Rpl7a

Functionⁱ

GO - Molecular functionⁱ

RNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

maturation of LSU-rRNA
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
translation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, Ribosomal protein

Molecular function

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 60S ribosomal protein L7a Alternative name(s): Surfeit locus protein 3
Gene namesⁱ	Name:Rpl7a Synonyms:Surf-3, Surf3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:1353472 Rpl7a

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000136748	1 – 266	60S ribosomal protein L7aAdd BLAST		266

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	11	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	20	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	21	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	34	N6-acetyllysineBy similarity	1
Cross-linkⁱ	48	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	97	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	97	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linkⁱ	125	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	217	N6-acetyllysineBy similarity	1
Cross-linkⁱ	245	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	P12970
PaxDbⁱ	P12970
PeptideAtlas More...PeptideAtlasⁱ	P12970
PRIDEⁱ	P12970

PTM databases

iPTMnetⁱ	P12970
PhosphoSitePlusⁱ	P12970
SwissPalmⁱ	P12970

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000062647 Expressed in 21 organ(s), highest expression level in female gonad
CleanExⁱ	MM_RPL7A
ExpressionAtlasⁱ	P12970 baseline and differential
Genevisibleⁱ	P12970 MM

Interactionⁱ

Subunit structureⁱ

Interacts with CRY1 (PubMed:19129230). Interacts with DICER1, AGO2, TARBP2, MOV10 and EIF6; they form a large RNA-induced silencing complex (RISC) (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridⁱ	205125, 4 interactors
CORUMⁱ	P12970
IntActⁱ	P12970, 9 interactors
Molecular INTeraction database More...MINTⁱ	P12970
STRINGⁱ	10090.ENSMUSP00000135914

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P12970
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the eukaryotic ribosomal protein eL8 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3166 Eukaryota COG1358 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004753
HOVERGENⁱ	HBG002936
InParanoidⁱ	P12970
KEGG Orthology (KO) More...KOⁱ	K02936
OMAⁱ	KWPRYVR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HPD
PhylomeDBⁱ	P12970
TreeFamⁱ	TF300788

Family and domain databases

Gene3Dⁱ	3.30.1330.210, 1 hit
InterProⁱ	View protein in InterPro IPR029064 L30e-like IPR001921 Ribosomal_L7A/L8 IPR038524 Ribosomal_L7A/L8_sf IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45 IPR018492 Ribosomal_L7Ae/L8/Nhp2 IPR004037 Ribosomal_L7Ae_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01248 Ribosomal_L7Ae, 1 hit
PRINTSⁱ	PR00881 L7ARS6FAMILY PR00882 RIBOSOMALL7A
SUPFAMⁱ	SSF55315 SSF55315, 1 hit
PROSITEⁱ	View protein in PROSITE PS01082 RIBOSOMAL_L7AE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P12970-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPKGKKAKGK KVAPAPAVVK KQEAKKVVNP LFEKRPKNFG IGQDIQPKRD 
        60         70         80         90        100
LTRFVKWPRY IRLQRQRAIL YKRLKVPPAI NQFTQALDRQ TATQLLKLAH 
       110        120        130        140        150
KYRPETKQEK KQRLLARAEK KAAGKGDVPT KRPPVLRAGV NTVTTLVENK 
       160        170        180        190        200
KAQLVVIAHD VDPIELVVFL PALCRKMGVP YCIIKGKARL GHLVHRKTCT 
       210        220        230        240        250
TVAFTQVNSE DKGALAKLVE AIRTNYNDRY DEIRRHWGGN VLGPKSVARI 
       260 
AKLEKAKAKE LATKLG

Length:266

Mass (Da):29,977

Last modified:January 23, 2007 - v2

Checksum:ⁱ54EF5F1CD3C519F6

GO

Sequence cautionⁱ

The sequence AAH16489 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14689 M14692 Genomic DNA Translation: AAA40152.1 AK019449 mRNA Translation: BAB31725.1 BC016489 mRNA Translation: AAH16489.1 Different initiation. BC080663 mRNA Translation: AAH80663.1 BC080669 mRNA Translation: AAH80669.1 BC080712 mRNA Translation: AAH80712.1 BC084678 mRNA Translation: AAH84678.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15815.1
PIRⁱ	A30241
NCBI Reference Sequences More...RefSeqⁱ	NP_038749.1, NM_013721.3
UniGeneⁱ	Mm.328601 Mm.398371

Genome annotation databases

Ensemblⁱ	ENSMUST00000102898; ENSMUSP00000099962; ENSMUSG00000062647
GeneIDⁱ	27176
KEGGⁱ	mmu:27176
UCSC genome browser More...UCSCⁱ	uc008iwf.1 mouse

Protein	Similar proteins		Species	Score	Length	Source
P12970	Rpl7a protein (Fragment)		MOUSE		270	UniRef100_P12970
60S ribosomal protein L7a		Daphnia magna		266
LOC100037086 protein		XENLA		266
MCG11348		MOUSE		266
LOC100037086 protein (Fragment)		XENLA		263
+1

Protein	Similar proteins		Species	Score	Length	Source
P12970	Rpl7a protein (Fragment)		MOUSE		270	UniRef90_P12970
60S ribosomal protein L7a		Daphnia magna		266
LOC100037086 protein		XENLA		266
Ribosomal protein L7a		FICAL		303
60S ribosomal protein L7a		Patagioenas fasciata monilis		290
+91

Protein	Similar proteins		Species	Score	Length	Source
P12970	60S ribosomal protein L7a		CHICK		266	UniRef50_P12970
60S ribosomal protein L7a		TAKRU		266
60S ribosomal protein L7a		ICTPU		266
60S ribosomal protein L7a		BOVIN		266
Rpl7a protein (Fragment)		MOUSE		270
+288

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14689 M14692 Genomic DNA Translation: AAA40152.1 AK019449 mRNA Translation: BAB31725.1 BC016489 mRNA Translation: AAH16489.1 Different initiation. BC080663 mRNA Translation: AAH80663.1 BC080669 mRNA Translation: AAH80669.1 BC080712 mRNA Translation: AAH80712.1 BC084678 mRNA Translation: AAH84678.1
CCDSⁱ	CCDS15815.1
PIRⁱ	A30241
RefSeqⁱ	NP_038749.1, NM_013721.3
UniGeneⁱ	Mm.328601 Mm.398371

3D structure databases

ProteinModelPortalⁱ	P12970
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	205125, 4 interactors
CORUMⁱ	P12970
IntActⁱ	P12970, 9 interactors
MINTⁱ	P12970
STRINGⁱ	10090.ENSMUSP00000135914

PTM databases

iPTMnetⁱ	P12970
PhosphoSitePlusⁱ	P12970
SwissPalmⁱ	P12970

Proteomic databases

EPDⁱ	P12970
PaxDbⁱ	P12970
PeptideAtlasⁱ	P12970
PRIDEⁱ	P12970

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000102898; ENSMUSP00000099962; ENSMUSG00000062647
GeneIDⁱ	27176
KEGGⁱ	mmu:27176
UCSCⁱ	uc008iwf.1 mouse

Organism-specific databases

CTDⁱ	6130
MGIⁱ	MGI:1353472 Rpl7a

Phylogenomic databases

eggNOGⁱ	KOG3166 Eukaryota COG1358 LUCA
GeneTreeⁱ	ENSGT00390000004753
HOVERGENⁱ	HBG002936
InParanoidⁱ	P12970
KOⁱ	K02936
OMAⁱ	KWPRYVR
OrthoDBⁱ	EOG091G0HPD
PhylomeDBⁱ	P12970
TreeFamⁱ	TF300788

Miscellaneous databases

ChiTaRSⁱ	Rpl7 mouse
Protein Ontology More...PROⁱ	PR:P12970
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000062647 Expressed in 21 organ(s), highest expression level in female gonad
CleanExⁱ	MM_RPL7A
ExpressionAtlasⁱ	P12970 baseline and differential
Genevisibleⁱ	P12970 MM

Family and domain databases

Gene3Dⁱ	3.30.1330.210, 1 hit
InterProⁱ	View protein in InterPro IPR029064 L30e-like IPR001921 Ribosomal_L7A/L8 IPR038524 Ribosomal_L7A/L8_sf IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45 IPR018492 Ribosomal_L7Ae/L8/Nhp2 IPR004037 Ribosomal_L7Ae_CS
Pfamⁱ	View protein in Pfam PF01248 Ribosomal_L7Ae, 1 hit
PRINTSⁱ	PR00881 L7ARS6FAMILY PR00882 RIBOSOMALL7A
SUPFAMⁱ	SSF55315 SSF55315, 1 hit
PROSITEⁱ	View protein in PROSITE PS01082 RIBOSOMAL_L7AE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RL7A_MOUSE
Accessionⁱ	P12970Primary (citable) accession number: P12970 Secondary accession number(s): Q91YM3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1989
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Ribosomal proteins
Ribosomal proteins families and list of entries
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P12970 (RL7A_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

60S ribosomal protein L7a

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ