity
Disulfide bondⁱ	230 ↔ 244	By similarity
Disulfide bondⁱ	232 ↔ 240	By similarity
Disulfide bondⁱ	270 ↔ 284	By similarity
Disulfide bondⁱ	272 ↔ 280	By similarity
Disulfide bondⁱ	310 ↔ 324	By similarity
Disulfide bondⁱ	312 ↔ 320	By similarity
Disulfide bondⁱ	350 ↔ 364	By similarity
Disulfide bondⁱ	352 ↔ 360	By similarity
Disulfide bondⁱ	390 ↔ 404	By similarity
Disulfide bondⁱ	392 ↔ 400	By similarity
Disulfide bondⁱ	430 ↔ 444	1 Publication
Disulfide bondⁱ	432 ↔ 440	1 Publication
Disulfide bondⁱ	470 ↔ 484	By similarity
Disulfide bondⁱ	472 ↔ 480	By similarity
Disulfide bondⁱ	510 ↔ 524	By similarity
Disulfide bondⁱ	512 ↔ 520	By similarity

Keywords - PTMⁱ

Disulfide bond

Expressionⁱ

Tissue specificityⁱ

Expressed by the venom gland.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Beta strandⁱ	433 – 435	Combined sources		3
Helixⁱ	438 – 444	Combined sources		7

Show more details

3D structure databases

ProteinModelPortalⁱ	P13208
SMRⁱ	P13208
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P13208

EvolutionaryTraceⁱ

P13208

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	51 – 90	1Add BLAST	40
Repeatⁱ	91 – 130	2Add BLAST	40
Repeatⁱ	131 – 170	3Add BLAST	40
Repeatⁱ	171 – 210	4Add BLAST	40
Repeatⁱ	211 – 250	5Add BLAST	40
Repeatⁱ	251 – 290	6Add BLAST	40
Repeatⁱ	291 – 330	7Add BLAST	40
Repeatⁱ	331 – 370	8Add BLAST	40
Repeatⁱ	371 – 410	9Add BLAST	40
Repeatⁱ	411 – 450	10Add BLAST	40
Repeatⁱ	451 – 490	11Add BLAST	40
Repeatⁱ	491 – 530	12Add BLAST	40

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	51 – 530	12 X 40 AA tandem repeatsAdd BLAST		480

Sequence similaritiesⁱ

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domainⁱ

Repeat, Signal

Phylogenomic databases

HOVERGENⁱ	HBG017852

HOVERGENⁱ

HBG017852

Family and domain databases

InterProⁱ	View protein in InterPro IPR019764 Endothelin_toxin_CS IPR001928 Endothln-like_toxin
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00322 Endothelin, 12 hits
SMARTⁱ	View protein in SMART SM00272 END, 12 hits
PROSITEⁱ	View protein in PROSITE PS00270 ENDOTHELIN, 12 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P13208-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALLPRLAAG GLLLLLALAA LEGKPAPSAL SQLLEKRSED QAAAGRIIDG 
        60         70         80         90        100
GDTKQAARDP SPQRNVEPLC SCKDMSDKEC LNFCHQDVIW RDTKQAARDP 
       110        120        130        140        150
SPQRNVEPLC TCNDMTDEEC LNFCHQDVIW RDTKQAARDP SPQRNVEPLC 
       160        170        180        190        200
SCKDMTDKEC LYFCHQDVIW RDTKQAARDP SPQRNVEPLC TCNDMTDEEC 
       210        220        230        240        250
LNFCHQDVIW RDTKQAARDP SPQRNVEPLC TCNDMTDEEC LNFCHQDVIW 
       260        270        280        290        300
RDTKQAARDP SPQRNVEPLC TCKDMTDKEC LYFCHQGIIW RDTKQAARDP 
       310        320        330        340        350
SPQRNVEPLC SCKDMSDKEC LNFCHQDVIW RDTKQAARDP SPQRNVEPLC 
       360        370        380        390        400
TCNDMTDEEC LNFCHQDVIW RDTKQAARDP SPQRNVEPLC TCNDMTDEEC 
       410        420        430        440        450
LNFCHQDVIW RDTKQAARDP SPQRNVEPLC SCKDMTDKEC LYFCHQDVIW 
       460        470        480        490        500
RDTKQAARDP SPQRNVEPLC SCKDMSDKEC LNFCHQDVIW RDTKQAARDP 
       510        520        530        540 
SPQRNVEPLC SCKDMTDKEC LNFCHQDVIW KNADTSANPE FLG

Length:543

Mass (Da):62,326

Last modified:February 1, 1994 - v2

Checksum:ⁱDF84A9631392FE4A

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L07528 mRNA Translation: AAA48515.1 D13322 Genomic DNA Translation: BAA02579.2
PIRⁱ	A46601

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L07528 mRNA Translation: AAA48515.1 D13322 Genomic DNA Translation: BAA02579.2
PIRⁱ	A46601

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1SRB	NMR	-	A	430-450	[»]
ProteinModelPortalⁱ	P13208
SMRⁱ	P13208
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

HOVERGENⁱ	HBG017852

HOVERGENⁱ

HBG017852

Miscellaneous databases

EvolutionaryTraceⁱ	P13208

EvolutionaryTraceⁱ

P13208

Family and domain databases

InterProⁱ	View protein in InterPro IPR019764 Endothelin_toxin_CS IPR001928 Endothln-like_toxin
Pfamⁱ	View protein in Pfam PF00322 Endothelin, 12 hits
SMARTⁱ	View protein in SMART SM00272 END, 12 hits
PROSITEⁱ	View protein in PROSITE PS00270 ENDOTHELIN, 12 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SRTX_ATREN
Accessionⁱ	P13208Primary (citable) accession number: P13208 Secondary accession number(s): P13209, P13210
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	February 1, 1994
	Last modified:	November 22, 2017
	This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Animal Toxin Annotation Program
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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Annotation systems

Supporting data

UniProtKB - P13208 (SRTX_ATREN)

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Sarafotoxin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ