LYL1

Functionⁱ

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18160048
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
protein dimerization activity Source: InterPro
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

B cell differentiation Source: UniProtKB
blood vessel maturation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20418284
definitive hemopoiesis Source: UniProtKB
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 18160048
regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 10023675
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	P12980

SIGNORⁱ

P12980

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein lyl-1 Alternative name(s): Class A basic helix-loop-helix protein 18 Short name: bHLHa18 Lymphoblastic leukemia-derived sequence 1
Gene namesⁱ	Name:LYL1 Synonyms:BHLHA18
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000104903.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6734 LYL1
MIMⁱ	151440 gene+phenotype
neXtProtⁱ	NX_P12980

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

A chromosomal aberration involving LYL1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;19)(q35;p13) with TCRB.

Keywords - Diseaseⁱ

Proto-oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4066
MIMⁱ	151440 gene+phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000104903
PharmGKBⁱ	PA30497

Polymorphism and mutation databases

BioMutaⁱ	LYL1
DMDMⁱ	226694149

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127262	1 – 280	Protein lyl-1Add BLAST		280

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	260	PhosphoserineCombined sources		1
Modified residueⁱ	276	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P12980
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P12980
PaxDbⁱ	P12980
PeptideAtlas More...PeptideAtlasⁱ	P12980
PRIDEⁱ	P12980
ProteomicsDBⁱ	52889

PTM databases

iPTMnetⁱ	P12980
PhosphoSitePlusⁱ	P12980

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000104903 Expressed in 175 organ(s), highest expression level in blood
CleanExⁱ	HS_LYL1
ExpressionAtlasⁱ	P12980 baseline and differential
Genevisibleⁱ	P12980 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA075004

HPAⁱ

HPA075004

Interactionⁱ

Subunit structureⁱ

Efficient DNA binding requires dimerization with another bHLH protein.

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110244, 9 interactors
Database of interacting proteins More...DIPⁱ	DIP-40885N
IntActⁱ	P12980, 2 interactors
STRINGⁱ	9606.ENSP00000264824

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P12980
SMRⁱ	P12980
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	150 – 202	bHLHPROSITE-ProRule annotationAdd BLAST		53

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119097
HOGENOMⁱ	HOG000113414
HOVERGENⁱ	HBG094957
InParanoidⁱ	P12980
KEGG Orthology (KO) More...KOⁱ	K15604
OMAⁱ	ARPIKME
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0ESI
PhylomeDBⁱ	P12980
TreeFamⁱ	TF315153

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P12980-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MCPPQAQAEV GPTMTEKAEM VCAPSPAPAP PPKPASPGPP QVEEVGHRGG 
        60         70         80         90        100
SSPPRLPPGV PVISLGHSRP PGVAMPTTEL GTLRPPLLQL STLGTAPPTL 
       110        120        130        140        150
ALHYHPHPFL NSVYIGPAGP FSIFPSSRLK RRPSHCELDL AEGHQPQKVA 
       160        170        180        190        200
RRVFTNSRER WRQQNVNGAF AELRKLLPTH PPDRKLSKNE VLRLAMKYIG 
       210        220        230        240        250
FLVRLLRDQA AALAAGPTPP GPRKRPVHRV PDDGARRGSG RRAEAAARSQ 
       260        270        280
PAPPADPDGS PGGAARPIKM EQTALSPEVR

Length:280

Mass (Da):29,938

Last modified:April 14, 2009 - v3

Checksum:ⁱ4A9D795FF74C59F8

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	K7ER61	K7ER61_HUMAN		Protein lyl-1 Protein lyl-1	LYL1	57	Annotation score:

Sequence cautionⁱ

The sequence AAA88084 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAA88085 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAA92488 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	235	A → P in AAA88084 (PubMed:2752424).Curated	1
Sequence conflictⁱ	235	A → P in AAA88085 (PubMed:2752424).Curated	1
Sequence conflictⁱ	235	A → P in AAA92488 (PubMed:2752424).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M22637 mRNA Translation: AAA88084.1 Different initiation. M22637 mRNA Translation: AAA88085.1 Different initiation. M22638 Genomic DNA Translation: AAA92488.1 Different initiation. AC005546 Genomic DNA Translation: AAC33149.1 AC007787 Genomic DNA No translation available. BC002796 mRNA Translation: AAH02796.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12292.1
PIRⁱ	A30988
NCBI Reference Sequences More...RefSeqⁱ	NP_005574.2, NM_005583.4
UniGeneⁱ	Hs.46446 Hs.728534

Genome annotation databases

Ensemblⁱ	ENST00000264824; ENSP00000264824; ENSG00000104903
GeneIDⁱ	4066
KEGGⁱ	hsa:4066
UCSC genome browser More...UCSCⁱ	uc002mwi.4 human

Keywords - Coding sequence diversityⁱ

Chromosomal rearrangement

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P12980	Protein lyl-1 (Fragment)		HUMAN		57	UniRef100_P12980
LYL1 isoform 1 (Fragment)		PONAB		57
LYL1 isoform 1 (Fragment)		PANTR		57
UPI0003EAEEFB		HUMAN		351
UPI00002034F2		HUMAN		206

Protein	Similar proteins		Species	Score	Length	Source
P12980	Protein lyl-1 (Fragment)		HUMAN		57	UniRef90_P12980
LYL1 isoform 1 (Fragment)		PONAB		57
LYL1 isoform 1 (Fragment)		PANTR		57
LYL1, basic helix-loop-helix family member		SAIBB		289
Uncharacterized protein		Cebus capucinus imitator		280
+8

Protein	Similar proteins		Species	Score	Length	Source
P12980	Protein lyl-1 (Fragment)		HUMAN		57	UniRef50_P12980
LYL1 isoform 1 (Fragment)		PONAB		57
LYL1 isoform 1 (Fragment)		PANTR		57
LYL1, basic helix-loop-helix family member		SAIBB		289
Uncharacterized protein		Cebus capucinus imitator		280
+14

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M22637 mRNA Translation: AAA88084.1 Different initiation. M22637 mRNA Translation: AAA88085.1 Different initiation. M22638 Genomic DNA Translation: AAA92488.1 Different initiation. AC005546 Genomic DNA Translation: AAC33149.1 AC007787 Genomic DNA No translation available. BC002796 mRNA Translation: AAH02796.2
CCDSⁱ	CCDS12292.1
PIRⁱ	A30988
RefSeqⁱ	NP_005574.2, NM_005583.4
UniGeneⁱ	Hs.46446 Hs.728534

3D structure databases

ProteinModelPortalⁱ	P12980
SMRⁱ	P12980
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110244, 9 interactors
DIPⁱ	DIP-40885N
IntActⁱ	P12980, 2 interactors
STRINGⁱ	9606.ENSP00000264824

PTM databases

iPTMnetⁱ	P12980
PhosphoSitePlusⁱ	P12980

Polymorphism and mutation databases

BioMutaⁱ	LYL1
DMDMⁱ	226694149

Proteomic databases

EPDⁱ	P12980
MaxQBⁱ	P12980
PaxDbⁱ	P12980
PeptideAtlasⁱ	P12980
PRIDEⁱ	P12980
ProteomicsDBⁱ	52889

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000264824; ENSP00000264824; ENSG00000104903
GeneIDⁱ	4066
KEGGⁱ	hsa:4066
UCSCⁱ	uc002mwi.4 human

Organism-specific databases

CTDⁱ	4066
DisGeNETⁱ	4066
EuPathDBⁱ	HostDB:ENSG00000104903.4
GeneCardsⁱ	LYL1
H-InvDBⁱ	HIX0014818
HGNCⁱ	HGNC:6734 LYL1
HPAⁱ	HPA075004
MIMⁱ	151440 gene+phenotype
neXtProtⁱ	NX_P12980
OpenTargetsⁱ	ENSG00000104903
PharmGKBⁱ	PA30497
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4029 Eukaryota ENOG411227D LUCA
GeneTreeⁱ	ENSGT00760000119097
HOGENOMⁱ	HOG000113414
HOVERGENⁱ	HBG094957
InParanoidⁱ	P12980
KOⁱ	K15604
OMAⁱ	ARPIKME
OrthoDBⁱ	EOG091G0ESI
PhylomeDBⁱ	P12980
TreeFamⁱ	TF315153

Enzyme and pathway databases

SIGNORⁱ	P12980

SIGNORⁱ

P12980

Miscellaneous databases

GeneWikiⁱ	LYL1
GenomeRNAiⁱ	4066
Protein Ontology More...PROⁱ	PR:P12980
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000104903 Expressed in 175 organ(s), highest expression level in blood
CleanExⁱ	HS_LYL1
ExpressionAtlasⁱ	P12980 baseline and differential
Genevisibleⁱ	P12980 HS

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LYL1_HUMAN
Accessionⁱ	P12980Primary (citable) accession number: P12980 Secondary accession number(s): O76102
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1990
	Last sequence update:	April 14, 2009
	Last modified:	November 7, 2018
	This is version 176 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P12980 (LYL1_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Protein lyl-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ