KIN2

Functionⁱ

Serine/threonine protein kinase involved in the regulation of exocytosis. Induces phosphorylation of SEC9 and its release from the plasma membrane to the cytosol.2 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	128	ATPPROSITE-ProRule annotation		1
Active siteⁱ	248	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	105 – 113	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
protein serine/threonine kinase activity
Source: SGD
Inferred from direct assayⁱ
- 8203145

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

exocytosis
Source: SGD
Inferred from genetic interactionⁱ
- 15563607
intracellular signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein autophosphorylation
Source: SGD
Inferred from direct assayⁱ
- 8203145
protein phosphorylation
Source: SGD
Inferred from direct assayⁱ
- 8203145

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Exocytosis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-32246-MONOMER
BRENDAⁱ	2.7.11.1 984

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein kinase KIN2 (EC:2.7.11.1)
Gene namesⁱ	Name:KIN2 Ordered Locus Names:YLR096W ORF Names:L8004.3
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome XII

Organism-specific databases

Saccharomyces Genome Database More...SGDⁱ	S000004086 KIN2

SGDⁱ

S000004086 KIN2

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086133	1 – 1147	Serine/threonine-protein kinase KIN2Add BLAST		1147

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	22	PhosphoserineCombined sources	1
Modified residueⁱ	146	PhosphoserineCombined sources	1
Modified residueⁱ	549	PhosphoserineCombined sources	1
Modified residueⁱ	609	PhosphoserineCombined sources	1
Modified residueⁱ	888	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P13186
PaxDbⁱ	P13186
PRIDEⁱ	P13186

PTM databases

iPTMnetⁱ	P13186

iPTMnetⁱ

P13186

Interactionⁱ

Subunit structureⁱ

Interacts with SEC9 and SRO7.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
BCK2	P33306	4	EBI-9723,EBI-3480
BUD14	P27637	4	EBI-9723,EBI-20747
RIM15	P43565	2	EBI-9723,EBI-15150

Protein-protein interaction databases

BioGridⁱ	31369, 202 interactors
Database of interacting proteins More...DIPⁱ	DIP-6276N
IntActⁱ	P13186, 66 interactors
Molecular INTeraction database More...MINTⁱ	P13186
STRINGⁱ	4932.YLR096W

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P13186
SMRⁱ	P13186
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	99 – 377	Protein kinasePROSITE-ProRule annotationAdd BLAST		279
Domainⁱ	1098 – 1147	KA1PROSITE-ProRule annotationAdd BLAST		50

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	527 – 536	Poly-Gln		10

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150878
HOGENOMⁱ	HOG000207352
InParanoidⁱ	P13186
KEGG Orthology (KO) More...KOⁱ	K19852
OMAⁱ	KFSIGNS
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C0QJU

Family and domain databases

InterProⁱ	View protein in InterPro IPR028375 KA1/Ssp2_C IPR001772 KA1_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02149 KA1, 1 hit PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF103243 SSF103243, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50032 KA1, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P13186-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPNPNTADYL VNPNFRTSKG GSLSPTPEAF NDTRVAAPAT LRMMGKQSGP 
        60         70         80         90        100
RNDQQQAPLM PPADIKQGKE QAAQRQNDAS RPNGAVELRQ FHRRSLGDWE 
       110        120        130        140        150
FLETVGAGSM GKVKLVKHRQ TKEICVIKIV NRASKAYLHK QHSLPSPKNE 
       160        170        180        190        200
SEILERQKRL EKEIARDKRT VREASLGQIL YHPHICRLFE MCTMSNHFYM 
       210        220        230        240        250
LFEYVSGGQL LDYIIQHGSL KEHHARKFAR GIASALQYLH ANNIVHRDLK 
       260        270        280        290        300
IENIMISSSG EIKIIDFGLS NIFDYRKQLH TFCGSLYFAA PELLKAQPYT 
       310        320        330        340        350
GPEVDIWSFG IVLYVLVCGK VPFDDENSSI LHEKIKKGKV DYPSHLSIEV 
       360        370        380        390        400
ISLLTRMIVV DPLRRATLKN VVEHPWMNRG YDFKAPSYVP NRVPLTPEMI 
       410        420        430        440        450
DSQVLKEMYR LEFIDDIEDT RRSLIRLVTE KEYIQLSQEY WDKLSNAKGL 
       460        470        480        490        500
SSSLNNNYLN STAQQTLIQN HITSNPSQSG YNEPDSNFED PTLAYHPLLS 
       510        520        530        540        550
IYHLVSEMVA RKLAKLQRRQ ALALQAQAQQ RQQQQQVALG TKVALNNNSP 
       560        570        580        590        600
DIMTKMRSPQ KEVVPNPGIF QVPAIGTSGT SNNTNTSNKP PLHVMVPPKL 
       610        620        630        640        650
TIPEQAHTSP TSRKSSDIHT ELNGVLKSTP VPVSGEYQQR SASPVVGEHQ 
       660        670        680        690        700
EKNTIGGIFR RISQSGQSQH PTRQQEPLPE REPPTYMSKS NEISIKVPKS 
       710        720        730        740        750
HSRTISDYIP SARRYPSYVP NSVDVKQKPA KNTTIAPPIR SVSQKQNSDL 
       760        770        780        790        800
PALPQNAELI VQKQRQKLLQ ENLDKLQIND NDNNNVNAVV DGINNDNSDH 
       810        820        830        840        850
YLSVPKGRKL HPSARAKSVG HARRESLKFT RPPIPAALPP SDMTNDNGFL 
       860        870        880        890        900
GEANKERYNP VSSNFSTVPE DSTTYSNDTN NRLTSVYSQE LTEKQILEEA 
       910        920        930        940        950
SKAPPGSMPS IDYPKSMFLK GFFSVQTTSS KPLPIVRHNI ISVLTRMNID 
       960        970        980        990       1000
FKEVKGGFIC VQQRPSIETA AVPVITTTGV GLDSGKAMDL QNSLDSQLSS 
      1010       1020       1030       1040       1050
SYHSTASSAS RNSSIKRQGS YKRGQNNIPL TPLATNTHQR NSSIPMSPNY 
      1060       1070       1080       1090       1100
GNQSNGTSGE LSSMSLDYVQ QQDDILTTSR AQNINNVNGQ TEQTNTSGIK 
      1110       1120       1130       1140 
ERPPIKFEIH IVKVRIVGLA GVHFKKVSGN TWLYKELASY ILKELNL

Length:1,147

Mass (Da):128,338

Last modified:December 15, 1998 - v3

Checksum:ⁱAC2660BF3CA69600

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	216 – 217	QH → HD in AAA34723 (PubMed:2957690).Curated	2
Sequence conflictⁱ	675 – 707	QEPLP…RTISD → SGTYSSKENLQHICQNQMKF PSKYRKAIVVLYQT (PubMed:2957690).CuratedAdd BLAST	33
Sequence conflictⁱ	756 – 758	NAE → KRQ in AAA34723 (PubMed:2957690).Curated	3
Sequence conflictⁱ	805	P → PLSVP (PubMed:2957690).Curated	1
Sequence conflictⁱ	1034 – 1037	ATNT → TTNSI (PubMed:2957690).Curated	4
Sequence conflictⁱ	1041 – 1042	NS → KT in AAA34723 (PubMed:2957690).Curated	2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M69018 Genomic DNA Translation: AAA34723.1 Z73268 Genomic DNA Translation: CAA97659.1 Z73269 Genomic DNA Translation: CAA97661.1 U53876 Genomic DNA Translation: AAB67540.1 BK006945 Genomic DNA Translation: DAA09412.1
PIRⁱ	S64930
NCBI Reference Sequences More...RefSeqⁱ	NP_013197.1, NM_001181983.1

Genome annotation databases

EnsemblFungiⁱ	YLR096W; YLR096W; YLR096W
GeneIDⁱ	850785
KEGGⁱ	sce:YLR096W

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P13186	Non-specific serine/threonine protein kinase		YEAS1		1147	UniRef100_P13186
Non-specific serine/threonine protein kinase		YEASA		1147
Non-specific serine/threonine protein kinase		Saccharomyces sp. 'boulardii'		1147
Non-specific serine/threonine protein kinase		YEASC		1147
Non-specific serine/threonine protein kinase		YEAS6		1147
+2

Protein	Similar proteins		Species	Score	Length	Source
P13186	Non-specific serine/threonine protein kinase		YEAS1		1147	UniRef90_P13186
Non-specific serine/threonine protein kinase		YEASA		1147
Non-specific serine/threonine protein kinase		Saccharomyces sp. 'boulardii'		1147
Non-specific serine/threonine protein kinase		YEASC		1147
Non-specific serine/threonine protein kinase		YEAS6		1147
+8

Protein	Similar proteins		Species	Score	Length	Source
P13186	Non-specific serine/threonine protein kinase		YEAS1		1147	UniRef50_P13186
Non-specific serine/threonine protein kinase		YEASA		1147
Non-specific serine/threonine protein kinase		Saccharomyces sp. 'boulardii'		1147
Non-specific serine/threonine protein kinase		YEASC		1147
Non-specific serine/threonine protein kinase		YEAS6		1147
+10

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M69018 Genomic DNA Translation: AAA34723.1 Z73268 Genomic DNA Translation: CAA97659.1 Z73269 Genomic DNA Translation: CAA97661.1 U53876 Genomic DNA Translation: AAB67540.1 BK006945 Genomic DNA Translation: DAA09412.1
PIRⁱ	S64930
RefSeqⁱ	NP_013197.1, NM_001181983.1

3D structure databases

ProteinModelPortalⁱ	P13186
SMRⁱ	P13186
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	31369, 202 interactors
DIPⁱ	DIP-6276N
IntActⁱ	P13186, 66 interactors
MINTⁱ	P13186
STRINGⁱ	4932.YLR096W

PTM databases

iPTMnetⁱ	P13186

iPTMnetⁱ

P13186

Proteomic databases

MaxQBⁱ	P13186
PaxDbⁱ	P13186
PRIDEⁱ	P13186

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YLR096W; YLR096W; YLR096W
GeneIDⁱ	850785
KEGGⁱ	sce:YLR096W

Organism-specific databases

SGDⁱ	S000004086 KIN2

Phylogenomic databases

GeneTreeⁱ	ENSGT00930000150878
HOGENOMⁱ	HOG000207352
InParanoidⁱ	P13186
KOⁱ	K19852
OMAⁱ	KFSIGNS
OrthoDBⁱ	EOG092C0QJU

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-32246-MONOMER
BRENDAⁱ	2.7.11.1 984

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P13186

PROⁱ

PR:P13186

Family and domain databases

InterProⁱ	View protein in InterPro IPR028375 KA1/Ssp2_C IPR001772 KA1_dom IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF02149 KA1, 1 hit PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF103243 SSF103243, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50032 KA1, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KIN2_YEAST
Accessionⁱ	P13186Primary (citable) accession number: P13186 Secondary accession number(s): D6VY96, Q12384
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	December 15, 1998
	Last modified:	November 7, 2018
	This is version 185 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Yeast chromosome XII
Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

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UniProtKB - P13186 (KIN2_YEAST)

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Serine/threonine-protein kinase KIN2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

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Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ