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Protein

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Gene

COX4I1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

  • cytochrome-c oxidase activity Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport
SIGNORiP13073

Protein family/group databases

TCDBi3.D.4.11.1 the proton-translocating cytochrome oxidase (cox) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
Short name:
COX IV-1
Gene namesi
Name:COX4I1
Synonyms:COX4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000131143.8
HGNCiHGNC:2265 COX4I1
MIMi123864 gene
neXtProtiNX_P13073

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1327
OpenTargetsiENSG00000131143
PharmGKBiPA26781

Chemistry databases

DrugBankiDB02659 Cholic Acid
DB04464 N-Formylmethionine

Polymorphism and mutation databases

BioMutaiCOX4I1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 22MitochondrionCombined sources1 PublicationAdd BLAST22
ChainiPRO_000000608423 – 169Cytochrome c oxidase subunit 4 isoform 1, mitochondrialAdd BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29N6-acetyllysine; alternateBy similarity1
Modified residuei29N6-succinyllysine; alternateBy similarity1
Modified residuei53N6-acetyllysineCombined sources1
Modified residuei56PhosphoserineBy similarity1
Modified residuei58PhosphoserineBy similarity1
Modified residuei60N6-acetyllysine; alternateCombined sources1
Modified residuei60N6-succinyllysine; alternateBy similarity1
Modified residuei67N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP13073
MaxQBiP13073
PaxDbiP13073
PeptideAtlasiP13073
PRIDEiP13073
ProteomicsDBi52896
TopDownProteomicsiP13073

PTM databases

CarbonylDBiP13073
iPTMnetiP13073
PhosphoSitePlusiP13073
SwissPalmiP13073

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000131143
CleanExiHS_COX4I1
ExpressionAtlasiP13073 baseline and differential
GenevisibleiP13073 HS

Organism-specific databases

HPAiCAB004080
HPA002485

Interactioni

Subunit structurei

Interacts with AFG1L (PubMed:26759378).1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107720, 62 interactors
CORUMiP13073
IntActiP13073, 108 interactors
MINTiP13073
STRINGi9606.ENSP00000253452

Structurei

3D structure databases

ProteinModelPortaliP13073
SMRiP13073
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4075 Eukaryota
ENOG4111T97 LUCA
GeneTreeiENSGT00390000002407
HOGENOMiHOG000231486
HOVERGENiHBG051087
InParanoidiP13073
KOiK02263
OMAiAMQTKRM
OrthoDBiEOG091G0XDH
PhylomeDBiP13073
TreeFamiTF105061

Family and domain databases

CDDicd00922 Cyt_c_Oxidase_IV, 1 hit
Gene3Di1.10.442.10, 1 hit
InterProiView protein in InterPro
IPR013288 Cyt_c_oxidase_su4
IPR004203 Cyt_c_oxidase_su4_fam
IPR036639 Cyt_c_oxidase_su4_sf
PANTHERiPTHR10707 PTHR10707, 1 hit
PfamiView protein in Pfam
PF02936 COX4, 1 hit
PRINTSiPR01873 CYTCOXIDASE4
SUPFAMiSSF81406 SSF81406, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P13073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLATRVFSLV GKRAISTSVC VRAHESVVKS EDFSLPAYMD RRDHPLPEVA
60 70 80 90 100
HVKHLSASQK ALKEKEKASW SSLSMDEKVE LYRIKFKESF AEMNRGSNEW
110 120 130 140 150
KTVVGGAMFF IGFTALVIMW QKHYVYGPLP QSFDKEWVAK QTKRMLDMKV
160
NPIQGLASKW DYEKNEWKK
Length:169
Mass (Da):19,577
Last modified:January 1, 1990 - v1
Checksum:iF6382FFDCF3BE4ED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0611273A → T1 PublicationCorresponds to variant dbSNP:rs11557187Ensembl.1
Natural variantiVAR_00217038Y → F. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21575 mRNA Translation: AAA99312.1
M34600 mRNA Translation: AAA52059.1
X54802 mRNA Translation: CAA38573.1
U90915 mRNA Translation: AAB51058.1
AF005889 Genomic DNA Translation: AAB94819.1
AF017115 Genomic DNA Translation: AAC99578.1
AH005828 Genomic DNA Translation: AAB97750.1
BT019825 mRNA Translation: AAV38628.1
AK311847 mRNA Translation: BAG34789.1
CH471114 Genomic DNA Translation: EAW95437.1
CH471114 Genomic DNA Translation: EAW95438.1
BC008704 mRNA Translation: AAH08704.1
BC021236 mRNA Translation: AAH21236.1
BC062437 mRNA Translation: AAH62437.1
CCDSiCCDS10955.1
PIRiS47012 OLHU4
RefSeqiNP_001305715.1, NM_001318786.1
NP_001305717.1, NM_001318788.1
NP_001305723.1, NM_001318794.1
NP_001305726.1, NM_001318797.1
NP_001305731.1, NM_001318802.1
NP_001852.1, NM_001861.4
UniGeneiHs.433419

Genome annotation databases

EnsembliENST00000253452; ENSP00000253452; ENSG00000131143
ENST00000561569; ENSP00000457015; ENSG00000131143
ENST00000562336; ENSP00000457513; ENSG00000131143
GeneIDi1327
KEGGihsa:1327
UCSCiuc002fje.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCOX41_HUMAN
AccessioniPrimary (citable) accession number: P13073
Secondary accession number(s): B2R4J2, D3DUM7, Q6P666
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: June 20, 2018
This is version 187 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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