UniProtKB - P13152 (GLHA1_ONCKE)
Protein
Glycoprotein hormones alpha chain 1
Gene
cgaa
Organism
Oncorhynchus keta (Chum salmon) (Salmo keta)
Status
Functioni
Involved in gametogenesis and steroidogenesis.
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
Keywordsi
Molecular function | Hormone |
Names & Taxonomyi
Protein namesi | Recommended name: Glycoprotein hormones alpha chain 1Alternative name(s): GTH-alpha Gonadotropin 1 alpha chain |
Gene namesi | Name:cgaa |
Organismi | Oncorhynchus keta (Chum salmon) (Salmo keta) |
Taxonomic identifieri | 8018 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Oncorhynchus |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | ‹1 – 13 | Add BLAST | ›13 | |
ChainiPRO_0000011669 | 14 – 108 | Glycoprotein hormones alpha chain 1Add BLAST | 95 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 24 ↔ 48 | By similarity | ||
Disulfide bondi | 27 ↔ 77 | By similarity | ||
Disulfide bondi | 45 ↔ 98 | By similarity | ||
Disulfide bondi | 49 ↔ 100 | By similarity | ||
Glycosylationi | 69 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 76 ↔ 103 | By similarity | ||
Glycosylationi | 94 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinInteractioni
Subunit structurei
Heterodimer of an alpha and a beta chain.
GO - Molecular functioni
- hormone activity Source: UniProtKB-KW
Family & Domainsi
Sequence similaritiesi
Belongs to the glycoprotein hormones subunit alpha family.Curated
Keywords - Domaini
SignalFamily and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000476, Glyco_hormone |
PANTHERi | PTHR11509, PTHR11509, 1 hit |
Pfami | View protein in Pfam PF00236, Hormone_6, 1 hit |
PRINTSi | PR00274, GLYCOHORMONE |
SMARTi | View protein in SMART SM00067, GHA, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00779, GLYCO_HORMONE_ALPHA_1, 1 hit PS00780, GLYCO_HORMONE_ALPHA_2, 1 hit PS50277, GLYCO_HORMONE_ALPHA_3, 1 hit |
i Sequence
Sequence statusi: Fragment.
: The displayed sequence is further processed into a mature form. Sequence processingi
P13152-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
SLILSILLYM ADSYQNSDMT NVGCEECKLK ENKVFSNPGA PVYQCTGCCF
60 70 80 90 100
SRAYPTPLQS KKAMLVPKNI TSEATCCVAK EGERVVVDNI KLTNHTECWC
NTCYHHKS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M27652 mRNA Translation: AAA49404.1 |
PIRi | JL0068, A60627 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M27652 mRNA Translation: AAA49404.1 |
PIRi | JL0068, A60627 |
3D structure databases
SMRi | P13152 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000476, Glyco_hormone |
PANTHERi | PTHR11509, PTHR11509, 1 hit |
Pfami | View protein in Pfam PF00236, Hormone_6, 1 hit |
PRINTSi | PR00274, GLYCOHORMONE |
SMARTi | View protein in SMART SM00067, GHA, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00779, GLYCO_HORMONE_ALPHA_1, 1 hit PS00780, GLYCO_HORMONE_ALPHA_2, 1 hit PS50277, GLYCO_HORMONE_ALPHA_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLHA1_ONCKE | |
Accessioni | P13152Primary (citable) accession number: P13152 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | January 1, 1990 | |
Last modified: | December 11, 2019 | |
This is version 82 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |