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UniProtKB - P12970 (RL7A_MOUSE)
Protein
60S ribosomal protein L7a
Gene
Rpl7a
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: GO_Central
- structural constituent of ribosome Source: MGI
GO - Biological processi
- maturation of LSU-rRNA Source: GO_Central
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
Reactomei | R-MMU-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-MMU-1799339, SRP-dependent cotranslational protein targeting to membrane R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-MMU-72689, Formation of a pool of free 40S subunits R-MMU-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-MMU-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-MMU-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: 60S ribosomal protein L7aAlternative name(s): Surfeit locus protein 3 |
Gene namesi | Name:Rpl7a Synonyms:Surf-3, Surf3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1353472, Rpl7a |
VEuPathDBi | HostDB:ENSMUSG00000062647 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
- cytosolic large ribosomal subunit Source: ComplexPortal
- cytosolic ribosome Source: MGI
Nucleus
- nucleolus Source: MGI
Other locations
- membrane Source: BHF-UCL
- polysomal ribosome Source: HGNC-UCL
- ribosome Source: MGI
- synapse Source: SynGO
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000136748 | 1 – 266 | 60S ribosomal protein L7aAdd BLAST | 266 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 11 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 20 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 21 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 34 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 48 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 97 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 97 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Cross-linki | 125 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 217 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 245 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity |
Keywords - PTMi
Acetylation, Isopeptide bond, Ubl conjugationProteomic databases
EPDi | P12970 |
jPOSTi | P12970 |
PaxDbi | P12970 |
PeptideAtlasi | P12970 |
PRIDEi | P12970 |
ProteomicsDBi | 299826 |
PTM databases
iPTMneti | P12970 |
PhosphoSitePlusi | P12970 |
SwissPalmi | P12970 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000062647, Expressed in epiblast (generic) and 72 other tissues |
ExpressionAtlasi | P12970, baseline and differential |
Genevisiblei | P12970, MM |
Interactioni
Subunit structurei
Interacts with CRY1 (PubMed:19129230).
Interacts with DICER1, AGO2, TARBP2, MOV10 and EIF6; they form a large RNA-induced silencing complex (RISC) (By similarity).
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 205125, 110 interactors |
ComplexPortali | CPX-5262, 60S cytosolic large ribosomal subunit |
CORUMi | P12970 |
IntActi | P12970, 5 interactors |
MINTi | P12970 |
STRINGi | 10090.ENSMUSP00000099962 |
Miscellaneous databases
RNActi | P12970, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the eukaryotic ribosomal protein eL8 family.Curated
Phylogenomic databases
eggNOGi | KOG3166, Eukaryota |
GeneTreei | ENSGT00940000153294 |
HOGENOMi | CLU_055193_0_1_1 |
InParanoidi | P12970 |
OMAi | RYVKWPK |
OrthoDBi | 1200503at2759 |
PhylomeDBi | P12970 |
TreeFami | TF300788 |
Family and domain databases
Gene3Di | 3.30.1330.30, 1 hit |
InterProi | View protein in InterPro IPR029064, L30e-like IPR001921, Ribosomal_L7A/L8 IPR004038, Ribosomal_L7Ae/L30e/S12e/Gad45 IPR018492, Ribosomal_L7Ae/L8/Nhp2 IPR004037, Ribosomal_L7Ae_CS |
Pfami | View protein in Pfam PF01248, Ribosomal_L7Ae, 1 hit |
PRINTSi | PR00881, L7ARS6FAMILY PR00882, RIBOSOMALL7A |
SUPFAMi | SSF55315, SSF55315, 1 hit |
PROSITEi | View protein in PROSITE PS01082, RIBOSOMAL_L7AE, 1 hit |
i Sequence
Sequence statusi: Complete.
P12970-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPKGKKAKGK KVAPAPAVVK KQEAKKVVNP LFEKRPKNFG IGQDIQPKRD
60 70 80 90 100
LTRFVKWPRY IRLQRQRAIL YKRLKVPPAI NQFTQALDRQ TATQLLKLAH
110 120 130 140 150
KYRPETKQEK KQRLLARAEK KAAGKGDVPT KRPPVLRAGV NTVTTLVENK
160 170 180 190 200
KAQLVVIAHD VDPIELVVFL PALCRKMGVP YCIIKGKARL GHLVHRKTCT
210 220 230 240 250
TVAFTQVNSE DKGALAKLVE AIRTNYNDRY DEIRRHWGGN VLGPKSVARI
260
AKLEKAKAKE LATKLG
Sequence cautioni
The sequence AAH16489 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14689 , M21455, M21456, M21457, M21458, M21459, M21460, M14692 Genomic DNA Translation: AAA40152.1 AK019449 mRNA Translation: BAB31725.1 BC016489 mRNA Translation: AAH16489.1 Different initiation. BC080663 mRNA Translation: AAH80663.1 BC080669 mRNA Translation: AAH80669.1 BC080712 mRNA Translation: AAH80712.1 BC084678 mRNA Translation: AAH84678.1 |
CCDSi | CCDS15815.1 |
PIRi | A30241 |
RefSeqi | NP_038749.1, NM_013721.3 |
Genome annotation databases
Ensembli | ENSMUST00000102898; ENSMUSP00000099962; ENSMUSG00000062647 |
GeneIDi | 27176 |
KEGGi | mmu:27176 |
UCSCi | uc008iwf.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14689 , M21455, M21456, M21457, M21458, M21459, M21460, M14692 Genomic DNA Translation: AAA40152.1 AK019449 mRNA Translation: BAB31725.1 BC016489 mRNA Translation: AAH16489.1 Different initiation. BC080663 mRNA Translation: AAH80663.1 BC080669 mRNA Translation: AAH80669.1 BC080712 mRNA Translation: AAH80712.1 BC084678 mRNA Translation: AAH84678.1 |
CCDSi | CCDS15815.1 |
PIRi | A30241 |
RefSeqi | NP_038749.1, NM_013721.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6SWA | electron microscopy | 3.10 | G | 1-266 | [»] | |
SMRi | P12970 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 205125, 110 interactors |
ComplexPortali | CPX-5262, 60S cytosolic large ribosomal subunit |
CORUMi | P12970 |
IntActi | P12970, 5 interactors |
MINTi | P12970 |
STRINGi | 10090.ENSMUSP00000099962 |
PTM databases
iPTMneti | P12970 |
PhosphoSitePlusi | P12970 |
SwissPalmi | P12970 |
Proteomic databases
EPDi | P12970 |
jPOSTi | P12970 |
PaxDbi | P12970 |
PeptideAtlasi | P12970 |
PRIDEi | P12970 |
ProteomicsDBi | 299826 |
Protocols and materials databases
Antibodypediai | 31830, 136 antibodies from 28 providers |
DNASUi | 27176 |
Genome annotation databases
Ensembli | ENSMUST00000102898; ENSMUSP00000099962; ENSMUSG00000062647 |
GeneIDi | 27176 |
KEGGi | mmu:27176 |
UCSCi | uc008iwf.1, mouse |
Organism-specific databases
CTDi | 6130 |
MGIi | MGI:1353472, Rpl7a |
VEuPathDBi | HostDB:ENSMUSG00000062647 |
Phylogenomic databases
eggNOGi | KOG3166, Eukaryota |
GeneTreei | ENSGT00940000153294 |
HOGENOMi | CLU_055193_0_1_1 |
InParanoidi | P12970 |
OMAi | RYVKWPK |
OrthoDBi | 1200503at2759 |
PhylomeDBi | P12970 |
TreeFami | TF300788 |
Enzyme and pathway databases
Reactomei | R-MMU-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-MMU-1799339, SRP-dependent cotranslational protein targeting to membrane R-MMU-6791226, Major pathway of rRNA processing in the nucleolus and cytosol R-MMU-72689, Formation of a pool of free 40S subunits R-MMU-72706, GTP hydrolysis and joining of the 60S ribosomal subunit R-MMU-975956, Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-MMU-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
BioGRID-ORCSi | 27176, 24 hits in 66 CRISPR screens |
ChiTaRSi | Rpl7a, mouse |
PROi | PR:P12970 |
RNActi | P12970, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000062647, Expressed in epiblast (generic) and 72 other tissues |
ExpressionAtlasi | P12970, baseline and differential |
Genevisiblei | P12970, MM |
Family and domain databases
Gene3Di | 3.30.1330.30, 1 hit |
InterProi | View protein in InterPro IPR029064, L30e-like IPR001921, Ribosomal_L7A/L8 IPR004038, Ribosomal_L7Ae/L30e/S12e/Gad45 IPR018492, Ribosomal_L7Ae/L8/Nhp2 IPR004037, Ribosomal_L7Ae_CS |
Pfami | View protein in Pfam PF01248, Ribosomal_L7Ae, 1 hit |
PRINTSi | PR00881, L7ARS6FAMILY PR00882, RIBOSOMALL7A |
SUPFAMi | SSF55315, SSF55315, 1 hit |
PROSITEi | View protein in PROSITE PS01082, RIBOSOMAL_L7AE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RL7A_MOUSE | |
Accessioni | P12970Primary (citable) accession number: P12970 Secondary accession number(s): Q91YM3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1989 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 188 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families