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UniProtKB - P12980 (LYL1_HUMAN)
Protein
Protein lyl-1
Gene
LYL1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- B cell differentiation Source: UniProtKB
- blood vessel maturation Source: UniProtKB
- definitive hemopoiesis Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P12980 |
Reactomei | R-HSA-9031628, NGF-stimulated transcription |
SignaLinki | P12980 |
SIGNORi | P12980 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein lyl-1Alternative name(s): Class A basic helix-loop-helix protein 18 Short name: bHLHa18 Lymphoblastic leukemia-derived sequence 1 |
Gene namesi | Name:LYL1 Synonyms:BHLHA18 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6734, LYL1 |
MIMi | 151440, gene+phenotype |
neXtProti | NX_P12980 |
VEuPathDBi | HostDB:ENSG00000104903 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleoplasm Source: Reactome
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB.
Keywords - Diseasei
Proto-oncogeneOrganism-specific databases
DisGeNETi | 4066 |
MIMi | 151440, gene+phenotype |
OpenTargetsi | ENSG00000104903 |
PharmGKBi | PA30497 |
Miscellaneous databases
Pharosi | P12980, Tbio |
Genetic variation databases
BioMutai | LYL1 |
DMDMi | 226694149 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127262 | 1 – 280 | Protein lyl-1Add BLAST | 280 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 260 | PhosphoserineCombined sources | 1 | |
Modified residuei | 276 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
CPTACi | CPTAC-1208 CPTAC-1209 |
EPDi | P12980 |
MassIVEi | P12980 |
MaxQBi | P12980 |
PaxDbi | P12980 |
PeptideAtlasi | P12980 |
PRIDEi | P12980 |
ProteomicsDBi | 52889 |
PTM databases
iPTMneti | P12980 |
PhosphoSitePlusi | P12980 |
Expressioni
Gene expression databases
Bgeei | ENSG00000104903, Expressed in blood and 194 other tissues |
ExpressionAtlasi | P12980, baseline and differential |
Genevisiblei | P12980, HS |
Organism-specific databases
HPAi | ENSG00000104903, Tissue enhanced (bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Efficient DNA binding requires dimerization with another bHLH protein.
GO - Molecular functioni
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
BioGRIDi | 110244, 11 interactors |
DIPi | DIP-40885N |
IntActi | P12980, 2 interactors |
STRINGi | 9606.ENSP00000264824 |
Miscellaneous databases
RNActi | P12980, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 150 – 202 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 60 | DisorderedSequence analysisAdd BLAST | 60 | |
Regioni | 214 – 280 | DisorderedSequence analysisAdd BLAST | 67 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 24 – 39 | Pro residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 225 – 243 | Basic and acidic residuesSequence analysisAdd BLAST | 19 |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000162404 |
HOGENOMi | CLU_047980_1_0_1 |
InParanoidi | P12980 |
OMAi | HRVPDDG |
OrthoDBi | 1453623at2759 |
PhylomeDBi | P12980 |
TreeFami | TF315153 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR040238, TAL-like |
PANTHERi | PTHR13864, PTHR13864, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P12980-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCPPQAQAEV GPTMTEKAEM VCAPSPAPAP PPKPASPGPP QVEEVGHRGG
60 70 80 90 100
SSPPRLPPGV PVISLGHSRP PGVAMPTTEL GTLRPPLLQL STLGTAPPTL
110 120 130 140 150
ALHYHPHPFL NSVYIGPAGP FSIFPSSRLK RRPSHCELDL AEGHQPQKVA
160 170 180 190 200
RRVFTNSRER WRQQNVNGAF AELRKLLPTH PPDRKLSKNE VLRLAMKYIG
210 220 230 240 250
FLVRLLRDQA AALAAGPTPP GPRKRPVHRV PDDGARRGSG RRAEAAARSQ
260 270 280
PAPPADPDGS PGGAARPIKM EQTALSPEVR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketK7ER61 | K7ER61_HUMAN | Protein lyl-1 | LYL1 | 57 | Annotation score: |
Sequence cautioni
The sequence AAA88084 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAA88085 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAA92488 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 235 | A → P in AAA88084 (PubMed:2752424).Curated | 1 | |
Sequence conflicti | 235 | A → P in AAA88085 (PubMed:2752424).Curated | 1 | |
Sequence conflicti | 235 | A → P in AAA92488 (PubMed:2752424).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22637 mRNA Translation: AAA88084.1 Different initiation. M22637 mRNA Translation: AAA88085.1 Different initiation. M22638 Genomic DNA Translation: AAA92488.1 Different initiation. AC005546 Genomic DNA Translation: AAC33149.1 AC007787 Genomic DNA No translation available. BC002796 mRNA Translation: AAH02796.2 |
CCDSi | CCDS12292.1 |
PIRi | A30988 |
RefSeqi | NP_005574.2, NM_005583.4 |
Genome annotation databases
Ensembli | ENST00000264824.5; ENSP00000264824.3; ENSG00000104903.5 |
GeneIDi | 4066 |
KEGGi | hsa:4066 |
MANE-Selecti | ENST00000264824.5; ENSP00000264824.3; NM_005583.5; NP_005574.2 |
UCSCi | uc002mwi.4, human |
Keywords - Coding sequence diversityi
Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M22637 mRNA Translation: AAA88084.1 Different initiation. M22637 mRNA Translation: AAA88085.1 Different initiation. M22638 Genomic DNA Translation: AAA92488.1 Different initiation. AC005546 Genomic DNA Translation: AAC33149.1 AC007787 Genomic DNA No translation available. BC002796 mRNA Translation: AAH02796.2 |
CCDSi | CCDS12292.1 |
PIRi | A30988 |
RefSeqi | NP_005574.2, NM_005583.4 |
3D structure databases
AlphaFoldDBi | P12980 |
SMRi | P12980 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 110244, 11 interactors |
DIPi | DIP-40885N |
IntActi | P12980, 2 interactors |
STRINGi | 9606.ENSP00000264824 |
PTM databases
iPTMneti | P12980 |
PhosphoSitePlusi | P12980 |
Genetic variation databases
BioMutai | LYL1 |
DMDMi | 226694149 |
Proteomic databases
CPTACi | CPTAC-1208 CPTAC-1209 |
EPDi | P12980 |
MassIVEi | P12980 |
MaxQBi | P12980 |
PaxDbi | P12980 |
PeptideAtlasi | P12980 |
PRIDEi | P12980 |
ProteomicsDBi | 52889 |
Protocols and materials databases
Antibodypediai | 26353, 166 antibodies from 25 providers |
DNASUi | 4066 |
Genome annotation databases
Ensembli | ENST00000264824.5; ENSP00000264824.3; ENSG00000104903.5 |
GeneIDi | 4066 |
KEGGi | hsa:4066 |
MANE-Selecti | ENST00000264824.5; ENSP00000264824.3; NM_005583.5; NP_005574.2 |
UCSCi | uc002mwi.4, human |
Organism-specific databases
CTDi | 4066 |
DisGeNETi | 4066 |
GeneCardsi | LYL1 |
HGNCi | HGNC:6734, LYL1 |
HPAi | ENSG00000104903, Tissue enhanced (bone marrow, lymphoid tissue) |
MIMi | 151440, gene+phenotype |
neXtProti | NX_P12980 |
OpenTargetsi | ENSG00000104903 |
PharmGKBi | PA30497 |
VEuPathDBi | HostDB:ENSG00000104903 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4029, Eukaryota |
GeneTreei | ENSGT00940000162404 |
HOGENOMi | CLU_047980_1_0_1 |
InParanoidi | P12980 |
OMAi | HRVPDDG |
OrthoDBi | 1453623at2759 |
PhylomeDBi | P12980 |
TreeFami | TF315153 |
Enzyme and pathway databases
PathwayCommonsi | P12980 |
Reactomei | R-HSA-9031628, NGF-stimulated transcription |
SignaLinki | P12980 |
SIGNORi | P12980 |
Miscellaneous databases
BioGRID-ORCSi | 4066, 34 hits in 1100 CRISPR screens |
ChiTaRSi | LYL1, human |
GeneWikii | LYL1 |
GenomeRNAii | 4066 |
Pharosi | P12980, Tbio |
PROi | PR:P12980 |
RNActi | P12980, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104903, Expressed in blood and 194 other tissues |
ExpressionAtlasi | P12980, baseline and differential |
Genevisiblei | P12980, HS |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR040238, TAL-like |
PANTHERi | PTHR13864, PTHR13864, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LYL1_HUMAN | |
Accessioni | P12980Primary (citable) accession number: P12980 Secondary accession number(s): O76102 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1990 |
Last sequence update: | April 14, 2009 | |
Last modified: | May 25, 2022 | |
This is version 195 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot