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Protein

Serine/threonine protein kinase KIN1

Gene

KIN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine protein kinase involved in the regulation of exocytosis. Induces phosphorylation of SEC9 and its release from the plasma membrane to the cytosol.3 Publications

Miscellaneous

Present with 279 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei149ATPPROSITE-ProRule annotation1
Active sitei269Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi126 – 134ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: SGD

GO - Biological processi

  • exocytosis Source: SGD
  • intracellular signal transduction Source: GO_Central
  • protein autophosphorylation Source: SGD
  • protein phosphorylation Source: SGD

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processExocytosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29722-MONOMER
BRENDAi2.7.11.1 984

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine protein kinase KIN1 (EC:2.7.11.1)
Gene namesi
Name:KIN1
Ordered Locus Names:YDR122W
ORF Names:YD9727.17
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

SGDiS000002529 KIN1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000861311 – 1064Serine/threonine protein kinase KIN1Add BLAST1064

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei534PhosphoserineCombined sources1
Modified residuei593PhosphoserineCombined sources1
Modified residuei646PhosphoserineCombined sources1
Modified residuei764PhosphoserineCombined sources1
Modified residuei986PhosphoserineCombined sources1

Post-translational modificationi

Autophosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP13185
PaxDbiP13185
PRIDEiP13185

PTM databases

iPTMnetiP13185

Interactioni

Subunit structurei

Interacts with SEC9 and SRO7.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SWE1P329443EBI-9716,EBI-18607

Protein-protein interaction databases

BioGridi32178, 119 interactors
DIPiDIP-1406N
IntActiP13185, 26 interactors
MINTiP13185
STRINGi4932.YDR122W

Structurei

3D structure databases

ProteinModelPortaliP13185
SMRiP13185
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini120 – 398Protein kinasePROSITE-ProRule annotationAdd BLAST279
Domaini1015 – 1064KA1PROSITE-ProRule annotationAdd BLAST50

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00930000150878
HOGENOMiHOG000207352
InParanoidiP13185
KOiK19852
OMAiNHPYICG
OrthoDBiEOG092C0QJU

Family and domain databases

InterProiView protein in InterPro
IPR028375 KA1/Ssp2_C
IPR001772 KA1_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF02149 KA1, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF103243 SSF103243, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50032 KA1, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

P13185-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDYHVNTAF SMGRGNQQDD GNSESNSMHT QPSTMAPATL RMMGKSPQQQ
60 70 80 90 100
QQQNTPLMPP ADIKYANNGN SHQAEQKERQ VELEGKSREN APKPNTTSQS
110 120 130 140 150
RVSSSQGMPK QFHRKSLGDW EFVETVGAGS MGKVKLAKHR YTNEVCAVKI
160 170 180 190 200
VNRATKAFLH KEQMLPPPKN EQDVLERQKK LEKEISRDKR TIREASLGQI
210 220 230 240 250
LYHPHICRLF EMCTLSNHFY MLFEYVSGGQ LLDYIIQHGS IREHQARKFA
260 270 280 290 300
RGIASALIYL HANNIVHRDL KIENIMISDS SEIKIIDFGL SNIYDSRKQL
310 320 330 340 350
HTFCGSLYFA APELLKANPY TGPEVDVWSF GVVLFVLVCG KVPFDDENSS
360 370 380 390 400
VLHEKIKQGK VEYPQHLSIE VISLLSKMLV VDPKRRATLK QVVEHHWMVR
410 420 430 440 450
GFNGPPPSYL PKRVPLTIEM LDINVLKEMY RLEFIDDVEE TRSVLVSIIT
460 470 480 490 500
DPTYVLLSRQ YWTLAAKMNA ESSDNGNAPN ITESFEDPTR AYHPMISIYY
510 520 530 540 550
LTSEMLDRKH AKIRNQQQRQ SHENIEKLSE IPESVKQRDV EVNTTAMKSE
560 570 580 590 600
PEATLATKDT SVPFTPKNSD GTEPPLHVLI PPRLAMPEQA HTSPTSRKSS
610 620 630 640 650
DNQRREMEYA LSPTPQGNDY QQFRVPSTTG DPSEKAKFGN IFRKLSQRRK
660 670 680 690 700
KTIEQTSVNS NNSINKPVQK THSRAVSDFV PGFAKPSYDS NYTMNEPVKT
710 720 730 740 750
NDSRGGNKGD FPALPADAEN MVEKQREKQI EEDIMKLHDI NKQNNEVAKG
760 770 780 790 800
SGREAYAAQK FEGSDDDENH PLPPLNVAKG RKLHPSARAK SVGHARRESL
810 820 830 840 850
KYMRPPMPSS AYPQQELIDT GFLESSDDNK SDSLGNVTSQ TNDSVSVHSV
860 870 880 890 900
NAHINSPSVE KELTDEEILQ EASRAPAGSM PSIDFPRSLF LKGFFSVQTT
910 920 930 940 950
SSKPLPIVRY KIMFVLRKMN IEFKEVKGGF VCMQRFSSNN VAAKREGTPR
960 970 980 990 1000
SIMPLSHHES IRRQGSNKYS PSSPLTTNSI HQRKTSITET YGDDKHSGTS
1010 1020 1030 1040 1050
LENIHQQGDG SEGMTTTEKE PIKFEIHIVK VRIVGLAGVH FKKISGNTWL
1060
YKELASSILK ELKL
Length:1,064
Mass (Da):120,071
Last modified:November 1, 1997 - v3
Checksum:iE4104B84A8E45C36
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25S → R in AAA34722 (PubMed:2957690).Curated1
Sequence conflicti453T → H (PubMed:2957690).Curated1
Sequence conflicti455V → G (PubMed:2957690).Curated1
Sequence conflicti718A → R in AAA34722 (PubMed:2957690).Curated1
Sequence conflicti920 – 921NI → IN in AAA34722 (PubMed:2957690).Curated2
Sequence conflicti976T → A in AAA34722 (PubMed:2957690).Curated1
Sequence conflicti979 – 980SI → T in AAA34722 (PubMed:2957690).Curated2
Sequence conflicti984 – 985KT → NS in AAA34722 (PubMed:2957690).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69017 Genomic DNA Translation: AAA34722.1
Z48758 Genomic DNA Translation: CAA88675.1
BK006938 Genomic DNA Translation: DAA11968.1
PIRiS52687
RefSeqiNP_010407.1, NM_001180430.1

Genome annotation databases

EnsemblFungiiYDR122W; YDR122W; YDR122W
GeneIDi851700
KEGGisce:YDR122W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M69017 Genomic DNA Translation: AAA34722.1
Z48758 Genomic DNA Translation: CAA88675.1
BK006938 Genomic DNA Translation: DAA11968.1
PIRiS52687
RefSeqiNP_010407.1, NM_001180430.1

3D structure databases

ProteinModelPortaliP13185
SMRiP13185
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32178, 119 interactors
DIPiDIP-1406N
IntActiP13185, 26 interactors
MINTiP13185
STRINGi4932.YDR122W

PTM databases

iPTMnetiP13185

Proteomic databases

MaxQBiP13185
PaxDbiP13185
PRIDEiP13185

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR122W; YDR122W; YDR122W
GeneIDi851700
KEGGisce:YDR122W

Organism-specific databases

SGDiS000002529 KIN1

Phylogenomic databases

GeneTreeiENSGT00930000150878
HOGENOMiHOG000207352
InParanoidiP13185
KOiK19852
OMAiNHPYICG
OrthoDBiEOG092C0QJU

Enzyme and pathway databases

BioCyciYEAST:G3O-29722-MONOMER
BRENDAi2.7.11.1 984

Miscellaneous databases

PROiPR:P13185

Family and domain databases

InterProiView protein in InterPro
IPR028375 KA1/Ssp2_C
IPR001772 KA1_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF02149 KA1, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF103243 SSF103243, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50032 KA1, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKIN1_YEAST
AccessioniPrimary (citable) accession number: P13185
Secondary accession number(s): D6VSA8, Q04606
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 190 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
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Main funding by: National Institutes of Health

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