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UniProtKB - P13191 (ALAT1_PIG)
Protein
Alanine aminotransferase 1
Gene
GPT
Organism
Sus scrofa (Pig)
Status
Functioni
Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity).
By similarityCatalytic activityi
- EC:2.6.1.2
Cofactori
: L-alanine degradation via transaminase pathway Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes pyruvate from L-alanine. This subpathway is part of the pathway L-alanine degradation via transaminase pathway, which is itself part of Amino-acid degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from L-alanine, the pathway L-alanine degradation via transaminase pathway and in Amino-acid degradation.
GO - Molecular functioni
- L-alanine:2-oxoglutarate aminotransferase activity Source: UniProtKB-EC
GO - Biological processi
- L-alanine catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Aminotransferase, Transferase |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
SABIO-RKi | P13191 |
UniPathwayi | UPA00528;UER00586 |
Names & Taxonomyi
Protein namesi | Recommended name: Alanine aminotransferase 1 (EC:2.6.1.2)Short name: ALT1 Alternative name(s): Glutamate pyruvate transaminase 1 Short name: GPT 1 Glutamic--alanine transaminase 1 Glutamic--pyruvic transaminase 1 |
Gene namesi | Name:GPT Synonyms:AAT1, GPT1 |
Organismi | Sus scrofa (Pig) |
Taxonomic identifieri | 9823 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000123935 | ‹1 – ›20 | Alanine aminotransferase 1Add BLAST | ›20 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 11 | N6-(pyridoxal phosphate)lysine | 1 | |
Glycosylationi | 11 | N-linked (Glc) (glycation) lysine; in vitro1 Publication | 1 |
Post-translational modificationi
Glycation of Lys-11 inactivates the enzyme.
Keywords - PTMi
Glycation, GlycoproteinProteomic databases
PaxDbi | P13191 |
PeptideAtlasi | P13191 |
Interactioni
Subunit structurei
Homodimer.
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000006308 |
Structurei
3D structure databases
AlphaFoldDBi | P13191 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0258, Eukaryota |
HOGENOMi | CLU_014254_3_1_1 |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit |
InterProi | View protein in InterPro IPR015421, PyrdxlP-dep_Trfase_major |
i Sequence
Sequence statusi: Fragment.
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 | ||
Non-terminal residuei | 20 | 1 |
Sequence databases
PIRi | A14344 |
Similar proteinsi
Cross-referencesi
Sequence databases
PIRi | A14344 |
3D structure databases
AlphaFoldDBi | P13191 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9823.ENSSSCP00000006308 |
Proteomic databases
PaxDbi | P13191 |
PeptideAtlasi | P13191 |
Phylogenomic databases
eggNOGi | KOG0258, Eukaryota |
HOGENOMi | CLU_014254_3_1_1 |
Enzyme and pathway databases
UniPathwayi | UPA00528;UER00586 |
SABIO-RKi | P13191 |
Gene expression databases
Genevisiblei | P13191, SS |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit |
InterProi | View protein in InterPro IPR015421, PyrdxlP-dep_Trfase_major |
MobiDBi | Search... |
Entry informationi
Entry namei | ALAT1_PIG | |
Accessioni | P13191Primary (citable) accession number: P13191 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | January 1, 1990 | |
Last modified: | May 25, 2022 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families