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Entry version 93 (02 Dec 2020)
Sequence version 1 (01 Jan 1990)
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Protein

RNA2 polyprotein

Gene
N/A
Organism
Grapevine chrome mosaic virus (GCMV) (Hungarian grapevine chrome mosaic virus)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

implicated in RNA2 replication. Could also be required for nematode transmission of the virus (By similarity).

By similarity

transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Acts by forming a tubular structure at the host plasmodesmata, enlarging it enough to allow free passage of virion capsids (By similarity).

By similarity

Miscellaneous

Virions are comprised of 60 copies of the coat protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionViral movement protein
Biological processTransport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA2 polyprotein
Alternative name(s):
P2
Cleaved into the following 3 chains:
Protein 2A
Short name:
P2A
Alternative name(s):
2B-MP
Alternative name(s):
2C-CP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGrapevine chrome mosaic virus (GCMV) (Hungarian grapevine chrome mosaic virus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri12273 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraePisuviricotaPisoniviricetesPicornaviralesSecoviridaeComovirinaeNepovirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiApium graveolens (Celery) [TaxID: 4045]
Vitis vinifera (Grape) [TaxID: 29760]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008624 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

  • host plasmodesma
  • Note: Assembles in tubules that are embedded within modified plasmodesmata (By similarity). Movement proteins are targeted preferentially to calreticulin-labeled foci within the youngest cross walls, where they assemble into tubules. During cell division, they colocalize in the cell plate with KNOLLE, a cytokinesis-specific syntaxin (By similarity).By similarity
  • Host cytoplasm By similarity
  • Host nucleus By similarity
  • Note: Cytoplasmic early in infection. Later in infection, it becomes progressively concentrated around the nucleus, where it forms large aggregates (By similarity).By similarity

Keywords - Cellular componenti

Capsid protein, Host cell junction, Host cytoplasm, Host nucleus, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000371211 – ?Protein 2ABy similarity
ChainiPRO_0000037122? – 810Movement proteinBy similarity
ChainiPRO_0000037123811 – 1324Coat proteinBy similarityAdd BLAST514

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo by the P1 encoded 3C-like protease yield mature proteins.By similarity
The N-terminus of the coat protein is blocked.

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P13026

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005054, Nepo_coat
IPR005305, Nepo_coat_C
IPR005306, Nepo_coat_N
IPR029053, Viral_coat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03391, Nepo_coat, 1 hit
PF03688, Nepo_coat_C, 1 hit
PF03689, Nepo_coat_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P13026-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGFSEFFASA LGTVARAKAT LQGGFARFLS ETVVTLQAAS PEMRKFAYSK
60 70 80 90 100
LWEEVDSVKE LKPLTAQELV ATLRKELWCA QVRAQKCTLA STSRFCTCGG
110 120 130 140 150
IPGEATPTVI KETVHVDECP NGRNLCRHGT RCLRHGGPGS FQQEREVQVD
160 170 180 190 200
APKCPHCAGT GIVPASASWR EIRRCWREQR KVHSLPSLPL HPDVLFEGTN
210 220 230 240 250
AWQTRLRWLK TWRHVLGDVK PCTPEKWMQA AQIMRTCAVP SFENPIPGQF
260 270 280 290 300
GYERLYNGEG KEEYWLQIPA TDKYTDLIIN WWHAKNTPGW EEPSSSLMDF
310 320 330 340 350
KRNRMGPCLH IVEKRVRNSY VAPPWKPWGE DIDILSVMDS LSSQLEDFLD
360 370 380 390 400
VFYDCAAQFD GELEFSLSND RLSSVTGELG GVPISIGAPS KISNTPPKVN
410 420 430 440 450
FAELYGNLVR HNHRKISALR PILMAHPDQD EIEDQLDHLE NKQGGEIVST
460 470 480 490 500
PSFIKMLKEK RKEVRGKEFE EGSEGRLVRS KDLELSKKDI FLAHTLMDKF
510 520 530 540 550
HGMSIVKKFG KSDPKLTKVC VDLTNQEEVI KYPVKELQTT SEGVLSAQTF
560 570 580 590 600
TVLNRPQFKE LNRLAEVGWK EAKSVCLNLH IRSYLPVHLP VYAFCVIMWG
610 620 630 640 650
HSSNAEQASL SGAYVYLGDQ EASVLQLPLL CGYIGNALED MEAYKRSLVL
660 670 680 690 700
STCFFGTSGL SPGQNMFGIT AVEFTEYLPT SYGGITHERD SWNQMLRNHQ
710 720 730 740 750
GVDKQRFISG FNVVDFVEAG KEKQLHFPDF DLQPVPKHQP IVRTFGKEKQ
760 770 780 790 800
PLLNKSRSMR VKTFTSFRAG NIPIGRQIDN TAEAINFELG RASTSNAINP
810 820 830 840 850
RLDTSETNLR AGGEFAFIHT IDLPTAVTEG QVLAKIDIFK KIQDAKSMVC
860 870 880 890 900
VQWMQAGYVN KNLTFISHLA PSQFCGVAIW YIFDAYGKIP SDVTTSLELE
910 920 930 940 950
IARSLCPHVH VLRDSKTSVW TIDFHKICGQ SLNFSGRGFS KPTLWVIAAS
960 970 980 990 1000
TAQLPWSAQV TYRLEALAQG DEIAHGLATR SIVTYPISLE HLKDIEIMLP
1010 1020 1030 1040 1050
PRQMAIGNAG SINFPLSFAV QQKSSSGRIA YSYAAGLLSH FLGIGGTIHF
1060 1070 1080 1090 1100
KIQCTSSAFV TARLRVALWG DTITLEQLSQ MPHVDCDVDV VSSLKIQSPF
1110 1120 1130 1140 1150
YATANFGDSG ARFWVTPMSS PMAPETMESK LEYYIQILGI DADPPMCRQI
1160 1170 1180 1190 1200
NYDQRFAWFT LLRPPDPKLS KILKLTLPSR VCNIAYKEAT VTNYVNAFAI
1210 1220 1230 1240 1250
MCATTGMHAG KCILHFSWTL NKGTSFKDLQ GHISFYSGMG DSTIGEHHGE
1260 1270 1280 1290 1300
FHLGGPLSSS LAVPFEFGSF AGPVTSGGTP FTSENWLRVE TAHWDWLTSL
1310 1320
TVDIQVLPGF RFYGRSAGPL TIPS
Length:1,324
Mass (Da):147,805
Last modified:January 1, 1990 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i302C286B2EA1756A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti400N → D. 1
Natural varianti1006I → T. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X15163 Genomic RNA Translation: CAA33255.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S06187

NCBI Reference Sequences

More...
RefSeqi
NP_619704.1, NC_003621.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
956640

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:956640

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15163 Genomic RNA Translation: CAA33255.1
PIRiS06187
RefSeqiNP_619704.1, NC_003621.1

3D structure databases

SMRiP13026
ModBaseiSearch...

Genome annotation databases

GeneIDi956640
KEGGivg:956640

Family and domain databases

Gene3Di2.60.120.20, 2 hits
InterProiView protein in InterPro
IPR005054, Nepo_coat
IPR005305, Nepo_coat_C
IPR005306, Nepo_coat_N
IPR029053, Viral_coat
PfamiView protein in Pfam
PF03391, Nepo_coat, 1 hit
PF03688, Nepo_coat_C, 1 hit
PF03689, Nepo_coat_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOL2_GCMV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P13026
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: December 2, 2020
This is version 93 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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