Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Islet amyloid polypeptide

Gene

Iapp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.By similarity

GO - Molecular functioni

  • hormone activity Source: RGD
  • identical protein binding Source: Ensembl

GO - Biological processi

  • amylin receptor signaling pathway Source: ARUK-UCL
  • eating behavior Source: RGD
  • glucose metabolic process Source: RGD
  • negative regulation of bone resorption Source: Ensembl
  • negative regulation of cell differentiation Source: Ensembl
  • positive regulation of cAMP metabolic process Source: ARUK-UCL
  • sensory perception of pain Source: Ensembl

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-418555 G alpha (s) signalling events
R-RNO-419812 Calcitonin-like ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Islet amyloid polypeptide
Alternative name(s):
Amylin
Diabetes-associated peptide
Short name:
DAP
Gene namesi
Name:Iapp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2854 Iapp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000000412124 – 35Add BLAST12
PeptideiPRO_000000412238 – 74Islet amyloid polypeptideAdd BLAST37
PropeptideiPRO_000000412378 – 93Add BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 441 Publication
Modified residuei74Tyrosine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP12969
PRIDEiP12969

Expressioni

Tissue specificityi

Abundant in the islets of Langerhans but is not present in the brain or seven other tissues examined.

Gene expression databases

BgeeiENSRNOG00000012417
GenevisibleiP12969 RN

Interactioni

Subunit structurei

Interacts with IDE and INS.By similarity

GO - Molecular functioni

  • hormone activity Source: RGD
  • identical protein binding Source: Ensembl

Protein-protein interaction databases

BioGridi246637, 1 interactor
STRINGi10116.ENSRNOP00000016614

Structurei

Secondary structure

193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi42 – 54Combined sources13
Helixi57 – 60Combined sources4

3D structure databases

SMRiP12969
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP12969

Family & Domainsi

Domaini

The mature protein is largely unstructured in the absence of a cognate ligand, but contrary to the human protein, it does not easily form fibrillar aggregates.1 Publication

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0NB Eukaryota
ENOG410Z7V7 LUCA
GeneTreeiENSGT00510000048671
HOGENOMiHOG000038203
HOVERGENiHBG096065
InParanoidiP12969
KOiK08039
OMAiSHQMEKR
OrthoDBiEOG091G15QG
PhylomeDBiP12969
TreeFamiTF330783

Family and domain databases

InterProiView protein in InterPro
IPR021117 Calcitonin-like
IPR021116 Calcitonin/adrenomedullin
IPR018360 Calcitonin_CS
IPR001693 Calcitonin_peptide-like
IPR000443 Pro-islet_amyloid_polypep
PANTHERiPTHR10505 PTHR10505, 1 hit
PTHR10505:SF4 PTHR10505:SF4, 1 hit
PfamiView protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit
PRINTSiPR00818 ISLETAMYLOID
SMARTiView protein in SMART
SM00113 CALCITONIN, 1 hit
PROSITEiView protein in PROSITE
PS00258 CALCITONIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12969-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCISRLPAV LLILSVALGH LRATPVGSGT NPQVDKRKCN TATCATQRLA
60 70 80 90
NFLVRSSNNL GPVLPPTNVG SNTYGKRNVA EDPNRESLDF LLL
Length:93
Mass (Da):10,015
Last modified:October 1, 1989 - v1
Checksum:i5A76C92E624DA962
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25390 mRNA Translation: AAA41359.1
J04544 mRNA Translation: AAA40730.1
X52820, X52821 Genomic DNA Translation: CAA37003.1
PIRiS13566 TCRTIA
RefSeqiNP_036718.1, NM_012586.2
XP_006237676.1, XM_006237614.3
UniGeneiRn.11394

Genome annotation databases

EnsembliENSRNOT00000016614; ENSRNOP00000016614; ENSRNOG00000012417
GeneIDi24476
KEGGirno:24476
UCSCiRGD:2854 rat

Similar proteinsi

Entry informationi

Entry nameiIAPP_RAT
AccessioniPrimary (citable) accession number: P12969
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: July 18, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health