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Protein

Cytochrome c oxidase subunit 7B, mitochondrial

Gene

COX7B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BRENDAi1.9.3.1 908

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 7B, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIIb
IHQ
Gene namesi
Name:COX7B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 32Mitochondrial matrix8
Transmembranei33 – 59HelicalAdd BLAST27
Topological domaini60 – 80Mitochondrial intermembraneAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24Mitochondrion1 PublicationAdd BLAST24
ChainiPRO_000000615725 – 80Cytochrome c oxidase subunit 7B, mitochondrialAdd BLAST56

Proteomic databases

PaxDbiP13183
PRIDEiP13183

Interactioni

Protein-protein interaction databases

CORUMiP13183
DIPiDIP-60939N
IntActiP13183, 1 interactor
STRINGi9913.ENSBTAP00000054163

Structurei

Secondary structure

180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00828
ProteinModelPortaliP13183
SMRiP13183
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP13183

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase VIIb family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J3GK Eukaryota
ENOG4112BN9 LUCA
HOGENOMiHOG000059529
HOVERGENiHBG051092
InParanoidiP13183
KOiK02271
TreeFamiTF105068

Family and domain databases

CDDicd01403 Cyt_c_Oxidase_VIIb, 1 hit
Gene3Di4.10.51.10, 1 hit
InterProiView protein in InterPro
IPR008433 Cyt_c_oxidase_suVIIB
IPR023272 Cyt_c_oxidase_suVIIB_dom_sf
PANTHERiPTHR16716 PTHR16716, 1 hit
PfamiView protein in Pfam
PF05392 COX7B, 1 hit
SUPFAMiSSF81423 SSF81423, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13183-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFPLAKNALS RLRVQSIQQA VARQIHQKRA PDFHDKYGNA VLASGATFCV
60 70 80
AVWVYMATQI GIEWNPSPVG RVTPKEWREQ
Length:80
Mass (Da):9,065
Last modified:October 31, 2006 - v3
Checksum:iD8EB7080C1CAEB16
GO

Sequence cautioni

The sequence AAA30489 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAI03175 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21V → VQAV in AAA30489 (PubMed:2550462).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05058 mRNA Translation: AAA30489.1 Different initiation.
BC103174 mRNA Translation: AAI03175.1 Different initiation.
PIRiA34410 OSBO7B
RefSeqiNP_786989.3, NM_175795.3
UniGeneiBt.91777

Genome annotation databases

GeneIDi100300550
KEGGibta:100300550

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J05058 mRNA Translation: AAA30489.1 Different initiation.
BC103174 mRNA Translation: AAI03175.1 Different initiation.
PIRiA34410 OSBO7B
RefSeqiNP_786989.3, NM_175795.3
UniGeneiBt.91777

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OCCX-ray2.80K/X25-80[»]
1OCOX-ray2.80K/X25-80[»]
1OCRX-ray2.35K/X25-80[»]
1OCZX-ray2.90K/X25-80[»]
1V54X-ray1.80K/X25-80[»]
1V55X-ray1.90K/X25-80[»]
2DYRX-ray1.80K/X25-80[»]
2DYSX-ray2.20K/X25-80[»]
2EIJX-ray1.90K/X25-80[»]
2EIKX-ray2.10K/X25-80[»]
2EILX-ray2.10K/X25-80[»]
2EIMX-ray2.60K/X25-80[»]
2EINX-ray2.70K/X25-80[»]
2OCCX-ray2.30K/X25-80[»]
2Y69X-ray1.95K/X1-80[»]
2YBBelectron microscopy19.00V25-80[»]
2ZXWX-ray2.50K/X25-80[»]
3ABKX-ray2.00K/X25-80[»]
3ABLX-ray2.10K/X25-80[»]
3ABMX-ray1.95K/X25-80[»]
3AG1X-ray2.20K/X25-80[»]
3AG2X-ray1.80K/X25-80[»]
3AG3X-ray1.80K/X25-80[»]
3AG4X-ray2.05K/X25-80[»]
3ASNX-ray3.00K/X25-80[»]
3ASOX-ray2.30K/X25-80[»]
3WG7X-ray1.90K/X25-80[»]
3X2QX-ray2.00K/X25-80[»]
5B1AX-ray1.50K/X25-80[»]
5B1BX-ray1.60K/X25-80[»]
5B3SX-ray1.68K/X25-80[»]
5GPNelectron microscopy5.40825-80[»]
5IY5X-ray2.00K/X30-78[»]
5LUFelectron microscopy9.10825-80[»]
5W97X-ray2.30K/k25-80[»]
5WAUX-ray1.95K/k25-80[»]
5X19X-ray2.20K/X25-80[»]
5X1BX-ray2.40K/X25-80[»]
5X1FX-ray2.20K/X25-80[»]
5XDQX-ray1.77K/X25-80[»]
5XDXX-ray1.99K/X25-80[»]
5XTHelectron microscopy3.90730-78[»]
5XTIelectron microscopy17.407/B730-78[»]
5Z84X-ray1.85K/X25-80[»]
5Z85X-ray1.85K/X25-80[»]
5Z86X-ray1.85K/X25-80[»]
5ZCOX-ray1.90K/X25-80[»]
5ZCPX-ray1.65K/X25-80[»]
5ZCQX-ray1.65K/X25-80[»]
DisProtiDP00828
ProteinModelPortaliP13183
SMRiP13183
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP13183
DIPiDIP-60939N
IntActiP13183, 1 interactor
STRINGi9913.ENSBTAP00000054163

Proteomic databases

PaxDbiP13183
PRIDEiP13183

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100300550
KEGGibta:100300550

Organism-specific databases

CTDi1349

Phylogenomic databases

eggNOGiENOG410J3GK Eukaryota
ENOG4112BN9 LUCA
HOGENOMiHOG000059529
HOVERGENiHBG051092
InParanoidiP13183
KOiK02271
TreeFamiTF105068

Enzyme and pathway databases

BRENDAi1.9.3.1 908

Miscellaneous databases

EvolutionaryTraceiP13183

Family and domain databases

CDDicd01403 Cyt_c_Oxidase_VIIb, 1 hit
Gene3Di4.10.51.10, 1 hit
InterProiView protein in InterPro
IPR008433 Cyt_c_oxidase_suVIIB
IPR023272 Cyt_c_oxidase_suVIIB_dom_sf
PANTHERiPTHR16716 PTHR16716, 1 hit
PfamiView protein in Pfam
PF05392 COX7B, 1 hit
SUPFAMiSSF81423 SSF81423, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOX7B_BOVIN
AccessioniPrimary (citable) accession number: P13183
Secondary accession number(s): Q3SZ39
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: October 31, 2006
Last modified: November 7, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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