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Protein

60S ribosomal protein L7a

Gene

Rpl7a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L7a
Alternative name(s):
Surfeit locus protein 3
Gene namesi
Name:Rpl7a
Synonyms:Surf-3, Surf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1353472 Rpl7a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001367481 – 26660S ribosomal protein L7aAdd BLAST266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki20Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki21Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei34N6-acetyllysineBy similarity1
Cross-linki48Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei97N6-acetyllysine; alternateBy similarity1
Cross-linki97Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki125Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei217N6-acetyllysineBy similarity1
Cross-linki245Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP12970
PaxDbiP12970
PeptideAtlasiP12970
PRIDEiP12970

PTM databases

iPTMnetiP12970
PhosphoSitePlusiP12970
SwissPalmiP12970

Expressioni

Gene expression databases

BgeeiENSMUSG00000062647 Expressed in 21 organ(s), highest expression level in female gonad
CleanExiMM_RPL7A
ExpressionAtlasiP12970 baseline and differential
GenevisibleiP12970 MM

Interactioni

Subunit structurei

Interacts with CRY1 (PubMed:19129230). Interacts with DICER1, AGO2, TARBP2, MOV10 and EIF6; they form a large RNA-induced silencing complex (RISC) (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi205125, 4 interactors
CORUMiP12970
IntActiP12970, 9 interactors
MINTiP12970
STRINGi10090.ENSMUSP00000135914

Structurei

3D structure databases

ProteinModelPortaliP12970
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3166 Eukaryota
COG1358 LUCA
GeneTreeiENSGT00390000004753
HOVERGENiHBG002936
InParanoidiP12970
KOiK02936
OMAiKWPRYVR
OrthoDBiEOG091G0HPD
PhylomeDBiP12970
TreeFamiTF300788

Family and domain databases

Gene3Di3.30.1330.210, 1 hit
InterProiView protein in InterPro
IPR029064 L30e-like
IPR001921 Ribosomal_L7A/L8
IPR038524 Ribosomal_L7A/L8_sf
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
IPR018492 Ribosomal_L7Ae/L8/Nhp2
IPR004037 Ribosomal_L7Ae_CS
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
PRINTSiPR00881 L7ARS6FAMILY
PR00882 RIBOSOMALL7A
SUPFAMiSSF55315 SSF55315, 1 hit
PROSITEiView protein in PROSITE
PS01082 RIBOSOMAL_L7AE, 1 hit

Sequencei

Sequence statusi: Complete.

P12970-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKGKKAKGK KVAPAPAVVK KQEAKKVVNP LFEKRPKNFG IGQDIQPKRD
60 70 80 90 100
LTRFVKWPRY IRLQRQRAIL YKRLKVPPAI NQFTQALDRQ TATQLLKLAH
110 120 130 140 150
KYRPETKQEK KQRLLARAEK KAAGKGDVPT KRPPVLRAGV NTVTTLVENK
160 170 180 190 200
KAQLVVIAHD VDPIELVVFL PALCRKMGVP YCIIKGKARL GHLVHRKTCT
210 220 230 240 250
TVAFTQVNSE DKGALAKLVE AIRTNYNDRY DEIRRHWGGN VLGPKSVARI
260
AKLEKAKAKE LATKLG
Length:266
Mass (Da):29,977
Last modified:January 23, 2007 - v2
Checksum:i54EF5F1CD3C519F6
GO

Sequence cautioni

The sequence AAH16489 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14689
, M21455, M21456, M21457, M21458, M21459, M21460, M14692 Genomic DNA Translation: AAA40152.1
AK019449 mRNA Translation: BAB31725.1
BC016489 mRNA Translation: AAH16489.1 Different initiation.
BC080663 mRNA Translation: AAH80663.1
BC080669 mRNA Translation: AAH80669.1
BC080712 mRNA Translation: AAH80712.1
BC084678 mRNA Translation: AAH84678.1
CCDSiCCDS15815.1
PIRiA30241
RefSeqiNP_038749.1, NM_013721.3
UniGeneiMm.328601
Mm.398371

Genome annotation databases

EnsembliENSMUST00000102898; ENSMUSP00000099962; ENSMUSG00000062647
GeneIDi27176
KEGGimmu:27176
UCSCiuc008iwf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14689
, M21455, M21456, M21457, M21458, M21459, M21460, M14692 Genomic DNA Translation: AAA40152.1
AK019449 mRNA Translation: BAB31725.1
BC016489 mRNA Translation: AAH16489.1 Different initiation.
BC080663 mRNA Translation: AAH80663.1
BC080669 mRNA Translation: AAH80669.1
BC080712 mRNA Translation: AAH80712.1
BC084678 mRNA Translation: AAH84678.1
CCDSiCCDS15815.1
PIRiA30241
RefSeqiNP_038749.1, NM_013721.3
UniGeneiMm.328601
Mm.398371

3D structure databases

ProteinModelPortaliP12970
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi205125, 4 interactors
CORUMiP12970
IntActiP12970, 9 interactors
MINTiP12970
STRINGi10090.ENSMUSP00000135914

PTM databases

iPTMnetiP12970
PhosphoSitePlusiP12970
SwissPalmiP12970

Proteomic databases

EPDiP12970
PaxDbiP12970
PeptideAtlasiP12970
PRIDEiP12970

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102898; ENSMUSP00000099962; ENSMUSG00000062647
GeneIDi27176
KEGGimmu:27176
UCSCiuc008iwf.1 mouse

Organism-specific databases

CTDi6130
MGIiMGI:1353472 Rpl7a

Phylogenomic databases

eggNOGiKOG3166 Eukaryota
COG1358 LUCA
GeneTreeiENSGT00390000004753
HOVERGENiHBG002936
InParanoidiP12970
KOiK02936
OMAiKWPRYVR
OrthoDBiEOG091G0HPD
PhylomeDBiP12970
TreeFamiTF300788

Miscellaneous databases

ChiTaRSiRpl7 mouse
PROiPR:P12970
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062647 Expressed in 21 organ(s), highest expression level in female gonad
CleanExiMM_RPL7A
ExpressionAtlasiP12970 baseline and differential
GenevisibleiP12970 MM

Family and domain databases

Gene3Di3.30.1330.210, 1 hit
InterProiView protein in InterPro
IPR029064 L30e-like
IPR001921 Ribosomal_L7A/L8
IPR038524 Ribosomal_L7A/L8_sf
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
IPR018492 Ribosomal_L7Ae/L8/Nhp2
IPR004037 Ribosomal_L7Ae_CS
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
PRINTSiPR00881 L7ARS6FAMILY
PR00882 RIBOSOMALL7A
SUPFAMiSSF55315 SSF55315, 1 hit
PROSITEiView protein in PROSITE
PS01082 RIBOSOMAL_L7AE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRL7A_MOUSE
AccessioniPrimary (citable) accession number: P12970
Secondary accession number(s): Q91YM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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