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Protein

Islet amyloid polypeptide

Gene

Iapp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.

GO - Molecular functioni

GO - Biological processi

  • amylin receptor signaling pathway Source: MGI
  • eating behavior Source: MGI
  • endocrine pancreas development Source: Reactome
  • negative regulation of bone resorption Source: MGI
  • negative regulation of cell differentiation Source: MGI
  • sensory perception of pain Source: MGI

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-419812 Calcitonin-like ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Islet amyloid polypeptide
Alternative name(s):
Amylin
Diabetes-associated peptide
Short name:
DAP
Gene namesi
Name:Iapp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:96382 Iapp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Amyloid, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000000411224 – 35Add BLAST12
PeptideiPRO_000000411338 – 74Islet amyloid polypeptideAdd BLAST37
PropeptideiPRO_000000411478 – 93Add BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 44By similarity
Modified residuei74Tyrosine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP12968
PRIDEiP12968

PTM databases

iPTMnetiP12968
PhosphoSitePlusiP12968

Expressioni

Gene expression databases

BgeeiENSMUSG00000041681
CleanExiMM_IAPP
GenevisibleiP12968 MM

Interactioni

Subunit structurei

Interacts with IDE and INS.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043956

Structurei

3D structure databases

ProteinModelPortaliP12968
SMRiP12968
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The mature protein is largely unstructured in the absence of a cognate ligand, but contrary to the human protein, it does not easily form fibrillar aggregates.

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0NB Eukaryota
ENOG410Z7V7 LUCA
GeneTreeiENSGT00510000048671
HOGENOMiHOG000038203
HOVERGENiHBG096065
InParanoidiP12968
KOiK08039
OMAiSHQMEKR
OrthoDBiEOG091G15QG
PhylomeDBiP12968
TreeFamiTF330783

Family and domain databases

InterProiView protein in InterPro
IPR021117 Calcitonin-like
IPR021116 Calcitonin/adrenomedullin
IPR018360 Calcitonin_CS
IPR001693 Calcitonin_peptide-like
IPR000443 Pro-islet_amyloid_polypep
PANTHERiPTHR10505 PTHR10505, 2 hits
PTHR10505:SF4 PTHR10505:SF4, 2 hits
PfamiView protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit
PRINTSiPR00818 ISLETAMYLOID
SMARTiView protein in SMART
SM00113 CALCITONIN, 1 hit
PROSITEiView protein in PROSITE
PS00258 CALCITONIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12968-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMCISKLPAV LLILSVALNH LRATPVRSGS NPQMDKRKCN TATCATQRLA
60 70 80 90
NFLVRSSNNL GPVLPPTNVG SNTYGKRNAA GDPNRESLDF LLV
Length:93
Mass (Da):10,022
Last modified:October 1, 1989 - v1
Checksum:iB135DBBC81475B15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25389 mRNA Translation: AAA37874.1
D31820 Genomic DNA Translation: BAA22051.1
BC027527 mRNA Translation: AAH27527.1
CCDSiCCDS39694.1
PIRiC33542
RefSeqiNP_034621.1, NM_010491.2
UniGeneiMm.415

Genome annotation databases

EnsembliENSMUST00000041993; ENSMUSP00000043956; ENSMUSG00000041681
GeneIDi15874
KEGGimmu:15874
UCSCiuc009epb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiIAPP_MOUSE
AccessioniPrimary (citable) accession number: P12968
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1989
Last sequence update: October 1, 1989
Last modified: June 20, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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