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Entry version 195 (17 Jun 2020)
Sequence version 2 (19 Jul 2005)
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Protein

Ecdysone-induced protein 75B, isoform B

Gene

Eip75B

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Implicated in the regulation of ecdysone-triggered gene hierarchies. Probably plays a key role in mediating the regulation of the larval molt by 20-OH-ecdysone.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi455 – 531Nuclear receptorPROSITE-ProRule annotationAdd BLAST77
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri458 – 478NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri495 – 514NR C4-typePROSITE-ProRule annotationAdd BLAST20

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-200425 Carnitine metabolism
R-DME-204174 Regulation of pyruvate dehydrogenase (PDH) complex
R-DME-381340 Transcriptional regulation of white adipocyte differentiation
R-DME-383280 Nuclear Receptor transcription pathway
R-DME-400206 Regulation of lipid metabolism by PPARalpha
R-DME-4090294 SUMOylation of intracellular receptors
R-DME-5362517 Signaling by Retinoic Acid
R-DME-9616222 Transcriptional regulation of granulopoiesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ecdysone-induced protein 75B, isoform B
Alternative name(s):
E75-C
Nuclear receptor subfamily 1 group D member 3, isoform B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Eip75B
Synonyms:NR1D3
ORF Names:CG8127
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0000568 Eip75B

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000535051 – 1412Ecdysone-induced protein 75B, isoform BAdd BLAST1412

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P13055

PRoteomics IDEntifications database

More...
PRIDEi
P13055

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In mid instar larvae salivary glands, levels increase during puff stage 1, then remain relatively constant until the premetamorphic pulse of ecdysone at puff stage 5. Levels increase again in late larvae at puff stages 9-10. At puff stage 1 expression is also seen in the gut. Levels are low in the gut, Malpighian tubules, fat body and wing disks between stages 1 and 11.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

The expression of this protein is developmentally regulated and is correlated with the 20-OH-ecdysone induced activity of puff 75B.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0000568 Expressed in head and 30 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P13055 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P13055 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
65284, 10 interactors

Protein interaction database and analysis system

More...
IntActi
P13055, 9 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0297726

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P13055

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini565 – 813NR LBDPROSITE-ProRule annotationAdd BLAST249

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi6 – 10Poly-Ala5
Compositional biasi180 – 395Gln-richAdd BLAST216
Compositional biasi265 – 298Pro-richAdd BLAST34
Compositional biasi351 – 445Ser-richAdd BLAST95
Compositional biasi934 – 969Gln-richAdd BLAST36
Compositional biasi1113 – 1316Ser-richAdd BLAST204

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri458 – 478NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri495 – 514NR C4-typePROSITE-ProRule annotationAdd BLAST20

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3575 Eukaryota
ENOG410XT74 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P13055

KEGG Orthology (KO)

More...
KOi
K08701

Identification of Orthologs from Complete Genome Data

More...
OMAi
GSCQYFQ

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P13055

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.565.10, 1 hit
3.30.50.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035500 NHR-like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48508 SSF48508, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: P13055-2) [UniParc]FASTAAdd to basket
Also known as: E75C

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAVQAAAAA TSSGGSSGSV PGSGSGSASK LIKTEPIDFE MLHLEENERQ
60 70 80 90 100
QDIEREPSSS NSNSNSNSLT PQRYTHVQVQ TVPPRQPTGL TTPGGTQKVI
110 120 130 140 150
LTPRVEYVQQ RATSSTGGGM KHVYSQQQGT AASRSAPPET TALLTTTSGT
160 170 180 190 200
PQIIITRTLP SNQHLSRRHS ASPSALHHYQ QQQPQRQQSP PPLHHQQQQQ
210 220 230 240 250
QQHVRVIRDG RLYDEATVVV AARRHSVSPP PLHHHSRSAP VSPVIARRGG
260 270 280 290 300
AAAYMDQQYQ QRQTPPLAPP PPPPPPPPPP PPPQQQQQQY ISTGVPPPTA
310 320 330 340 350
AARKFVVSTS TRHVNVIASN HFQQQQQQHQ AQQHQQQHQQ HQQHQQHVIA
360 370 380 390 400
SVSSSSSSSA IGSGGSSSSH IFRTPVVSSS SSSNMHHQQQ QQQQQSSLGN
410 420 430 440 450
SVMRPPPPPP PPKVKHASSS SSGNSSSSNT NNSSSSSNGE EPSSSIPDLE
460 470 480 490 500
FDGTTVLCRV CGDKASGFHY GVHSCEGCKG FFRRSIQQKI QYRPCTKNQQ
510 520 530 540 550
CSILRINRNR CQYCRLKKCI AVGMSRDAVR FGRVPKREKA RILAAMQQST
560 570 580 590 600
QNRGQQRALA TELDDQPRLL AAVLRAHLET CEFTKEKVSA MRQRARDCPS
610 620 630 640 650
YSMPTLLACP LNPAPELQSE QEFSQRFAHV IRGVIDFAGM IPGFQLLTQD
660 670 680 690 700
DKFTLLKAGL FDALFVRLIC MFDSSINSII CLNGQVMRRD AIQNGANARF
710 720 730 740 750
LVDSTFNFAE RMNSMNLTDA EIGLFCAIVL ITPDRPGLRN LELIEKMYSR
760 770 780 790 800
LKGCLQYIVA QNRPDQPEFL AKLLETMPDL RTLSTLHTEK LVVFRTEHKE
810 820 830 840 850
LLRQQMWSME DGNNSDGQQN KSPSGSWADA MDVEAAKSPL GSVSSTESAD
860 870 880 890 900
LDYGSPSSSQ PQGVSLPSPP QQQPSALASS APLLAATLSG GCPLRNRANS
910 920 930 940 950
GSSGDSGAAE MDIVGSHAHL TQNGLTITPI VRHQQQQQQQ QQIGILNNAH
960 970 980 990 1000
SRNLNGGHAM CQQQQQHPQL HHHLTAGAAR YRKLDSPTDS GIESGNEKNE
1010 1020 1030 1040 1050
CKAVSSGGSS SCSSPRSSVD DALDCSDAAA NHNQVVQHPQ LSVVSVSPVR
1060 1070 1080 1090 1100
SPQPSTSSHL KRQIVEDMPV LKRVLQAPPL YDTNSLMDEA YKPHKKFRAL
1110 1120 1130 1140 1150
RHREFETAEA DASSSTSGSN SLSAGSPRQS PVPNSVATPP PSAASAAAGN
1160 1170 1180 1190 1200
PAQSQLHMHL TRSSPKASMA SSHSVLAKSL MAEPRMTPEQ MKRSDIIQNY
1210 1220 1230 1240 1250
LKRENSTAAS STTNGVGNRS PSSSSTPPPS AVQNQQRWGS SSVITTTCQQ
1260 1270 1280 1290 1300
RQQSVSPHSN GSSSSSSSSS SSSSSSSSTS SNCSSSSASS CQYFQSPHST
1310 1320 1330 1340 1350
SNGTSAPASS SSGSNSATPL LELQVDIADS AQPLNLSKKS PTPPPSKLHA
1360 1370 1380 1390 1400
LVAAANAVQR YPTLSADVTV TASNGGPPSA AASPAPSSSP PASVGSPNPG
1410
LSAAVHKVML EA
Length:1,412
Mass (Da):151,292
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F4C21B075443F8C
GO
Isoform C (identifier: P17671-1) [UniParc]FASTAAdd to basket
Also known as: E75A
The sequence of this isoform can be found in the external entry P17671.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,199
Mass (Da):128,534
GO
Isoform A (identifier: P17672-1) [UniParc]FASTAAdd to basket
Also known as: E75B
The sequence of this isoform can be found in the external entry P17672.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:1,355
Mass (Da):147,171
GO
Isoform D (identifier: P17671-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P17671.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:906
Mass (Da):96,437
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9NED3M9NED3_DROME
Ecdysone-induced protein 75B, isofo...
Eip75B 57B, 75B, anon-WO0172774.31, anon-WO0172774.32, BcDNA:GM02640
1,412Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0S0WIG6A0A0S0WIG6_DROME
Ecdysone-induced protein 75B, isofo...
Eip75B 57B, 75B, anon-WO0172774.31, anon-WO0172774.32, BcDNA:GM02640
991Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA33611 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti20V → F in CAA33611 (PubMed:2508058).Curated1
Sequence conflicti183Q → QQ in CAA33611 (PubMed:2508058).Curated1
Sequence conflicti337 – 342Missing (PubMed:2508058).Curated6
Sequence conflicti1142S → V in CAA33611 (PubMed:2508058).Curated1
Sequence conflicti1216V → L in CAA33611 (PubMed:2508058).Curated1
Sequence conflicti1231Missing in CAA33611 (PubMed:2508058).Curated1
Sequence conflicti1302N → I in CAA33611 (PubMed:2508058).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X15586 mRNA Translation: CAA33611.1 Frameshift.
AE014296 Genomic DNA Translation: AAF49282.3

Protein sequence database of the Protein Information Resource

More...
PIRi
S05979

NCBI Reference Sequences

More...
RefSeqi
NP_001246821.1, NM_001259892.1 [P13055-2]
NP_001246822.1, NM_001259893.2 [P13055-2]
NP_730321.1, NM_168755.1 [P13055-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0075148; FBpp0074914; FBgn0000568 [P13055-2]
FBtr0306813; FBpp0297725; FBgn0000568 [P13055-2]
FBtr0306814; FBpp0297726; FBgn0000568 [P13055-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
39999

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG8127

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15586 mRNA Translation: CAA33611.1 Frameshift.
AE014296 Genomic DNA Translation: AAF49282.3
PIRiS05979
RefSeqiNP_001246821.1, NM_001259892.1 [P13055-2]
NP_001246822.1, NM_001259893.2 [P13055-2]
NP_730321.1, NM_168755.1 [P13055-2]

3D structure databases

SMRiP13055
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi65284, 10 interactors
IntActiP13055, 9 interactors
STRINGi7227.FBpp0297726

Proteomic databases

PaxDbiP13055
PRIDEiP13055

Genome annotation databases

EnsemblMetazoaiFBtr0075148; FBpp0074914; FBgn0000568 [P13055-2]
FBtr0306813; FBpp0297725; FBgn0000568 [P13055-2]
FBtr0306814; FBpp0297726; FBgn0000568 [P13055-2]
GeneIDi39999
KEGGidme:Dmel_CG8127

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
39999
FlyBaseiFBgn0000568 Eip75B

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XT74 LUCA
InParanoidiP13055
KOiK08701
OMAiGSCQYFQ
PhylomeDBiP13055

Enzyme and pathway databases

ReactomeiR-DME-200425 Carnitine metabolism
R-DME-204174 Regulation of pyruvate dehydrogenase (PDH) complex
R-DME-381340 Transcriptional regulation of white adipocyte differentiation
R-DME-383280 Nuclear Receptor transcription pathway
R-DME-400206 Regulation of lipid metabolism by PPARalpha
R-DME-4090294 SUMOylation of intracellular receptors
R-DME-5362517 Signaling by Retinoic Acid
R-DME-9616222 Transcriptional regulation of granulopoiesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
39999 1 hit in 5 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Eip75B fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
39999

Gene expression databases

BgeeiFBgn0000568 Expressed in head and 30 other tissues
ExpressionAtlasiP13055 baseline and differential
GenevisibleiP13055 DM

Family and domain databases

Gene3Di1.10.565.10, 1 hit
3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR-like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001728 ThyrH_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00546 THYROIDHORMR
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiE75BB_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13055
Secondary accession number(s): Q9VVM9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: July 19, 2005
Last modified: June 17, 2020
This is version 195 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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