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Protein

Contactin-1

Gene

Cntn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.3 Publications

Miscellaneous

F3 shares with L1, N-CAM, MAG, and other cell adhesion molecules from nervous tissue the L2/HNK-1 carbohydrate epitope.

GO - Molecular functioni

  • carbohydrate binding Source: MGI

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • cerebellum development Source: MGI
  • neuron projection development Source: MGI
  • Notch signaling pathway Source: UniProtKB-KW
  • positive regulation of gene expression Source: MGI
  • positive regulation of neuron projection development Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of sodium ion transport Source: MGI

Keywordsi

Biological processCell adhesion, Notch signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-1
Alternative name(s):
Neural cell surface protein F3
Gene namesi
Name:Cntn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:105980 Cntn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001468721 – 1001Contactin-1Add BLAST981
PropeptideiPRO_00000146881002 – 1020Removed in mature formAdd BLAST19

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi65 ↔ 114PROSITE-ProRule annotation
Disulfide bondi158 ↔ 211PROSITE-ProRule annotation
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi263 ↔ 310PROSITE-ProRule annotation
Glycosylationi338N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi352 ↔ 391PROSITE-ProRule annotation
Disulfide bondi436 ↔ 484PROSITE-ProRule annotation
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi473N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi494N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi521N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi526 ↔ 585PROSITE-ProRule annotation
Glycosylationi593N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi935N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi1001GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

MaxQBiP12960
PaxDbiP12960
PeptideAtlasiP12960
PRIDEiP12960

PTM databases

iPTMnetiP12960
PhosphoSitePlusiP12960
SwissPalmiP12960

Expressioni

Gene expression databases

BgeeiENSMUSG00000055022
CleanExiMM_CNTN1
GenevisibleiP12960 MM

Interactioni

Subunit structurei

Monomer. Interacts with CNTNAP1 in cis form (By similarity). Binds to the carbonic-anhydrase like domain of PTPRZ1 (PubMed:20133774). Interacts with NOTCH1 and TNR (PubMed:7678967, PubMed:14567914). Detected in a complex with NRCAM and PTPRB (PubMed:11564762).By similarity3 Publications

Protein-protein interaction databases

BioGridi198797, 5 interactors
IntActiP12960, 10 interactors
MINTiP12960
STRINGi10090.ENSMUSP00000000109

Structurei

3D structure databases

ProteinModelPortaliP12960
SMRiP12960
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 131Ig-like C2-type 1Add BLAST91
Domaini137 – 223Ig-like C2-type 2Add BLAST87
Domaini241 – 326Ig-like C2-type 3Add BLAST86
Domaini331 – 407Ig-like C2-type 4Add BLAST77
Domaini413 – 500Ig-like C2-type 5Add BLAST88
Domaini504 – 603Ig-like C2-type 6Add BLAST100
Domaini608 – 706Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini711 – 808Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini813 – 908Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini909 – 1002Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi604 – 611Gly/Pro-rich8

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513 Eukaryota
ENOG410XSVG LUCA
GeneTreeiENSGT00760000118840
HOGENOMiHOG000059617
HOVERGENiHBG051047
InParanoidiP12960
KOiK06759
OMAiHYGNNFG
OrthoDBiEOG091G00X7
PhylomeDBiP12960
TreeFamiTF351103

Family and domain databases

CDDicd00063 FN3, 4 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR036992 Contactin-1
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013151 Immunoglobulin
PANTHERiPTHR43905:SF2 PTHR43905:SF2, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 3 hits
PF07679 I-set, 2 hits
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 4 hits
SM00409 IG, 6 hits
SM00408 IGc2, 5 hits
SUPFAMiSSF48726 SSF48726, 6 hits
SSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 4 hits
PS50835 IG_LIKE, 6 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P12960-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMPLLVSHL LLISLTSCLG DFTWHRRYGH GVSEEDKGFG PIFEEQPINT
60 70 80 90 100
IYPEESLEGK VSLNCRARAS PFPVYKWRMN NGDVDLTNDR YSMVGGNLVI
110 120 130 140 150
NNPDKQKDAG VYYCLASNNY GMVRSTEATL SFGYLDPFPP EERPEVKVKE
160 170 180 190 200
GKGMVLLCDP PYHFPDDLSY RWLLNEFPVF ITMDKRRFVS QTNGNLYIAN
210 220 230 240 250
VESSDRGNYS CFVSSPSITK SVFSKFIPLI PIPERTTKPY PADIVVQFKD
260 270 280 290 300
IYTMMGQNVT LECFALGNPV PDIRWRKVLE PMPSTAEIST SGAVLKIFNI
310 320 330 340 350
QLEDEGLYEC EAENIRGKDK HQARIYVQAF PEWVEHINDT EVDIGSDLYW
360 370 380 390 400
PCIATGKPIP TIRWLKNGYS YHKGELRLYD VTFENAGMYQ CIAENAYGSI
410 420 430 440 450
YANAELKILA LAPTFEMNPM KKKILAAKGG RVIIECKPKA APKPKFSWSK
460 470 480 490 500
GTEWLVNSSR ILIWEDGSLE INNITRNDGG IYTCFAENNR GKANSTGTLV
510 520 530 540 550
ITNPTRIILA PINADITVGE NATMQCAASF DPALDLTFVW SFNGYVIDFN
560 570 580 590 600
KEITHIHYQR NFMLDANGEL LIRNAQLKHA GRYTCTAQTI VDNSSASADL
610 620 630 640 650
VVRGPPGPPG GLRIEDIRAT SVALTWSRGS DNHSPISKYT IQTKTILSDD
660 670 680 690 700
WKDAKTDPPI IEGNMESAKA VDLIPWMEYE FRVVATNTLG TGEPSIPSNR
710 720 730 740 750
IKTDGAAPNV APSDVGGGGG TNRELTITWA PLSREYHYGN NFGYIVAFKP
760 770 780 790 800
FDGEEWKKVT VTNPDTGRYV HKDETMTPST AFQVKVKAFN NKGDGPYSLV
810 820 830 840 850
AVINSAQDAP SEAPTEVGVK VLSSSEISVH WKHVLEKIVE SYQIRYWAGH
860 870 880 890 900
DKEAAAHRVQ VTSQEYSARL ENLLPDTQYF IEVGACNSAG CGPSSDVIET
910 920 930 940 950
FTRKAPPSQP PRIISSVRSG SRYIITWDHV VALSNESTVT GYKILYRPDG
960 970 980 990 1000
QHDGKLFSTH KHSIEVPIPR DGEYVVEVRA HSDGGDGVVS QVKISGVSTL
1010 1020
SSSLLSLLLP SLGFLVYSEF
Length:1,020
Mass (Da):113,388
Last modified:January 1, 1990 - v1
Checksum:i9DCDAA40EAA4CBC7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti433I → V in AAH66864 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14943 mRNA Translation: CAA33075.1
BC066864 mRNA Translation: AAH66864.1
AK045710 mRNA Translation: BAC32466.1
AK076273 mRNA Translation: BAC36282.1
CCDSiCCDS27763.1
PIRiS05944
RefSeqiNP_001153119.1, NM_001159647.1
NP_001153120.1, NM_001159648.1
NP_031753.1, NM_007727.2
XP_017171911.1, XM_017316422.1
UniGeneiMm.470343
Mm.4911

Genome annotation databases

EnsembliENSMUST00000000109; ENSMUSP00000000109; ENSMUSG00000055022
ENSMUST00000068378; ENSMUSP00000067842; ENSMUSG00000055022
ENSMUST00000169825; ENSMUSP00000133063; ENSMUSG00000055022
GeneIDi12805
KEGGimmu:12805
UCSCiuc007xik.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCNTN1_MOUSE
AccessioniPrimary (citable) accession number: P12960
Secondary accession number(s): Q6NXV7, Q8BR42, Q8C6A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1990
Last sequence update: January 1, 1990
Last modified: July 18, 2018
This is version 184 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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