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Protein

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Gene

COX4I1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytochrome-c oxidase activity Source: ProtInc

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P13073

Protein family/group databases

Transport Classification Database

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TCDBi
3.D.4.11.1 the proton-translocating cytochrome oxidase (cox) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide IV
Cytochrome c oxidase subunit IV isoform 1
Short name:
COX IV-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COX4I1
Synonyms:COX4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000131143.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2265 COX4I1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
123864 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P13073

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1327

Open Targets

More...
OpenTargetsi
ENSG00000131143

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26781

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02659 Cholic Acid
DB04464 N-Formylmethionine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
COX4I1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 22MitochondrionCombined sources1 PublicationAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000608423 – 169Cytochrome c oxidase subunit 4 isoform 1, mitochondrialAdd BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei29N6-acetyllysine; alternateBy similarity1
Modified residuei29N6-succinyllysine; alternateBy similarity1
Modified residuei53N6-acetyllysineCombined sources1
Modified residuei56PhosphoserineBy similarity1
Modified residuei58PhosphoserineBy similarity1
Modified residuei60N6-acetyllysine; alternateCombined sources1
Modified residuei60N6-succinyllysine; alternateBy similarity1
Modified residuei67N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P13073

MaxQB - The MaxQuant DataBase

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MaxQBi
P13073

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P13073

PeptideAtlas

More...
PeptideAtlasi
P13073

PRoteomics IDEntifications database

More...
PRIDEi
P13073

ProteomicsDB human proteome resource

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ProteomicsDBi
52896

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P13073

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P13073

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P13073

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P13073

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P13073

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000131143 Expressed in 229 organ(s), highest expression level in anterior cingulate cortex

CleanEx database of gene expression profiles

More...
CleanExi
HS_COX4I1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P13073 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P13073 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004080
HPA002485

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AFG1L (PubMed:26759378).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107720, 62 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P13073

Protein interaction database and analysis system

More...
IntActi
P13073, 110 interactors

Molecular INTeraction database

More...
MINTi
P13073

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000253452

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P13073

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P13073

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome c oxidase IV family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4075 Eukaryota
ENOG4111T97 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002407

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231486

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG051087

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P13073

KEGG Orthology (KO)

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KOi
K02263

Identification of Orthologs from Complete Genome Data

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OMAi
EKHYVYG

Database of Orthologous Groups

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OrthoDBi
EOG091G0XDH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P13073

TreeFam database of animal gene trees

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TreeFami
TF105061

Family and domain databases

Conserved Domains Database

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CDDi
cd00922 Cyt_c_Oxidase_IV, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.442.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013288 Cyt_c_oxidase_su4
IPR004203 Cyt_c_oxidase_su4_fam
IPR036639 Cyt_c_oxidase_su4_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10707 PTHR10707, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02936 COX4, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01873 CYTCOXIDASE4

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81406 SSF81406, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

P13073-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLATRVFSLV GKRAISTSVC VRAHESVVKS EDFSLPAYMD RRDHPLPEVA
60 70 80 90 100
HVKHLSASQK ALKEKEKASW SSLSMDEKVE LYRIKFKESF AEMNRGSNEW
110 120 130 140 150
KTVVGGAMFF IGFTALVIMW QKHYVYGPLP QSFDKEWVAK QTKRMLDMKV
160
NPIQGLASKW DYEKNEWKK
Length:169
Mass (Da):19,577
Last modified:January 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6382FFDCF3BE4ED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BNV9H3BNV9_HUMAN
Cytochrome c oxidase subunit 4 isof...
COX4I1
139Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BN72H3BN72_HUMAN
Cytochrome c oxidase subunit 4 isof...
COX4I1
126Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPG0H3BPG0_HUMAN
Cytochrome c oxidase subunit 4 isof...
COX4I1
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q86WV2Q86WV2_HUMAN
COX4I1 protein
COX4I1
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNI5H3BNI5_HUMAN
Cytochrome c oxidase subunit 4 isof...
COX4I1
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPR4H3BPR4_HUMAN
Cytochrome c oxidase subunit 4 isof...
COX4I1
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0611273A → T1 PublicationCorresponds to variant dbSNP:rs11557187Ensembl.1
Natural variantiVAR_00217038Y → F. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M21575 mRNA Translation: AAA99312.1
M34600 mRNA Translation: AAA52059.1
X54802 mRNA Translation: CAA38573.1
U90915 mRNA Translation: AAB51058.1
AF005889 Genomic DNA Translation: AAB94819.1
AF017115 Genomic DNA Translation: AAC99578.1
AH005828 Genomic DNA Translation: AAB97750.1
BT019825 mRNA Translation: AAV38628.1
AK311847 mRNA Translation: BAG34789.1
CH471114 Genomic DNA Translation: EAW95437.1
CH471114 Genomic DNA Translation: EAW95438.1
BC008704 mRNA Translation: AAH08704.1
BC021236 mRNA Translation: AAH21236.1
BC062437 mRNA Translation: AAH62437.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10955.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S47012 OLHU4

NCBI Reference Sequences

More...
RefSeqi
NP_001305715.1, NM_001318786.1
NP_001305717.1, NM_001318788.1
NP_001305723.1, NM_001318794.1
NP_001305726.1, NM_001318797.1
NP_001305731.1, NM_001318802.1
NP_001852.1, NM_001861.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.433419

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000253452; ENSP00000253452; ENSG00000131143
ENST00000561569; ENSP00000457015; ENSG00000131143
ENST00000562336; ENSP00000457513; ENSG00000131143

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1327

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1327

UCSC genome browser

More...
UCSCi
uc002fje.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M21575 mRNA Translation: AAA99312.1
M34600 mRNA Translation: AAA52059.1
X54802 mRNA Translation: CAA38573.1
U90915 mRNA Translation: AAB51058.1
AF005889 Genomic DNA Translation: AAB94819.1
AF017115 Genomic DNA Translation: AAC99578.1
AH005828 Genomic DNA Translation: AAB97750.1
BT019825 mRNA Translation: AAV38628.1
AK311847 mRNA Translation: BAG34789.1
CH471114 Genomic DNA Translation: EAW95437.1
CH471114 Genomic DNA Translation: EAW95438.1
BC008704 mRNA Translation: AAH08704.1
BC021236 mRNA Translation: AAH21236.1
BC062437 mRNA Translation: AAH62437.1
CCDSiCCDS10955.1
PIRiS47012 OLHU4
RefSeqiNP_001305715.1, NM_001318786.1
NP_001305717.1, NM_001318788.1
NP_001305723.1, NM_001318794.1
NP_001305726.1, NM_001318797.1
NP_001305731.1, NM_001318802.1
NP_001852.1, NM_001861.4
UniGeneiHs.433419

3D structure databases

ProteinModelPortaliP13073
SMRiP13073
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107720, 62 interactors
CORUMiP13073
IntActiP13073, 110 interactors
MINTiP13073
STRINGi9606.ENSP00000253452

Chemistry databases

DrugBankiDB02659 Cholic Acid
DB04464 N-Formylmethionine

Protein family/group databases

TCDBi3.D.4.11.1 the proton-translocating cytochrome oxidase (cox) superfamily

PTM databases

CarbonylDBiP13073
iPTMnetiP13073
PhosphoSitePlusiP13073
SwissPalmiP13073

Polymorphism and mutation databases

BioMutaiCOX4I1

Proteomic databases

EPDiP13073
MaxQBiP13073
PaxDbiP13073
PeptideAtlasiP13073
PRIDEiP13073
ProteomicsDBi52896
TopDownProteomicsiP13073

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1327
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253452; ENSP00000253452; ENSG00000131143
ENST00000561569; ENSP00000457015; ENSG00000131143
ENST00000562336; ENSP00000457513; ENSG00000131143
GeneIDi1327
KEGGihsa:1327
UCSCiuc002fje.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1327
DisGeNETi1327
EuPathDBiHostDB:ENSG00000131143.8

GeneCards: human genes, protein and diseases

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GeneCardsi
COX4I1
HGNCiHGNC:2265 COX4I1
HPAiCAB004080
HPA002485
MIMi123864 gene
neXtProtiNX_P13073
OpenTargetsiENSG00000131143
PharmGKBiPA26781

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4075 Eukaryota
ENOG4111T97 LUCA
GeneTreeiENSGT00390000002407
HOGENOMiHOG000231486
HOVERGENiHBG051087
InParanoidiP13073
KOiK02263
OMAiEKHYVYG
OrthoDBiEOG091G0XDH
PhylomeDBiP13073
TreeFamiTF105061

Enzyme and pathway databases

ReactomeiR-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-611105 Respiratory electron transport
SIGNORiP13073

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
COX4I1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
COX4I1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1327

Protein Ontology

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PROi
PR:P13073

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000131143 Expressed in 229 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_COX4I1
ExpressionAtlasiP13073 baseline and differential
GenevisibleiP13073 HS

Family and domain databases

CDDicd00922 Cyt_c_Oxidase_IV, 1 hit
Gene3Di1.10.442.10, 1 hit
InterProiView protein in InterPro
IPR013288 Cyt_c_oxidase_su4
IPR004203 Cyt_c_oxidase_su4_fam
IPR036639 Cyt_c_oxidase_su4_sf
PANTHERiPTHR10707 PTHR10707, 1 hit
PfamiView protein in Pfam
PF02936 COX4, 1 hit
PRINTSiPR01873 CYTCOXIDASE4
SUPFAMiSSF81406 SSF81406, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOX41_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13073
Secondary accession number(s): B2R4J2, D3DUM7, Q6P666
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: November 7, 2018
This is version 190 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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