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Protein

Serine/threonine-protein kinase KIN2

Gene

KIN2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase involved in the regulation of exocytosis. Induces phosphorylation of SEC9 and its release from the plasma membrane to the cytosol.2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei128ATPPROSITE-ProRule annotation1
Active sitei248Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi105 – 113ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

  • exocytosis Source: SGD
  • intracellular signal transduction Source: GO_Central
  • protein autophosphorylation Source: SGD
  • protein phosphorylation Source: SGD

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processExocytosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32246-MONOMER
BRENDAi2.7.11.1 984

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase KIN2 (EC:2.7.11.1)
Gene namesi
Name:KIN2
Ordered Locus Names:YLR096W
ORF Names:L8004.3
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

SGDiS000004086 KIN2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000861331 – 1147Serine/threonine-protein kinase KIN2Add BLAST1147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1
Modified residuei549PhosphoserineCombined sources1
Modified residuei609PhosphoserineCombined sources1
Modified residuei888PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP13186
PaxDbiP13186
PRIDEiP13186

PTM databases

iPTMnetiP13186

Interactioni

Subunit structurei

Interacts with SEC9 and SRO7.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi31369, 202 interactors
DIPiDIP-6276N
IntActiP13186, 66 interactors
MINTiP13186
STRINGi4932.YLR096W

Structurei

3D structure databases

ProteinModelPortaliP13186
SMRiP13186
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini99 – 377Protein kinasePROSITE-ProRule annotationAdd BLAST279
Domaini1098 – 1147KA1PROSITE-ProRule annotationAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi527 – 536Poly-Gln10

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00930000150878
HOGENOMiHOG000207352
InParanoidiP13186
KOiK19852
OMAiKFSIGNS
OrthoDBiEOG092C0QJU

Family and domain databases

InterProiView protein in InterPro
IPR028375 KA1/Ssp2_C
IPR001772 KA1_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF02149 KA1, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF103243 SSF103243, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50032 KA1, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P13186-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPNPNTADYL VNPNFRTSKG GSLSPTPEAF NDTRVAAPAT LRMMGKQSGP
60 70 80 90 100
RNDQQQAPLM PPADIKQGKE QAAQRQNDAS RPNGAVELRQ FHRRSLGDWE
110 120 130 140 150
FLETVGAGSM GKVKLVKHRQ TKEICVIKIV NRASKAYLHK QHSLPSPKNE
160 170 180 190 200
SEILERQKRL EKEIARDKRT VREASLGQIL YHPHICRLFE MCTMSNHFYM
210 220 230 240 250
LFEYVSGGQL LDYIIQHGSL KEHHARKFAR GIASALQYLH ANNIVHRDLK
260 270 280 290 300
IENIMISSSG EIKIIDFGLS NIFDYRKQLH TFCGSLYFAA PELLKAQPYT
310 320 330 340 350
GPEVDIWSFG IVLYVLVCGK VPFDDENSSI LHEKIKKGKV DYPSHLSIEV
360 370 380 390 400
ISLLTRMIVV DPLRRATLKN VVEHPWMNRG YDFKAPSYVP NRVPLTPEMI
410 420 430 440 450
DSQVLKEMYR LEFIDDIEDT RRSLIRLVTE KEYIQLSQEY WDKLSNAKGL
460 470 480 490 500
SSSLNNNYLN STAQQTLIQN HITSNPSQSG YNEPDSNFED PTLAYHPLLS
510 520 530 540 550
IYHLVSEMVA RKLAKLQRRQ ALALQAQAQQ RQQQQQVALG TKVALNNNSP
560 570 580 590 600
DIMTKMRSPQ KEVVPNPGIF QVPAIGTSGT SNNTNTSNKP PLHVMVPPKL
610 620 630 640 650
TIPEQAHTSP TSRKSSDIHT ELNGVLKSTP VPVSGEYQQR SASPVVGEHQ
660 670 680 690 700
EKNTIGGIFR RISQSGQSQH PTRQQEPLPE REPPTYMSKS NEISIKVPKS
710 720 730 740 750
HSRTISDYIP SARRYPSYVP NSVDVKQKPA KNTTIAPPIR SVSQKQNSDL
760 770 780 790 800
PALPQNAELI VQKQRQKLLQ ENLDKLQIND NDNNNVNAVV DGINNDNSDH
810 820 830 840 850
YLSVPKGRKL HPSARAKSVG HARRESLKFT RPPIPAALPP SDMTNDNGFL
860 870 880 890 900
GEANKERYNP VSSNFSTVPE DSTTYSNDTN NRLTSVYSQE LTEKQILEEA
910 920 930 940 950
SKAPPGSMPS IDYPKSMFLK GFFSVQTTSS KPLPIVRHNI ISVLTRMNID
960 970 980 990 1000
FKEVKGGFIC VQQRPSIETA AVPVITTTGV GLDSGKAMDL QNSLDSQLSS
1010 1020 1030 1040 1050
SYHSTASSAS RNSSIKRQGS YKRGQNNIPL TPLATNTHQR NSSIPMSPNY
1060 1070 1080 1090 1100
GNQSNGTSGE LSSMSLDYVQ QQDDILTTSR AQNINNVNGQ TEQTNTSGIK
1110 1120 1130 1140
ERPPIKFEIH IVKVRIVGLA GVHFKKVSGN TWLYKELASY ILKELNL
Length:1,147
Mass (Da):128,338
Last modified:December 15, 1998 - v3
Checksum:iAC2660BF3CA69600
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216 – 217QH → HD in AAA34723 (PubMed:2957690).Curated2
Sequence conflicti675 – 707QEPLP…RTISD → SGTYSSKENLQHICQNQMKF PSKYRKAIVVLYQT (PubMed:2957690).CuratedAdd BLAST33
Sequence conflicti756 – 758NAE → KRQ in AAA34723 (PubMed:2957690).Curated3
Sequence conflicti805P → PLSVP (PubMed:2957690).Curated1
Sequence conflicti1034 – 1037ATNT → TTNSI (PubMed:2957690).Curated4
Sequence conflicti1041 – 1042NS → KT in AAA34723 (PubMed:2957690).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69018 Genomic DNA Translation: AAA34723.1
Z73268 Genomic DNA Translation: CAA97659.1
Z73269 Genomic DNA Translation: CAA97661.1
U53876 Genomic DNA Translation: AAB67540.1
BK006945 Genomic DNA Translation: DAA09412.1
PIRiS64930
RefSeqiNP_013197.1, NM_001181983.1

Genome annotation databases

EnsemblFungiiYLR096W; YLR096W; YLR096W
GeneIDi850785
KEGGisce:YLR096W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69018 Genomic DNA Translation: AAA34723.1
Z73268 Genomic DNA Translation: CAA97659.1
Z73269 Genomic DNA Translation: CAA97661.1
U53876 Genomic DNA Translation: AAB67540.1
BK006945 Genomic DNA Translation: DAA09412.1
PIRiS64930
RefSeqiNP_013197.1, NM_001181983.1

3D structure databases

ProteinModelPortaliP13186
SMRiP13186
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31369, 202 interactors
DIPiDIP-6276N
IntActiP13186, 66 interactors
MINTiP13186
STRINGi4932.YLR096W

PTM databases

iPTMnetiP13186

Proteomic databases

MaxQBiP13186
PaxDbiP13186
PRIDEiP13186

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR096W; YLR096W; YLR096W
GeneIDi850785
KEGGisce:YLR096W

Organism-specific databases

SGDiS000004086 KIN2

Phylogenomic databases

GeneTreeiENSGT00930000150878
HOGENOMiHOG000207352
InParanoidiP13186
KOiK19852
OMAiKFSIGNS
OrthoDBiEOG092C0QJU

Enzyme and pathway databases

BioCyciYEAST:G3O-32246-MONOMER
BRENDAi2.7.11.1 984

Miscellaneous databases

PROiPR:P13186

Family and domain databases

InterProiView protein in InterPro
IPR028375 KA1/Ssp2_C
IPR001772 KA1_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF02149 KA1, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF103243 SSF103243, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50032 KA1, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKIN2_YEAST
AccessioniPrimary (citable) accession number: P13186
Secondary accession number(s): D6VY96, Q12384
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: December 15, 1998
Last modified: November 7, 2018
This is version 185 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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