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Protein

Miraculin

Gene
N/A
Organism
Synsepalum dulcificum (Miracle fruit) (Richadella dulcifica)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miraculin has the property of modifying a sour taste into a sweet taste. This alteration of taste perception persists for many minutes.

GO - Molecular functioni

Keywordsi

Molecular functionTaste-modifying protein

Protein family/group databases

MEROPSiI03.030

Names & Taxonomyi

Protein namesi
Recommended name:
Miraculin
Short name:
MIR
OrganismiSynsepalum dulcificum (Miracle fruit) (Richadella dulcifica)
Taxonomic identifieri3743 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridsEricalesSapotaceaeChrysophylloideaeSynsepalum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 292 PublicationsAdd BLAST29
ChainiPRO_000001693530 – 220MiraculinAdd BLAST191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
GlycosylationiCAR_00013271N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi76 ↔ 1211 Publication
Disulfide bondi167Interchain1 Publication
Disulfide bondi177 ↔ 1881 Publication
Disulfide bondi181 ↔ 1841 Publication
GlycosylationiCAR_000133215N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

Glycosylated; contains as much as 13,9% of sugars (glucosamine, mannose, galactose, xylose, and fucose).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

PTM databases

GlyConnecti369
UniCarbKBiP13087

Expressioni

Tissue specificityi

Expressed in fruit pulp after pollination. Not expressed in seeds, stems or leaves.1 Publication

Interactioni

Subunit structurei

Homotetramer; dimer of homodimer.

Structurei

3D structure databases

ProteinModelPortaliP13087
SMRiP13087
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

CDDicd00178 STI, 1 hit
InterProiView protein in InterPro
IPR011065 Kunitz_inhibitor_STI-like_sf
IPR002160 Prot_inh_Kunz-lg
PANTHERiPTHR33107 PTHR33107, 1 hit
PfamiView protein in Pfam
PF00197 Kunitz_legume, 1 hit
PRINTSiPR00291 KUNITZINHBTR
SMARTiView protein in SMART
SM00452 STI, 1 hit
SUPFAMiSSF50386 SSF50386, 1 hit
PROSITEiView protein in PROSITE
PS00283 SOYBEAN_KUNITZ, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13087-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKELTMLSLS FFFVSALLAA AANPLLSAAD SAPNPVLDID GEKLRTGTNY
60 70 80 90 100
YIVPVLRDHG GGLTVSATTP NGTFVCPPRV VQTRKEVDHD RPLAFFPENP
110 120 130 140 150
KEDVVRVSTD LNINFSAFMP CRWTSSTVWR LDKYDESTGQ YFVTIGGVKG
160 170 180 190 200
NPGPETISSW FKIEEFCGSG FYKLVFCPTV CGSCKVKCGD VGIYIDQKGR
210 220
RRLALSDKPF AFEFNKTVYF
Length:220
Mass (Da):24,367
Last modified:July 15, 1999 - v3
Checksum:iBD7E70CE1AAEE520
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129W → S AA sequence (PubMed:2708331).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38598 mRNA Translation: BAA07603.1
PIRiJC4232 A33872

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

The sweet side of life - Issue 17 of December 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38598 mRNA Translation: BAA07603.1
PIRiJC4232 A33872

3D structure databases

ProteinModelPortaliP13087
SMRiP13087
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiI03.030

PTM databases

GlyConnecti369
UniCarbKBiP13087

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

CDDicd00178 STI, 1 hit
InterProiView protein in InterPro
IPR011065 Kunitz_inhibitor_STI-like_sf
IPR002160 Prot_inh_Kunz-lg
PANTHERiPTHR33107 PTHR33107, 1 hit
PfamiView protein in Pfam
PF00197 Kunitz_legume, 1 hit
PRINTSiPR00291 KUNITZINHBTR
SMARTiView protein in SMART
SM00452 STI, 1 hit
SUPFAMiSSF50386 SSF50386, 1 hit
PROSITEiView protein in PROSITE
PS00283 SOYBEAN_KUNITZ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMIRA_SYNDU
AccessioniPrimary (citable) accession number: P13087
Secondary accession number(s): Q41153
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 15, 1999
Last modified: April 25, 2018
This is version 93 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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